Literature for peptidase C03.020: enterovirus picornain 2A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Bakhache,W., Symonds-Orr,W. and Dolan,P.T. Genotype-by-Inhibitor Interactions to Dissect Enterovirus Replication Res Sq (2025) PubMed Europe PubMed DOI PMC EPMC
Hu,S., Zhong,Q., Xie,X., Zhang,S., Wang,J., Liu,H. and Dai,W. Research progress on critical viral protease inhibitors for coronaviruses and enteroviruses Bioorg Med Chem Lett (2025) 122, 130168-130168. PubMed Europe PubMed DOI
Zinn,K.M., McLaren,M.W., Imai,M.T., Jayaram,M.M., Rothstein,J.D. and Elrick,M.J. Enterovirus D68 2A protease causes nuclear pore complex dysfunction and motor neuron toxicity bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC

2024

Gao,X., Wang,B., Zhu,K., Wang,L., Qin,B., Shang,K., Ding,W., Wang,J. and Cui,S. The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction Nat Commun (2024) 15, 4176-4176. PubMed Europe PubMed DOI PMC EPMC
Lithgo,R.M., Tomlinson,C.W.E., Fairhead,M., Winokan,M., Thompson,W., Wild,C., Aschenbrenner,J.C., Balcomb,B.H., Marples,P.G., Chandran,A.V., Golding,M., Koekemoer,L., Williams,E.P., Wang,S., Ni,X., MacLean,E., Giroud,C., Godoy,A.S., Xavier,M.A., Walsh,M., Fearon,D. and von Delft,F. Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals bioRxiv (2024) PubMed Europe PubMed DOI PMC EPMC
Shen,S., Guo,H., Li,Y., Zhang,L., Tang,Y., Li,H., Li,X., Wang,P.H., Yu,X.F. and Wei,W. SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis J Virol (2024) 98, e0190923-e0190923. PubMed Europe PubMed DOI PMC EPMC
Wang,S., Pang,Z., Fan,H. and Tong,Y. Advances in anti-EV-A71 drug development research J Adv Res (2024) 56, 137-156. PubMed Europe PubMed DOI V

2023

Tan,B., Liu,C., Li,K., Jadhav,P., Lambrinidis,G., Zhu,L., Olson,L., Tan,H., Wen,Y., Kolocouris,A., Liu,W. and Wang,J. Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors J Med Chem (2023) 66, 14544-14563. PubMed Europe PubMed DOI I
Wang,Y., Zou,W., Niu,Y., Wang,S., Chen,B., Xiong,R., Zhang,P., Luo,Z., Wu,Y., Fan,C., Zhong,Z., Xu,P. and Peng,Y. Phosphorylation of enteroviral 2A(pro) at Ser/Thr125 benefits its proteolytic activity and viral pathogenesis J Med Virol (2023) 95, e28400-e28400. PubMed Europe PubMed DOI PMC EPMC
Zang,L., Yang,X., Chen,Y., Huang,F., Yuan,Y., Chen,X., Zuo,Y., Miao,Y., Gu,J., Guo,H., Xia,W., Peng,Y., Tang,M., Huang,Z., Wang,Y., Ma,J., Jiang,J., Zhou,W., Zheng,H. and Shi,W. Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease J Virol (2023) 97, e0078623-e0078623. PubMed Europe PubMed DOI PMC EPMC

2022

Chen,T., Grauffel,C., Yang,W.Z., Chen,Y.P., Yuan,H.S. and Lim,C. Efficient Strategy to Design Protease Inhibitors: Application to Enterovirus 71 2A Protease ACS Bio Med Chem Au (2022) 2, 437-449. PubMed Europe PubMed DOI PMC EPMC
Peters,C.E., Schulze-Gahmen,U., Eckhardt,M., Jang,G.M., Xu,J., Pulido,E.H., Bardine,C., Craik,C.S., Ott,M., Gozani,O., Verba,K.A., Huttenhain,R., Carette,J.E. and Krogan,N.J. Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3 Nat Commun (2022) 13, 5282-5282. PubMed Europe PubMed DOI PMC EPMC
Serganov,A.A., Udi,Y., Stein,M.E., Patel,V., Fridy,P.C., Rice,C.M., Saeed,M., Jacobs,E.Y., Chait,B.T. and Rout,M.P. Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease J Biol Chem (2022) 298, 101882-101882. PubMed Europe PubMed DOI PMC EPMC

