$VAR1 = undef;

Summary for peptidase C14.011: caspase-10

Names
MEROPS Name	caspase-10
Other names	Mch4, FLICE2

Domain architecture

MEROPS Classification
Classification	Clan CD >> Subclan (none) >> Family C14 >> Subfamily A >> C14.011
Holotype	caspase-10 (Homo sapiens), Uniprot accession Q92851 (peptidase unit: 243-514), MERNUM MER0002579
History	Identifier created: MEROPS 3.02 (25 June 1998)

Activity
Catalytic type	Cysteine
NC-IUBMB	Subclass 3.4 (Peptidases) >> Sub-subclass 3.4.22 (Cysteine endopeptidases) >> Peptidase 3.4.22.63
Enzymology	BRENDA database
Proteolytic events	CutDB database (4 cleavages)
Physiology	One of the "initator" caspases in mammalian cell apoptosis. Taxol induces FADD-dependent apoptosis primarily through activation of caspase-10 (Park et al., 2004).
Knockout	Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II (Wang et al., 1999).
Pathways	KEGG	Apoptosis
	KEGG	Hepatitis B
	KEGG	RIG-I-like receptor signalling pathway
	KEGG	TNF signaling pathway
	KEGG	Tuberculosis
Other databases	WIKIPEDIA	http://en.wikipedia.org/wiki/Caspase_10
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/eqs/tv/Ds/-/-/- (based on 10 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	0	0	0	0	2	2	1	1
Pro	0	0	0	0	0	0	0	1
Ala	1	1	1	0	2	0	1	0
Val	1	0	3	0	1	0	1	0
Leu	0	0	1	0	0	1	1	0
Ile	2	0	0	0	0	0	0	1
Met	0	0	0	0	0	0	0	0
Phe	0	0	0	0	0	0	0	1
Tyr	0	0	0	0	0	0	0	0
Trp	0	0	0	0	0	0	0	0
Ser	2	2	0	0	3	1	1	2
Thr	0	0	3	0	0	0	1	1
Cys	0	0	0	0	0	1	1	0
Asn	1	0	0	0	0	0	1	0
Gln	0	2	0	0	0	0	0	0
Asp	1	1	0	10	0	1	1	2
Glu	2	4	1	0	0	0	0	0
Lys	0	0	0	0	0	3	0	0
Arg	0	0	0	0	1	0	0	0
His	0	0	1	0	0	0	0	0

Human genetics
Gene symbol	Locus	Megabases	Ensembl	Entrez gene	Gene Cards	OMIM
CASP10	2q33-q34		ENSG00000003400	843	CASP10	601762