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Literature for peptidase C03.020: enterovirus picornain 2A

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Zinn,K.M., McLaren,M.W., Imai,M.T., Jayaram,M.M., Rothstein,J.D. and Elrick,M.J.
    Enterovirus D68 2A protease causes nuclear pore complex dysfunction and motor neuron toxicity
    bioRxiv PubMed  Europe PubMed DOI
    2. 2024
  2. Gao,X., Wang,B., Zhu,K., Wang,L., Qin,B., Shang,K., Ding,W., Wang,J. and Cui,S.
    The EV71 2A protease occupies the central cleft of SETD3 and disrupts SETD3-actin interaction
    Nat Commun15, 4176-4176. PubMed  Europe PubMed DOI
  3. Lithgo,R.M., Tomlinson,C.W.E., Fairhead,M., Winokan,M., Thompson,W., Wild,C., Aschenbrenner,J.C., Balcomb,B.H., Marples,P.G., Chandran,A.V., Golding,M., Koekemoer,L., Williams,E.P., Wang,S., Ni,X., MacLean,E., Giroud,C., Godoy,A.S., Xavier,M.A., Walsh,M., Fearon,D. and von Delft,F.
    Crystallographic Fragment Screen of Coxsackievirus A16 2A Protease identifies new opportunities for the development of broad-spectrum anti-enterovirals
    bioRxiv PubMed  Europe PubMed DOI
  4. Shen,S., Guo,H., Li,Y., Zhang,L., Tang,Y., Li,H., Li,X., Wang,P.H., Yu,X.F. and Wei,W.
    SARS-CoV-2 and oncolytic EV-D68-encoded proteases differentially regulate pyroptosis
    J Virol98, e0190923-e0190923. PubMed  Europe PubMed DOI
  5. Wang,S., Pang,Z., Fan,H. and Tong,Y.
    Advances in anti-EV-A71 drug development research
    J Adv Res56, 137-156. PubMed  Europe PubMed DOI  V
    6. 2023
  6. Tan,B., Liu,C., Li,K., Jadhav,P., Lambrinidis,G., Zhu,L., Olson,L., Tan,H., Wen,Y., Kolocouris,A., Liu,W. and Wang,J.
    Structure-Based Lead Optimization of Enterovirus D68 2A Protease Inhibitors
    J Med Chem66, 14544-14563. PubMed  Europe PubMed DOI  I
  7. Wang,Y., Zou,W., Niu,Y., Wang,S., Chen,B., Xiong,R., Zhang,P., Luo,Z., Wu,Y., Fan,C., Zhong,Z., Xu,P. and Peng,Y.
    Phosphorylation of enteroviral 2A(pro) at Ser/Thr125 benefits its proteolytic activity and viral pathogenesis
    J Med Virol95, e28400-e28400. PubMed  Europe PubMed DOI
  8. Zang,L., Yang,X., Chen,Y., Huang,F., Yuan,Y., Chen,X., Zuo,Y., Miao,Y., Gu,J., Guo,H., Xia,W., Peng,Y., Tang,M., Huang,Z., Wang,Y., Ma,J., Jiang,J., Zhou,W., Zheng,H. and Shi,W.
    Ubiquitin E3 ligase SPOP is a host negative regulator of enterovirus 71-encoded 2A protease
    J Virol97, e0078623-e0078623. PubMed  Europe PubMed DOI
    9. 2022
  9. Chen,T., Grauffel,C., Yang,W.Z., Chen,Y.P., Yuan,H.S. and Lim,C.
    Efficient Strategy to Design Protease Inhibitors: Application to Enterovirus 71 2A Protease
    ACS Bio Med Chem Au2, 437-449. PubMed  Europe PubMed DOI
  10. Peters,C.E., Schulze-Gahmen,U., Eckhardt,M., Jang,G.M., Xu,J., Pulido,E.H., Bardine,C., Craik,C.S., Ott,M., Gozani,O., Verba,K.A., Huttenhain,R., Carette,J.E. and Krogan,N.J.
