Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P29279

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site Peptidase Residue range Cleavage type Description Evidence Reference
26 unknown peptidase 1-349 P NT <%Agarwal et al., 2012[]%>
180 matrix metallopeptidase-2 27-349 P NT Dean et al., 2007
181 matrix metallopeptidase-3 27-349 P normal turnover Hashimoto et al., 2002
181 matrix metallopeptidase-7 27-349 P normal turnover Hashimoto et al., 2002
181 membrane-type matrix metallopeptidase-1 27-349 P Tam et al., 2004
181 ADAM28 peptidase (Homo sapiens-type) 27-349 P NT Mochizuki et al., 2004
183 matrix metallopeptidase-7 27-349 P normal turnover Hashimoto et al., 2002
183 matrix metallopeptidase-13 27-349 P normal turnover Hashimoto et al., 2002
191 ADAM28 peptidase (Homo sapiens-type) 27-349 P NT Mochizuki et al., 2004
194 matrix metallopeptidase-1 27-349 P normal turnover Hashimoto et al., 2002
194 matrix metallopeptidase-3 27-349 P normal turnover Hashimoto et al., 2002
194 matrix metallopeptidase-7 27-349 P normal turnover Hashimoto et al., 2002
194 matrix metallopeptidase-13 27-349 P normal turnover Hashimoto et al., 2002
199 matrix metallopeptidase-1 27-349 P normal turnover Hashimoto et al., 2002
199 matrix metallopeptidase-7 27-349 P normal turnover Hashimoto et al., 2002
199 matrix metallopeptidase-13 27-349 P normal turnover Hashimoto et al., 2002