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Literature for peptidase A01.023: plasmepsin-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Mishra,V., Deshmukh,A., Rathore,I., Chakraborty,S., Patankar,S., Gustchina,A., Wlodawer,A., Yada,R.Y. and Bhaumik,P.
    Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery
    Curr Res Struct Biol7, 100128-100128. PubMed  Europe PubMed DOI  I
    2. 2023
  2. Meller,A., Bhakat,S., Solieva,S. and Bowman,G.R.
    Accelerating Cryptic Pocket Discovery Using AlphaFold
    J Chem Theory Comput19, 4355-4363. PubMed  Europe PubMed DOI
    3. 2022
  3. Bhakat,S. and Soderhjelm,P.
    Flap Dynamics in Pepsin-Like Aspartic Proteases: A Computational Perspective Using Plasmepsin-II and BACE-1 as Model Systems
    J Chem Inf Model62, 914-926. PubMed  Europe PubMed DOI
  4. En-Nahli,F., Baammi,S., Hajji,H., Alaqarbeh,M., Lakhlifi,T. and Bouachrine,M.
    High-throughput virtual screening approach of natural compounds as target inhibitors of plasmepsin-II
    J Biomol Struct Dyn1-11. PubMed  Europe PubMed DOI
    5. 2020
  5. Asua,V., Conrad,M.D., Aydemir,O., Duvalsaint,M., Legac,J., Duarte,E., Tumwebaze,P., Chin,D.M., Cooper,R.A., Yeka,A., Kamya,M.R., Dorsey,G., Nsobya,S.L., Bailey,J. and Rosenthal,P.J.
    Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda
    J Infect Dis PubMed  Europe PubMed DOI  I
  6. Manhas,A., Kumar,S. and Jha,P.C.
    Identification of the natural compound inhibitors against Plasmodium falciparum plasmepsin-II via common feature based screening and molecular dynamics simulations
    J Biomol Struct Dyn1-13. PubMed  Europe PubMed DOI
  7. Nasamu,A.S., Polino,A.J., Istvan,E.S. and Goldberg,D.E.
    Malaria parasite plasmepsins: more than just plain old degradative pepsins
    J Biol Chem PubMed  Europe PubMed DOI
    8. 2019
  8. Bobrovs,R., Jaudzems,K. and Jirgensons,A.
    Exploiting structural dynamics to design open-flap inhibitors of malarial aspartic proteases
    J Med Chem62, 8931-8950. PubMed  Europe PubMed DOI  I
    9. 2018
  9. Inoue,J., Silva,M., Fofana,B., Sanogo,K., Martensson,A., Sagara,I., Bjorkman,A., Veiga,M.I., Ferreira,P.E., Djimde,A. and Gil,J.P.
    Piperaquine resistance in Plasmodium falciparum, West Africa
    Emerg Infect Dis24, PubMed  Europe PubMed DOI
  10. Kinena,L., Leitis,G., Kanepe-Lapsa,I., Bobrovs,R., Jaudzems,K., Ozola,V., Suna,E. and Jirgensons,A.
    Azole-based non-peptidomimetic plasmepsin inhibitors
    Arch Pharm (Weinheim)351, e1800151-e1800151. PubMed  Europe PubMed DOI  I
  11. Kumar Singh,A., Rajendran,V., Singh,S., Kumar,P., Kumar,Y., Singh,A., Miller,W., Potemkin,V., Poonam, Grishina,M., Gupta,N., Kempaiah,P., Durvasula,R., Singh,B.K., Dunn,B.M. and Rathi,B.
    Antiplasmodial activity of hydroxyethylamine analogs: synthesis, biological activity and structure activity relationship of plasmepsin inhibitors
    Bioorg Med Chem26, 3837-3844. PubMed  Europe PubMed DOI  I
  12. Mishra,V., Rathore,I., Arekar,A., Sthanam,L.K., Xiao,H., Kiso,Y., Sen,S., Patankar,S., Gustchina,A., Hidaka,K., Wlodawer,A., Yada,R.Y. and Bhaumik,P.
    Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights
    FEBS J285, 3077-3096. PubMed  Europe PubMed DOI  S  I
  13. Rasina,D., Stakanovs,G., Borysov,O.V., Pantelejevs,T., Bobrovs,R., Kanepe-Lapsa,I., Tars,K., Jaudzems,K. and Jirgensons,A.
    2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity
    Bioorg Med Chem26, 2488-2500. PubMed  Europe PubMed DOI  I
  14. Robert,M.G., Foguim Tsombeng,F., Gendrot,M., Mosnier,J., Amalvict,R., Benoit,N., Torrentino-Madamet,M. and Pradines,B.
