Literature for peptidase C48.007: SENP2 peptidase

(Topics flags: S Structure, A Assay, M Mutation, P Specificity, K Knockout, I Inhibitor. To select only the references relevant to a single topic, click the link above. See explanation.)

2025
1. Demir,U. and Erdogdu,R.
   Targeting Prostate Cancer Cells by an Isopeptidase Inhibitor NSC632839
   Urol Res Pract (2025) 51, 33-37. PubMed  Europe PubMed DOI  PMC  EPMC  I
2024
2. Chen,X., Li,D., Su,Q., Ling,X., Ding,S., Xu,R., Liu,Z., Qin,Y., Zhang,J., Yang,Z., Kang,X., Qi,Y. and Wu,H.
   MicroRNA-145-5p inhibits the tumorigenesis of breast cancer through SENP2-regulated ubiquitination of ERK2
   Cell Mol Life Sci (2024) 81, 461-461. PubMed  Europe PubMed DOI  PMC  EPMC
3. Sun,L., Ma,K., Zhang,S., Gu,J., Wang,H. and Tan,L.
   SENP2 promotes ESCC proliferation through SETDB1 deSUMOylation and enhanced fatty acid metabolism
   Heliyon (2024) 10, e34010-e34010. PubMed  Europe PubMed DOI  PMC  EPMC
2023
4. Kim,P.C., Lee,J.S., Chung,S.S. and Park,K.S.
   Role of SUMO-Specific Protease 2 in Leptin-Induced Fatty Acid Metabolism in White Adipocytes
   Diabetes Metab J (2023) 47, 382-393. PubMed  Europe PubMed DOI  PMC  EPMC  K
5. Krapf,S.A., Lund,J., Bakke,H.G., Nyman,T.A., Bartesaghi,S., Peng,X.R., Rustan,A.C., Thoresen,G.H. and Kase,E.T.
   SENP2 knockdown in human adipocytes reduces glucose metabolism and lipid accumulation, while increases lipid oxidation
   Metabol Open (2023) 18, 100234-100234. PubMed  Europe PubMed DOI  PMC  EPMC
6. Lee,J.S., Min,J.E., Choe,H.J., Park,K.S. and Chung,S.S.
   SUMO-specific protease 2 regulates lipid droplet size through ERRalpha-mediated CIDEA expression in adipocytes
   Biochem Biophys Res Commun (2023) 681, 29-35. PubMed  Europe PubMed DOI  K
7. Luo,Y., Zhou,S., Xu,T., Wu,W., Shang,P., Wang,S., Pan,D. and Li,D.
   SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
   Chin Med J (Engl) (2023) 136, 2496-2507. PubMed  Europe PubMed DOI  PMC  EPMC
2022
8. Brand,M., Bommeli,E.B., Rutimann,M., Lindenmann,U. and Riedl,R.
   Discovery of a Dual SENP1 and SENP2 Inhibitor
   Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC  I
9. Lee,J.S., Chae,S., Nan,J., Koo,Y.D., Lee,S.A., Park,Y.J., Hwang,D., Han,W., Lee,D.S., Kim,Y.B., Chung,S.S. and Park,K.S.
   SENP2 suppresses browning of white adipose tissues by de-conjugating SUMO from C/EBPbeta
   Cell Rep (2022) 38, 110408-110408. PubMed  Europe PubMed DOI  K
10. Liang,M., Cai,Z., Jiang,Y., Huo,H., Shen,L. and He,B.
    SENP2 Promotes VSMC Phenotypic Switching via Myocardin De-SUMOylation
    Int J Mol Sci (2022) 23 PubMed  Europe PubMed DOI  PMC  EPMC
11. Nan,J., Lee,J.S., Moon,J.H., Lee,S.A., Park,Y.J., Lee,D.S., Chung,S.S. and Park,K.S.
    SENP2 regulates mitochondrial function and insulin secretion in pancreatic beta cells
    Exp Mol Med (2022) 54, 72-80. PubMed  Europe PubMed DOI  PMC  EPMC  K
2021
12. Chen,X., Zhang,Y., Ren,X., Su,Q., Liu,Y., Dang,X., Qin,Y., Yang,X., Xing,Z., Shen,Y., Wang,Y., Bai,Z., Yeh,E.T.H., Wu,H. and Qi,Y.
