Literature for peptidase C01.064: RD21 peptidase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Li,C., Li,S., Feng,L., Cheng,J., Xie,J., Lin,Y., Fu,Y., Tsuda,K., Jiang,D. and Chen,T. Arabidopsis OTU2 deubiquitinates cysteine protease RD21A to enhance clubroot resistance Plant J (2025) 122, e70148-e70148. PubMed Europe PubMed DOI PMC EPMC
Zhong,K., Xu,G., Shi,J., Liu,P., Tu,A., Wu,M., Liu,J., Chen,J. and Yang,J. NbPIRIN promotes the protease activity of papain-like cysteine protease NbRD21 to inhibit Chinese wheat mosaic virus infection PLoS Pathog (2025) 21, e1013037-e1013037. PubMed Europe PubMed DOI PMC EPMC

2020

Liu,Y., Wang,K., Cheng,Q., Kong,D., Zhang,X., Wang,Z., Wang,Q., Qi,X., Yan,J., Chu,J., Ling,H., Li,Q., Miao,J. and Zhao,B. Cysteine protease RD21A regulated by E3 ligase SINAT4 is required for drought-induced resistance to Pseudomonas syringae in Arabidopsis J Exp Bot (2020) PubMed Europe PubMed DOI

2019

Jutras,P.V., Grosse-Holz,F., Kaschani,F., Kaiser,M., Michaud,D. and van der Hoorn,R.A.L. Activity-based proteomics reveals nine target proteases for the recombinant protein-stabilizing inhibitor SlCYS8 in Nicotiana benthamiana Plant Biotechnol J (2019) 17, 1670-1678. PubMed Europe PubMed DOI
Ormancey,M., Thuleau,P., van der Hoorn,R.A.L., Grat,S., Testard,A., Kamal,K.Y., Boudsocq,M., Cotelle,V. and Mazars,C. Sphingolipid-induced cell death in Arabidopsis is negatively regulated by the papain-like cysteine protease RD21 Plant Sci (2019) 280, 12-17. PubMed Europe PubMed DOI
Pogorelko,G.V., Juvale,P.S., Rutter,W.B., Hutten,M., Maier,T.R., Hewezi,T., Paulus,J., Van Der Hoorn,R.A., Grundler,F.M., Siddique,S., Lionetti,V., Zabotina,O.A. and Baum,T.J. Re-targeting of a plant defense protease by a cyst nematode effector Plant J (2019) 98, 1000-1014. PubMed Europe PubMed DOI

2018

Rustgi,S., Boex-Fontvieille,E., Reinbothe,C., Von Wettstein,D. and Reinbothe,S. The complex world of plant protease inhibitors: insights into a Kunitz-type cysteine protease inhibitor of Arabidopsis thaliana Commun Integr Biol (2018) 11, e1368599-e1368599. PubMed Europe PubMed DOI PMC EPMC

2017

Rustgi,S., Boex-Fontvieille,E., Reinbothe,C., Von Wettstein,D. and Reinbothe,S. Serpin1 and WSCP differentially regulate the activity of the cysteine protease RD21 during plant development in Arabidopsis thaliana Proc Natl Acad Sci U S A (2017) 114, 2212-2217. PubMed Europe PubMed DOI

2016

Boex-Fontvieille,E., Rustgi,S., Von Wettstein,D., Pollmann,S., Reinbothe,S. and Reinbothe,C. An ethylene-protected Achilles' heel of etiolated seedlings for arthropod deterrence Front Plant Sci (2016) 7, 1246-1246. PubMed Europe PubMed DOI PMC EPMC
Misas-Villamil,J.C., Van Der Hoorn,R.A. and Doehlemann,G. Papain-like cysteine proteases as hubs in plant immunity New Phytol (2016) 212, 902-907. PubMed Europe PubMed DOI V

2015

Boex-Fontvieille,E., Rustgi,S., Von Wettstein,D., Reinbothe,S. and Reinbothe,C. Water-soluble chlorophyll protein is involved in herbivore resistance activation during greening of Arabidopsis thaliana Proc Natl Acad Sci U S A (2015) 112, 7303-7308. PubMed Europe PubMed DOI
Boex-Fontvieille,E., Rustgi,S., Reinbothe,S. and Reinbothe,C. A Kunitz-type protease inhibitor regulates programmed cell death during flower development in Arabidopsis thaliana J Exp Bot (2015) 66, 6119-6135. PubMed Europe PubMed DOI

