Literature for peptidase C48.007: SENP2 peptidase

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, I Inhibitor, K Knockout. To select only the references relevant to a single topic, click the link above. See explanation.)

2024
1. Chen,X., Li,D., Su,Q., Ling,X., Ding,S., Xu,R., Liu,Z., Qin,Y., Zhang,J., Yang,Z., Kang,X., Qi,Y. and Wu,H.
   MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
   Cell Mol Life Sci81, 461-461. PubMed  Europe PubMed DOI
2. Sun,L., Ma,K., Zhang,S., Gu,J., Wang,H. and Tan,L.
   SENP2 promotes ESCC proliferation through SETDB1 deSUMOylation and enhanced fatty acid metabolism
   Heliyon10, e34010-e34010. PubMed  Europe PubMed DOI
2023
3. Kim,P.C., Lee,J.S., Chung,S.S. and Park,K.S.
   Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes
   Diabetes Metab J47, 382-393. PubMed  Europe PubMed DOI  K
4. Krapf,S.A., Lund,J., Bakke,H.G., Nyman,T.A., Bartesaghi,S., Peng,X.R., Rustan,A.C., Thoresen,G.H. and Kase,E.T.
   SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation
   Metabol Open18, 100234-100234. PubMed  Europe PubMed DOI
5. Lee,J.S., Min,J.E., Choe,H.J., Park,K.S. and Chung,S.S.
   SUMO-specific protease 2 regulates lipid droplet size through ERRalpha-mediated CIDEA expression in adipocytes
   Biochem Biophys Res Commun681, 29-35. PubMed  Europe PubMed DOI  K
6. Luo,Y., Zhou,S., Xu,T., Wu,W., Shang,P., Wang,S., Pan,D. and Li,D.
   SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
   Chin Med J (Engl)136, 2496-2507. PubMed  Europe PubMed DOI
2022
7. Brand,M., Bommeli,E.B., Rutimann,M., Lindenmann,U. and Riedl,R.
   Discovery of a Dual SENP1 and SENP2 Inhibitor
   Int J Mol Sci23, PubMed  Europe PubMed DOI  I
8. Lee,J.S., Chae,S., Nan,J., Koo,Y.D., Lee,S.A., Park,Y.J., Hwang,D., Han,W., Lee,D.S., Kim,Y.B., Chung,S.S. and Park,K.S.
   SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPbeta
   Cell Rep38, 110408-110408. PubMed  Europe PubMed DOI  K
9. Liang,M., Cai,Z., Jiang,Y., Huo,H., Shen,L. and He,B.
   SENP2 Promotes VSMC Phenotypic Switching via Myocardin De-SUMOylation
   Int J Mol Sci23, PubMed  Europe PubMed DOI
10. Nan,J., Lee,J.S., Moon,J.H., Lee,S.A., Park,Y.J., Lee,D.S., Chung,S.S. and Park,K.S.
    SENP2 regulates mitochondrial function and insulin secretion in pancreatic beta cells
    Exp Mol Med54, 72-80. PubMed  Europe PubMed DOI  K
2021
11. Chen,X., Zhang,Y., Ren,X., Su,Q., Liu,Y., Dang,X., Qin,Y., Yang,X., Xing,Z., Shen,Y., Wang,Y., Bai,Z., Yeh,E.T.H., Wu,H. and Qi,Y.
    The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels
    J Biol Chem297, 101183-101183. PubMed  Europe PubMed DOI
12. Chen,Y., Xu,T., Li,M., Li,C., Ma,Y., Chen,G., Sun,Y., Zheng,H., Wu,G., Liao,W., Liao,Y., Chen,Y. and Bin,J.
    Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway
    Clin Sci (Lond)135, 811-828. PubMed  Europe PubMed DOI
13. Liu,Y., Dou,X., Zhou,W.Y., Ding,M., Liu,L., Du,R.Q., Guo,L., Qian,S.W., Tang,Y., Yang,Q.Q., Pan,D.N., Li,X.Y., Lu,Y., Cheng,J.K. and Tang,Q.Q.
    Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk
    Hepatology PubMed  Europe PubMed DOI
14. Lund,J., Krapf,S.A., Sistek,M., Bakke,H.G., Bartesaghi,S., Peng,X.R., Rustan,A.C., Thoresen,G.H. and Kase,E.T.
    SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells
    Curr Res Pharmacol Drug Discov2, 100061-100061. PubMed  Europe PubMed DOI
15. Zhang,Y., Chen,X., Wang,Q., Du,C., Lu,W., Yuan,H., Zhang,Z., Li,D., Ling,X., Ren,X., Zhao,Y., Su,Q., Xing,Z., Qin,Y., Yang,X., Shen,Y., Wu,H. and Qi,Y.
    Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology
    J Mol Med (Berl)99, 1797-1813. PubMed  Europe PubMed DOI
2020
16. Huang,D., Liu,H., Zhu,A., Zhou,Y. and Li,Y.
    Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior
    Mol Brain13, 59-59. PubMed  Europe PubMed DOI  K
2019
17. Chen,X.L., Wang,S.F., Liang,X.T., Liang,H.X., Wang,T.T., Wu,S.Q., Qiu,Z.J., Zhan,R. and Xu,Z.S.
    SENP2 exerts an antitumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NFkappaB signaling pathways
    Int J Oncol54, 455-466. PubMed  Europe PubMed DOI
18. Koo,Y.D., Lee,J.S., Lee,S.A., Quaresma,P.G.F., Bhat,R., Haynes,W.G., Park,Y.J., Kim,Y.B., Chung,S.S. and Park,K.S.
    SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle
    Metabolism95, 27-35. PubMed  Europe PubMed DOI
19. Wang,H. and You,G.
    The SUMO-specific protease Senp2 regulates sumoylation, expression and function of human organic anion transporter 3
    Biochim Biophys Acta Biomembr1861, 1293-1301. PubMed  Europe PubMed DOI
20. Xiao,N., Li,H., Yu,W., Gu,C., Fang,H., Peng,Y., Mao,H., Fang,Y., Ni,W. and Yao,M.
    SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation
    FASEB J33, 163-174. PubMed  Europe PubMed DOI
2018
21. Bernstock,J.D., Ye,D., Smith,J.A., Lee,Y.J., Gessler,F.A., Yasgar,A., Kouznetsova,J., Jadhav,A., Wang,Z., Pluchino,S., Zheng,W., Simeonov,A., Hallenbeck,J.M. and Yang,W.
    Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2
    FASEB J32, 1677-1691. PubMed  Europe PubMed DOI
22. Chang,C.C., Huang,Y.S., Lin,Y.M., Lin,C.J., Jeng,J.C., Liu,S.M., Ho,T.L., Chang,R.T., Changou,C.A., Ho,C.C. and Shih,H.M.
    The role of sentrin-specific protease 2 substrate recognition in TGF-beta-induced tumorigenesis
    Sci Rep8, 9786-9786. PubMed  Europe PubMed DOI
23. Liu,S.L. and Gao,F.H.
    SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions
    Biochimie152, 6-13. PubMed  Europe PubMed DOI
24. Odeh,H.M., Coyaud,E., Raught,B. and Matunis,M.J.
    The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-Terminal amphipathic alpha-helix
    Mol Biol Cell29, 1878-1890. PubMed  Europe PubMed DOI
25. Pei,H., Chen,L., Liao,Q.M., Wang,K.J., Chen,S.G., Liu,Z.J. and Zhang,Z.C.
    SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation
    Exp Ther Med16, 5359-5365. PubMed  Europe PubMed DOI
2017
26. Besir,H.
    A generic protocol for purifying disulfide-bonded domains and random protein fragments using fusion proteins with SUMO3 and cleavage by SenP2 protease
    Methods Mol Biol1586, 141-154. PubMed  Europe PubMed DOI
27. Hu,X.Y., Liu,Z., Zhang,K.L., Feng,J., Liu,X.F., Wang,L.Y. and Wang,Z.W.
    SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells
    Cancer Biomark21, 195-201. PubMed  Europe PubMed DOI
28. Tan,M., Zhang,D., Zhang,E., Xu,D., Liu,Z., Qiu,J., Fan,Y. and Shen,B.
    SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-betaRI
    Mol Carcinog56, 2332-2341. PubMed  Europe PubMed DOI
2016
29. Maruyama,E.O., Lin,H., Chiu,S.Y., Yu,H.M., Porter,G.A. and Hsu,W.
    Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development
    Sci Rep6, 20999-20999. PubMed  Europe PubMed DOI
30. Mirecka,A., Morawiec,Z. and Wozniak,K.
    Genetic polymorphism of SUMO-specific cysteine proteases - SENP1 and SENP2 in breast cancer
    Pathol Oncol Res22, 817-823. PubMed  Europe PubMed DOI  M
2015
31. Heo,K.S., Le,N.T., Cushman,H.J., Giancursio,C.J., Chang,E., Woo,C.H., Sullivan,M.A., Taunton,J., Yeh,E.T., Fujiwara,K. and Abe,J.
    Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function
    J Clin Invest125, 1299-1310. PubMed  Europe PubMed DOI
32. Koo,Y.D., Choi,J.W., Kim,M., Chae,S., Ahn,B.Y., Kim,M., Oh,B.C., Hwang,D., Seol,J.H., Kim,Y.B., Park,Y.J., Chung,S.S. and Park,K.S.