    The SUMO-specific protease SENP2 plays an essential role in the regulation of Kv7.2 and Kv7.3 potassium channels
    J Biol Chem (2021) 297, 101183-101183. PubMed  Europe PubMed DOI  PMC  EPMC
13. Chen,Y., Xu,T., Li,M., Li,C., Ma,Y., Chen,G., Sun,Y., Zheng,H., Wu,G., Liao,W., Liao,Y., Chen,Y. and Bin,J.
    Inhibition of SENP2-mediated Akt deSUMOylation promotes cardiac regeneration via activating Akt pathway
    Clin Sci (Lond) (2021) 135, 811-828. PubMed  Europe PubMed DOI
14. Liu,Y., Dou,X., Zhou,W.Y., Ding,M., Liu,L., Du,R.Q., Guo,L., Qian,S.W., Tang,Y., Yang,Q.Q., Pan,D.N., Li,X.Y., Lu,Y., Cheng,J.K. and Tang,Q.Q.
    Hepatic SENP2 Controls Systemic Metabolism via SUMOylation-dependent Regulation of Liver-Adipose Tissue Crosstalk
    Hepatology (2021) PubMed  Europe PubMed DOI
15. Lund,J., Krapf,S.A., Sistek,M., Bakke,H.G., Bartesaghi,S., Peng,X.R., Rustan,A.C., Thoresen,G.H. and Kase,E.T.
    SENP2 is vital for optimal insulin signaling and insulin-stimulated glycogen synthesis in human skeletal muscle cells
    Curr Res Pharmacol Drug Discov (2021) 2, 100061-100061. PubMed  Europe PubMed DOI  PMC  EPMC
16. Zhang,Y., Chen,X., Wang,Q., Du,C., Lu,W., Yuan,H., Zhang,Z., Li,D., Ling,X., Ren,X., Zhao,Y., Su,Q., Xing,Z., Qin,Y., Yang,X., Shen,Y., Wu,H. and Qi,Y.
    Hyper-SUMOylation of SMN induced by SENP2 deficiency decreases its stability and leads to spinal muscular atrophy-like pathology
    J Mol Med (Berl) (2021) 99, 1797-1813. PubMed  Europe PubMed DOI
2020
17. Huang,D., Liu,H., Zhu,A., Zhou,Y. and Li,Y.
    Forebrain excitatory neuron-specific SENP2 knockout mouse displays hyperactivity, impaired learning and memory, and anxiolytic-like behavior
    Mol Brain (2020) 13, 59-59. PubMed  Europe PubMed DOI  PMC  EPMC  K
2019
18. Chen,X.L., Wang,S.F., Liang,X.T., Liang,H.X., Wang,T.T., Wu,S.Q., Qiu,Z.J., Zhan,R. and Xu,Z.S.
    SENP2 exerts an antitumor effect on chronic lymphocytic leukemia cells through the inhibition of the Notch and NFkappaB signaling pathways
    Int J Oncol (2019) 54, 455-466. PubMed  Europe PubMed DOI
19. Koo,Y.D., Lee,J.S., Lee,S.A., Quaresma,P.G.F., Bhat,R., Haynes,W.G., Park,Y.J., Kim,Y.B., Chung,S.S. and Park,K.S.
    SUMO-specific protease 2 mediates leptin-induced fatty acid oxidation in skeletal muscle
    Metabolism (2019) 95, 27-35. PubMed  Europe PubMed DOI
20. Wang,H. and You,G.
    The SUMO-specific protease Senp2 regulates sumoylation, expression and function of human organic anion transporter 3
    Biochim Biophys Acta Biomembr (2019) 1861, 1293-1301. PubMed  Europe PubMed DOI
21. Xiao,N., Li,H., Yu,W., Gu,C., Fang,H., Peng,Y., Mao,H., Fang,Y., Ni,W. and Yao,M.
    SUMO-specific protease 2 (SENP2) suppresses keratinocyte migration by targeting NDR1 for de-SUMOylation
    FASEB J (2019) 33, 163-174. PubMed  Europe PubMed DOI
2018
22. Bernstock,J.D., Ye,D., Smith,J.A., Lee,Y.J., Gessler,F.A., Yasgar,A., Kouznetsova,J., Jadhav,A., Wang,Z., Pluchino,S., Zheng,W., Simeonov,A., Hallenbeck,J.M. and Yang,W.
