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Literature for peptidase M12.301: procollagen I N-peptidase

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Aymaz,E.M., Alper,M., Kalfa,Y. and Kockar,F.
    TNF-alpha orchestrates ADAM metallopeptidase with thrombospondin type 1 motif 2 upregulation and extracellular matrix remodeling through multimodal signaling in osteosarcoma cells
    Mol Biol Rep (2026) 53, 342-342. PubMed  Europe PubMed DOI
    2. 2025
  2. Joannes,L., Dupont,L., Stock,L., Arpigny,E., Hubert,P., Ancion,M., Luyckx,M., Abinet,J., Peng,W., Calaldo,D., Noel,A., Marichal,T., Herfs,M., Deroanne,C. and Colige,A.
    The ADAMTS2 metalloproteinase inhibits tumor growth by regulating the innate immune system
    Cancer Cell Int (2025) 25, 229-229. PubMed  Europe PubMed DOI  PMC  EPMC
  3. Long,D., Zhan,J., Tu,C., Yu,S., Rao,J., Luo,Q., Huang,Z. and Li,J.
    Analysis of expression and its clinical significance of the ADAMTS-2 in systemic lupus erythematosus
    Clin Rheumatol (2025) PubMed  Europe PubMed DOI
    4. 2024
  4. Carter,E.P., Yoneten,K.K., Gavara,N., Tyler,E.J., Gauthier,V., Murray,E.R., ten Dijke,P., Cameron,A.J., Pearce,O. and Grose,R.P.
    Opposing roles for ADAMTS2 and ADAMTS14 in myofibroblast differentiation and function
    J Pathol (2024) 262, 90-104. PubMed  Europe PubMed DOI
    5. 2023
  5. Altuntas,C., Alper,M., Keles,Y., Sav,F.N. and Kockar,F.
    Hypoxic regulation of ADAMTS-2 and -3 (a disintegrin and matrix metalloproteinase with thrombospondin motifs 2 and 3) procollagen N proteinases by HIF-1alpha in endothelial cells
    Mol Cell Biochem (2023) 478, 1151-1160. PubMed  Europe PubMed DOI
  6. Simon,R., Kiener,S., Thom,N., Schafer,L., Muller,J., Schlohsarczyk,E.K., Gartner,U., Herden,C., Leeb,T. and Luhken,G.
    Identification of an ADAMTS2 frameshift variant in a cat family with Ehlers-Danlos syndrome
    G3 (Bethesda) (2023) 13 PubMed  Europe PubMed DOI  PMC  EPMC
    7. 2022
  7. Dupont,L., Joannes,L., Morfoisse,F., Blacher,S., Monseur,C., Deroanne,C.F., Noel,A. and Colige,A.C.
    ADAMTS2 and ADAMTS14 can substitute for ADAMTS3 in adults for pro-VEGFC activation and lymphatic homeostasis
    JCI Insight (2022) 7, e151509-e151509. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Yao,S., Zhou,X., Vona,B., Fan,L., Zhang,C., Li,D., Yuan,H., Du,Y., Ma,L. and Pan,Y.
    Skeletal Class III Malocclusion Is Associated with ADAMTS2 Variants and Reduced Expression in a Familial Case
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
  9. Zhang,Y., Li,J., Ji,Y., Cheng,Y. and Fu,X.
    Mutations in the TBX15-ADAMTS2 pathway associate with a novel soft palate dysplasia
    Hum Mutat (2022) 43, 2102-2115. PubMed  Europe PubMed DOI
    10. 2019
  10. Yamakage,Y., Kato,M., Hongo,A., Ogino,H., Ishii,K., Ishizuka,T., Kamei,T., Tsuiji,H., Miyamoto,T., Oishi,H., Kohno,T. and Hattori,M.
