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Literature for peptidase M12.138: jararhagin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: I Inhibitor, E Expression, U Therapeutic, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Schluga,P.H.C., Larangote,D., de Melo,A.M., Lobermayer,G.K., Torrejon,D., de Oliveira,L.S., Alvarenga,V.G., Vivas-Ruiz,D.E., Veiga,S.S., Sanchez,E.F. and Gremski,L.H.<br>A Novel P-III Metalloproteinase from Bothrops barnetti Venom Degrades Extracellular Matrix Proteins, Inhibits Platelet Aggregation, and Disrupts Endothelial Cell Adhesion via alpha5beta1 Integrin Receptors to Arginine-Glycine-Aspartic Acid (RGD)-Containing Molecules<br>Toxins (Basel) (2024) 16 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2020
  2. Bastos,V.A., Gomes-Neto,F., Rocha,S.L.G., Teixeira-Ferreira,A., Perales,J., Neves-Ferreira,A.G.C. and Valente,R.H.<br>The interaction between the natural metalloendopeptidase inhibitor BJ46a and its target toxin jararhagin analyzed by structural mass spectrometry and molecular modeling<br>J Proteomics (2020) 221, 103761-103761. PubMed  Europe PubMed DOI
  3. Zychar,B.C., Clissa,P.B., Carvalho,E., Baldo,C. and Goncalves,L.R.C.<br>Leukocyte recruitment induced by snake venom metalloproteinases: role of the catalytic domain<br>Biochem Biophys Res Commun (2020) 521, 402-407. PubMed  Europe PubMed DOI
    4. 2018
  4. Ferreira,B.A., Deconte,S.R., de Moura,F.B.R., Tomiosso,T.C., Clissa,P.B., Andrade,S.P. and Araujo,F.A.<br>Inflammation, angiogenesis and fibrogenesis are differentially modulated by distinct domains of the snake venom metalloproteinase jararhagin<br>Int J Biol Macromol (2018) 119, 1179-1187. PubMed  Europe PubMed DOI
    5. 2015
  5. Baldo,C., Lopes,D.S., Faquim-Mauro,E.L., Jacysyn,J.F., Niland,S., Eble,J.A., Clissa,P.B. and Moura-da-Silva,A.M.<br>Jararhagin disruption of endothelial cell anchorage is enhanced in collagen enriched matrices<br>Toxicon (2015) 108, 240-248. PubMed  Europe PubMed DOI
  6. Freitas-de-Sousa,L.A., Amazonas,D.R., Sousa,L.F., Sant'Anna,S.S., Nishiyama,M.Y., Jr., Serrano,S.M., Junqueira-de-Azevedo,I.L., Chalkidis,H.M., Moura-da-Silva,A.M. and Mourao,R.H.<br>Comparison of venoms from wild and long-term captive Bothrops atrox snakes and characterization of batroxrhagin, the predominant class PIII metalloproteinase from the venom of this species<br>Biochimie (2015) 118, 60-70. PubMed  Europe PubMed DOI
    7. 2014
  7. Serrano,S.M.T., Oliveira,A.K., Menezes,M.C. and Zelanis,A.<br>The proteinase-rich proteome of Bothrops jararaca venom<br>Toxin Rev (2014) 33, 169-184. DOI  V
    8. 2012
  8. Moura-da-Silva,A.M. and Baldo,C.<br>Jararhagin, a hemorrhagic snake venom metalloproteinase from Bothrops jararaca<br>Toxicon (2012) 60, 280-289. PubMed  Europe PubMed DOI  V
  9. Moura-da-Silva,A.M. and Paine,M.J.I.<br>Jararhagin<br>[ISSN:978-0-12-407744-7] (2012) 3, 987-990. DOI
    10. 2011
  10. Klein,A., Capitanio,J.S., Maria,D.A. and Ruiz,I.R.<br>Gene expression in SK-Mel-28 human melanoma cells treated with the snake venom jararhagin<br>Toxicon (2011) 57, 1-8. PubMed  Europe PubMed DOI  U
    11. 2010