2021

Jimbo,E., Kobayashi,T., Takeshita,A., Mine,K., Nagafuchi,S., Fukui,T. and Yagihashi,S. Immunohistochemical detection of enteroviruses in pancreatic tissues of patients with type 1 diabetes using a polyclonal antibody against 2A protease of Coxsackievirus J Diabetes Investig (2021) PubMed Europe PubMed DOI

2020

Kang,J., Pang,Z., Zhou,Z., Li,X., Liu,S., Cheng,J., Liu,P., Tan,W., Wang,Z. and Wang,T. Enterovirus D68 Protease 2A(pro) Targets TRAF3 to Subvert Host Innate Immune Responses J Virol (2020) PubMed Europe PubMed DOI

2019

Diep,J., Ooi,Y.S., Wilkinson,A.W., Peters,C.E., Foy,E., Johnson,J.R., Zengel,J., Ding,S., Weng,K.F., Laufman,O., Jang,G., Xu,J., Young,T., Verschueren,E., Kobluk,K.J., Elias,J.E., Sarnow,P., Greenberg,H.B., Huttenhain,R., Nagamine,C.M., Andino,R., Krogan,N.J., Gozani,O. and Carette,J.E. Enterovirus pathogenesis requires the host methyltransferase SETD3 Nat Microbiol (2019) 4, 2523-2537. PubMed Europe PubMed DOI T
Hanson,P.J., Hossain,A.R., Qiu,Y., Zhang,H.M., Zhao,G., Li,C., Lin,V., Sulaimon,S., Vlok,M., Fung,G., Chen,V.H., Jan,E., McManus,B.M., Granville,D.J. and Yang,D. Cleavage and sub-cellular redistribution of nuclear pore protein 98 by coxsackievirus B3 protease 2A impairs cardioprotection Front Cell Infect Microbiol (2019) 9, 265-265. PubMed Europe PubMed DOI PMC EPMC
Musharrafieh,R., Ma,C., Zhang,J., Hu,Y., Diesing,J.M., Marty,M.T. and Wang,J. Validating enterovirus D68-2A(pro) as an antiviral drug target and the discovery of telaprevir as a potent D68-2A(pro) inhibitor J Virol (2019) 93, e02221-18-e02221-18. PubMed Europe PubMed DOI I
Visser,L.J., Langereis,M.A., Rabouw,H.H., Wahedi,M., Muntjewerff,E.M., de Groot,R.J. and van Kuppeveld,F.J.M. Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I interferon J Virol (2019) 93, e00222-19-e00222-19. PubMed Europe PubMed DOI

