Literature for peptidase C48.007: SENP2 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, K Knockout, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Demir,U. and Erdogdu,R. Targeting Prostate Cancer Cells by an Isopeptidase Inhibitor NSC632839 Urol Res Pract (2025) 51, 33-37. PubMed Europe PubMed DOI PMC EPMC I

2024

Chen,X., Li,D., Su,Q., Ling,X., Ding,S., Xu,R., Liu,Z., Qin,Y., Zhang,J., Yang,Z., Kang,X., Qi,Y. and Wu,H. MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2 Cell Mol Life Sci (2024) 81, 461-461. PubMed Europe PubMed DOI PMC EPMC
Sun,L., Ma,K., Zhang,S., Gu,J., Wang,H. and Tan,L. SENP2 promotes ESCC proliferation through SETDB1 deSUMOylation and enhanced fatty acid metabolism Heliyon (2024) 10, e34010-e34010. PubMed Europe PubMed DOI PMC EPMC

2023

Kim,P.C., Lee,J.S., Chung,S.S. and Park,K.S. Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes Diabetes Metab J (2023) 47, 382-393. PubMed Europe PubMed DOI PMC EPMC K
Krapf,S.A., Lund,J., Bakke,H.G., Nyman,T.A., Bartesaghi,S., Peng,X.R., Rustan,A.C., Thoresen,G.H. and Kase,E.T. SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation Metabol Open (2023) 18, 100234-100234. PubMed Europe PubMed DOI PMC EPMC
Lee,J.S., Min,J.E., Choe,H.J., Park,K.S. and Chung,S.S. SUMO-specific protease 2 regulates lipid droplet size through ERRalpha-mediated CIDEA expression in adipocytes Biochem Biophys Res Commun (2023) 681, 29-35. PubMed Europe PubMed DOI K
Luo,Y., Zhou,S., Xu,T., Wu,W., Shang,P., Wang,S., Pan,D. and Li,D. SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury Chin Med J (Engl) (2023) 136, 2496-2507. PubMed Europe PubMed DOI PMC EPMC

2022

Brand,M., Bommeli,E.B., Rutimann,M., Lindenmann,U. and Riedl,R. Discovery of a Dual SENP1 and SENP2 Inhibitor Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC I
Lee,J.S., Chae,S., Nan,J., Koo,Y.D., Lee,S.A., Park,Y.J., Hwang,D., Han,W., Lee,D.S., Kim,Y.B., Chung,S.S. and Park,K.S. SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPbeta Cell Rep (2022) 38, 110408-110408. PubMed Europe PubMed DOI K
Liang,M., Cai,Z., Jiang,Y., Huo,H., Shen,L. and He,B. SENP2 Promotes VSMC Phenotypic Switching via Myocardin De-SUMOylation Int J Mol Sci (2022) 23 PubMed Europe PubMed DOI PMC EPMC
Nan,J., Lee,J.S., Moon,J.H., Lee,S.A., Park,Y.J., Lee,D.S., Chung,S.S. and Park,K.S. SENP2 regulates mitochondrial function and insulin secretion in pancreatic beta cells Exp Mol Med (2022) 54, 72-80. PubMed Europe PubMed DOI PMC EPMC K

2021

Chen,X., Zhang,Y., Ren,X., Su,Q., Liu,Y., Dang,X., Qin,Y., Yang,X., Xing,Z., Shen,Y., Wang,Y., Bai,Z., Yeh,E.T.H., Wu,H. and Qi,Y. The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels J Biol Chem (2021) 297, 101183-101183. PubMed Europe PubMed DOI PMC EPMC
Chen,Y., Xu,T., Li,M., Li,C., Ma,Y., Chen,G., Sun,Y., Zheng,H., Wu,G., Liao,W., Liao,Y., Chen,Y. and Bin,J. Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway Clin Sci (Lond) (2021) 135, 811-828. PubMed Europe PubMed DOI
Liu,Y., Dou,X., Zhou,W.Y., Ding,M., Liu,L., Du,R.Q., Guo,L., Qian,S.W., Tang,Y., Yang,Q.Q., Pan,D.N., Li,X.Y., Lu,Y., Cheng,J.K. and Tang,Q.Q. Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk Hepatology (2021) PubMed Europe PubMed DOI
Lund,J., Krapf,S.A., Sistek,M., Bakke,H.G., Bartesaghi,S., Peng,X.R., Rustan,A.C., Thoresen,G.H. and Kase,E.T. SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells Curr Res Pharmacol Drug Discov (2021) 2, 100061-100061. PubMed Europe PubMed DOI PMC EPMC
Zhang,Y., Chen,X., Wang,Q., Du,C., Lu,W., Yuan,H., Zhang,Z., Li,D., Ling,X., Ren,X., Zhao,Y., Su,Q., Xing,Z., Qin,Y., Yang,X., Shen,Y., Wu,H. and Qi,Y. Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology J Mol Med (Berl) (2021) 99, 1797-1813. PubMed Europe PubMed DOI