    Structure-function analysis of enterovirus protease 2A in complex with its essential host factor SETD3
    Nat Commun13, 5282-5282. PubMed  Europe PubMed DOI
  11. Serganov,A.A., Udi,Y., Stein,M.E., Patel,V., Fridy,P.C., Rice,C.M., Saeed,M., Jacobs,E.Y., Chait,B.T. and Rout,M.P.
    Proteomic elucidation of the targets and primary functions of the picornavirus 2A protease
    J Biol Chem298, 101882-101882. PubMed  Europe PubMed DOI
    12. 2021
  12. Jimbo,E., Kobayashi,T., Takeshita,A., Mine,K., Nagafuchi,S., Fukui,T. and Yagihashi,S.
    Immunohistochemical detection of enteroviruses in pancreatic tissues of patients with type 1 diabetes using a polyclonal antibody against 2A protease of Coxsackievirus
    J Diabetes Investig PubMed  Europe PubMed DOI
    13. 2020
  13. Kang,J., Pang,Z., Zhou,Z., Li,X., Liu,S., Cheng,J., Liu,P., Tan,W., Wang,Z. and Wang,T.
    Enterovirus D68 Protease 2A(pro) Targets TRAF3 to Subvert Host Innate Immune Responses
    J Virol PubMed  Europe PubMed DOI
    14. 2019
  14. Diep,J., Ooi,Y.S., Wilkinson,A.W., Peters,C.E., Foy,E., Johnson,J.R., Zengel,J., Ding,S., Weng,K.F., Laufman,O., Jang,G., Xu,J., Young,T., Verschueren,E., Kobluk,K.J., Elias,J.E., Sarnow,P., Greenberg,H.B., Huttenhain,R., Nagamine,C.M., Andino,R., Krogan,N.J., Gozani,O. and Carette,J.E.
    Enterovirus pathogenesis requires the host methyltransferase SETD3
    Nat Microbiol4, 2523-2537. PubMed  Europe PubMed DOI  T
  15. Hanson,P.J., Hossain,A.R., Qiu,Y., Zhang,H.M., Zhao,G., Li,C., Lin,V., Sulaimon,S., Vlok,M., Fung,G., Chen,V.H., Jan,E., McManus,B.M., Granville,D.J. and Yang,D.
    Cleavage and sub-cellular redistribution of nuclear pore protein 98 by coxsackievirus B3 protease 2A impairs cardioprotection
    Front Cell Infect Microbiol9, 265-265. PubMed  Europe PubMed DOI
  16. Musharrafieh,R., Ma,C., Zhang,J., Hu,Y., Diesing,J.M., Marty,M.T. and Wang,J.
    Validating enterovirus D68-2A(pro) as an antiviral drug target and the discovery of telaprevir as a potent D68-2A(pro) inhibitor
    J Virol93, e02221-18-e02221-18. PubMed  Europe PubMed DOI  I
  17. Visser,L.J., Langereis,M.A., Rabouw,H.H., Wahedi,M., Muntjewerff,E.M., de Groot,R.J. and van Kuppeveld,F.J.M.
    Essential role of enterovirus 2A protease in counteracting stress granule formation and the induction of type I interferon
    J Virol93, e00222-19-e00222-19. PubMed  Europe PubMed DOI
    18. 2018
  18. Chen,K.R., Yu,C.K., Kung,S.H., Chen,S.H., Chang,C.F., Ho,T.C., Lee,Y.P., Chang,H.C., Huang,L.Y., Lo,S.Y., Chang,J.C. and Ling,P.
    Toll-like receptor 3 is involved in detection of enterovirus A71 infection and targeted by viral 2A protease
    Viruses10, PubMed  Europe PubMed DOI
  19. Laitinen,O.H., Svedin,E., Kapell,S., Hankaniemi,M.M., Larsson,P.G., Domsgen,E., Stone,V.M., Maatta,J.A.E., Hyoty,H., Hytonen,V.P. and Flodstrom-Tullberg,M.
    New Coxsackievirus 2A(pro) and 3C(pro) protease antibodies for virus detection and discovery of pathogenic mechanisms
    J Virol Methods255, 29-37. PubMed  Europe PubMed DOI
  20. Rasti,M., Khanbabaei,H. and Teimoori,A.
    An update on enterovirus 71 infection and interferon type I response
    Rev Med Virole2016-e2016. PubMed  Europe PubMed DOI
  21. Schulz,R., Atef,A., Becker,D., Gottschalk,F., Tauber,C., Wagner,S., Arkona,C., Abdel-Hafez,A.A., Farag,H.H., Rademann,J. and Wolber,G.