2018

Chen,K.R., Yu,C.K., Kung,S.H., Chen,S.H., Chang,C.F., Ho,T.C., Lee,Y.P., Chang,H.C., Huang,L.Y., Lo,S.Y., Chang,J.C. and Ling,P. Toll-like receptor 3 is involved in detection of enterovirus A71 infection and targeted by viral 2A protease Viruses (2018) 10 PubMed Europe PubMed DOI
Laitinen,O.H., Svedin,E., Kapell,S., Hankaniemi,M.M., Larsson,P.G., Domsgen,E., Stone,V.M., Maatta,J.A.E., Hyoty,H., Hytonen,V.P. and Flodstrom-Tullberg,M. New Coxsackievirus 2A(pro) and 3C(pro) protease antibodies for virus detection and discovery of pathogenic mechanisms J Virol Methods (2018) 255, 29-37. PubMed Europe PubMed DOI
Rasti,M., Khanbabaei,H. and Teimoori,A. An update on enterovirus 71 infection and interferon type I response Rev Med Virol (2018) , e2016-e2016. PubMed Europe PubMed DOI
Schulz,R., Atef,A., Becker,D., Gottschalk,F., Tauber,C., Wagner,S., Arkona,C., Abdel-Hafez,A.A., Farag,H.H., Rademann,J. and Wolber,G. Phenylthiomethyl ketone-based fragments show selective and irreversible inhibition of enteroviral 3C proteases J Med Chem (2018) 61, 1218-1230. PubMed Europe PubMed DOI I
Yang,X., Hu,Z., Fan,S., Zhang,Q., Zhong,Y., Guo,D., Qin,Y. and Chen,M. Picornavirus 2A protease regulates stress granule formation to facilitate viral translation PLoS Pathog (2018) 14, e1006901-e1006901. PubMed Europe PubMed DOI

2017

Deng,H., Fung,G., Qiu,Y., Wang,C., Zhang,J., Jin,Z.G. and Luo,H. Cleavage of Grb2-associated binding protein 2 by viral proteinase 2A during Coxsackievirus infection Front Cell Infect Microbiol (2017) 7, 85-85. PubMed Europe PubMed DOI PMC EPMC
Li,C., Qiao,Q., Hao,S.B., Dong,Z., Zhao,L., Ji,J., Wang,Z.Y. and Wen,H.L. Nonstructural protein 2A modulates replication and virulence of enterovirus 71 Virus Res (2017) 244, 262-269. PubMed Europe PubMed DOI

2016

Guo,Y., Wang,Y., Cao,L., Wang,P., Qing,J., Zheng,Q., Shang,L., Yin,Z. and Sun,Y. A conserved inhibitory mechanism of a lycorine derivative against enterovirus and hepatitis C virus Antimicrob Agents Chemother (2016) 60, 913-924. PubMed Europe PubMed DOI I
Hanson,P.J., Ye,X., Qiu,Y., Zhang,H.M., Hemida,M.G., Wang,F., Lim,T., Gu,A., Cho,B., Kim,H., Fung,G., Granville,D.J. and Yang,D. Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes Cell Death Differ (2016) 23, 828-840. PubMed Europe PubMed DOI
Laitinen,O.H., Svedin,E., Kapell,S., Nurminen,A., Hytonen,V.P. and Flodstrom-Tullberg,M. Enteroviral proteases: structure, host interactions and pathogenicity Rev Med Virol (2016) 26, 251-267. PubMed Europe PubMed DOI

2015

Aumayr,M., Fedosyuk,S., Ruzicska,K., Sousa-Blin,C., Kontaxis,G. and Skern,T. NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII Protein Sci (2015) 24, 1979-1996. PubMed Europe PubMed DOI
Barnabei,M.S., Sjaastad,F.V., Townsend,D., Bedada,F.B. and Metzger,J.M. Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment Sci Transl Med (2015) 7, 294ra106-294ra. PubMed Europe PubMed DOI
Deng,H., Fung,G., Shi,J., Xu,S., Wang,C., Yin,M., Hou,J., Zhang,J., Jin,Z.G. and Luo,H. Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1 FASEB J (2015) 29, 4523-4531. PubMed Europe PubMed DOI
Dougherty,J.D., Tsai,W.C. and Lloyd,R.E. Multiple poliovirus proteins repress cytoplasmic RNA granules Viruses (2015) 7, 6127-6140. PubMed Europe PubMed DOI
Fung,G., Shi,J., Deng,H., Hou,J., Wang,C., Hong,A., Zhang,J., Jia,W. and Luo,H. Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis Cell Death Differ (2015) 22, 2087-2097. PubMed Europe PubMed DOI
Song,Q.Q., Lu,M.Z., Song,J., Chi,M.M., Sheng,L.J., Yu,J., Luo,X.N., Zhang,L., Yao,H.L. and Han,J. Coxsackievirus B3 2A protease promotes encephalomyocarditis virus replication Virus Res (2015) 208, 22-29. PubMed Europe PubMed DOI
Wang,C.Y., Huang,A.C., Hour,M.J., Huang,S.H., Kung,S.H., Chen,C.H., Chen,I.C., Chang,Y.S., Lien,J.C. and Lin,C.W. Antiviral potential of a novel compound CW-33 against enterovirus A71 via inhibition of viral 2A protease Viruses (2015) 7, 3155-3171. PubMed Europe PubMed DOI PMC EPMC I
Xiang,Z., Liu,L., Lei,X., Zhou,Z., He,B. and Wang,J. 3C Protease of enterovirus D68 inhibits cellular defense mediated by interferon regulatory factor 7 J Virol (2015) 90, 1613-1621. PubMed Europe PubMed DOI

