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Literature for peptidase M12.138: jararhagin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Schluga,P.H.C., Larangote,D., de Melo,A.M., Lobermayer,G.K., Torrejon,D., de Oliveira,L.S., Alvarenga,V.G., Vivas-Ruiz,D.E., Veiga,S.S., Sanchez,E.F. and Gremski,L.H.
    A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via alpha5beta1 Integrin Receptors to Arginine-Glycine-Aspartic Acid (RGD)-Containing Molecules
    Toxins (Basel) (2024) 16 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Bastos,V.A., Gomes-Neto,F., Rocha,S.L.G., Teixeira-Ferreira,A., Perales,J., Neves-Ferreira,A.G.C. and Valente,R.H.
    The interaction between the natural metalloendopeptidase inhibitor BJ46a and its target toxin jararhagin analyzed by structural mass spectrometry and molecular modeling
    J Proteomics (2020) 221, 103761-103761. PubMed  Europe PubMed DOI
  3. Zychar,B.C., Clissa,P.B., Carvalho,E., Baldo,C. and Goncalves,L.R.C.
    Leukocyte recruitment induced by snake venom metalloproteinases: role of the catalytic domain
    Biochem Biophys Res Commun (2020) 521, 402-407. PubMed  Europe PubMed DOI
    4. 2018
  4. Ferreira,B.A., Deconte,S.R., de Moura,F.B.R., Tomiosso,T.C., Clissa,P.B., Andrade,S.P. and Araujo,F.A.
    Inflammation, angiogenesis and fibrogenesis are differentially modulated by distinct domains of the snake venom metalloproteinase jararhagin
    Int J Biol Macromol (2018) 119, 1179-1187. PubMed  Europe PubMed DOI
    5. 2015
  5. Baldo,C., Lopes,D.S., Faquim-Mauro,E.L., Jacysyn,J.F., Niland,S., Eble,J.A., Clissa,P.B. and Moura-da-Silva,A.M.
    Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices
    Toxicon (2015) 108, 240-248. PubMed  Europe PubMed DOI
  6. Freitas-de-Sousa,L.A., Amazonas,D.R., Sousa,L.F., Sant'Anna,S.S., Nishiyama,M.Y., Jr., Serrano,S.M., Junqueira-de-Azevedo,I.L., Chalkidis,H.M., Moura-da-Silva,A.M. and Mourao,R.H.
    Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species
    Biochimie (2015) 118, 60-70. PubMed  Europe PubMed DOI
    7. 2014
  7. Serrano,S.M.T., Oliveira,A.K., Menezes,M.C. and Zelanis,A.
    The proteinase-rich proteome of Bothrops jararaca venom
    Toxin Rev (2014) 33, 169-184. DOI  V
    8. 2012
  8. Moura-da-Silva,A.M. and Baldo,C.
    Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca
    Toxicon (2012) 60, 280-289. PubMed  Europe PubMed DOI  V
  9. Moura-da-Silva,A.M. and Paine,M.J.I.
    Jararhagin
    [ISSN:978-0-12-407744-7] (2012) 3, 987-990. DOI
    10. 2011
  10. Klein,A., Capitanio,J.S., Maria,D.A. and Ruiz,I.R.
    Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin
    Toxicon (2011) 57, 1-8. PubMed  Europe PubMed DOI  U
    11. 2010
  11. Baldo,C., Jamora,C., Yamanouye,N., Zorn,T.M. and Moura-da-Silva,A.M.
    Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis
    PLoS Negl Trop Dis (2010) 4, e727-e727. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Tanjoni,I., Evangelista,K., Della-Casa,M.S., Butera,D., Magalhaes,G.S., Baldo,C., Clissa,P.B., Fernandes,I., Eble,J. and Moura-da-Silva,A.M.
    Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to alpha2beta1 integrin and collagen
    Toxicon (2010) 55, 1093-1099. PubMed  Europe PubMed DOI
    13. 2008
  13. Costa,E.P., Del Debbio,C.B., Cintra,L.C., da Fontoura Costa,L., Hamassaki,D.E. and Santos,M.F.
    Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells
    Toxicon (2008) 52, 380-384. PubMed  Europe PubMed DOI
  14. Moura-da-Silva,A.M., Ramos,O.H., Baldo,C., Niland,S., Hansen,U., Ventura,J.S., Furlan,S., Butera,D., Della-Casa,M.S., Tanjoni,I., Clissa,P.B., Fernandes,I., Chudzinski-Tavassi,A.M. and Eble,J.A.
    Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases
    Biochimie (2008) 90, 484-492. PubMed  Europe PubMed DOI
    15. 2007
  15. Serrano,S.M., Wang,D., Shannon,J.D., Pinto,A.F., Polanowska-Grabowska,R.K. and Fox,J.W.
    Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation
    FEBS J (2007) 274, 3611-3621. PubMed  Europe PubMed DOI
    16. 2006
  16. Clissa,P.B., Lopes-Ferreira,M., Della-Casa,M.S., Farsky,S.H. and Moura-da-Silva,A.M.
    Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response
    Toxicon (2006) 47, 591-596. PubMed  Europe PubMed DOI
  17. [YEAR:6-10-2006]Escalante,T., Shannon,J., Moura-da-Silva,A.M., Gutierrez,J.M. and Fox,J.W.
    Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study
    Arch Biochem Biophys (6-10-2006) 455, 144-153. PubMed  Europe PubMed DOI
    18. 2005
  18. [YEAR:2-8-2005]Gallagher,P., Bao,Y., Serrano,S.M., Laing,G.D., Theakston,R.D., Gutierrez,J.M., Escalante,T., Zigrino,P., Moura-da-Silva,A.M., Nischt,R., Mauch,C., Moskaluk,C. and Fox,J.W.
    Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin
    Arch Biochem Biophys (2-8-2005) 441, 1-15. PubMed  Europe PubMed DOI
  19. Laing,G.D. and Moura-da-Silva,A.M.
    Jararhagin and its multiple effects on hemostasis
    Toxicon (2005) 45, 987-996. PubMed  Europe PubMed DOI
  20. Tanjoni,I., Weinlich,R., Della-Casa,M.S., Clissa,P.B., Saldanha-Gama,R.F., de Freitas,M.S., Barja-Fidalgo,C., Amarante-Mendes,G.P. and Moura-da-Silva,A.M.
    Jararhagin, a snake venom metalloproteinase, induces a specialized form of apoptosis (anoikis) selective to endothelial cells
    Apoptosis (2005) 10, 851-861. PubMed  Europe PubMed DOI
    21. 2004
  21. [YEAR:15-12-2004]Costa,E.P. and Santos,M.F.
    Jararhagin, a snake venom metalloproteinase-disintegrin, stimulates epithelial cell migration in an in vitro restitution model
    Toxicon (15-12-2004) 44, 861-870. PubMed  Europe PubMed DOI
  22. Garcia,L.T., Parreiras e Silva, Ramos,O.H., Carmona,A.K., Bersanetti,P.A. and Selistre-De-Araujo,H.S.
    The effect of post-translational modifications on the hemorrhagic activity of snake venom metalloproteinases
    Comp Biochem Physiol C Toxicol Pharmacol (2004) 138, 23-32. PubMed  Europe PubMed DOI  E
  23. Laing,G.D. and Paine,M.J.I.
    Jararhagin
    [ISSN:0-12-079610-4] (2004) 2, 654-656.  V
    24. 2003
  24. Laing,G.D., Clissa,P.B., Theakston,R.D., Moura-da-Silva,A.M. and Taylor,M.J.
    Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis
    Eur J Immunol (2003) 33, 3458-3463. PubMed  Europe PubMed DOI
  25. Maria,D.A., Vassao,R.C. and Ruiz,I.R.
    Haematopoietic effects induced in mice by the snake venom toxin jararhagin
    Toxicon (2003) 42, 579-585. PubMed  Europe PubMed DOI
  26. [YEAR:15-1-2003]Moura-da-Silva,A.M., Della-Casa,M.S., David,A.S., Assakura,M.T., Butera,D., Lebrun,I., Shannon,J.D., Serrano,S.M. and Fox,J.W.
    Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability
    Arch Biochem Biophys (15-1-2003) 409, 395-401. PubMed  Europe PubMed DOI
  27. Tanjoni,I., Butera,D., Bento,L., Della-Casa,M.S., Marques-Porto,R., Takehara,H.A., Gutierrez,J.M., Fernandes,I. and Moura-da-Silva,A.M.
    Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies
    Toxicon (2003) 42, 801-808. PubMed  Europe PubMed DOI
    28. 2002
  28. Anai,K., Sugiki,M., Yoshida,E. and Maruyama,M.
    Neutralization of a snake venom hemorrhagic metalloproteinase prevents coagulopathy after subcutaneous injection of Bothrops jararaca venom in rats
    Toxicon (2002) 40, 63-68. PubMed  Europe PubMed DOI
  29. Carneiro,S.M., Assakura,M.T., Barrence,F.A., Cardoso,S.R., de Martins Camargo,A.C. and Sesso,A.
    Immunolocalization of venom metalloproteases in venom glands of adult and of newborn snakes of Bothrops jararaca
    Tissue Cell (2002) 34, 381-389. PubMed  Europe PubMed DOI
  30. Kawano,J., Anai,K., Sugiki,M., Yoshida,E. and Maruyama,M.
    Vascular endothelial cell injury induced by Bothrops jararaca venom; non-significance of hemorrhagic metalloproteinase
    Toxicon (2002) 40, 1553-1562. PubMed  Europe PubMed DOI
  31. Maruyama,M., Sugiki,M., Anai,K. and Yoshida,E.
    N-terminal amino acid sequences and some characteristics of fibrinolytic/hemorrhagic metalloproteinases purified from Bothrops jararaca venom
    Toxicon (2002) 40, 1223-1226. PubMed  Europe PubMed DOI
  32. [YEAR:25-10-2002]Zigrino,P., Kamiguti,A.S., Eble,J., Drescher,C., Nischt,R., Fox,J.W. and Mauch,C.
    The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling
    J Biol Chem (25-10-2002) 277, 40528-40535. PubMed  Europe PubMed DOI
    33. 2001
  33. Clissa,P.B., Laing,G.D., Theakston,R.D.G., Mota,I., Taylor,M.J. and Moura-da-Silva,A.M.
    The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells
    Toxicon (2001) 39, 1567-1573. PubMed  Europe PubMed DOI
  34. [YEAR:15-4-2001]Moura-da-Silva,A.M., Marcinkiewicz,C., Marcinkiewicz,M. and Niewiarowski,S.
    Selective recognition of alpha2beta1 integrin by jararhagin, a metalloproteinase/disintegrin from Bothrops jararaca venom
    Thromb Res (15-4-2001) 102, 153-159. PubMed  Europe PubMed DOI
  35. Souza,D.H., Selistre-De-Araujo,H.S., Moura-da-Silva,A.M., Della-Casa,M.S., Oliva,G. and Garratt,R.C.
    Crystallization and preliminary X-ray analysis of jararhagin, a metalloproteinase/disintegrin from Bothrops jararaca snake venom
    Acta Crystallogr D Biol Crystallogr (2001) 57, 1135-1137. PubMed  Europe PubMed DOI
  36. Valente,R.H., Dragulev,B., Perales,J., Fox,J.W. and Domont,G.B.
    BJ46a, a snake venom metalloproteinase inhibitor. Isolation, characterization, cloning and insights into its mechanism of action
    Eur J Biochem (2001) 268, 3042-3052. PubMed  Europe PubMed DOI
    37. 2000
  37. Harrison,R.A., Moura-da-Silva,A.M., Laing,G.D., Wu,Y., Richards,A., Broadhead,A., Bianco,A.E. and Theakston,R.D.G.
    Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom
    Clin Exp Immunol (2000) 121, 358-363. PubMed  Europe PubMed DOI  PMC  EPMC
  38. [YEAR:1-5-2000]Neves-Ferreira,A.G., Cardinale,N., Rocha,S.L., Perales,J. and Domont,G.B.
    Isolation and characterization of DM40 and DM43, two snake venom metalloproteinase inhibitors from Didelphis marsupialis serum
    Biochim Biophys Acta (1-5-2000) 1474, 309-320. PubMed  Europe PubMed DOI
    39. 1998
  39. Anai,K., Sugiki,M., Yoshida,E. and Maruyama,M.
    Inhibition of a snake venom hemorrhagic metalloproteinase by human and rat alpha-macroglobulins
    Toxicon (1998) 36, 1127-1139. PubMed  Europe PubMed DOI
  40. Sugiki,M., Yoshida,E., Anai,K. and Maruyama,M.
    Activation of single-chain urokinase-type plasminogen activator by a hemorrhagic metalloproteinase, jararafibrase I, in Bothrops jararaca venom
    Toxicon (1998) 36, 993-1000. PubMed  Europe PubMed DOI
    41. 1997
  41. [YEAR:19-12-1997]Kamiguti,A.S., Markland,F.S., Zhou,Q., Laing,G.D., Theakston,R.D. and Zuzel,M.