    Quantitative high-throughput screening identifies cytoprotective molecules that enhance SUMO conjugation via the inhibition of SUMO-specific protease (SENP)2
    FASEB J (2018) 32, 1677-1691. PubMed  Europe PubMed DOI
23. Chang,C.C., Huang,Y.S., Lin,Y.M., Lin,C.J., Jeng,J.C., Liu,S.M., Ho,T.L., Chang,R.T., Changou,C.A., Ho,C.C. and Shih,H.M.
    The role of sentrin-specific protease 2 substrate recognition in TGF-beta-induced tumorigenesis
    Sci Rep (2018) 8, 9786-9786. PubMed  Europe PubMed DOI  PMC  EPMC
24. Liu,S.L. and Gao,F.H.
    SUMO1/sentrin/SMT3 specific peptidase 2 modulates target molecules and its corresponding functions
    Biochimie (2018) 152, 6-13. PubMed  Europe PubMed DOI
25. Odeh,H.M., Coyaud,E., Raught,B. and Matunis,M.J.
    The SUMO-specific isopeptidase SENP2 is targeted to intracellular membranes via a predicted N-Terminal amphipathic alpha-helix
    Mol Biol Cell (2018) 29, 1878-1890. PubMed  Europe PubMed DOI
26. Pei,H., Chen,L., Liao,Q.M., Wang,K.J., Chen,S.G., Liu,Z.J. and Zhang,Z.C.
    SUMO-specific protease 2 (SENP2) functions as a tumor suppressor in osteosarcoma via SOX9 degradation
    Exp Ther Med (2018) 16, 5359-5365. PubMed  Europe PubMed DOI  PMC  EPMC
2017
27. Besir,H.
    A generic protocol for purifying disulfide-bonded domains and random protein fragments using fusion proteins with SUMO3 and cleavage by SenP2 protease
    Methods Mol Biol (2017) 1586, 141-154. PubMed  Europe PubMed DOI
28. Hu,X.Y., Liu,Z., Zhang,K.L., Feng,J., Liu,X.F., Wang,L.Y. and Wang,Z.W.
    SUMO-specific protease 2-mediated deSUMOylation is required for NDRG2 stabilization in gastric cancer cells
    Cancer Biomark (2017) 21, 195-201. PubMed  Europe PubMed DOI
29. Tan,M., Zhang,D., Zhang,E., Xu,D., Liu,Z., Qiu,J., Fan,Y. and Shen,B.
    SENP2 suppresses epithelial-mesenchymal transition of bladder cancer cells through deSUMOylation of TGF-betaRI
    Mol Carcinog (2017) 56, 2332-2341. PubMed  Europe PubMed DOI
2016
30. Maruyama,E.O., Lin,H., Chiu,S.Y., Yu,H.M., Porter,G.A. and Hsu,W.
    Extraembryonic but not embryonic SUMO-specific protease 2 is required for heart development
    Sci Rep (2016) 6, 20999-20999. PubMed  Europe PubMed DOI  PMC  EPMC
31. Mirecka,A., Morawiec,Z. and Wozniak,K.
    Genetic polymorphism of SUMO-specific cysteine proteases - SENP1 and SENP2 in breast cancer
    Pathol Oncol Res (2016) 22, 817-823. PubMed  Europe PubMed DOI  M
2015
32. Heo,K.S., Le,N.T., Cushman,H.J., Giancursio,C.J., Chang,E., Woo,C.H., Sullivan,M.A., Taunton,J., Yeh,E.T., Fujiwara,K. and Abe,J.
    Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function
    J Clin Invest (2015) 125, 1299-1310. PubMed  Europe PubMed DOI
33. Koo,Y.D., Choi,J.W., Kim,M., Chae,S., Ahn,B.Y., Kim,M., Oh,B.C., Hwang,D., Seol,J.H., Kim,Y.B., Park,Y.J., Chung,S.S. and Park,K.S.
    SUMO-specific protease 2 (SENP2) is an important regulator of fatty acid metabolism in skeletal muscle
    Diabetes (2015) 64, 2420-2431. PubMed  Europe PubMed DOI
34. Liu,Y., Shen,Y., Zheng,S. and Liao,J.
    A novel robust quantitative Forster resonance energy transfer assay for protease SENP2 kinetics determination against its all natural substrates
    Mol Biosyst (2015) 11, 3407-3414. PubMed  Europe PubMed DOI  A
2014
35. Alegre,K.O. and Reverter,D.
    Structural insights into the SENP6 loop1 structure in complex with SUMO2
    Protein Sci (2014) 23, 433-441. PubMed  Europe PubMed DOI  S
36. Chow,K.-H., Elgort,S., Dasso,M., Powers,M.A. and Ullman,K.S.
    The SUMO proteases SENP1 and SENP2 play a critical role in nucleoporin homeostasis and nuclear pore complex function
    Mol Biol Cell (2014) 25, 160-168. PubMed  Europe PubMed DOI
37. Fu,J., Yu,H.M., Chiu,S.Y., Mirando,A.J., Maruyama,E.O., Cheng,J.G. and Hsu,W.
    Disruption of SUMO-specific protease 2 induces mitochondria mediated neurodegeneration
    PLoS Genet (2014) 10, e1004579-e1004579. PubMed  Europe PubMed DOI  PMC  EPMC
38. Kumar,A., Ito,A., Takemoto,M., Yoshida,M. and Zhang,K.Y.
    Identification of 1,2,5-oxadiazoles as a new class of SENP2 inhibitors using structure based virtual screening
    J Chem Inf Model (2014) 54, 870-880. PubMed  Europe PubMed DOI  I
39. Lee,W.P., Jena,S., Doherty,D., Ventakesh,J., Schimdt,J., Furmick,J., Widener,T., Lemau,J., Jurutka,P.W. and Thompson,P.D.
    Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling
    PLoS ONE (2014) 9, e89506-e89506. PubMed  Europe PubMed DOI  PMC  EPMC
40. Liu,Y., Kieslich,C.A., Morikis,D. and Liao,J.
    Engineering pre-SUMO4 as efficient substrate of SENP2
    Protein Eng Des Sel (2014) 27, 117-126. PubMed  Europe PubMed DOI
41. Qi,Y., Wang,J., Bomben,V.C., Li,D.P., Chen,S.R., Sun,H., Xi,Y., Reed,J.G., Cheng,J., Pan,H.L., Noebels,J.L. and Yeh,E.T.
    Hyper-SUMOylation of the Kv7 potassium channel diminishes the M-current leading to seizures and sudden death
    Neuron (2014) 83, 1159-1171. PubMed  Europe PubMed DOI  K
2013
42. Heo,K.S., Chang,E., Le,N.T., Cushman,H., Yeh,E.T., Fujiwara,K. and Abe,J.
    De-sumoylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis
    Circ Res (2013) 112, 911-923. PubMed  Europe PubMed DOI  K
43. Tan,M.Y., Mu,X.Y., Liu,B., Wang,Y., Bao,E.D., Qiu,J.X. and Fan,Y.
    SUMO-specific protease 2 suppresses cell migration and invasion through inhibiting the expression of MMP13 in bladder cancer cells