    Phenylthiomethyl ketone-based fragments show selective and irreversible inhibition of enteroviral 3C proteases
    J Med Chem61, 1218-1230. PubMed  Europe PubMed DOI  I
  22. Yang,X., Hu,Z., Fan,S., Zhang,Q., Zhong,Y., Guo,D., Qin,Y. and Chen,M.
    Picornavirus 2A protease regulates stress granule formation to facilitate viral translation
    PLoS Pathog14, e1006901-e1006901. PubMed  Europe PubMed DOI
    23. 2017
  23. Deng,H., Fung,G., Qiu,Y., Wang,C., Zhang,J., Jin,Z.G. and Luo,H.
    Cleavage of Grb2-associated binding protein 2 by viral proteinase 2A during Coxsackievirus infection
    Front Cell Infect Microbiol7, 85-85. PubMed  Europe PubMed DOI
  24. Li,C., Qiao,Q., Hao,S.B., Dong,Z., Zhao,L., Ji,J., Wang,Z.Y. and Wen,H.L.
    Nonstructural protein 2A modulates replication and virulence of enterovirus 71
    Virus Res244, 262-269. PubMed  Europe PubMed DOI
    25. 2016
  25. Guo,Y., Wang,Y., Cao,L., Wang,P., Qing,J., Zheng,Q., Shang,L., Yin,Z. and Sun,Y.
    A conserved inhibitory mechanism of a lycorine derivative against enterovirus and hepatitis C virus
    Antimicrob Agents Chemother60, 913-924. PubMed  Europe PubMed DOI  I
  26. Hanson,P.J., Ye,X., Qiu,Y., Zhang,H.M., Hemida,M.G., Wang,F., Lim,T., Gu,A., Cho,B., Kim,H., Fung,G., Granville,D.J. and Yang,D.
    Cleavage of DAP5 by coxsackievirus B3 2A protease facilitates viral replication and enhances apoptosis by altering translation of IRES-containing genes
    Cell Death Differ23, 828-840. PubMed  Europe PubMed DOI
  27. Laitinen,O.H., Svedin,E., Kapell,S., Nurminen,A., Hytonen,V.P. and Flodstrom-Tullberg,M.
    Enteroviral proteases: structure, host interactions and pathogenicity
    Rev Med Virol26, 251-267. PubMed  Europe PubMed DOI
    28. 2015
  28. Aumayr,M., Fedosyuk,S., Ruzicska,K., Sousa-Blin,C., Kontaxis,G. and Skern,T.
    NMR analysis of the interaction of picornaviral proteinases Lb and 2A with their substrate eukaryotic initiation factor 4GII
    Protein Sci24, 1979-1996. PubMed  Europe PubMed DOI
  29. Barnabei,M.S., Sjaastad,F.V., Townsend,D., Bedada,F.B. and Metzger,J.M.
    Severe dystrophic cardiomyopathy caused by the enteroviral protease 2A-mediated C-terminal dystrophin cleavage fragment
    Sci Transl Med7, 294ra106-294ra. PubMed  Europe PubMed DOI
  30. Deng,H., Fung,G., Shi,J., Xu,S., Wang,C., Yin,M., Hou,J., Zhang,J., Jin,Z.G. and Luo,H.
    Enhanced enteroviral infectivity via viral protease-mediated cleavage of Grb2-associated binder 1
    FASEB J29, 4523-4531. PubMed  Europe PubMed DOI
  31. Dougherty,J.D., Tsai,W.C. and Lloyd,R.E.
    Multiple poliovirus proteins repress cytoplasmic RNA granules
    Viruses7, 6127-6140. PubMed  Europe PubMed DOI
  32. Fung,G., Shi,J., Deng,H., Hou,J., Wang,C., Hong,A., Zhang,J., Jia,W. and Luo,H.
    Cytoplasmic translocation, aggregation, and cleavage of TDP-43 by enteroviral proteases modulate viral pathogenesis
    Cell Death Differ22, 2087-2097. PubMed  Europe PubMed DOI
  33. Song,Q.Q., Lu,M.Z., Song,J., Chi,M.M., Sheng,L.J., Yu,J., Luo,X.N., Zhang,L., Yao,H.L. and Han,J.
    Coxsackievirus B3 2A protease promotes encephalomyocarditis virus replication
    Virus Res208, 22-29. PubMed  Europe PubMed DOI
  34. Wang,C.Y., Huang,A.C., Hour,M.J., Huang,S.H., Kung,S.H., Chen,C.H., Chen,I.C., Chang,Y.S., Lien,J.C. and Lin,C.W.
    Antiviral potential of a novel compound CW-33 against enterovirus A71 via inhibition of viral 2A protease
