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Literature for peptidase M12.301: procollagen I N-peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Aymaz,E.M., Alper,M., Kalfa,Y. and Kockar,F.<br>TNF-alpha orchestrates ADAM metallopeptidase with thrombospondin type 1 motif 2 upregulation and extracellular matrix remodeling through multimodal signaling in osteosarcoma cells<br>Mol Biol Rep (2026) 53, 342-342. PubMed  Europe PubMed DOI
    2. 2025
  2. Joannes,L., Dupont,L., Stock,L., Arpigny,E., Hubert,P., Ancion,M., Luyckx,M., Abinet,J., Peng,W., Calaldo,D., Noel,A., Marichal,T., Herfs,M., Deroanne,C. and Colige,A.<br>The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system<br>Cancer Cell Int (2025) 25, 229-229. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Long,D., Zhan,J., Tu,C., Yu,S., Rao,J., Luo,Q., Huang,Z. and Li,J.<br>Analysis of expression and its clinical significance of the ADAMTS-2 in systemic lupus erythematosus<br>Clin Rheumatol (2025) PubMed  Europe PubMed DOI
    4. 2024
  4. Carter,E.P., Yoneten,K.K., Gavara,N., Tyler,E.J., Gauthier,V., Murray,E.R., ten Dijke,P., Cameron,A.J., Pearce,O. and Grose,R.P.<br>Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function<br>J Pathol (2024) 262, 90-104. PubMed  Europe PubMed DOI
    5. 2023
  5. Altuntas,C., Alper,M., Keles,Y., Sav,F.N. and Kockar,F.<br>Hypoxic regulation of ADAMTS-2 and -3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1alpha in endothelial cells<br>Mol Cell Biochem (2023) 478, 1151-1160. PubMed  Europe PubMed DOI
  6. Simon,R., Kiener,S., Thom,N., Schafer,L., Muller,J., Schlohsarczyk,E.K., Gartner,U., Herden,C., Leeb,T. and Luhken,G.<br>Identification of an ADAMTS2 frameshift variant in a cat family with Ehlers-Danlos syndrome<br>G3 (Bethesda) (2023) 13 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Dupont,L., Joannes,L., Morfoisse,F., Blacher,S., Monseur,C., Deroanne,C.F., Noel,A. and Colige,A.C.<br>ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis<br>JCI Insight (2022) 7, e151509-e151509. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Yao,S., Zhou,X., Vona,B., Fan,L., Zhang,C., Li,D., Yuan,H., Du,Y., Ma,L. and Pan,Y.<br>Skeletal Class III Malocclusion Is Associated with ADAMTS2 Variants and Reduced Expression in a Familial Case<br>Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Zhang,Y., Li,J., Ji,Y., Cheng,Y. and Fu,X.<br>Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft palate dysplasia<br>Hum Mutat (2022) 43, 2102-2115. PubMed  Europe PubMed DOI
    10. 2019
  10. Yamakage,Y., Kato,M., Hongo,A., Ogino,H., Ishii,K., Ishizuka,T., Kamei,T., Tsuiji,H., Miyamoto,T., Oishi,H., Kohno,T. and Hattori,M.<br>A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum<br>Mol Cell Neurosci (2019) 100, 103401-103401. PubMed  Europe PubMed DOI
    11. 2015
  11. Bekhouche,M. and Colige,A.<br>The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology<br>Matrix Biol (2015) 44-46C, 46-53. PubMed  Europe PubMed DOI
  12. Dubail,J. and Apte,S.S.<br>Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics<br>Matrix Biol (2015) 44-46, 24-37. PubMed  Europe PubMed DOI
    13. 2012
  13. Colige,A.<br>Procollagen N-endopeptidases<br>[ISSN:978-0-12-407744-7] (2012) 3, 1161-1166. DOI
    14. 2010
  14. Dubail,J., Kesteloot,F., Deroanne,C., Motte,P., Lambert,V., Rakic,J.M., Lapiere,C., Nusgens,B. and Colige,A.<br>ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity<br>Cell Mol Life Sci (2010) 67, 4213-4232. PubMed  Europe PubMed DOI
    15. 2007
  15. Kesteloot,F., Desmouliere,A., Leclercq,I., Thiry,M., Arrese,J.E., Prockop,D.J., Lapiere,C.M., Nusgens,B.V. and Colige,A.<br>ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice<br>Hepatology (2007) 46, 1620-1631. PubMed  Europe PubMed DOI  K
    16. 2006
  16. [YEAR:14-6-2006]Wang,W.M., Ge,G., Lim,N.H., Nagase,H. and Greenspan,D.S.<br>TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2<br>Biochem J (14-6-2006) 398, 515-519. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2005