2013

Lampl,N., Alkan,N., Davydov,O. and Fluhr,R. Set-point control of RD21 protease activity by AtSerpin1 controls cell death in Arabidopsis Plant J (2013) 74, 498-510. PubMed Europe PubMed DOI

2012

Gu,C., Shabab,M., Strasser,R., Wolters,P.J., Shindo,T., Niemer,M., Kaschani,F., Mach,L. and Van Der Hoorn,R.A. Post-translational regulation and trafficking of the granulin-containing protease RD21 of Arabidopsis thaliana PLoS ONE (2012) 7, e32422-e32422. PubMed Europe PubMed DOI PMC EPMC
Shindo,T., Misas-Villamil,J.C., Horger,A.C., Song,J. and Van Der Hoorn,R.A. A role in immunity for Arabidopsis cysteine protease RD21, the ortholog of the tomato immune protease C14 PLoS ONE (2012) 7, e29317-e29317. PubMed Europe PubMed DOI PMC EPMC
van der Hoorn,R.A.L. RD21 peptidase [ISSN:978-0-12-407743-0] (2012) 3, 1892-1896. DOI

2010

Lampl,N., Budai-Hadrian,O., Davydov,O., Joss,T.V., Harrop,S.J., Curmi,P.M., Roberts,T.H. and Fluhr,R. Arabidopsis AtSerpin1, crystal structure and in vivo interaction with its target protease RESPONSIVE TO DESICCATION-21 (RD21) J Biol Chem (2010) 285, 13550-13560. PubMed Europe PubMed DOI S I

2008

Carrico,I. Unexpected N-terminal editing: a cysteine protease that cuts and pastes Nat Chem Biol (2008) 4, 525-526. PubMed Europe PubMed DOI
Kikuchi,Y., Saika,H., Yuasa,K., Nagahama,M. and Tsuji,A. Isolation and biochemical characterization of two forms of RD21 from cotyledons of daikon radish (Raphanus sativus) J Biochem (2008) 144, 789-798. PubMed Europe PubMed DOI P
Peng,S.Q., Zhu,J.H., Li,H.L. and Tian,W.M. Cloning and characterization of a novel cysteine protease gene (HbCP1) from Hevea brasiliensis J Biosci (2008) 33, 681-690. PubMed Europe PubMed DOI
Wang,Z., Gu,C., Colby,T., Shindo,T., Balamurugan,R., Waldmann,H., Kaiser,M. and Van Der Hoorn,R.A. beta-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana Nat Chem Biol (2008) 4, 557-563. PubMed Europe PubMed DOI

2006

Halls,C.E., Rogers,S.W., Oufattole,M., Ostergard,O., Svensson,B. and Rogers,J.C. A Kunitz-type cysteine protease inhibitor from cauliflower and Arabidopsis Plant Sci (2006) 170, 1102-1110.

2005

Halls,C.E., Rogers,S.W. and Rogers,J.C. Purification of a proaleurain maturation protease Plant Sci (2005) 168, 1267-1279.

2001

Cervantes,E., De Diego,J.G., Gomez,M.D., Las Rivas,J., Igual,J.M., Velazquez,E., Grappin,P., Cercos,M. and Carbonell,J. Expression of cysteine proteinase mRNA in chickpea (Cicer arietinum L.) is localized to provascular cells in the developing root J Plant Physiol (2001) 158, 1463-1469.
Hayashi,Y., Yamada,K., Shimada,T., Matsushima,R., Nishizawa,N.K., Nishimura,M. and Hara-Nishimura,I. A proteinase-storing body that prepares for cell death or stresses in the epidermal cells of Arabidopsis Plant Cell Physiol (2001) 42, 894-899. PubMed Europe PubMed
Yamada,K., Matsushima,R., Nishimura,M. and Hara-Nishimura,I. A slow maturation of a cysteine protease with a granulin domain in the vacuoles of senescing Arabidopsis leaves Plant Physiol (2001) 127, 1626-1634. PubMed Europe PubMed DOI PMC EPMC

1993

Koizumi,M., Yamaguchi-Shinozaki,K., Tsuji,H. and Shinozaki,K. Structure and expression of two genes that encode distinct drought-inducible cysteine proteinases in Arabidopsis thaliana Gene (1993) 129, 175-182. PubMed Europe PubMed DOI