2014

Wu,S., Wang,Y., Lin,L., Si,X., Wang,T., Zhong,X., Tong,L., Luan,Y., Chen,Y., Li,X., Zhang,F., Zhao,W. and Zhong,Z. Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections Virol J (2014) 11, 192-192. PubMed Europe PubMed DOI

2013

Cai,Q., Yameen,M., Liu,W., Gao,Z., Li,Y., Peng,X., Cai,Y., Wu,C., Zheng,Q., Li,J. and Lin,T. Conformational plasticity of the 2A proteinase from enterovirus 71 J Virol (2013) 87, 7348-7356. PubMed Europe PubMed DOI S
Lim,B.K., Peter,A.K., Xiong,D., Narezkina,A., Yung,A., Dalton,N.D., Hwang,K.K., Yajima,T., Chen,J. and Knowlton,K.U. Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy J Clin Invest (2013) 123, 5146-5151. PubMed Europe PubMed DOI
Mu,Z., Wang,B., Zhang,X., Gao,X., Qin,B., Zhao,Z. and Cui,S. Crystal structure of 2A proteinase from hand, foot and mouth disease virus J Mol Biol (2013) 425, 4530-4543. PubMed Europe PubMed DOI S
Neubauer,D., Aumayr,M., Gosler,I. and Skern,T. Specificity of human rhinovirus 2A(pro) is determined by combined spatial properties of four cleavage site residues J Gen Virol (2013) 94, 1535-1546. PubMed Europe PubMed DOI P
Sun,Y., Wang,X., Yuan,S., Dang,M., Li,X., Zhang,X.C. and Rao,Z. An open conformation determined by a structural switch for 2A protease from coxsackievirus A16 Protein Cell (2013) 4, 782-792. PubMed Europe PubMed DOI S
Wang,B., Xi,X., Lei,X., Zhang,X., Cui,S., Wang,J., Jin,Q. and Zhao,Z. Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses PLoS Pathog (2013) 9, e1003231-e1003231. PubMed Europe PubMed DOI PMC EPMC P
Zhang,Y.Z., Gan,X., Song,J., Sun,P., Song,Q.Q., Li,G.Q., Sheng,L.J., Wang,B.D., Lu,M.Z., Li,L.M. and Han,J. [The 2A protease of enterovirus 71 cleaves nup62 to inhibit nuclear transport] Bing Du Xue Bao (2013) 29, 421-425. PubMed Europe PubMed

2012

Falah,N., Montserret,R., Lelogeais,V., Schuffenecker,I., Lina,B., Cortay,J.C. and Violot,S. Blocking human enterovirus 71 replication by targeting viral 2A protease J Antimicrob Chemother (2012) 67, 2865-2869. PubMed Europe PubMed DOI I
Lu,J., Yi,L., Zhao,J., Yu,J., Chen,Y., Lin,M.C., Kung,H.F. and He,M.L. Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1 J Virol (2012) 86, 3767-3776. PubMed Europe PubMed DOI
Skern,T. Picornain 2A [ISSN:978-0-12-407743-0] (2012) 3, 2406-2411. DOI
Wong,J., Zhang,J., Yanagawa,B., Luo,Z., Yang,X., Chang,J., McManus,B. and Luo,H. Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function Cell Res (2012) 22, 360-371. PubMed Europe PubMed DOI