  11. Baldo,C., Jamora,C., Yamanouye,N., Zorn,T.M. and Moura-da-Silva,A.M.<br>Mechanisms of vascular damage by hemorrhagic snake venom metalloproteinases: tissue distribution and in situ hydrolysis<br>PLoS Negl Trop Dis (2010) 4, e727-e727. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Tanjoni,I., Evangelista,K., Della-Casa,M.S., Butera,D., Magalhaes,G.S., Baldo,C., Clissa,P.B., Fernandes,I., Eble,J. and Moura-da-Silva,A.M.<br>Different regions of the class P-III snake venom metalloproteinase jararhagin are involved in binding to alpha2beta1 integrin and collagen<br>Toxicon (2010) 55, 1093-1099. PubMed  Europe PubMed DOI
    13. 2008
  13. Costa,E.P., Del Debbio,C.B., Cintra,L.C., da Fontoura Costa,L., Hamassaki,D.E. and Santos,M.F.<br>Jararhagin, a snake venom metalloprotease-disintegrin, activates the Rac1 GTPase and stimulates neurite outgrowth in neuroblastoma cells<br>Toxicon (2008) 52, 380-384. PubMed  Europe PubMed DOI
  14. Moura-da-Silva,A.M., Ramos,O.H., Baldo,C., Niland,S., Hansen,U., Ventura,J.S., Furlan,S., Butera,D., Della-Casa,M.S., Tanjoni,I., Clissa,P.B., Fernandes,I., Chudzinski-Tavassi,A.M. and Eble,J.A.<br>Collagen binding is a key factor for the hemorrhagic activity of snake venom metalloproteinases<br>Biochimie (2008) 90, 484-492. PubMed  Europe PubMed DOI
    15. 2007
  15. Serrano,S.M., Wang,D., Shannon,J.D., Pinto,A.F., Polanowska-Grabowska,R.K. and Fox,J.W.<br>Interaction of the cysteine-rich domain of snake venom metalloproteinases with the A1 domain of von Willebrand factor promotes site-specific proteolysis of von Willebrand factor and inhibition of von Willebrand factor-mediated platelet aggregation<br>FEBS J (2007) 274, 3611-3621. PubMed  Europe PubMed DOI
    16. 2006
  16. Clissa,P.B., Lopes-Ferreira,M., Della-Casa,M.S., Farsky,S.H. and Moura-da-Silva,A.M.<br>Importance of jararhagin disintegrin-like and cysteine-rich domains in the early events of local inflammatory response<br>Toxicon (2006) 47, 591-596. PubMed  Europe PubMed DOI
  17. [YEAR:6-10-2006]Escalante,T., Shannon,J., Moura-da-Silva,A.M., Gutierrez,J.M. and Fox,J.W.<br>Novel insights into capillary vessel basement membrane damage by snake venom hemorrhagic metalloproteinases: a biochemical and immunohistochemical study<br>Arch Biochem Biophys (6-10-2006) 455, 144-153. PubMed  Europe PubMed DOI
    18. 2005
  18. [YEAR:2-8-2005]Gallagher,P., Bao,Y., Serrano,S.M., Laing,G.D., Theakston,R.D., Gutierrez,J.M., Escalante,T., Zigrino,P., Moura-da-Silva,A.M., Nischt,R., Mauch,C., Moskaluk,C. and Fox,J.W.<br>Role of the snake venom toxin jararhagin in proinflammatory pathogenesis: in vitro and in vivo gene expression analysis of the effects of the toxin<br>Arch Biochem Biophys (2-8-2005) 441, 1-15. PubMed  Europe PubMed DOI
  19. Laing,G.D. and Moura-da-Silva,A.M.<br>Jararhagin and its multiple effects on hemostasis<br>Toxicon (2005) 45, 987-996. PubMed  Europe PubMed DOI
  20. Tanjoni,I., Weinlich,R., Della-Casa,M.S., Clissa,P.B., Saldanha-Gama,R.F., de Freitas,M.S., Barja-Fidalgo,C., Amarante-Mendes,G.P. and Moura-da-Silva,A.M.<br>Jararhagin, a snake venom metalloproteinase, induces a specialized form of apoptosis (anoikis) selective to endothelial cells<br>Apoptosis (2005) 10, 851-861. PubMed  Europe PubMed DOI