    A disintegrin and metalloproteinase with thrombospondin motifs 2 cleaves and inactivates reelin in the postnatal cerebral cortex and hippocampus, but not in the cerebellum
    Mol Cell Neurosci (2019) 100, 103401-103401. PubMed  Europe PubMed DOI
    11. 2015
  11. Bekhouche,M. and Colige,A.
    The procollagen N-proteinases ADAMTS2, 3 and 14 in pathophysiology
    Matrix Biol (2015) 44-46C, 46-53. PubMed  Europe PubMed DOI
  12. Dubail,J. and Apte,S.S.
    Insights on ADAMTS proteases and ADAMTS-like proteins from mammalian genetics
    Matrix Biol (2015) 44-46, 24-37. PubMed  Europe PubMed DOI
    13. 2012
  13. Colige,A.
    Procollagen N-endopeptidases
    [ISSN:978-0-12-407744-7] (2012) 3, 1161-1166. DOI
    14. 2010
  14. Dubail,J., Kesteloot,F., Deroanne,C., Motte,P., Lambert,V., Rakic,J.M., Lapiere,C., Nusgens,B. and Colige,A.
    ADAMTS-2 functions as anti-angiogenic and anti-tumoral molecule independently of its catalytic activity
    Cell Mol Life Sci (2010) 67, 4213-4232. PubMed  Europe PubMed DOI
    15. 2007
  15. Kesteloot,F., Desmouliere,A., Leclercq,I., Thiry,M., Arrese,J.E., Prockop,D.J., Lapiere,C.M., Nusgens,B.V. and Colige,A.
    ADAM metallopeptidase with thrombospondin type 1 motif 2 inactivation reduces the extent and stability of carbon tetrachloride-induced hepatic fibrosis in mice
    Hepatology (2007) 46, 1620-1631. PubMed  Europe PubMed DOI  K
    16. 2006
  16. [YEAR:14-6-2006]Wang,W.M., Ge,G., Lim,N.H., Nagase,H. and Greenspan,D.S.
    TIMP-3 inhibits the procollagen N-proteinase ADAMTS-2
    Biochem J (14-6-2006) 398, 515-519. PubMed  Europe PubMed DOI  PMC  EPMC
    17. 2005
  17. [YEAR:26-7-2005]Colige,A., Ruggiero,F., Vandenberghe,I., Dubail,J., Kesteloot,F., Van Beeumen,J., Beschin,A., Brys,L., Lapiere,C.M. and Nusgens,B.
    Domains and maturation processes that regulate the activity of ADAMTS-2, a metalloproteinase cleaving the aminopropeptide of fibrillar procollagens types I-III and V
    J Biol Chem (26-7-2005) 280, 34397-34408. PubMed  Europe PubMed DOI
    18. 2004
  18. Colige,A.
    Procollagen III N-proteinase
    [ISSN:0-12-079610-4] (2004) 2, 458-460.  V
  19. Colige,A.
    Procollagen N-endopeptidase, ADAMTS2
    [ISSN:0-12-079610-4] (2004) 2, 737-740.  V
    20. 2003
  20. [YEAR:23-5-2003]Wang,W.M., Lee,S., Steiglitz,B.M., Scott,I.C., Lebares,C.C., Allen,M.L., Brenner,M.C., Takahara,K. and Greenspan,D.S.
    Transforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase
    J Biol Chem (23-5-2003) 278, 19549-19557. PubMed  Europe PubMed DOI
    21. 2001
  21. [YEAR:15-4-2001]Li,S.W., Arita,M., Fertala,A., Bao,Y.H., Kopen,G.C., Langsjo,T.K., Hyttinen,M.M., Helminen,H.J. and Prockop,D.J.
    Transgenic mice with inactive alleles for procollagen N-proteinase (ADAMTS-2) develop fragile skin and male sterility
    Biochem J (15-4-2001) 355, 271-278. PubMed  Europe PubMed DOI  PMC  EPMC  K
    22. 1999
  22. Colige,A., Sieron,A.L., Li,S.W., Schwarze,U., Petty,E., Wertelecki,W., Wilcox,W., Krakow,D., Cohn,D.H., Reardon,W., Byers,P.H., Lapiere,C.M., Prockop,D.J. and Nusgens,B.V.
    Human Ehlers-Danlos syndrome type VIIC and bovine dermatosparaxis are caused by mutations in the procollagen I N-proteinase gene
    Am J Hum Genet (1999) 65, 308-317. PubMed  Europe PubMed DOI  PMC  EPMC  K
  23. [YEAR:26-2-1999]Tang,B.L. and Hong,W.