    Viruses7, 3155-3171. PubMed  Europe PubMed DOI  I
  35. Xiang,Z., Liu,L., Lei,X., Zhou,Z., He,B. and Wang,J.
    3C Protease of enterovirus D68 inhibits cellular defense mediated by interferon regulatory factor 7
    J Virol90, 1613-1621. PubMed  Europe PubMed DOI
    36. 2014
  36. Wu,S., Wang,Y., Lin,L., Si,X., Wang,T., Zhong,X., Tong,L., Luan,Y., Chen,Y., Li,X., Zhang,F., Zhao,W. and Zhong,Z.
    Protease 2A induces stress granule formation during coxsackievirus B3 and enterovirus 71 infections
    Virol J11, 192-192. PubMed  Europe PubMed DOI
    37. 2013
  37. Cai,Q., Yameen,M., Liu,W., Gao,Z., Li,Y., Peng,X., Cai,Y., Wu,C., Zheng,Q., Li,J. and Lin,T.
    Conformational plasticity of the 2A proteinase from enterovirus 71
    J Virol87, 7348-7356. PubMed  Europe PubMed DOI  S
  38. Lim,B.K., Peter,A.K., Xiong,D., Narezkina,A., Yung,A., Dalton,N.D., Hwang,K.K., Yajima,T., Chen,J. and Knowlton,K.U.
    Inhibition of Coxsackievirus-associated dystrophin cleavage prevents cardiomyopathy
    J Clin Invest123, 5146-5151. PubMed  Europe PubMed DOI
  39. Mu,Z., Wang,B., Zhang,X., Gao,X., Qin,B., Zhao,Z. and Cui,S.
    Crystal structure of 2A proteinase from hand, foot and mouth disease virus
    J Mol Biol425, 4530-4543. PubMed  Europe PubMed DOI  S
  40. Neubauer,D., Aumayr,M., Gosler,I. and Skern,T.
    Specificity of human rhinovirus 2A(pro) is determined by combined spatial properties of four cleavage site residues
    J Gen Virol94, 1535-1546. PubMed  Europe PubMed DOI  P
  41. Sun,Y., Wang,X., Yuan,S., Dang,M., Li,X., Zhang,X.C. and Rao,Z.
    An open conformation determined by a structural switch for 2A protease from coxsackievirus A16
    Protein Cell4, 782-792. PubMed  Europe PubMed DOI  S
  42. Wang,B., Xi,X., Lei,X., Zhang,X., Cui,S., Wang,J., Jin,Q. and Zhao,Z.
    Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses
    PLoS Pathog9, e1003231-e1003231. PubMed  Europe PubMed DOI  P
  43. Zhang,Y.Z., Gan,X., Song,J., Sun,P., Song,Q.Q., Li,G.Q., Sheng,L.J., Wang,B.D., Lu,M.Z., Li,L.M. and Han,J.
    [The 2A protease of enterovirus 71 cleaves nup62 to inhibit nuclear transport]
    Bing Du Xue Bao29, 421-425. PubMed  Europe PubMed
    44. 2012
  44. Falah,N., Montserret,R., Lelogeais,V., Schuffenecker,I., Lina,B., Cortay,J.C. and Violot,S.
    Blocking human enterovirus 71 replication by targeting viral 2A protease
    J Antimicrob Chemother67, 2865-2869. PubMed  Europe PubMed DOI  I
  45. Lu,J., Yi,L., Zhao,J., Yu,J., Chen,Y., Lin,M.C., Kung,H.F. and He,M.L.
    Enterovirus 71 disrupts interferon signaling by reducing the level of interferon receptor 1
    J Virol86, 3767-3776. PubMed  Europe PubMed DOI
  46. Skern,T.
    Picornain 2A
    [ISSN:978-0-12-407743-0]3, 2406-2411. DOI
  47. Wong,J., Zhang,J., Yanagawa,B., Luo,Z., Yang,X., Chang,J., McManus,B. and Luo,H.
    Cleavage of serum response factor mediated by enteroviral protease 2A contributes to impaired cardiac function
    Cell Res22, 360-371. PubMed  Europe PubMed DOI
    48. 2011
  48. Alvarez,E., Castello,A., Carrasco,L. and Izquierdo,J.M.
    Alternative splicing, a new target to block cellular gene expression by poliovirus 2A protease
    Biochem Biophys Res Commun414, 142-147. PubMed  Europe PubMed DOI
  49. Cantera,J.L., Chen,W. and Yates,M.V.
    A fluorescence resonance energy transfer-based fluorometer assay for screening anti-coxsackievirus B3 compounds
    J Virol Methods171, 176-182. PubMed  Europe PubMed DOI  A
  50. Castello,A., Alvarez,E. and Carrasco,L.
    The multifaceted poliovirus 2A protease: regulation of gene expression by picornavirus proteases
    J Biomed Biotechnol2011, 369648-369648. PubMed  Europe PubMed DOI
  51. Maghsoudi,A.H., Khodagholi,F., Hadi-Alijanvand,H., Esfandiarei,M., Sabbaghian,M., Zakeri,Z., Shaerzadeh,F., Abtahi,S. and Maghsoudi,N.
