$VAR1 = undef;

Summary for peptidase M12.214: ADAM19 peptidase

Names
MEROPS Name	ADAM19 peptidase
Other names	adamalysin-19, meltrin beta, metalloprotease and disintegrin dendritic antigen marker, MADDAM

Domain architecture

MEROPS Classification
Classification	Clan MA >> Subclan MA(M) >> Family M12 >> Subfamily B >> M12.214
Holotype	ADAM19 peptidase (Mus musculus), Uniprot accession O35674 (peptidase unit: 207-409), MERNUM MER0002459
History	Identifier created: MEROPS 3.03 (10 September 1998)

Activity
Catalytic type	Metallo
NC-IUBMB	Not yet included in IUBMB recommendations.
Proteolytic events	CutDB database (10 cleavages)
Activity status	human: active (Wei et al., 2001) mouse: active (Shirakabe et al. (2001))
Knockout	Mice deficient in ADAM19 endopeptidase show severe vascular defects (Zhou et al., 2004).
Other databases	TREEFAM	http://www.treefam.org/family/TF314733
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	glp/vpa/-/aS/s/l/- (based on 13 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	3	0	0	0	0	0	2	1
Pro	3	3	0	1	0	0	0	0
Ala	1	2	3	5	2	0	2	1
Val	0	5	1	0	0	0	0	2
Leu	3	1	2	1	1	0	4	0
Ile	0	0	0	0	0	0	0	0
Met	0	0	0	0	0	0	1	0
Phe	0	0	0	0	1	0	1	0
Tyr	0	1	0	0	0	1	0	0
Trp	0	0	0	0	0	0	0	0
Ser	0	1	2	2	8	6	1	1
Thr	0	0	0	0	0	1	0	1
Cys	0	0	0	0	0	0	0	0
Asn	0	0	0	0	0	1	0	0
Gln	1	0	2	0	1	1	0	1
Asp	1	0	0	0	0	0	0	1
Glu	0	0	1	1	0	0	0	0
Lys	0	0	1	1	0	1	1	0
Arg	1	0	1	2	0	1	1	4
His	0	0	0	0	0	1	0	1