    21. 2004
  21. [YEAR:15-12-2004]Costa,E.P. and Santos,M.F.<br>Jararhagin, a snake venom metalloproteinase-disintegrin, stimulates epithelial cell migration in an in vitro restitution model<br>Toxicon (15-12-2004) 44, 861-870. PubMed  Europe PubMed DOI
  22. Garcia,L.T., Parreiras e Silva, Ramos,O.H., Carmona,A.K., Bersanetti,P.A. and Selistre-De-Araujo,H.S.<br>The effect of post-translational modifications on the hemorrhagic activity of snake venom metalloproteinases<br>Comp Biochem Physiol C Toxicol Pharmacol (2004) 138, 23-32. PubMed  Europe PubMed DOI  E
  23. Laing,G.D. and Paine,M.J.I.<br>Jararhagin<br>[ISSN:0-12-079610-4] (2004) 2, 654-656.  V
    24. 2003
  24. Laing,G.D., Clissa,P.B., Theakston,R.D., Moura-da-Silva,A.M. and Taylor,M.J.<br>Inflammatory pathogenesis of snake venom metalloproteinase-induced skin necrosis<br>Eur J Immunol (2003) 33, 3458-3463. PubMed  Europe PubMed DOI
  25. Maria,D.A., Vassao,R.C. and Ruiz,I.R.<br>Haematopoietic effects induced in mice by the snake venom toxin jararhagin<br>Toxicon (2003) 42, 579-585. PubMed  Europe PubMed DOI
  26. [YEAR:15-1-2003]Moura-da-Silva,A.M., Della-Casa,M.S., David,A.S., Assakura,M.T., Butera,D., Lebrun,I., Shannon,J.D., Serrano,S.M. and Fox,J.W.<br>Evidence for heterogeneous forms of the snake venom metalloproteinase jararhagin: a factor contributing to snake venom variability<br>Arch Biochem Biophys (15-1-2003) 409, 395-401. PubMed  Europe PubMed DOI
  27. Tanjoni,I., Butera,D., Bento,L., Della-Casa,M.S., Marques-Porto,R., Takehara,H.A., Gutierrez,J.M., Fernandes,I. and Moura-da-Silva,A.M.<br>Snake venom metalloproteinases: structure/function relationships studies using monoclonal antibodies<br>Toxicon (2003) 42, 801-808. PubMed  Europe PubMed DOI
    28. 2002
  28. Anai,K., Sugiki,M., Yoshida,E. and Maruyama,M.<br>Neutralization of a snake venom hemorrhagic metalloproteinase prevents coagulopathy after subcutaneous injection of Bothrops jararaca venom in rats<br>Toxicon (2002) 40, 63-68. PubMed  Europe PubMed DOI
  29. Carneiro,S.M., Assakura,M.T., Barrence,F.A., Cardoso,S.R., de Martins Camargo,A.C. and Sesso,A.<br>Immunolocalization of venom metalloproteases in venom glands of adult and of newborn snakes of Bothrops jararaca<br>Tissue Cell (2002) 34, 381-389. PubMed  Europe PubMed DOI
  30. Kawano,J., Anai,K., Sugiki,M., Yoshida,E. and Maruyama,M.<br>Vascular endothelial cell injury induced by Bothrops jararaca venom; non-significance of hemorrhagic metalloproteinase<br>Toxicon (2002) 40, 1553-1562. PubMed  Europe PubMed DOI
  31. Maruyama,M., Sugiki,M., Anai,K. and Yoshida,E.<br>N-terminal amino acid sequences and some characteristics of fibrinolytic/hemorrhagic metalloproteinases purified from Bothrops jararaca venom<br>Toxicon (2002) 40, 1223-1226. PubMed  Europe PubMed DOI
  32. [YEAR:25-10-2002]Zigrino,P., Kamiguti,A.S., Eble,J., Drescher,C., Nischt,R., Fox,J.W. and Mauch,C.<br>The reprolysin jararhagin, a snake venom metalloproteinase, functions as a fibrillar collagen agonist involved in fibroblast cell adhesion and signaling<br>J Biol Chem (25-10-2002) 277, 40528-40535. PubMed  Europe PubMed DOI