  17. [YEAR:26-7-2005]Colige,A., Ruggiero,F., Vandenberghe,I., Dubail,J., Kesteloot,F., Van Beeumen,J., Beschin,A., Brys,L., Lapiere,C.M. and Nusgens,B.<br>Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V<br>J Biol Chem (26-7-2005) 280, 34397-34408. PubMed  Europe PubMed DOI
    18. 2004
  18. Colige,A.<br>Procollagen III N-proteinase<br>[ISSN:0-12-079610-4] (2004) 2, 458-460.  V
  19. Colige,A.<br>Procollagen N-endopeptidase, ADAMTS2<br>[ISSN:0-12-079610-4] (2004) 2, 737-740.  V
    20. 2003
  20. [YEAR:23-5-2003]Wang,W.M., Lee,S., Steiglitz,B.M., Scott,I.C., Lebares,C.C., Allen,M.L., Brenner,M.C., Takahara,K. and Greenspan,D.S.<br>Transforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase<br>J Biol Chem (23-5-2003) 278, 19549-19557. PubMed  Europe PubMed DOI
    21. 2001
  21. [YEAR:15-4-2001]Li,S.W., Arita,M., Fertala,A., Bao,Y.H., Kopen,G.C., Langsjo,T.K., Hyttinen,M.M., Helminen,H.J. and Prockop,D.J.<br>Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility<br>Biochem J (15-4-2001) 355, 271-278. PubMed  Europe PubMed DOI  PMC  EPMC  K
    22. 1999
  22. Colige,A., Sieron,A.L., Li,S.W., Schwarze,U., Petty,E., Wertelecki,W., Wilcox,W., Krakow,D., Cohn,D.H., Reardon,W., Byers,P.H., Lapiere,C.M., Prockop,D.J. and Nusgens,B.V.<br>Human Ehlers-Danlos syndrome type VIIC and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene<br>Am J Hum Genet (1999) 65, 308-317. PubMed  Europe PubMed DOI  PMC  EPMC  K
  23. [YEAR:26-2-1999]Tang,B.L. and Hong,W.<br>ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats<br>FEBS Lett (26-2-1999) 445, 223-225. PubMed  Europe PubMed DOI
    24. 1998
  24. Prockop,D.J., Sieron,A.L. and Li,S.W.<br>Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling<br>Matrix Biol (1998) 16, 399-408. PubMed  Europe PubMed DOI
    25. 1997
  25. Colige,A., Li,S.W., Sieron,A.L., Nusgens,B.V., Prockop,D.J. and Lapiere,C.M.<br>cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components<br>Proc Natl Acad Sci U S A (1997) 94, 2374-2379. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 1995
  26. Colige,A., Beschin,A., Samyn,B., Goebels,Y., Van Beeumen,J., Nusgens,B.V. and Lapiere,C.M.<br>Characterization and partial amino acid sequencing of a 107-kDa procollagen I N-proteinase purified by affinity chromatography on immobilized type XIV collagen<br>J Biol Chem (1995) 270, 16724-16730. PubMed  Europe PubMed DOI
  27. Kadler,K.E., Lightfoot,S.J. and Watson,R.B.<br>Procollagen N-peptidases: procollagen N-proteinases<br>Methods Enzymol (1995) 248, 756-771. PubMed  Europe PubMed DOI  V
    28. 1994
  28. Hojima,Y., Behta,B., Romanic,A.M. and Prockop,D.J.<br>Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase<br>Matrix Biol (1994) 14, 113-120. PubMed  Europe PubMed
    29. 1992
  29. Nusgens,B.V., Verellen-Dumoulin,C., Hermanns-Le,T., De Paepe,A., Nuytinck,L., Pierard,G.E. and Lapiere,C.M.<br>Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis<br>Nat Genet (1992) 1, 214-217. PubMed  Europe PubMed DOI
    30. 1989
  30. Hojima,Y., McKenzie,J.A., van der Rest,M. and Prockop,D.J.<br>Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides<br>J Biol Chem (1989) 264, 11336-11345. PubMed  Europe PubMed
    31. 1986
  31. [YEAR:1-10-1986]Halila,R. and Peltonen,L.<br>Purification of human procollagen type III N-proteinase from placenta and preparation of antiserum<br>Biochem J (1-10-1986) 239, 47-52. PubMed  Europe PubMed  PMC  EPMC
    32. 1984
  32. [YEAR:13-3-1984]Halila,R. and Peltonen,L.<br>Neutral protease cleaving the N-terminal propeptide of type III procollagen: partial purification and characterization of the enzyme from smooth muscle cells of bovine aorta<br>Biochemistry (13-3-1984) 23, 1251-1256. PubMed  Europe PubMed
    33. 1979
  33. Leung,M.K., Fessler,L.I., Greenberg,D.B. and Fessler,J.H.<br>Separate amino and carboxyl procollagen peptidases in chick embryo tendon<br>J Biol Chem (1979) 254, 224-232. PubMed  Europe PubMed
    34. 1974
  34. Kohn,L.D., Isersky,C., Zupnik,J., Lenaers,A., Lee,G. and Lapiere,C.M.<br>Calf tendon procollagen peptidase: its purification and endopeptidase mode of action<br>Proc Natl Acad Sci U S A (1974) 71, 40-44. PubMed  Europe PubMed  PMC  EPMC

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