Substrates for peptidase C48.007: SENP2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
ac-Gln-Gln-Tyr-Gly-Gly-amino-trifluoromethylcoumarin			ac-Gln-Gln-Tyr-Gly-Gly+amino-trifluoromethylcoumarin	S		Gln	Tyr	Gly	Gly	AFC	-	-	-	Drag et al., 2008
ac-Gln-Thr-Gly-Gly-amino-trifluoromethylcoumarin			ac-Gln-Thr-Gly-Gly+amino-trifluoromethylcoumarin	S		Gln	Thr	Gly	Gly	AFC	-	-	-	Drag et al., 2008
ac-Gln-Tyr-Gly-Gly-amino-trifluoromethylcoumarin			ac-Gln-Tyr-Gly-Gly+amino-trifluoromethylcoumarin	S		Gln	Tyr	Gly	Gly	AFC	-	-	-	Drag et al., 2008
ac-Glu-Gln-Tyr-Gly-Gly-amino-trifluoromethylcoumarin			ac-Glu-Gln-Tyr-Gly-Gly+amino-trifluoromethylcoumarin	S		Gln	Tyr	Gly	Gly	AFC	-	-	-	Drag et al., 2008
Boc-Gln-Thr-Gly-Gly-amino-trifluoromethylcoumarin			Boc-Gln-Thr-Gly-Gly+amino-trifluoromethylcoumarin	S		Gln	Thr	Gly	Gly	AFC	-	-	-	Drag et al., 2008
PolySUMO2/SUMO3	P61956		peptide-Gly93+Lys11-peptide	N		Gln	Thr	Gly	Gly	Lys	Thr	Glu	Asn	Mendes et al., 2015
Ran GTPase-activating protein 1–polySUMO-2/SUMO-3 conjugate	P46060		peptide-Gly93+Lys8-peptide	N		Gln	Thr	Gly	Gly	Lys	Leu	Ala	Glu	Mendes et al., 2015
Ran GTPase-activating protein 1–SUMO-1 conjugate	P46060		peptide-Gly93+Lys8-peptide	N		Gln	Thr	Gly	Gly	Lys	Leu	Ala	Glu	Mendes et al., 2015
Small ubiquitin-related modifier 1 precursor	P63165	2-101	Peptide-Gly97+His-Ser-Thr-Val	P	AB	Gln	Thr	Gly	Gly	His	Ser	Thr	Val	Nishida et al., 2001
small ubiquitin-related modifier 2	P61956	1-95	peptide-Gly93+Val-Tyr	P	CS	Gln	Thr	Gly	Gly	Val	Tyr	'-'	'-'	Mendes et al., 2015
Small ubiquitin-related modifier 2 precursor	P61956	1-95	Peptide-Gly93+Val-Tyr	P	AB	Gln	Thr	Gly	Gly	Val	Tyr	-	-	Nishida et al., 2001
small ubiquitin-related modifier 3	P55854	1-103	peptide-Gly92+Val-peptide	P	CS	Gln	Thr	Gly	Gly	Val	Pro	Glu	Ser	Mendes et al., 2015
Small ubiquitin-related modifier 3 precursor	P55854	1-103	Peptide-Gly92+Val-Peptide	P	AB	Gln	Thr	Gly	Gly	Val	Pro	Glu	Ser	Nishida et al., 2001
SUMO-Lys-91-VDR conjugate	P11473	1-427	Peptide-Gly93+Lys91-Peptide	P	MU	Gln	Thr	Gly	Gly	Lys	Glu	Phe	Ile	Lee et al., 2014
sumoylated paired amphipathic helix protein Sin3a	P63165/Q96ST3	2-97	peptide-Gly97+Lys-peptide	P		Gln	Thr	Gly	Gly	Lys	Xaa	Xaa	Xaa	Pungaliya et al., 2007
sumoylated protein PML	P63165/P29590	2-97	peptide-Gly97+Lys65-peptide	P		Gln	Thr	Gly	Gly	Lys	Cys	Pro	Lys	Best et al., 2002
sumoylated protein PML	P63165/P29590	2-97	peptide-Gly97+Lys160-peptide	P		Gln	Thr	Gly	Gly	Lys	His	Glu	Ala	Best et al., 2002
sumoylated protein PML	P63165/P29590	2-97	peptide-Gly97+Lys490-peptide	P		Gln	Thr	Gly	Gly	Lys	Met	Glu	Ser	Best et al., 2002
sumoylated protein PML	P63165/P29590	2-97	peptide-Gly97+Lys497-peptide	P		Gln	Thr	Gly	Gly	Lys	Glu	Ala	Arg	Best et al., 2002
sumoylated transcription factor 7-like 2	P63165/Q9NQB0	2-97	peptide-Gly97+Lys320-peptide	P		Gln	Thr	Gly	Gly	Lys	Gln	Glu	Ser