    ADAMTS: A novel family of proteases with an ADAM protease domain and thrombospondin 1 repeats
    FEBS Lett (26-2-1999) 445, 223-225. PubMed  Europe PubMed DOI
    24. 1998
  24. Prockop,D.J., Sieron,A.L. and Li,S.W.
    Procollagen N-proteinase and procollagen C-proteinase. Two unusual metalloproteinases that are essential for procollagen processing probably have important roles in development and cell signaling
    Matrix Biol (1998) 16, 399-408. PubMed  Europe PubMed DOI
    25. 1997
  25. Colige,A., Li,S.W., Sieron,A.L., Nusgens,B.V., Prockop,D.J. and Lapiere,C.M.
    cDNA cloning and expression of bovine procollagen I N-proteinase: a new member of the superfamily of zinc-metalloproteinases with binding sites for cells and other matrix components
    Proc Natl Acad Sci U S A (1997) 94, 2374-2379. PubMed  Europe PubMed DOI  PMC  EPMC
    26. 1995
  26. Colige,A., Beschin,A., Samyn,B., Goebels,Y., Van Beeumen,J., Nusgens,B.V. and Lapiere,C.M.
    Characterization and partial amino acid sequencing of a 107-kDa procollagen I N-proteinase purified by affinity chromatography on immobilized type XIV collagen
    J Biol Chem (1995) 270, 16724-16730. PubMed  Europe PubMed DOI
  27. Kadler,K.E., Lightfoot,S.J. and Watson,R.B.
    Procollagen N-peptidases: procollagen N-proteinases
    Methods Enzymol (1995) 248, 756-771. PubMed  Europe PubMed DOI  V
    28. 1994
  28. Hojima,Y., Behta,B., Romanic,A.M. and Prockop,D.J.
    Cadmium ions inhibit procollagen C-proteinase and cupric ions inhibit procollagen N-proteinase
    Matrix Biol (1994) 14, 113-120. PubMed  Europe PubMed
    29. 1992
  29. Nusgens,B.V., Verellen-Dumoulin,C., Hermanns-Le,T., De Paepe,A., Nuytinck,L., Pierard,G.E. and Lapiere,C.M.
    Evidence for a relationship between Ehlers-Danlos type VII C in humans and bovine dermatosparaxis
    Nat Genet (1992) 1, 214-217. PubMed  Europe PubMed DOI
    30. 1989
  30. Hojima,Y., McKenzie,J.A., van der Rest,M. and Prockop,D.J.
    Type I procollagen N-proteinase from chick embryo tendons. Purification of a new 500-kDa form of the enzyme and identification of the catalytically active polypeptides
    J Biol Chem (1989) 264, 11336-11345. PubMed  Europe PubMed
    31. 1986
  31. [YEAR:1-10-1986]Halila,R. and Peltonen,L.
    Purification of human procollagen type III N-proteinase from placenta and preparation of antiserum
    Biochem J (1-10-1986) 239, 47-52. PubMed  Europe PubMed  PMC  EPMC
    32. 1984
  32. [YEAR:13-3-1984]Halila,R. and Peltonen,L.
    Neutral protease cleaving the N-terminal propeptide of type III procollagen: partial purification and characterization of the enzyme from smooth muscle cells of bovine aorta
    Biochemistry (13-3-1984) 23, 1251-1256. PubMed  Europe PubMed
    33. 1979
  33. Leung,M.K., Fessler,L.I., Greenberg,D.B. and Fessler,J.H.
    Separate amino and carboxyl procollagen peptidases in chick embryo tendon
    J Biol Chem (1979) 254, 224-232. PubMed  Europe PubMed
    34. 1974
  34. Kohn,L.D., Isersky,C., Zupnik,J., Lenaers,A., Lee,G. and Lapiere,C.M.
    Calf tendon procollagen peptidase: its purification and endopeptidase mode of action
    Proc Natl Acad Sci U S A (1974) 71, 40-44. PubMed  Europe PubMed  PMC  EPMC

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