Substrates for peptidase C14.013: caspase-12

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Ala-Thr-Ala-Asp-AFC			Ala-Thr-Ala-Asp+AFC	S	CS	Ala	Thr	Ala	Asp	AFC	-	-	-
caspase-12 precursor	O08736	1-419	peptide-Asp318+Thr-peptide	P		Ala	Thr	Ala	Asp	Thr	Asp	Glu	Glu	Fujita et al., 2002	26879
caspase-12 precursor	O08736	1-419	peptide-Asp341+Phe-peptide	P		Val	Glu	Thr	Asp	Phe	Ile	Ala	Phe	Rao et al., 2001	19425
TAR DNA-binding protein 43	Q13148	1-414	Peptide-Asp89+Ala-Peptide	P	MU	Asp	Glu	Thr	Asp	Ala	Ser	Ser	Ala	Suzuki et al., 2011
TAR DNA-binding protein 43	Q13148	1-414	Peptide-Asp169+Gly-Peptide	P	MU	His	Met	Ile	Asp	Gly	Arg	Trp	Cys	Suzuki et al., 2011