    SUMO-specific protease 2 (SENP2) is an important regulator of fatty acid metabolism in skeletal muscle
    Diabetes64, 2420-2431. PubMed  Europe PubMed DOI
33. Liu,Y., Shen,Y., Zheng,S. and Liao,J.
    A novel robust quantitative Forster resonance energy transfer assay for protease SENP2 kinetics determination against its all natural substrates
    Mol Biosyst11, 3407-3414. PubMed  Europe PubMed DOI  A
2014
34. Alegre,K.O. and Reverter,D.
    Structural insights into the SENP6 loop1 structure in complex with SUMO2
    Protein Sci23, 433-441. PubMed  Europe PubMed DOI  S
35. Chow,K.-H., Elgort,S., Dasso,M., Powers,M.A. and Ullman,K.S.
    The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
    Mol Biol Cell25, 160-168. PubMed  Europe PubMed DOI
36. Fu,J., Yu,H.M., Chiu,S.Y., Mirando,A.J., Maruyama,E.O., Cheng,J.G. and Hsu,W.
    Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration
    PLoS Genet10, e1004579-e1004579. PubMed  Europe PubMed DOI
37. Kumar,A., Ito,A., Takemoto,M., Yoshida,M. and Zhang,K.Y.
    Identification of 1,2,5-oxadiazoles as a new class of SENP2 inhibitors using structure based virtual screening
    J Chem Inf Model54, 870-880. PubMed  Europe PubMed DOI  I
38. Lee,W.P., Jena,S., Doherty,D., Ventakesh,J., Schimdt,J., Furmick,J., Widener,T., Lemau,J., Jurutka,P.W. and Thompson,P.D.
    Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling
    PLoS ONE9, e89506-e89506. PubMed  Europe PubMed DOI
39. Liu,Y., Kieslich,C.A., Morikis,D. and Liao,J.
    Engineering pre-SUMO4 as efficient substrate of SENP2
    Protein Eng Des Sel27, 117-126. PubMed  Europe PubMed DOI
40. Qi,Y., Wang,J., Bomben,V.C., Li,D.P., Chen,S.R., Sun,H., Xi,Y., Reed,J.G., Cheng,J., Pan,H.L., Noebels,J.L. and Yeh,E.T.
    Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death
    Neuron83, 1159-1171. PubMed  Europe PubMed DOI  K
2013
41. Heo,K.S., Chang,E., Le,N.T., Cushman,H., Yeh,E.T., Fujiwara,K. and Abe,J.
    De-sumoylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis
    Circ Res112, 911-923. PubMed  Europe PubMed DOI  K
42. Tan,M.Y., Mu,X.Y., Liu,B., Wang,Y., Bao,E.D., Qiu,J.X. and Fan,Y.
    SUMO-specific protease 2 suppresses cell migration and invasion through inhibiting the expression of MMP13 in bladder cancer cells
    Cell Physiol Biochem32, 542-548. PubMed  Europe PubMed DOI
43. Tang,S., Huang,G., Tong,X., Xu,L., Cai,R., Li,J., Zhou,X., Song,S., Huang,C. and Cheng,J.
    Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism
    PLoS ONE8, e63965-e63965. PubMed  Europe PubMed DOI
2012
44. Kim,E.Y., Chen,L., Ma,Y., Yu,W., Chang,J., Moskowitz,I.P. and Wang,J.
    Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction
    J Mol Cell Cardiol52, 638-649. PubMed  Europe PubMed DOI
45. Yeh,E.T.H. and Dou,H.
    SENP1 and SENP2 peptidases
    [ISSN:978-0-12-407743-0]3, 2365-2370. DOI
2011
46. Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M.
    Development of small molecule inhibitors and probes of human SUMO deconjugating proteases
    Chem Biol18, 722-732. PubMed  Europe PubMed DOI  I
47. Ban,R., Nishida,T. and Urano,T.
    Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis
    Genes Cells16, 652-669. PubMed  Europe PubMed DOI
48. Chung,S.S., Ahn,B.Y., Kim,M., Kho,J.H., Jung,H.S. and Park,K.S.
    SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor gamma in C2C12 myotubes
    Biochem J433, 155-161. PubMed  Europe PubMed DOI
49. Jiang,M., Chiu,S.Y. and Hsu,W.
    SUMO-specific protease 2 in Mdm2-mediated regulation of p53
    Cell Death Differ18, 1005-1015. PubMed  Europe PubMed DOI
50. Lee,M.H., Mabb,A.M., Gill,G.B., Yeh,E.T. and Miyamoto,S.
    NF-kappaB induction of the SUMO protease SENP2: a negative feedback loop to attenuate cell survival response to genotoxic stress
    Mol Cell43, 180-191. PubMed  Europe PubMed DOI
51. Ran,Y., Liu,T.T., Zhou,Q., Li,S., Mao,A.P., Li,Y., Liu,L.J., Cheng,J.K. and Shu,H.B.
    SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation
    J Mol Cell Biol3, 283-292. PubMed  Europe PubMed DOI
2010
52. Chung,S.S., Ahn,B.Y., Kim,M., Choi,H.H., Park,H.S., Kang,S., Park,S.G., Kim,Y.B., Cho,Y.M., Lee,H.K., Chung,C.H. and Park,K.S.
