Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P61956

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
6	peptidyl-Lys metallopeptidase	1-95	N		MS
20	peptidyl-Lys metallopeptidase	1-95	N		MS
21	trypsin 1	1-93	N		MS	Schilling & Overall, 2008
23	cathepsin K	21-33	N		MS	Schilling & Overall, 2008
32	peptidyl-Lys metallopeptidase	1-95	N		MS
33	trypsin 1	1-93	N		MS	Schilling & Overall, 2008
93	SENP3 peptidase	1-93	P			Nishida et al., 2000
93	SENP2 peptidase	1-95	P		AB	Nishida et al., 2001
93	SENP5 peptidase	1-95	P		AB	Gong & Yeh, 2006
93	USPL1 peptidase	1-95	P		NT	Schulz et al., 2012