2011

Alvarez,E., Castello,A., Carrasco,L. and Izquierdo,J.M. Alternative splicing, a new target to block cellular gene expression by poliovirus 2A protease Biochem Biophys Res Commun (2011) 414, 142-147. PubMed Europe PubMed DOI
Cantera,J.L., Chen,W. and Yates,M.V. A fluorescence resonance energy transfer-based fluorometer assay for screening anti-coxsackievirus B3 compounds J Virol Methods (2011) 171, 176-182. PubMed Europe PubMed DOI A
Castello,A., Alvarez,E. and Carrasco,L. The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases J Biomed Biotechnol (2011) 2011, 369648-369648. PubMed Europe PubMed DOI PMC EPMC
Maghsoudi,A.H., Khodagholi,F., Hadi-Alijanvand,H., Esfandiarei,M., Sabbaghian,M., Zakeri,Z., Shaerzadeh,F., Abtahi,S. and Maghsoudi,N. Homology modeling, docking, molecular dynamics simulation, and structural analyses of coxsakievirus B3 2A protease: an enzyme involved in the pathogenesis of inflammatory myocarditis Int J Biol Macromol (2011) 49, 487-492. PubMed Europe PubMed DOI
Redondo,N., Sanz,M.A., Welnowska,E. and Carrasco,L. Translation without eIF2 promoted by poliovirus 2A protease PLoS ONE (2011) 6, e25699-e25699. PubMed Europe PubMed DOI PMC EPMC

2010

Cantera,J.L., Chen,W. and Yates,M.V. Detection of infective poliovirus by a simple, rapid, and sensitive flow cytometry method based on fluorescence resonance energy transfer technology Appl Environ Microbiol (2010) 76, 584-588. PubMed Europe PubMed DOI
Maghsoudi,N., Tafreshi,N.K., Khodagholi,F., Zakeri,Z., Esfandiarei,M., Hadi-Alijanvand,H., Sabbaghian,M., Maghsoudi,A.H., Sajadi,M., Zohri,M., Moosavi,M. and Zeinoddini,M. Targeting enteroviral 2A protease by a 16-mer synthetic peptide: inhibition of 2Apro-induced apoptosis in a stable Tet-on HeLa cell line Virology (2010) 399, 39-45. PubMed Europe PubMed DOI I
Sanz,M.A., Welnowska,E., Redondo,N. and Carrasco,L. Translation driven by picornavirus IRES is hampered from Sindbis virus replicons: rescue by poliovirus 2A protease J Mol Biol (2010) 402, 101-117. PubMed Europe PubMed DOI
Yang,C.H., Li,H.C., Jiang,J.G., Hsu,C.F., Wang,Y.J., Lai,M.J., Juang,Y.L. and Lo,S.Y. Enterovirus type 71 2A protease functions as a transcriptional activator in yeast J Biomed Sci (2010) 17, 65-65. PubMed Europe PubMed DOI

2009

Castello,A., Izquierdo,J.M., Welnowska,E. and Carrasco,L. RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage J Cell Sci (2009) 122, 3799-3809. PubMed Europe PubMed DOI
Morrison,J.M. and Racaniello,V.R. Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells J Virol (2009) 83, 4412-4422. PubMed Europe PubMed DOI PMC EPMC

2008

Kempf,B.J. and Barton,D.J. Poliovirus 2A(pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G J Virol (2008) 82, 5847-5859. PubMed Europe PubMed DOI PMC EPMC
Maghsoudi,N., Khodagholi,F., Sadjadi,M., Zeinodini,M. and Sabbaghian,M. Purification and partial characterization of coxsackievirus B3 2A protease expressed in Escherichia coli Int J Biol Macromol (2008) 43, 238-244. PubMed Europe PubMed DOI
Rivera,C.I. and Lloyd,R.E. Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors Virology (2008) 375, 59-72. PubMed Europe PubMed DOI PMC EPMC