    Proteolytic cleavage of the beta1 subunit of platelet alpha2beta1 integrin by the metalloproteinase jararhagin compromises collagen-stimulated phosphorylation of pp72(syk)
    J Biol Chem (19-12-1997) 272, 32599-32605. PubMed  Europe PubMed DOI
  42. Kamiguti,A.S., Moura-da-Silva,A.M., Laing,G.D., Knapp,T., Zuzel,M., Crampton,J.M. and Theakston,R.D.
    Collagen-induced secretion-dependent phase of platelet aggregation is inhibited by the snake venom metalloproteinase jararhagin
    Biochim Biophys Acta (1997) 1335, 209-217. PubMed  Europe PubMed DOI
    43. 1996
  43. Moura-da-Silva,A.M., Laing,G.D., Paine,M.J., Dennison,J.M., Politi,V., Crampton,J.M. and Theakston,R.D.
    Processing of pro-tumor necrosis factor-alpha by venom metalloproteinases: A hypothesis explaining local tissue damage following snake bite
    Eur J Immunol (1996) 26, 2000-2005. PubMed  Europe PubMed DOI  I
    44. 1995
  44. De Luca,M., Ward,C.M., Ohmori,K., Andrews,R.K. and Berndt,M.C.
    Jararhagin and jaracetin: novel snake venom inhibitors of the integrin collagen receptor, alpha 2 beta 1
    Biochem Biophys Res Commun (1995) 206, 570-576. PubMed  Europe PubMed DOI
  45. Sugiki,M., Maruyama,M., Yoshida,E., Mihara,H., Kamiguti,A.S. and Theakston,D.G.
    Enhancement of plasma fibrinolysis in vitro by jararhagin, the main haemorrhagic metalloproteinase in Bothrops jararaca venom
    Toxicon (1995) 33, 1605-1617. PubMed  Europe PubMed DOI
  46. Zhou,Q., Smith,J.B. and Grossman,M.H.
    Molecular cloning and expression of catrocollastatin, a snake-venom protein from Crotalus atrox (Western diamondback rattlesnake) which inhibits platelet adhesion to collagen
    Biochem J (1995) 307, 411-417. PubMed  Europe PubMed  PMC  EPMC
    47. 1994
  47. Kamiguti,A.S., Slupsky,J.R., Zuzel,M. and Hay,C.R.
    Properties of fibrinogen cleaved by jararhagin, a metalloproteinase from the venom of Bothrops jararaca
    Thromb Haemost (1994) 72, 244-249. PubMed  Europe PubMed
  48. Kamiguti,A.S., Desmond,H.P., Theakston,R.D., Hay,C.R. and Zuzel,M.
    Ineffectiveness of the inhibition of the main haemorrhagic metalloproteinase from Bothrops jararaca venom by its only plasma inhibitor, alpha2-macroglobulin
    Biochim Biophys Acta (1994) 1200, 307-314. PubMed  Europe PubMed DOI
  49. Usami,Y., Fujimura,Y., Miura,S., Shima,H., Yoshida,E., Yoshioka,A., Hirano,K., Suzuki,M. and Titani,K.
    A 28 kDa-protein with disintegrin-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation
    Biochem Biophys Res Commun (1994) 201, 331-339. PubMed  Europe PubMed DOI
    50. 1992
  50. Maruyama,M., Sugiki,M., Yoshida,E., Shimaya,K. and Mihara,H.
    Broad substrate specificity of snake venom fibrinolytic enzymes: possible role in haemorrhage
    Toxicon (1992) 30, 1387-1397. PubMed  Europe PubMed DOI
  51. [YEAR:15-11-1992]Paine,M.J., Desmond,H.P., Theakston,R.D. and Crampton,J.M.
    Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family
    J Biol Chem (15-11-1992) 267, 22869-22876. PubMed  Europe PubMed
    52. 1986
  52. Assakura,M.T., Reichl,A.P. and Mandelbaum,F.R.
    Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)
    Toxicon (1986) 24, 943-946. PubMed  Europe PubMed
    53. 1976
  53. Mandelbaum,F.R., Reichl,A.P. and Assakura,M.T.
    Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca
     (1976) , 111-121.

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