    Cell Physiol Biochem (2013) 32, 542-548. PubMed  Europe PubMed DOI
44. Tang,S., Huang,G., Tong,X., Xu,L., Cai,R., Li,J., Zhou,X., Song,S., Huang,C. and Cheng,J.
    Role of SUMO-specific protease 2 in reprogramming cellular glucose metabolism
    PLoS ONE (2013) 8, e63965-e63965. PubMed  Europe PubMed DOI  PMC  EPMC
2012
45. Kim,E.Y., Chen,L., Ma,Y., Yu,W., Chang,J., Moskowitz,I.P. and Wang,J.
    Enhanced desumoylation in murine hearts by overexpressed SENP2 leads to congenital heart defects and cardiac dysfunction
    J Mol Cell Cardiol (2012) 52, 638-649. PubMed  Europe PubMed DOI
46. Yeh,E.T.H. and Dou,H.
    SENP1 and SENP2 peptidases
    [ISSN:978-0-12-407743-0] (2012) 3, 2365-2370. DOI
2011
47. Albrow,V.E., Ponder,E.L., Fasci,D., Bekes,M., Deu,E., Salvesen,G.S. and Bogyo,M.
    Development of small molecule inhibitors and probes of human SUMO deconjugating proteases
    Chem Biol (2011) 18, 722-732. PubMed  Europe PubMed DOI  I
48. Ban,R., Nishida,T. and Urano,T.
    Mitotic kinase Aurora-B is regulated by SUMO-2/3 conjugation/deconjugation during mitosis
    Genes Cells (2011) 16, 652-669. PubMed  Europe PubMed DOI
49. Chung,S.S., Ahn,B.Y., Kim,M., Kho,J.H., Jung,H.S. and Park,K.S.
    SUMO modification selectively regulates transcriptional activity of peroxisome-proliferator-activated receptor gamma in C2C12 myotubes
    Biochem J (2011) 433, 155-161. PubMed  Europe PubMed DOI
50. Jiang,M., Chiu,S.Y. and Hsu,W.
    SUMO-specific protease 2 in Mdm2-mediated regulation of p53
    Cell Death Differ (2011) 18, 1005-1015. PubMed  Europe PubMed DOI
51. Lee,M.H., Mabb,A.M., Gill,G.B., Yeh,E.T. and Miyamoto,S.
    NF-kappaB induction of the SUMO protease SENP2: a negative feedback loop to attenuate cell survival response to genotoxic stress
    Mol Cell (2011) 43, 180-191. PubMed  Europe PubMed DOI
52. Ran,Y., Liu,T.T., Zhou,Q., Li,S., Mao,A.P., Li,Y., Liu,L.J., Cheng,J.K. and Shu,H.B.
    SENP2 negatively regulates cellular antiviral response by deSUMOylating IRF3 and conditioning it for ubiquitination and degradation
    J Mol Cell Biol (2011) 3, 283-292. PubMed  Europe PubMed DOI
2010
53. Chung,S.S., Ahn,B.Y., Kim,M., Choi,H.H., Park,H.S., Kang,S., Park,S.G., Kim,Y.B., Cho,Y.M., Lee,H.K., Chung,C.H. and Park,K.S.
    Control of adipogenesis by the SUMO-specific protease SENP2
    Mol Cell Biol (2010) 30, 2135-2146. PubMed  Europe PubMed DOI
54. Kang,X., Qi,Y., Zuo,Y., Wang,Q., Zou,Y., Schwartz,R.J., Cheng,J. and Yeh,E.T.
    SUMO-specific protease 2 is essential for suppression of polycomb group protein-mediated gene silencing during embryonic development
    Mol Cell (2010) 38, 191-201. PubMed  Europe PubMed DOI  K
55. Wang,Z.B., Ou,X.H., Tong,J.S., Li,S., Wei,L., Ouyang,Y.C., Hou,Y., Schatten,H. and Sun,Q.Y.
    The SUMO pathway functions in mouse oocyte maturation
    Cell Cycle (2010) 9, 2640-2646. PubMed  Europe PubMed DOI
2008
56. Chiu,S.Y., Asai,N., Costantini,F. and Hsu,W.
    SUMO-Specific protease 2 is essential for modulating p53-Mdm2 in development of trophoblast stem cell niches and lineages