    Homology modeling, docking, molecular dynamics simulation, and structural analyses of coxsakievirus B3 2A protease: an enzyme involved in the pathogenesis of inflammatory myocarditis
    Int J Biol Macromol49, 487-492. PubMed  Europe PubMed DOI
  52. Redondo,N., Sanz,M.A., Welnowska,E. and Carrasco,L.
    Translation without eIF2 promoted by poliovirus 2A protease
    PLoS ONE6, e25699-e25699. PubMed  Europe PubMed DOI
    53. 2010
  53. Cantera,J.L., Chen,W. and Yates,M.V.
    Detection of infective poliovirus by a simple, rapid, and sensitive flow cytometry method based on fluorescence resonance energy transfer technology
    Appl Environ Microbiol76, 584-588. PubMed  Europe PubMed DOI
  54. Maghsoudi,N., Tafreshi,N.K., Khodagholi,F., Zakeri,Z., Esfandiarei,M., Hadi-Alijanvand,H., Sabbaghian,M., Maghsoudi,A.H., Sajadi,M., Zohri,M., Moosavi,M. and Zeinoddini,M.
    Targeting enteroviral 2A protease by a 16-mer synthetic peptide: inhibition of 2Apro-induced apoptosis in a stable Tet-on HeLa cell line
    Virology399, 39-45. PubMed  Europe PubMed DOI  I
  55. Sanz,M.A., Welnowska,E., Redondo,N. and Carrasco,L.
    Translation driven by picornavirus IRES is hampered from Sindbis virus replicons: rescue by poliovirus 2A protease
    J Mol Biol402, 101-117. PubMed  Europe PubMed DOI
  56. Yang,C.H., Li,H.C., Jiang,J.G., Hsu,C.F., Wang,Y.J., Lai,M.J., Juang,Y.L. and Lo,S.Y.
    Enterovirus type 71 2A protease functions as a transcriptional activator in yeast
    J Biomed Sci17, 65-65. PubMed  Europe PubMed DOI
    57. 2009
  57. Castello,A., Izquierdo,J.M., Welnowska,E. and Carrasco,L.
    RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage
    J Cell Sci122, 3799-3809. PubMed  Europe PubMed DOI
  58. Morrison,J.M. and Racaniello,V.R.
    Proteinase 2Apro is essential for enterovirus replication in type I interferon-treated cells
    J Virol83, 4412-4422. PubMed  Europe PubMed DOI
    59. 2008
  59. Kempf,B.J. and Barton,D.J.
    Poliovirus 2A(pro) increases viral mRNA and polysome stability coordinately in time with cleavage of eIF4G
    J Virol82, 5847-5859. PubMed  Europe PubMed DOI
  60. Maghsoudi,N., Khodagholi,F., Sadjadi,M., Zeinodini,M. and Sabbaghian,M.
    Purification and partial characterization of coxsackievirus B3 2A protease expressed in Escherichia coli
    Int J Biol Macromol43, 238-244. PubMed  Europe PubMed DOI
  61. Rivera,C.I. and Lloyd,R.E.
    Modulation of enteroviral proteinase cleavage of poly(A)-binding protein (PABP) by conformation and PABP-associated factors
    Virology375, 59-72. PubMed  Europe PubMed DOI
    62. 2007
  62. Almstead,L.L. and Sarnow,P.
    Inhibition of U snRNP assembly by a virus-encoded proteinase
    Genes Dev21, 1086-1097. PubMed  Europe PubMed DOI
  63. Chau,D.H., Yuan,J., Zhang,H., Cheung,P., Lim,T., Liu,Z., Sall,A. and Yang,D.
    Coxsackievirus B3 proteases 2A and 3C induce apoptotic cell death through mitochondrial injury and cleavage of eIF4GI but not DAP5/p97/NAT1
    Apoptosis12, 513-524. PubMed  Europe PubMed DOI
  64. Ghukasyan,V., Hsu,Y.Y., Kung,S.H. and Kao,F.J.
    Application of fluorescence resonance energy transfer resolved by fluorescence lifetime imaging microscopy for the detection of enterovirus 71 infection in cells
    J Biomed Opt12, 024016-024016. PubMed  Europe PubMed DOI
  65. [YEAR:23-2-2007]Hsu,Y.Y., Liu,Y.N., Wang,W., Kao,F.J. and Kung,S.H.
