$VAR1 = undef;
Summary for peptidase C14.012: caspase-11
| Names | |
|---|---|
| MEROPS Name | caspase-11 |
| Domain architecture |
|---|
| MEROPS Classification | |
|---|---|
| Classification | Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.012 |
| Holotype | caspase-11 (Mus musculus), Uniprot accession P70343 (peptidase unit: 89-373), MERNUM MER0003194 |
| History | Identifier created: MEROPS 3.02 (25 June 1998) |
| Activity | |||
|---|---|---|---|
| Catalytic type | Cysteine | ||
| NC-IUBMB | Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.64 | ||
| Enzymology | BRENDA database | ||
| Proteolytic events | CutDB database (1 cleavage) | ||
| Knockout | Caspase-11 knockout mice have been described (Arai et al., 2004). | ||
| Pharmaceutical relevance | Caspase-11 is reported to play a crucial role in lipopolysaccharide-induced septic shock in mice (Arai et al., 2004). | ||
| Other databases | TREEFAM | http://www.treefam.org/family/TF102023 | |
| Mouse genetics | ||||||
|---|---|---|---|---|---|---|
| Gene symbol | Position | Megabases | Ensembl | Entrez gene | MGI | |
| Casp11 | 9:A1 | ENSMUSG00000033538 | 12363 | MGI:107700 | ||