2007

Almstead,L.L. and Sarnow,P. Inhibition of U snRNP assembly by a virus-encoded proteinase Genes Dev (2007) 21, 1086-1097. PubMed Europe PubMed DOI PMC EPMC
Chau,D.H., Yuan,J., Zhang,H., Cheung,P., Lim,T., Liu,Z., Sall,A. and Yang,D. Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1 Apoptosis (2007) 12, 513-524. PubMed Europe PubMed DOI
Ghukasyan,V., Hsu,Y.Y., Kung,S.H. and Kao,F.J. Application of fluorescence resonance energy transfer resolved by fluorescence lifetime imaging microscopy for the detection of enterovirus 71 infection in cells J Biomed Opt (2007) 12, 024016-024016. PubMed Europe PubMed DOI
[YEAR:23-2-2007]Hsu,Y.Y., Liu,Y.N., Wang,W., Kao,F.J. and Kung,S.H. In vivo dynamics of enterovirus protease revealed by fluorescence resonance emission transfer (FRET) based on a novel FRET pair Biochem Biophys Res Commun (23-2-2007) 353, 939-945. PubMed Europe PubMed DOI
Inoue,T., Zhang,Z., Wang,L., West,L., Bashiruddin,J.B. and Belsham,G.J. Significance of arginine 20 in the 2A protease for swine vesicular disease virus pathogenicity J Gen Virol (2007) 88, 2275-2279. PubMed Europe PubMed DOI
[YEAR:2-1-2007]Xiong,D., Yajima,T., Lim,B.K., Stenbit,A., Dublin,A., Dalton,N.D., Summers-Torres,D., Molkentin,J.D., Duplain,H., Wessely,R., Chen,J. and Knowlton,K.U. Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy Circulation (2-1-2007) 115, 94-102. PubMed Europe PubMed DOI

2006

Baxter,N.J., Roetzer,A., Liebig,H.D., Sedelnikova,S.E., Hounslow,A.M., Skern,T. and Waltho,J.P. Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease J Virol (2006) 80, 1451-1462. PubMed Europe PubMed DOI PMC EPMC S
Hwang,Y.C., Chen,W. and Yates,M.V. Use of fluorescence resonance energy transfer for rapid detection of enteroviral infection in vivo Appl Environ Microbiol (2006) 72, 3710-3715. PubMed Europe PubMed DOI PMC EPMC
[YEAR:16-11-2006]Jurgens,C.K., Barton,D.J., Sharma,N., Morasco,B.J., Ogram,S.A. and Flanegan,J.B. 2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA Virology (16-11-2006) 345, 346-357. PubMed Europe PubMed DOI
[YEAR:6-10-2006]Muto,S., Miyoshi,H., Nishikawa,H. and Nakashima,H. Novel recognition sequence of coxsackievirus 2A proteinase Biochem Biophys Res Commun (6-10-2006) 348, 1436-1442. PubMed Europe PubMed DOI P

2005

Inoue,T., Alexandersen,S., Clark,A.T., Murphy,C., Quan,M., Reid,S.M., Sakoda,Y., Johns,H.L. and Belsham,G.J. Importance of arginine 20 of the swine vesicular disease virus 2A protease for activity and virulence J Virol (2005) 79, 428-440. PubMed Europe PubMed DOI PMC EPMC
[YEAR:5-4-2005]Merl,S., Michaelis,C., Jaschke,B., Vorpahl,M., Seidl,S. and Wessely,R. Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice Circulation (5-4-2005) 111, 1583-1592. PubMed Europe PubMed DOI