    In vivo dynamics of enterovirus protease revealed by fluorescence resonance emission transfer (FRET) based on a novel FRET pair
    Biochem Biophys Res Commun353, 939-945. PubMed  Europe PubMed DOI
  66. Inoue,T., Zhang,Z., Wang,L., West,L., Bashiruddin,J.B. and Belsham,G.J.
    Significance of arginine 20 in the 2A protease for swine vesicular disease virus pathogenicity
    J Gen Virol88, 2275-2279. PubMed  Europe PubMed DOI
  67. [YEAR:2-1-2007]Xiong,D., Yajima,T., Lim,B.K., Stenbit,A., Dublin,A., Dalton,N.D., Summers-Torres,D., Molkentin,J.D., Duplain,H., Wessely,R., Chen,J. and Knowlton,K.U.
    Inducible cardiac-restricted expression of enteroviral protease 2A is sufficient to induce dilated cardiomyopathy
    Circulation115, 94-102. PubMed  Europe PubMed DOI
    68. 2006
  68. Baxter,N.J., Roetzer,A., Liebig,H.D., Sedelnikova,S.E., Hounslow,A.M., Skern,T. and Waltho,J.P.
    Structure and dynamics of coxsackievirus B4 2A proteinase, an enyzme involved in the etiology of heart disease
    J Virol80, 1451-1462. PubMed  Europe PubMed DOI  S
  69. Hwang,Y.C., Chen,W. and Yates,M.V.
    Use of fluorescence resonance energy transfer for rapid detection of enteroviral infection in vivo
    Appl Environ Microbiol72, 3710-3715. PubMed  Europe PubMed DOI
  70. [YEAR:16-11-2006]Jurgens,C.K., Barton,D.J., Sharma,N., Morasco,B.J., Ogram,S.A. and Flanegan,J.B.
    2Apro is a multifunctional protein that regulates the stability, translation and replication of poliovirus RNA
    Virology345, 346-357. PubMed  Europe PubMed DOI
  71. [YEAR:6-10-2006]Muto,S., Miyoshi,H., Nishikawa,H. and Nakashima,H.
    Novel recognition sequence of coxsackievirus 2A proteinase
    Biochem Biophys Res Commun348, 1436-1442. PubMed  Europe PubMed DOI  P
    72. 2005
  72. Inoue,T., Alexandersen,S., Clark,A.T., Murphy,C., Quan,M., Reid,S.M., Sakoda,Y., Johns,H.L. and Belsham,G.J.
    Importance of arginine 20 of the swine vesicular disease virus 2A protease for activity and virulence
    J Virol79, 428-440. PubMed  Europe PubMed DOI
  73. [YEAR:5-4-2005]Merl,S., Michaelis,C., Jaschke,B., Vorpahl,M., Seidl,S. and Wessely,R.
    Targeting 2A protease by RNA interference attenuates coxsackieviral cytopathogenicity and promotes survival in highly susceptible mice
    Circulation111, 1583-1592. PubMed  Europe PubMed DOI
    74. 2004
  74. Badorff,C.
    Coxsackie B virus picornain 2A
    [ISSN:0-12-079610-4]2, 1365-1368.  V
  75. [YEAR:12-8-2004]Badorff,C. and Knowlton,K.U.
    Dystrophin disruption in enterovirus-induced myocarditis and dilated cardiomyopathy: from bench to bedside
    Med Microbiol Immunol (Berl)193, 121-126. PubMed  Europe PubMed DOI
  76. Calandria,C., Irurzun,A., Barco,A. and Carrasco,L.
    Individual expression of poliovirus 2Apro and 3Cpro induces activation of caspase-3 and PARP cleavage in HeLa cells
    Virus Res104, 39-49. PubMed  Europe PubMed DOI
  77. Skern,T.
    Picornain 2A
    [ISSN:0-12-079610-4]2, 1361-1365.  V
    78. 2003
  78. [YEAR:14-2-2003]Zhao,X., Lamphear,B.J., Xiong,D., Knowlton,K. and Rhoads,R.E.
