$VAR1 = undef;

Summary for peptidase M13.091: PHEX peptidase

Names
MEROPS Name	PHEX peptidase
Other names	Per g.p. (Mus musculus), PEX [obs.] g.p. (Homo sapiens), PHEX g.p. (Homo sapiens), phosphate-regulating gene with homologies to endopeptidase on the X chromosome

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(E) >> Family M13 >> Subfamily (none) >> M13.091
Holotype	PHEX peptidase (Homo sapiens), Uniprot accession P78562 (peptidase unit: 49-749), MERNUM MER0002062
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Metallo
Peplist	Included in the Peplist with identifier PL00205
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (1 cleavage)
Activity status	human: active (Boileau, 2004) mouse: active (Guo et al., 2001)
Knockout	Mutations in the gene lead to X-linked hypophosphatemic rickets in humans and other mammals (Sabbagh et al., 2000).
Other databases	TREEFAM	http://www.treefam.org/family/TF315192
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	s/-/s/sDE/s/-/d (based on 54 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	1	3	0	1	0	1	1	5
Pro	4	1	3	2	0	0	2	0
Ala	0	6	2	0	0	2	1	4
Val	2	2	1	3	0	2	5	3
Leu	0	4	3	3	0	5	2	1
Ile	1	1	0	1	0	1	1	1
Met	3	1	1	2	0	1	1	0
Phe	2	1	1	0	0	5	0	0
Tyr	0	0	1	2	0	1	1	1
Trp	0	0	1	1	0	1	0	0
Ser	13	3	16	17	0	16	12	4
Thr	0	0	2	3	0	4	1	4
Cys	0	0	0	0	0	0	0	0
Asn	4	1	1	0	0	0	5	1
Gln	1	2	2	2	0	1	2	5
Asp	7	12	6	9	39	4	5	13
Glu	2	4	6	4	15	7	4	4
Lys	3	3	0	1	0	1	0	2
Arg	1	2	3	1	0	0	5	0
His	4	8	5	2	0	2	5	3