    Absence of high level of duplication of the plasmepsin 2 gene in Africa
    Antimicrob Agents Chemother62, e00374-18-e00374-18. PubMed  Europe PubMed DOI
  15. Santos Souza,S., L'Episcopia,M., Severini,C., Udhayakumar,V. and Lucchi,N.W.
    Photo-Induced Electron Transfer Real-Time PCR for Detection of Plasmodium falciparum plasmepsin 2 gene copy number
    Antimicrob Agents Chemother62, e00317-18-e00317-18. PubMed  Europe PubMed DOI
    16. 2017
  16. Kumar,P., Kaalia,R., Srinivasan,A. and Ghosh,I.
    Multiple target-based pharmacophore design from active site structures
    SAR QSAR Environ Res1-19. PubMed  Europe PubMed DOI  I
    17. 2016
  17. Guerra,Y., Valiente,P.A., Pons,T., Berry,C. and Rudino-Pinera,E.
    Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?
    J Struct Biol195, 259-271. PubMed  Europe PubMed DOI  S
  18. Jaafar,A.H., Xiao,H., Dee,D.R., Bryksa,B.C., Bhaumik,P. and Yada,R.Y.
    The prosegment catalyzes native folding of Plasmodium falciparum plasmepsin II
    Biochim Biophys Acta1864, 1356-1362. PubMed  Europe PubMed DOI
  19. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.
    Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites
    Malar J15, 51-51. PubMed  Europe PubMed DOI
  20. Rasina,D., Otikovs,M., Leitans,J., Recacha,R., Borysov,O.V., Kanepe-Lapsa,I., Domraceva,I., Pantelejevs,T., Tars,K., Blackman,M.J., Jaudzems,K. and Jirgensons,A.
    Fragment-based discovery of 2-aminoquinazolin-4(3h)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV
    J Med Chem59, 374-387. PubMed  Europe PubMed DOI  I
    21. 2015
  21. Dan,N. and Bhakat,S.
    New paradigm of an old target: an update on structural biology and current progress in drug design towards plasmepsin II
    Eur J Med Chem95, 324-348. PubMed  Europe PubMed DOI
  22. Karubiu,W., Bhakat,S., McGillewie,L. and Soliman,M.E.
    Flap dynamics of plasmepsin proteases: insight into proposed parameters and molecular dynamics
    Mol Biosyst11, 1061-1066. PubMed  Europe PubMed DOI  S
  23. McGillewie,L. and Soliman,M.E.
    Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses
    Proteins83, 1693-1705. PubMed  Europe PubMed DOI
  24. Recacha,R., Leitans,J., Akopjana,I., Aprupe,L., Trapencieris,P., Jaudzems,K., Jirgensons,A. and Tars,K.
    Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors
    Acta Crystallogr F Struct Biol Commun71, 1531-1539. PubMed  Europe PubMed DOI  S  I
  25. Singh,A.K., Rathore,S., Tang,Y., Goldfarb,N.E., Dunn,B.M., Rajendran,V., Ghosh,P.C., Singh,N., Latha,N., Singh,B.K., Rawat,M. and Rathi,B.
    Hydroxyethylamine based phthalimides as new class of plasmepsin hits: design, synthesis and antimalarial evaluation
    PLoS ONE10, e0139347-e0139347. PubMed  Europe PubMed DOI  I
    26. 2014
  26. Jin,H., Xu,Z., Cui,K., Zhang,T., Lu,W. and Huang,J.
    Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II
    Fitoterapia94, 55-61. PubMed  Europe PubMed DOI  I
  27. Lerdsirisuk,P., Maicheen,C. and Ungwitayatorn,J.
    Antimalarial activity of HIV-1 protease inhibitor in chromone series
    Bioorg Chem57, 142-147. PubMed  Europe PubMed DOI  I
  28. Meyers,M.J., Tortorella,M.D., Xu,J., Qin,L., He,Z., Lang,X., Zeng,W., Xu,W., Qin,L., Prinsen,M.J., Sverdrup,F.M., Eickhoff,C.S., Griggs,D.W., Oliva,J., Ruminski,P.G., Jacobsen,E.J., Campbell,M.A., Wood,D.C., Goldberg,D.E., Liu,X., Lu,Y., Lu,X., Tu,Z., Lu,X., Ding,K. and Chen,X.
    Evaluation of aminohydantoins as a novel class of antimalarial agents
    ACS Med Chem Lett5, 89-93. PubMed  Europe PubMed DOI  I
  29. Miura,T., Hidaka,K., Azai,Y., Kashimoto,K., Kawasaki,Y., Chen,S.E., de Freitas,R.F., Freire,E. and Kiso,Y.
    Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum
    Bioorg Med Chem Lett24, 1698-1701. PubMed  Europe PubMed DOI  I
    30. 2013
  30. Aureggi,V., Ehmke,V., Wieland,J., Schweizer,W.B., Bernet,B., Bur,D., Meyer,S., Rottmann,M., Freymond,C., Brun,R., Breit,B. and Diederich,F.
    Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes
    Chemistry19, 155-164. PubMed  Europe PubMed DOI  I
  31. Bhattacharjya Sharma,R. and Chetia,D.
    Docking studies on quinine analogs for plasmepsin-II of malaria parasite using bioinformatics tools
    Int J Pharmcy Pharm Sci5, 681-685.  I
  32. Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P.
    Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum
    Proc Natl Acad Sci U S A110, 5392-5397. PubMed  Europe PubMed DOI
  33. de Oliveira,M.E., Cenzi,G., Nunes,R.R., Andrighetti,C.R., de Sousa Valadao,D.M., Dos Reis,C., Simoes,C.M., Nunes,R.J., Junior,M.C., Taranto,A.G., Sanchez,B.A., Viana,G.H. and de Pilla Varotti,F.
    Antimalarial activity of 4-metoxychalcones: Docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate
    Molecules18, 15276-15287. PubMed  Europe PubMed DOI  I
  34. Song,Y., Jin,H., Liu,X., Zhu,L., Huang,J. and Li,H.
    Discovery of non-peptide inhibitors of plasmepsin II by structure-based virtual screening
    Bioorg Med Chem Lett23, 2078-2082. PubMed  Europe PubMed DOI  I
    35. 2012
  35. Berry,C. and Goldberg,D.E.
    Food vacuole plasmepsins
    [ISSN:978-0-12-407744-7]3, 98-103. DOI
  36. Bhaumik,P., Gustchina,A. and Wlodawer,A.
    Structural studies of vacuolar plasmepsins
    Biochim Biophys Acta1824, 207-223. PubMed  Europe PubMed DOI  S
  37. Dali,B., Keita,M., Megnassan,E., Frecer,V. and Miertus,S.
    Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human cathepsin D
    Chem Biol Drug Des79, 411-430. PubMed  Europe PubMed DOI  I
  38. Meyers,M.J. and Goldberg,D.E.
    Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts
    Curr Top Med Chem12, 445-455. PubMed  Europe PubMed DOI  I
  39. Saify,Z.S., Azim,M.K., Ahmad,W., Nisa,M., Goldberg,D.E., Hussain,S.A., Akhtar,S., Akram,A., Arayne,A., Oksman,A. and Khan,I.A.
    New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: synthesis and analysis of structure-activity relationships
    Bioorg Med Chem Lett22, 1282-1286. PubMed  Europe PubMed DOI  I
    40. 2011
  40. Chullai,C., Nongrum,E. and Namdeo,R.
    Proposing de-novo generated, iteratively optimized new lead molecules targeting Plasmodium falciparum plasmepsin-II frederick
    Int J ChemTech Res3, 1538-1547.  I
  41. Gil,L., Valiente,P.A., Pascutti,P.G. and Pons,T.
    Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design
    J Trop Med2011, 657483-657483. PubMed  Europe PubMed DOI  V
  42. McKay,P.B., Peters,M.B., Carta,G., Flood,C.T., Dempsey,E., Bell,A., Berry,C., Lloyd,D.G. and Fayne,D.
    Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design
    Bioorg Med Chem Lett21, 3335-3341. PubMed  Europe PubMed DOI  I
  43. Ojha,P.K. and Roy,K.
    Exploring molecular docking and QSAR studies of plasmepsin-II inhibitor di-tertiary amines as potential antimalarial compounds
    Mol Simul37, 779-803. DOI  I
  44. Saify,Z.S., Nisa,M., Azhar,K.F., Azim,M.K., Rasheed,H., Mushtaq,N., Arain,M.A., Haider,S., Khanum,M. and Ahmed,W.
    Characterisation of Plasmodium falciparum aspartic protease inhibition by piperidine derivatives