    Protection of cap-dependent protein synthesis in vivo and in vitro with an eIF4G-1 variant highly resistant to cleavage by coxsackievirus 2A protease
    J Biol Chem278, 4449-4457. PubMed  Europe PubMed DOI
    79. 2002
  79. Badorff,C., Fichtlscherer,B., Muelsch,A., Zeiher,A.M. and Dimmeler,S.
    Selective delivery of nitric oxide to a cellular target: a pseudosubstrate-coupled dinitrosyl-iron complex inhibits the enteroviral protease 2A
    Nitric Oxide6, 305-312. PubMed  Europe PubMed DOI
  80. Kuo,R.L., Kung,S.H., Hsu,Y.Y. and Liu,W.T.
    Infection with enterovirus 71 or expression of its 2A protease induces apoptotic cell death
    J Gen Virol83, 1367-1376. PubMed  Europe PubMed
  81. Kuyumcu-Martinez,N.M., Joachims,M. and Lloyd,R.E.
    Efficient cleavage of ribosome-associated poly(A)-binding protein by enterovirus 3C protease
    J Virol76, 2062-2074. PubMed  Europe PubMed DOI
  82. Tong,L.
    Viral proteases
    Chem Rev102, 4609-4626. PubMed  Europe PubMed DOI  V
    83. 2000
  83. [YEAR:14-4-2000]Badorff,C., Berkely,N., Mehrotra,S., Talhouk,J.W., Rhoads,R.E. and Knowlton,K.U.
    Enteroviral protease 2A directly cleaves dystrophin and is inhibited by a dystrophin-based substrate analogue
    J Biol Chem275, 11191-11197. PubMed  Europe PubMed DOI
  84. [YEAR:31-10-2000]Badorff,C., Fichtlscherer,B., Rhoads,R.E., Zeiher,A.M., Muelsch,A., Dimmeler,S. and Knowlton,K.U.
    Nitric oxide inhibits dystrophin proteolysis by coxsackieviral protease 2A through S-nitrosylation: a protective mechanism against enteroviral cardiomyopathy
    Circulation102, 2276-2281. PubMed  Europe PubMed
  85. Goldstaub,D., Gradi,A., Bercovitch,Z., Grosmann,Z., Nophar,Y., Luria,S., Sonenberg,N. and Kahana,C.
    Poliovirus 2A protease induces apoptotic cell death
    Mol Cell Biol20, 1271-1277. PubMed  Europe PubMed DOI
    86. 1999
  86. Badorff,C., Lee,G.H., Lamphear,B.J., Martone,M.E., Campbell,K.P., Rhoads,R.E. and Knowlton,K.U.
    Enteroviral protease 2A cleaves dystrophin: evidence of cytoskeletal disruption in an acquired cardiomyopathy
    Nat Med5, 320-326. PubMed  Europe PubMed DOI
  87. Kerekatte,V., Keiper,B.D., Badorff,C., Cai,A., Knowlton,K.U. and Rhoads,R.E.
    Cleavage of poly(A)-binding protein by coxsackievirus 2A protease in vitro and in vivo: Another mechanism for host protein synthesis shutoff?
    J Virol73, 709-717. PubMed  Europe PubMed
    88. 1998
  88. [YEAR:5-6-1998]Bovee,M.L., Lamphear,B.J., Rhoads,R.E. and Lloyd,R.E.
    Direct cleavage of elF4G by poliovirus 2A protease is inefficient in vitro
    Virology245, 241-249. PubMed  Europe PubMed DOI
  89. [YEAR:15-9-1998]Gradi,A., Svitkin,Y.V., Imataka,H. and Sonenberg,N.
    Proteolysis of human eukaryotic translation initiation factor eIF4GII, but not eIF4GI, coincides with the shutoff of host protein synthesis after poliovirus infection
    Proc Natl Acad Sci U S A95, 11089-11094. PubMed  Europe PubMed DOI
    90. 1997
  90. Yalamanchili,P., Banerjee,R. and Dasgupta,A.
    Poliovirus-encoded protease 2APro cleaves the TATA-binding protein but does not inhibit host cell RNA polymerase II transcription in vitro
    J Virol71, 6881-6886. PubMed  Europe PubMed
    91. 1996
  91. Blom,N., Hansen,J., Blaas,D. and Brunak,S.
    Cleavage site analysis in picornaviral polyproteins: discovering cellular targets by neural networks