2020

Huang,D., Liu,H., Zhu,A., Zhou,Y. and Li,Y. Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior Mol Brain (2020) 13, 59-59. PubMed Europe PubMed DOI PMC EPMC K

2019

Chen,X.L., Wang,S.F., Liang,X.T., Liang,H.X., Wang,T.T., Wu,S.Q., Qiu,Z.J., Zhan,R. and Xu,Z.S. SENP2 exerts an antitumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NFkappaB signaling pathways Int J Oncol (2019) 54, 455-466. PubMed Europe PubMed DOI
Koo,Y.D., Lee,J.S., Lee,S.A., Quaresma,P.G.F., Bhat,R., Haynes,W.G., Park,Y.J., Kim,Y.B., Chung,S.S. and Park,K.S. SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle Metabolism (2019) 95, 27-35. PubMed Europe PubMed DOI
Wang,H. and You,G. The SUMO-specific protease Senp2 regulates sumoylation, expression and function of human organic anion transporter 3 Biochim Biophys Acta Biomembr (2019) 1861, 1293-1301. PubMed Europe PubMed DOI
Xiao,N., Li,H., Yu,W., Gu,C., Fang,H., Peng,Y., Mao,H., Fang,Y., Ni,W. and Yao,M. SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation FASEB J (2019) 33, 163-174. PubMed Europe PubMed DOI

2018

Bernstock,J.D., Ye,D., Smith,J.A., Lee,Y.J., Gessler,F.A., Yasgar,A., Kouznetsova,J., Jadhav,A., Wang,Z., Pluchino,S., Zheng,W., Simeonov,A., Hallenbeck,J.M. and Yang,W. Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2 FASEB J (2018) 32, 1677-1691. PubMed Europe PubMed DOI
Chang,C.C., Huang,Y.S., Lin,Y.M., Lin,C.J., Jeng,J.C., Liu,S.M., Ho,T.L., Chang,R.T., Changou,C.A., Ho,C.C. and Shih,H.M. The role of sentrin-specific protease 2 substrate recognition in TGF-beta-induced tumorigenesis Sci Rep (2018) 8, 9786-9786. PubMed Europe PubMed DOI PMC EPMC
Liu,S.L. and Gao,F.H. SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions Biochimie (2018) 152, 6-13. PubMed Europe PubMed DOI
Odeh,H.M., Coyaud,E., Raught,B. and Matunis,M.J. The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-Terminal amphipathic alpha-helix Mol Biol Cell (2018) 29, 1878-1890. PubMed Europe PubMed DOI
Pei,H., Chen,L., Liao,Q.M., Wang,K.J., Chen,S.G., Liu,Z.J. and Zhang,Z.C. SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation Exp Ther Med (2018) 16, 5359-5365. PubMed Europe PubMed DOI PMC EPMC

2017

Besir,H. A generic protocol for purifying disulfide-bonded domains and random protein fragments using fusion proteins with SUMO3 and cleavage by SenP2 protease Methods Mol Biol (2017) 1586, 141-154. PubMed Europe PubMed DOI
Hu,X.Y., Liu,Z., Zhang,K.L., Feng,J., Liu,X.F., Wang,L.Y. and Wang,Z.W. SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells Cancer Biomark (2017) 21, 195-201. PubMed Europe PubMed DOI
Tan,M., Zhang,D., Zhang,E., Xu,D., Liu,Z., Qiu,J., Fan,Y. and Shen,B. SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-betaRI Mol Carcinog (2017) 56, 2332-2341. PubMed Europe PubMed DOI

2016

Maruyama,E.O., Lin,H., Chiu,S.Y., Yu,H.M., Porter,G.A. and Hsu,W. Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development Sci Rep (2016) 6, 20999-20999. PubMed Europe PubMed DOI PMC EPMC
Mirecka,A., Morawiec,Z. and Wozniak,K. Genetic polymorphism of SUMO-specific cysteine proteases - SENP1 and SENP2 in breast cancer Pathol Oncol Res (2016) 22, 817-823. PubMed Europe PubMed DOI M