2004

Badorff,C. Coxsackie B virus picornain 2A [ISSN:0-12-079610-4] (2004) 2, 1365-1368. V
[YEAR:12-8-2004]Badorff,C. and Knowlton,K.U. Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside Med Microbiol Immunol (Berl) (12-8-2004) 193, 121-126. PubMed Europe PubMed DOI
Calandria,C., Irurzun,A., Barco,A. and Carrasco,L. Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells Virus Res (2004) 104, 39-49. PubMed Europe PubMed DOI
Skern,T. Picornain 2A [ISSN:0-12-079610-4] (2004) 2, 1361-1365. V

2003

[YEAR:14-2-2003]Zhao,X., Lamphear,B.J., Xiong,D., Knowlton,K. and Rhoads,R.E. Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by coxsackievirus 2A protease J Biol Chem (14-2-2003) 278, 4449-4457. PubMed Europe PubMed DOI

2002

Badorff,C., Fichtlscherer,B., Muelsch,A., Zeiher,A.M. and Dimmeler,S. Selective delivery of nitric oxide to a cellular target: a pseudosubstrate-coupled dinitrosyl-iron complex inhibits the enteroviral protease 2A Nitric Oxide (2002) 6, 305-312. PubMed Europe PubMed DOI
Kuo,R.L., Kung,S.H., Hsu,Y.Y. and Liu,W.T. Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death J Gen Virol (2002) 83, 1367-1376. PubMed Europe PubMed
Kuyumcu-Martinez,N.M., Joachims,M. and Lloyd,R.E. Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease J Virol (2002) 76, 2062-2074. PubMed Europe PubMed DOI PMC EPMC
Tong,L. Viral proteases Chem Rev (2002) 102, 4609-4626. PubMed Europe PubMed DOI V

2000

[YEAR:31-10-2000]Badorff,C., Fichtlscherer,B., Rhoads,R.E., Zeiher,A.M., Muelsch,A., Dimmeler,S. and Knowlton,K.U. Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: a protective mechanism against enteroviral cardiomyopathy Circulation (31-10-2000) 102, 2276-2281. PubMed Europe PubMed
[YEAR:14-4-2000]Badorff,C., Berkely,N., Mehrotra,S., Talhouk,J.W., Rhoads,R.E. and Knowlton,K.U. Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue J Biol Chem (14-4-2000) 275, 11191-11197. PubMed Europe PubMed DOI
Goldstaub,D., Gradi,A., Bercovitch,Z., Grosmann,Z., Nophar,Y., Luria,S., Sonenberg,N. and Kahana,C. Poliovirus 2A protease induces apoptotic cell death Mol Cell Biol (2000) 20, 1271-1277. PubMed Europe PubMed DOI PMC EPMC

1999

Badorff,C., Lee,G.H., Lamphear,B.J., Martone,M.E., Campbell,K.P., Rhoads,R.E. and Knowlton,K.U. Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy Nat Med (1999) 5, 320-326. PubMed Europe PubMed DOI
Kerekatte,V., Keiper,B.D., Badorff,C., Cai,A., Knowlton,K.U. and Rhoads,R.E. Cleavage of poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: Another mechanism for host protein synthesis shutoff? J Virol (1999) 73, 709-717. PubMed Europe PubMed PMC EPMC

1998

[YEAR:5-6-1998]Bovee,M.L., Lamphear,B.J., Rhoads,R.E. and Lloyd,R.E. Direct cleavage of elF4G by poliovirus 2A protease is inefficient in vitro Virology (5-6-1998) 245, 241-249. PubMed Europe PubMed DOI
[YEAR:15-9-1998]Gradi,A., Svitkin,Y.V., Imataka,H. and Sonenberg,N. Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection Proc Natl Acad Sci U S A (15-9-1998) 95, 11089-11094. PubMed Europe PubMed DOI PMC EPMC

1997

Yalamanchili,P., Banerjee,R. and Dasgupta,A. Poliovirus-encoded protease 2APro cleaves the TATA-binding protein but does not inhibit host cell RNA polymerase II transcription in vitro J Virol (1997) 71, 6881-6886. PubMed Europe PubMed PMC EPMC