    33. 2001
  33. Clissa,P.B., Laing,G.D., Theakston,R.D.G., Mota,I., Taylor,M.J. and Moura-da-Silva,A.M.<br>The effect of jararhagin, a metalloproteinase from Bothrops jararaca venom, on pro-inflammatory cytokines released by murine peritoneal adherent cells<br>Toxicon (2001) 39, 1567-1573. PubMed  Europe PubMed DOI
  34. [YEAR:15-4-2001]Moura-da-Silva,A.M., Marcinkiewicz,C., Marcinkiewicz,M. and Niewiarowski,S.<br>Selective recognition of alpha2beta1 integrin by jararhagin, a metalloproteinase/disintegrin from Bothrops jararaca venom<br>Thromb Res (15-4-2001) 102, 153-159. PubMed  Europe PubMed DOI
  35. Souza,D.H., Selistre-De-Araujo,H.S., Moura-da-Silva,A.M., Della-Casa,M.S., Oliva,G. and Garratt,R.C.<br>Crystallization and preliminary X-ray analysis of jararhagin, a metalloproteinase/disintegrin from Bothrops jararaca snake venom<br>Acta Crystallogr D Biol Crystallogr (2001) 57, 1135-1137. PubMed  Europe PubMed DOI
  36. Valente,R.H., Dragulev,B., Perales,J., Fox,J.W. and Domont,G.B.<br>BJ46a, a snake venom metalloproteinase inhibitor. Isolation, characterization, cloning and insights into its mechanism of action<br>Eur J Biochem (2001) 268, 3042-3052. PubMed  Europe PubMed DOI
    37. 2000
  37. Harrison,R.A., Moura-da-Silva,A.M., Laing,G.D., Wu,Y., Richards,A., Broadhead,A., Bianco,A.E. and Theakston,R.D.G.<br>Antibody from mice immunized with DNA encoding the carboxyl-disintegrin and cysteine-rich domain (JD9) of the haemorrhagic metalloprotease, Jararhagin, inhibits the main lethal component of viper venom<br>Clin Exp Immunol (2000) 121, 358-363. PubMed  Europe PubMed DOI  PMC  EPMC
  38. [YEAR:1-5-2000]Neves-Ferreira,A.G., Cardinale,N., Rocha,S.L., Perales,J. and Domont,G.B.<br>Isolation and characterization of DM40 and DM43, two snake venom metalloproteinase inhibitors from Didelphis marsupialis serum<br>Biochim Biophys Acta (1-5-2000) 1474, 309-320. PubMed  Europe PubMed DOI
    39. 1998
  39. Anai,K., Sugiki,M., Yoshida,E. and Maruyama,M.<br>Inhibition of a snake venom hemorrhagic metalloproteinase by human and rat alpha-macroglobulins<br>Toxicon (1998) 36, 1127-1139. PubMed  Europe PubMed DOI
  40. Sugiki,M., Yoshida,E., Anai,K. and Maruyama,M.<br>Activation of single-chain urokinase-type plasminogen activator by a hemorrhagic metalloproteinase, jararafibrase I, in Bothrops jararaca venom<br>Toxicon (1998) 36, 993-1000. PubMed  Europe PubMed DOI
    41. 1997
  41. [YEAR:19-12-1997]Kamiguti,A.S., Markland,F.S., Zhou,Q., Laing,G.D., Theakston,R.D. and Zuzel,M.<br>Proteolytic cleavage of the beta1 subunit of platelet alpha2beta1 integrin by the metalloproteinase jararhagin compromises collagen-stimulated phosphorylation of pp72(syk)<br>J Biol Chem (19-12-1997) 272, 32599-32605. PubMed  Europe PubMed DOI
  42. Kamiguti,A.S., Moura-da-Silva,A.M., Laing,G.D., Knapp,T., Zuzel,M., Crampton,J.M. and Theakston,R.D.<br>Collagen-induced secretion-dependent phase of platelet aggregation is inhibited by the snake venom metalloproteinase jararhagin<br>Biochim Biophys Acta (1997) 1335, 209-217. PubMed  Europe PubMed DOI
    43. 1996
