Substrates for peptidase M14.012: metallocarboxypeptidase Z
Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.
| Substrate | Uniprot | Residue range | Cleavage Site | Cleavage type | Evidence | P4 | P3 | P2 | P1 | P1' | P2' | P3' | P4' | Reference | CutDB | MERNUM |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 10 kDa heat shock protein, mitochondrial | P61604 | 48-66 | Ala-Val-Gly-Ser-Gly-Ser-Lys-Gly-Lys-Gly-Gly-Glu-Ile-Gln-Pro-Val-Ser-Val+Lys | N | Pro | Val | Ser | Val | Lys | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| Dns-Phe-Ala-Arg | Dns-Phe-Ala+Arg | S | - | Dns | Phe | Ala | Arg | - | - | - | Fricker, 2004 | |||||
| Dns-Phe-Gly-Arg | Dns-Phe-Gly+Arg | S | - | Dns | Phe | Gly | Arg | - | - | - | Fricker, 2004 | |||||
| Dns-Phe-Phe-Arg | Dns-Phe-Phe+Arg | S | - | Dns | Phe | Phe | Arg | - | - | - | Fricker, 2004 | |||||
| eukaryotic translation initiation factor 5A-1 | P63241 | 139-154 | Ser-Ala-Met-Thr-Glu-Glu-Ala-Ala-Val-Ala-Ile-Lys-Ala-Met-Ala+Lys | N | Lys | Ala | Met | Ala | Lys | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| eukaryotic translation initiation factor 5A-1 | P63241 | 78-86 | Asn-Met-Asp-Val-Pro-Asn-Ile-Lys+Arg | N | Pro | Asn | Ile | Lys | Arg | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| histidine triad nucleotide-binding protein 1 | P49773 | 2-12 | Ala-Asp-Glu-Ile-Ala-Lys-Ala-Gln-Val-Ala+Arg | N | Ala | Gln | Val | Ala | Arg | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| jupiter microtubule associated homolog 1 | Q9UK76 | 2-19 | Thr-Thr-Thr-Thr-Thr-Phe-Lys-Gly-Val-Asp-Pro-Asn-Ser-Arg-Asn-Ser-Ser+Arg | N | Arg | Asn | Ser | Ser | Arg | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| nucleophosmin | P06748 | 232-250 | Glu-Lys-Thr-Pro-Lys-Thr-Pro-Lys-Gly-Pro-Ser-Ser-Val-Glu-Asp-Ile-Lys-Ala+Lys | N | Asp | Ile | Lys | Ala | Lys | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| peptidyl-prolyl cis-trans isomerase A | P62937 | 26-37 | Ala-Asp-Lys-Val-Pro-Lys-Thr-Ala-Glu-Asn-Phe+Arg | N | Ala | Glu | Asn | Phe | Arg | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| peptidyl-prolyl cis-trans isomerase FKBP1A | P62942 | 99-106 | Val-Phe-Asp-Val-Glu-Leu-Leu+Lys | N | Val | Glu | Leu | Leu | Lys | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| Protein Wnt-4 | P56705 | 23-351 | peptide-Cys350+Arg | N | Leu | His | Thr | Cys | Arg | - | - | - | Wang et al., 2009 | |||
| ubiquitin-60S ribosomal protein L40 | P62987 | 77-83 | Ile-Ile-Glu-Pro-Ser-Leu+Arg | N | Glu | Pro | Ser | Leu | Arg | '-' | '-' | '-' | Garcia-Pardo et al., 2020 | |||
| vimentin | P08670 | 133-145 | Ala-Glu-Leu-Glu-Gln-Leu-Lys-Gly-Gln-Gly-Lys-Ser+Arg | N | Gln | Gly | Lys | Ser | Arg | '-' | '-' | '-' | Garcia-Pardo et al., 2020 |