1996

Blom,N., Hansen,J., Blaas,D. and Brunak,S. Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks Protein Sci (1996) 5, 2203-2216. PubMed Europe PubMed DOI PMC EPMC P
Haghighat,A., Svitkin,Y., Novoa,I., Kuechler,E., Skern,T. and Sonenberg,N. The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase J Virol (1996) 70, 8444-8450. PubMed Europe PubMed PMC EPMC
Lamphear,B.J. and Rhoads,R.E. A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases Biochemistry (1996) 35, 15726-15733. PubMed Europe PubMed DOI

1995

Aldabe,R., Feduchi,E., Novoa,I. and Carrasco,L. Expression of poliovirus 2Apro in mammalian cells: Effects on translation FEBS Lett (1995) 377, 1-5. PubMed Europe PubMed DOI
Ansardi,D.C., Pal-Ghosh,R., Porter,D. and Morrow,C.D. Encapsidation and serial passage of a poliovirus replicon which expresses an inactive 2A proteinase J Virol (1995) 69, 1359-1366. PubMed Europe PubMed PMC EPMC
Voss,T., Meyer,R. and Sommergruber,W. Spectroscopic characterization of rhinoviral protease 2A: Zn is essential for the structural integrity Protein Sci (1995) 4, 2526-2531. PubMed Europe PubMed DOI PMC EPMC

1994

Skern,T. and Liebig,H.D. Picornains 2A and 3C Methods Enzymol (1994) 244, 583-595. PubMed Europe PubMed DOI V I
Sommergruber,W., Ahorn,H., Klump,H., Seipelt,J., Zoephel,A., Fessl,F., Krystek,E., Blaas,D., Kuechler,E., Liebig,H.D. and Skern,T. 2A proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motif Virology (1994) 198, 741-745. PubMed Europe PubMed

1993

[YEAR:27-7-1993]Liebig,H.D., Ziegler,E., Yan,R., Hartmuth,K., Klump,H., Kowalski,H., Blaas,D., Sommergruber,W., Frasel,L. and Lamphear,B. Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translation Biochemistry (27-7-1993) 32, 7581-7588. PubMed Europe PubMed
Martinez-Abarca,F., Alonso,M.A. and Carrasco,L. High level expression in Escherichia coli cells and purification of poliovirus protein 2Apro J Gen Virol (1993) 74, 2645-2652. PubMed Europe PubMed E
Molla,A., Hellen,C.U. and Wimmer,E. Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors J Virol (1993) 67, 4688-4695. PubMed Europe PubMed PMC EPMC I

1992

Hellen,C.U., Lee,C.K. and Wimmer,E. Determinants of substrate recognition by poliovirus 2A proteinase J Virol (1992) 66, 3330-3338. PubMed Europe PubMed PMC EPMC
Yu,S.F. and Lloyd,R.E. Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease Virology (1992) 186, 725-735. PubMed Europe PubMed DOI

1991

Alvey,J.C., Wyckoff,E.E., Yu,S.F., Lloyd,R. and Ehrenfeld,E. cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli J Virol (1991) 65, 6077-6083. PubMed Europe PubMed PMC EPMC

1988

Konig,H. and Rosenwirth,B. Purification and partial characterization of poliovirus protease 2A by means of a functional assay J Virol (1988) 62, 1243-1250. PubMed Europe PubMed PMC EPMC

1987

Krausslich,H.G., Nicklin,M.J., Toyoda,H., Etchison,D. and Wimmer,E. Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220 J Virol (1987) 61, 2711-2718. PubMed Europe PubMed PMC EPMC

1986

Toyoda,H., Nicklin,M.J., Murray,M.G., Anderson,C.W., Dunn,J.J., Studier,F.W. and Wimmer,E. A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein Cell (1986) 45, 761-770. PubMed Europe PubMed