2015

Heo,K.S., Le,N.T., Cushman,H.J., Giancursio,C.J., Chang,E., Woo,C.H., Sullivan,M.A., Taunton,J., Yeh,E.T., Fujiwara,K. and Abe,J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function J Clin Invest (2015) 125, 1299-1310. PubMed Europe PubMed DOI
Koo,Y.D., Choi,J.W., Kim,M., Chae,S., Ahn,B.Y., Kim,M., Oh,B.C., Hwang,D., Seol,J.H., Kim,Y.B., Park,Y.J., Chung,S.S. and Park,K.S. SUMO-specific protease 2 (SENP2) is an important regulator of fatty acid metabolism in skeletal muscle Diabetes (2015) 64, 2420-2431. PubMed Europe PubMed DOI
Liu,Y., Shen,Y., Zheng,S. and Liao,J. A novel robust quantitative Forster resonance energy transfer assay for protease SENP2 kinetics determination against its all natural substrates Mol Biosyst (2015) 11, 3407-3414. PubMed Europe PubMed DOI A

2014

Alegre,K.O. and Reverter,D. Structural insights into the SENP6 loop1 structure in complex with SUMO2 Protein Sci (2014) 23, 433-441. PubMed Europe PubMed DOI S
Chow,K.-H., Elgort,S., Dasso,M., Powers,M.A. and Ullman,K.S. The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function Mol Biol Cell (2014) 25, 160-168. PubMed Europe PubMed DOI
Fu,J., Yu,H.M., Chiu,S.Y., Mirando,A.J., Maruyama,E.O., Cheng,J.G. and Hsu,W. Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration PLoS Genet (2014) 10, e1004579-e1004579. PubMed Europe PubMed DOI PMC EPMC
Kumar,A., Ito,A., Takemoto,M., Yoshida,M. and Zhang,K.Y. Identification of 1,2,5-oxadiazoles as a new class of SENP2 inhibitors using structure based virtual screening J Chem Inf Model (2014) 54, 870-880. PubMed Europe PubMed DOI I
Lee,W.P., Jena,S., Doherty,D., Ventakesh,J., Schimdt,J., Furmick,J., Widener,T., Lemau,J., Jurutka,P.W. and Thompson,P.D. Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling PLoS ONE (2014) 9, e89506-e89506. PubMed Europe PubMed DOI PMC EPMC
Liu,Y., Kieslich,C.A., Morikis,D. and Liao,J. Engineering pre-SUMO4 as efficient substrate of SENP2 Protein Eng Des Sel (2014) 27, 117-126. PubMed Europe PubMed DOI
Qi,Y., Wang,J., Bomben,V.C., Li,D.P., Chen,S.R., Sun,H., Xi,Y., Reed,J.G., Cheng,J., Pan,H.L., Noebels,J.L. and Yeh,E.T. Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death Neuron (2014) 83, 1159-1171. PubMed Europe PubMed DOI K

2013

Heo,K.S., Chang,E., Le,N.T., Cushman,H., Yeh,E.T., Fujiwara,K. and Abe,J. De-sumoylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis Circ Res (2013) 112, 911-923. PubMed Europe PubMed DOI K
Tan,M.Y., Mu,X.Y., Liu,B., Wang,Y., Bao,E.D., Qiu,J.X. and Fan,Y. SUMO-specific protease 2 suppresses cell migration and invasion through inhibiting the expression of MMP13 in bladder cancer cells Cell Physiol Biochem (2013) 32, 542-548. PubMed Europe PubMed DOI
Tang,S., Huang,G., Tong,X., Xu,L., Cai,R., Li,J., Zhou,X., Song,S., Huang,C. and Cheng,J. Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism PLoS ONE (2013) 8, e63965-e63965. PubMed Europe PubMed DOI PMC EPMC

2012

Kim,E.Y., Chen,L., Ma,Y., Yu,W., Chang,J., Moskowitz,I.P. and Wang,J. Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction J Mol Cell Cardiol (2012) 52, 638-649. PubMed Europe PubMed DOI
Yeh,E.T.H. and Dou,H. SENP1 and SENP2 peptidases [ISSN:978-0-12-407743-0] (2012) 3, 2365-2370. DOI

2011

Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M. Development of small molecule inhibitors and probes of human SUMO deconjugating proteases Chem Biol (2011) 18, 722-732. PubMed Europe PubMed DOI I
Ban,R., Nishida,T. and Urano,T. Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis Genes Cells (2011) 16, 652-669. PubMed Europe PubMed DOI
Chung,S.S., Ahn,B.Y., Kim,M., Kho,J.H., Jung,H.S. and Park,K.S. SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor gamma in C2C12 myotubes Biochem J (2011) 433, 155-161. PubMed Europe PubMed DOI
Jiang,M., Chiu,S.Y. and Hsu,W. SUMO-specific protease 2 in Mdm2-mediated regulation of p53 Cell Death Differ (2011) 18, 1005-1015. PubMed Europe PubMed DOI
Lee,M.H., Mabb,A.M., Gill,G.B., Yeh,E.T. and Miyamoto,S. NF-kappaB induction of the SUMO protease SENP2: a negative feedback loop to attenuate cell survival response to genotoxic stress Mol Cell (2011) 43, 180-191. PubMed Europe PubMed DOI
Ran,Y., Liu,T.T., Zhou,Q., Li,S., Mao,A.P., Li,Y., Liu,L.J., Cheng,J.K. and Shu,H.B. SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation J Mol Cell Biol (2011) 3, 283-292. PubMed Europe PubMed DOI