  43. Moura-da-Silva,A.M., Laing,G.D., Paine,M.J., Dennison,J.M., Politi,V., Crampton,J.M. and Theakston,R.D.<br>Processing of pro-tumor necrosis factor-alpha by venom metalloproteinases: A hypothesis explaining local tissue damage following snake bite<br>Eur J Immunol (1996) 26, 2000-2005. PubMed  Europe PubMed DOI  I
    44. 1995
  44. De Luca,M., Ward,C.M., Ohmori,K., Andrews,R.K. and Berndt,M.C.<br>Jararhagin and jaracetin: novel snake venom inhibitors of the integrin collagen receptor, alpha 2 beta 1<br>Biochem Biophys Res Commun (1995) 206, 570-576. PubMed  Europe PubMed DOI
  45. Sugiki,M., Maruyama,M., Yoshida,E., Mihara,H., Kamiguti,A.S. and Theakston,D.G.<br>Enhancement of plasma fibrinolysis in vitro by jararhagin, the main haemorrhagic metalloproteinase in Bothrops jararaca venom<br>Toxicon (1995) 33, 1605-1617. PubMed  Europe PubMed DOI
  46. Zhou,Q., Smith,J.B. and Grossman,M.H.<br>Molecular cloning and expression of catrocollastatin, a snake-venom protein from Crotalus atrox (Western diamondback rattlesnake) which inhibits platelet adhesion to collagen<br>Biochem J (1995) 307, 411-417. PubMed  Europe PubMed  PMC  EPMC
    47. 1994
  47. Kamiguti,A.S., Slupsky,J.R., Zuzel,M. and Hay,C.R.<br>Properties of fibrinogen cleaved by jararhagin, a metalloproteinase from the venom of Bothrops jararaca<br>Thromb Haemost (1994) 72, 244-249. PubMed  Europe PubMed
  48. Kamiguti,A.S., Desmond,H.P., Theakston,R.D., Hay,C.R. and Zuzel,M.<br>Ineffectiveness of the inhibition of the main haemorrhagic metalloproteinase from Bothrops jararaca venom by its only plasma inhibitor, alpha2-macroglobulin<br>Biochim Biophys Acta (1994) 1200, 307-314. PubMed  Europe PubMed DOI
  49. Usami,Y., Fujimura,Y., Miura,S., Shima,H., Yoshida,E., Yoshioka,A., Hirano,K., Suzuki,M. and Titani,K.<br>A 28 kDa-protein with disintegrin-like structure (jararhagin-C) purified from Bothrops jararaca venom inhibits collagen- and ADP-induced platelet aggregation<br>Biochem Biophys Res Commun (1994) 201, 331-339. PubMed  Europe PubMed DOI
    50. 1992
  50. Maruyama,M., Sugiki,M., Yoshida,E., Shimaya,K. and Mihara,H.<br>Broad substrate specificity of snake venom fibrinolytic enzymes: possible role in haemorrhage<br>Toxicon (1992) 30, 1387-1397. PubMed  Europe PubMed DOI
  51. [YEAR:15-11-1992]Paine,M.J., Desmond,H.P., Theakston,R.D. and Crampton,J.M.<br>Purification, cloning, and molecular characterization of a high molecular weight hemorrhagic metalloprotease, jararhagin, from Bothrops jararaca venom. Insights into the disintegrin gene family<br>J Biol Chem (15-11-1992) 267, 22869-22876. PubMed  Europe PubMed
    52. 1986
  52. Assakura,M.T., Reichl,A.P. and Mandelbaum,F.R.<br>Comparison of immunological, biochemical and biophysical properties of three hemorrhagic factors isolated from the venom of Bothrops jararaca (jararaca)<br>Toxicon (1986) 24, 943-946. PubMed  Europe PubMed
    53. 1976
  53. Mandelbaum,F.R., Reichl,A.P. and Assakura,M.T.<br>Some physical and biochemical characteristics of HF2, one of the hemorrhagic factors in the venom of Bothrops jararaca<br> (1976) , 111-121.

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