    PLoS Biol (2008) 6, e310-e310. PubMed  Europe PubMed DOI  PMC  EPMC
57. Drag,M., Mikolajczyk,J., Krishnakumar,I.M., Huang,Z. and Salvesen,G.S.
    Activity profiling of human deSUMOylating enzymes (SENPs) with synthetic substrates suggests an unexpected specificity of two newly characterized members of the family
    Biochem J (2008) 409, 461-469. PubMed  Europe PubMed DOI  P
58. Xu,Z., Lam,L.S., Lam,L.H., Chau,S.F., Ng,T.B. and Au,S.W.
    Molecular basis of the redox regulation of SUMO proteases: a protective mechanism of intermolecular disulfide linkage against irreversible sulfhydryl oxidation
    FASEB J (2008) 22, 127-137. PubMed  Europe PubMed DOI
2007
59. Mikolajczyk,J., Drag,M., Bekes,M., Cao,J.T., Ronai,Z. and Salvesen,G.S.
    Small Ubiquitin-related Modifier (SUMO)-specific proteases: profiling the specificities and activities of human SENPs
    J Biol Chem (2007) 282, 26217-26224. PubMed  Europe PubMed DOI  P
60. Pungaliya,P., Kulkarni,D., Park,H.J., Marshall,H., Zheng,H., Lackland,H., Saleem,A. and Rubin,E.H.
    TOPORS functions as a SUMO-1 E3 ligase for chromatin-modifying proteins
    J Proteome Res (2007) 6, 3918-3923. PubMed  Europe PubMed DOI
2006
61. Itahana,Y., Yeh,E.T. and Zhang,Y.
    Nucleocytoplasmic shuttling modulates activity and ubiquitination-dependent turnover of SUMO-specific protease 2
    Mol Cell Biol (2006) 26, 4675-4689. PubMed  Europe PubMed DOI  PMC  EPMC
62. Reverter,D. and Lima,C.D.
    Structural basis for SENP2 protease interactions with SUMO precursors and conjugated substrates
    Nat Struct Mol Biol (2006) 13, 1060-1068. PubMed  Europe PubMed DOI
2005
63. [YEAR:8-2-2005]Cheng,J., Perkins,N.D. and Yeh,E.T.
    Differential regulation of c-Jun-dependent transcription by SUMO-specific proteases
    J Biol Chem (8-2-2005) 280, 14492-14498. PubMed  Europe PubMed DOI
2004
64. Reverter,D. and Lima,C.D.
    A basis for SUMO protease specificity provided by analysis of human Senp2 and a Senp2-SUMO complex
    Structure (2004) 12, 1519-1531. PubMed  Europe PubMed DOI  S
2003
65. Yamamoto,H., Ihara,M., Matsuura,Y. and Kikuchi,A.
    Sumoylation is involved in beta-catenin-dependent activation of Tcf-4
    EMBO J (2003) 22, 2047-2059. PubMed  Europe PubMed DOI  PMC  EPMC
2002
66. Best,J.L., Ganiatsas,S., Agarwal,S., Changou,A., Salomoni,P., Shirihai,O., Meluh,P.B., Pandolfi,P.P. and Zon,L.I.
    SUMO-1 protease-1 regulates gene transcription through PML
    Mol Cell (2002) 10, 843-855. PubMed  Europe PubMed DOI
67. [YEAR:31-5-2002]Hang,J. and Dasso,M.
    Association of the human SUMO-1 protease SENP2 with the nuclear pore
    J Biol Chem (31-5-2002) 277, 19961-19966. PubMed  Europe PubMed DOI
68. Zhang,H., Saitoh,H. and Matunis,M.J.
    Enzymes of the SUMO modification pathway localize to filaments of the nuclear pore complex
    Mol Cell Biol (2002) 22, 6498-6508. PubMed  Europe PubMed DOI  PMC  EPMC
2001
69. [YEAR:19-10-2001]Nishida,T., Kaneko,F., Kitagawa,M. and Yasuda,H.
    Characterization of a novel mammalian SUMO-1/Smt3-specific isopeptidase, a homologue of rat Axam, which is an Axin-binding protein promoting beta-catenin degradation
    J Biol Chem (19-10-2001) 276, 39060-39066. PubMed  Europe PubMed DOI
2000
70. Yeh,E.T., Gong,L. and Kamitani,T.
    Ubiquitin-like proteins: new wines in new bottles
    Gene (2000) 248, 1-14. PubMed  Europe PubMed DOI