2010

Chung,S.S., Ahn,B.Y., Kim,M., Choi,H.H., Park,H.S., Kang,S., Park,S.G., Kim,Y.B., Cho,Y.M., Lee,H.K., Chung,C.H. and Park,K.S. Control of adipogenesis by the SUMO-specific protease SENP2 Mol Cell Biol (2010) 30, 2135-2146. PubMed Europe PubMed DOI
Kang,X., Qi,Y., Zuo,Y., Wang,Q., Zou,Y., Schwartz,R.J., Cheng,J. and Yeh,E.T. SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development Mol Cell (2010) 38, 191-201. PubMed Europe PubMed DOI K
Wang,Z.B., Ou,X.H., Tong,J.S., Li,S., Wei,L., Ouyang,Y.C., Hou,Y., Schatten,H. and Sun,Q.Y. The SUMO pathway functions in mouse oocyte maturation Cell Cycle (2010) 9, 2640-2646. PubMed Europe PubMed DOI

2008

Chiu,S.Y., Asai,N., Costantini,F. and Hsu,W. SUMO-Specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages PLoS Biol (2008) 6, e310-e310. PubMed Europe PubMed DOI PMC EPMC
Drag,M., Mikolajczyk,J., Krishnakumar,I.M., Huang,Z. and Salvesen,G.S. Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family Biochem J (2008) 409, 461-469. PubMed Europe PubMed DOI P
Xu,Z., Lam,L.S., Lam,L.H., Chau,S.F., Ng,T.B. and Au,S.W. Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation FASEB J (2008) 22, 127-137. PubMed Europe PubMed DOI

2007

Mikolajczyk,J., Drag,M., Bekes,M., Cao,J.T., Ronai,Z. and Salvesen,G.S. Small Ubiquitin-related Modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs J Biol Chem (2007) 282, 26217-26224. PubMed Europe PubMed DOI P
Pungaliya,P., Kulkarni,D., Park,H.J., Marshall,H., Zheng,H., Lackland,H., Saleem,A. and Rubin,E.H. TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins J Proteome Res (2007) 6, 3918-3923. PubMed Europe PubMed DOI

2006

Itahana,Y., Yeh,E.T. and Zhang,Y. Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2 Mol Cell Biol (2006) 26, 4675-4689. PubMed Europe PubMed DOI PMC EPMC
Reverter,D. and Lima,C.D. Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates Nat Struct Mol Biol (2006) 13, 1060-1068. PubMed Europe PubMed DOI

2005

[YEAR:8-2-2005]Cheng,J., Perkins,N.D. and Yeh,E.T. Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases J Biol Chem (8-2-2005) 280, 14492-14498. PubMed Europe PubMed DOI

2004

Reverter,D. and Lima,C.D. A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex Structure (2004) 12, 1519-1531. PubMed Europe PubMed DOI S

2003

Yamamoto,H., Ihara,M., Matsuura,Y. and Kikuchi,A. Sumoylation is involved in beta-catenin-dependent activation of Tcf-4 EMBO J (2003) 22, 2047-2059. PubMed Europe PubMed DOI PMC EPMC

2002

Best,J.L., Ganiatsas,S., Agarwal,S., Changou,A., Salomoni,P., Shirihai,O., Meluh,P.B., Pandolfi,P.P. and Zon,L.I. SUMO-1 protease-1 regulates gene transcription through PML Mol Cell (2002) 10, 843-855. PubMed Europe PubMed DOI
[YEAR:31-5-2002]Hang,J. and Dasso,M. Association of the human SUMO-1 protease SENP2 with the nuclear pore J Biol Chem (31-5-2002) 277, 19961-19966. PubMed Europe PubMed DOI
Zhang,H., Saitoh,H. and Matunis,M.J. Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex Mol Cell Biol (2002) 22, 6498-6508. PubMed Europe PubMed DOI PMC EPMC

2001

[YEAR:19-10-2001]Nishida,T., Kaneko,F., Kitagawa,M. and Yasuda,H. Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat Axam, which is an Axin-binding protein promoting beta-catenin degradation J Biol Chem (19-10-2001) 276, 39060-39066. PubMed Europe PubMed DOI

2000

Yeh,E.T., Gong,L. and Kamitani,T. Ubiquitin-like proteins: new wines in new bottles Gene (2000) 248, 1-14. PubMed Europe PubMed DOI