    Control of adipogenesis by the SUMO-specific protease SENP2
    Mol Cell Biol30, 2135-2146. PubMed  Europe PubMed DOI
53. Kang,X., Qi,Y., Zuo,Y., Wang,Q., Zou,Y., Schwartz,R.J., Cheng,J. and Yeh,E.T.
    SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development
    Mol Cell38, 191-201. PubMed  Europe PubMed DOI  K
54. Wang,Z.B., Ou,X.H., Tong,J.S., Li,S., Wei,L., Ouyang,Y.C., Hou,Y., Schatten,H. and Sun,Q.Y.
    The SUMO pathway functions in mouse oocyte maturation
    Cell Cycle9, 2640-2646. PubMed  Europe PubMed DOI
2008
55. Chiu,S.Y., Asai,N., Costantini,F. and Hsu,W.
    SUMO-Specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    PLoS Biol6, e310-e310. PubMed  Europe PubMed DOI
56. Drag,M., Mikolajczyk,J., Krishnakumar,I.M., Huang,Z. and Salvesen,G.S.
    Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
    Biochem J409, 461-469. PubMed  Europe PubMed DOI  P
57. Xu,Z., Lam,L.S., Lam,L.H., Chau,S.F., Ng,T.B. and Au,S.W.
    Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation
    FASEB J22, 127-137. PubMed  Europe PubMed DOI
2007
58. Mikolajczyk,J., Drag,M., Bekes,M., Cao,J.T., Ronai,Z. and Salvesen,G.S.
    Small Ubiquitin-related Modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
    J Biol Chem282, 26217-26224. PubMed  Europe PubMed DOI  P
59. Pungaliya,P., Kulkarni,D., Park,H.J., Marshall,H., Zheng,H., Lackland,H., Saleem,A. and Rubin,E.H.
    TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins
    J Proteome Res6, 3918-3923. PubMed  Europe PubMed DOI
2006
60. Itahana,Y., Yeh,E.T. and Zhang,Y.
    Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
    Mol Cell Biol26, 4675-4689. PubMed  Europe PubMed DOI
61. Reverter,D. and Lima,C.D.
    Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates
    Nat Struct Mol Biol13, 1060-1068. PubMed  Europe PubMed DOI
2005
62. [YEAR:8-2-2005]Cheng,J., Perkins,N.D. and Yeh,E.T.
    Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases
    J Biol Chem280, 14492-14498. PubMed  Europe PubMed DOI
2004
63. Reverter,D. and Lima,C.D.
    A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
    Structure12, 1519-1531. PubMed  Europe PubMed DOI  S
2003
64. Yamamoto,H., Ihara,M., Matsuura,Y. and Kikuchi,A.
    Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
    EMBO J22, 2047-2059. PubMed  Europe PubMed DOI
2002
65. Best,J.L., Ganiatsas,S., Agarwal,S., Changou,A., Salomoni,P., Shirihai,O., Meluh,P.B., Pandolfi,P.P. and Zon,L.I.
    SUMO-1 protease-1 regulates gene transcription through PML
    Mol Cell10, 843-855. PubMed  Europe PubMed DOI
66. [YEAR:31-5-2002]Hang,J. and Dasso,M.
    Association of the human SUMO-1 protease SENP2 with the nuclear pore
    J Biol Chem277, 19961-19966. PubMed  Europe PubMed DOI
67. Zhang,H., Saitoh,H. and Matunis,M.J.
    Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex
    Mol Cell Biol22, 6498-6508. PubMed  Europe PubMed DOI
2001
68. [YEAR:19-10-2001]Nishida,T., Kaneko,F., Kitagawa,M. and Yasuda,H.
    Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat Axam, which is an Axin-binding protein promoting beta-catenin degradation
    J Biol Chem276, 39060-39066. PubMed  Europe PubMed DOI
2000
69. Yeh,E.T., Gong,L. and Kamitani,T.
    Ubiquitin-like proteins: new wines in new bottles
    Gene248, 1-14. PubMed  Europe PubMed DOI