    Protein Sci5, 2203-2216. PubMed  Europe PubMed DOI  P
  92. Haghighat,A., Svitkin,Y., Novoa,I., Kuechler,E., Skern,T. and Sonenberg,N.
    The eIF4G-eIF4E complex is the target for direct cleavage by the rhinovirus 2A proteinase
    J Virol70, 8444-8450. PubMed  Europe PubMed
  93. Lamphear,B.J. and Rhoads,R.E.
    A single amino acid change in protein synthesis initiation factor 4G renders cap-dependent translation resistant to picornaviral 2A proteases
    Biochemistry35, 15726-15733. PubMed  Europe PubMed DOI
    94. 1995
  94. Aldabe,R., Feduchi,E., Novoa,I. and Carrasco,L.
    Expression of poliovirus 2Apro in mammalian cells: Effects on translation
    FEBS Lett377, 1-5. PubMed  Europe PubMed DOI
  95. Ansardi,D.C., Pal-Ghosh,R., Porter,D. and Morrow,C.D.
    Encapsidation and serial passage of a poliovirus replicon which expresses an inactive 2A proteinase
    J Virol69, 1359-1366. PubMed  Europe PubMed
  96. Voss,T., Meyer,R. and Sommergruber,W.
    Spectroscopic characterization of rhinoviral protease 2A: Zn is essential for the structural integrity
    Protein Sci4, 2526-2531. PubMed  Europe PubMed DOI
    97. 1994
  97. Skern,T. and Liebig,H.D.
    Picornains 2A and 3C
    Methods Enzymol244, 583-595. PubMed  Europe PubMed DOI  V  I
  98. Sommergruber,W., Ahorn,H., Klump,H., Seipelt,J., Zoephel,A., Fessl,F., Krystek,E., Blaas,D., Kuechler,E., Liebig,H.D. and Skern,T.
    2A proteinases of coxsackie- and rhinovirus cleave peptides derived from eIF-4 gamma via a common recognition motif
    Virology198, 741-745. PubMed  Europe PubMed
    99. 1993
  99. [YEAR:27-7-1993]Liebig,H.D., Ziegler,E., Yan,R., Hartmuth,K., Klump,H., Kowalski,H., Blaas,D., Sommergruber,W., Frasel,L. and Lamphear,B.
    Purification of two picornaviral 2A proteinases: interaction with eIF-4 gamma and influence on in vitro translation
    Biochemistry32, 7581-7588. PubMed  Europe PubMed
  100. Martinez-Abarca,F., Alonso,M.A. and Carrasco,L.
    High level expression in Escherichia coli cells and purification of poliovirus protein 2Apro
    J Gen Virol74, 2645-2652. PubMed  Europe PubMed  E
  101. Molla,A., Hellen,C.U. and Wimmer,E.
    Inhibition of proteolytic activity of poliovirus and rhinovirus 2A proteinases by elastase-specific inhibitors
    J Virol67, 4688-4695. PubMed  Europe PubMed  I
    102. 1992
  102. Hellen,C.U., Lee,C.K. and Wimmer,E.
    Determinants of substrate recognition by poliovirus 2A proteinase
    J Virol66, 3330-3338. PubMed  Europe PubMed
  103. Yu,S.F. and Lloyd,R.E.
    Characterization of the roles of conserved cysteine and histidine residues in poliovirus 2A protease
    Virology186, 725-735. PubMed  Europe PubMed DOI
    104. 1991
  104. Alvey,J.C., Wyckoff,E.E., Yu,S.F., Lloyd,R. and Ehrenfeld,E.
    cis- and trans-cleavage activities of poliovirus 2A protease expressed in Escherichia coli
    J Virol65, 6077-6083. PubMed  Europe PubMed
    105. 1988
  105. Konig,H. and Rosenwirth,B.
    Purification and partial characterization of poliovirus protease 2A by means of a functional assay
    J Virol62, 1243-1250. PubMed  Europe PubMed
    106. 1987
  106. Krausslich,H.G., Nicklin,M.J., Toyoda,H., Etchison,D. and Wimmer,E.
    Poliovirus proteinase 2A induces cleavage of eucaryotic initiation factor 4F polypeptide p220
    J Virol61, 2711-2718. PubMed  Europe PubMed
    107. 1986
  107. Toyoda,H., Nicklin,M.J., Murray,M.G., Anderson,C.W., Dunn,J.J., Studier,F.W. and Wimmer,E.
    A second virus-encoded proteinase involved in proteolytic processing of poliovirus polyprotein
    Cell45, 761-770. PubMed  Europe PubMed

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