    Nat Prod Res25, 1965-1968. PubMed  Europe PubMed DOI  I
  45. Steiner,D., Oostenbrink,C., Diederich,F., Zurcher,M. and van Gunsteren,W.F.
    Calculation of binding free energies of inhibitors to plasmepsin II
    J Comput Chem32, 1801-1812. PubMed  Europe PubMed DOI  I
  46. Xiao,H., Dee,D. and Yada,R.Y.
    The native conformation of plasmepsin II is kinetically trapped at neutral pH
    Arch Biochem Biophys513, 102-109. PubMed  Europe PubMed DOI
    47. 2010
  47. Ahmed,W., Rani,M., Khan,I.A., Iqbal,A., Khan,K.M., Haleem,M.A. and Azim,M.K.
    Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors
    J Enzyme Inhib Med Chem25, 673-678. PubMed  Europe PubMed DOI  I
  48. Friedman,R. and Caflisch,A.
    On the orientation of the catalytic dyad in aspartic proteases
    Proteins78, 1575-1582. PubMed  Europe PubMed DOI  S
  49. Gupta,D., Yedidi,R.S., Varghese,S., Kovari,L.C. and Woster,P.M.
    Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents
    J Med Chem53, 4234-4247. PubMed  Europe PubMed DOI  I
  50. Luksch,T., Blum,A., Klee,N., Diederich,W.E., Sotriffer,C.A. and Klebe,G.
    Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein
    ChemMedChem5, 443-454. PubMed  Europe PubMed DOI  I
  51. Miura,T., Hidaka,K., Uemura,T., Kashimoto,K., Hori,Y., Kawasaki,Y., Ruben,A.J., Freire,E., Kimura,T. and Kiso,Y.
    Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution
    Bioorg Med Chem Lett20, 4836-4839. PubMed  Europe PubMed DOI  I
  52. Mohapatra,S.C., Tiwari,H.K., Singla,M., Rathi,B., Sharma,A., Mahiya,K., Kumar,M., Sinha,S. and Chauhan,S.S.
    Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum
    J Biol Inorg Chem15, 373-385. PubMed  Europe PubMed DOI  I
  53. Parr-Vasquez,C.L. and Yada,R.Y.
    Functional chimera of porcine pepsin prosegment and Plasmodium falciparum plasmepsin II
    Protein Eng Des Sel23, 19-26. PubMed  Europe PubMed DOI
  54. Valiente,P.A., Gil,A., Batista,P.R., Caffarena,E.R., Pons,T. and Pascutti,P.G.
    New parameterization approaches of the LIE method to improve free energy calculations of PlmII-inhibitors complexes
    J Comput Chem31, 2723-2734. PubMed  Europe PubMed DOI  I
    55. 2009
  55. Degliesposti,G., Kasam,V., Da Costa,A., Kang,H.K., Kim,N., Kim,D.W., Breton,V., Kim,D. and Rastelli,G.
    Design and discovery of plasmepsin II inhibitors using an automated workflow on large-scale grids
    ChemMedChem4, 1164-1173. PubMed  Europe PubMed DOI  I
  56. Dell'Agli,M., Galli,G.V., Corbett,Y., Taramelli,D., Lucantoni,L., Habluetzel,A., Maschi,O., Caruso,D., Giavarini,F., Romeo,S., Bhattacharya,D. and Bosisio,E.
    Antiplasmodial activity of Punica granatum L. fruit rind
    J Ethnopharmacol125, 279-285. PubMed  Europe PubMed DOI  I
  57. Fah,C., Hardegger,L.A., Baitsch,L., Schweizer,W.B., Meyer,S., Bur,D. and Diederich,F.
    New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates
    Org Biomol Chem7, 3947-3957. PubMed  Europe PubMed DOI  I
  58. Friedman,R. and Caflisch,A.
    Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring
    ChemMedChem4, 1317-1326. PubMed  Europe PubMed DOI  I
  59. Moura,P.A., Dame,J.B. and Fidock,D.A.
    Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors
    Antimicrobial Agents Chemother53, 4968-4978. PubMed  Europe PubMed DOI  I
  60. Orrling,K.M., Marzahn,M.R., Gutierrez-de-Teran,H., Aqvist,J., Dunn,B.M. and Larhed,M.
    alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases
    Bioorg Med Chem17, 5933-5949. PubMed  Europe PubMed DOI  I
  61. Ramirez,A.R., Guerra,Y., Otero,A., Garcia,B., Berry,C., Mendiola,J., Hernandez-Zanui,A. and Chavez,M.
    Generation of an affinity matrix useful in the purification of natural inhibitors of plasmepsin II, an antimalarial-drug target
    Biotechnol Appl Biochem52, 149-157. PubMed  Europe PubMed DOI  I
  62. Robbins,A.H., Dunn,B.M., Agbandje-McKenna,M. and McKenna,R.
    Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank
    Acta Crystallogr D Biol Crystallogr65, 294-296. PubMed  Europe PubMed DOI  S
    63. 2008
  63. Aberathne,P., Mahabaduge,J. and Silva,S.J.
    Computer aided docking of small molecules to the active site of the malarial aspartic protease, plasmepsin II
    J Natl Sci Found Sri Lanka36, 171-178.  I
  64. Azim,M.K., Ahmed,W., Khan,I.A., Rao,N.A. and Khan,K.M.
    Identification of acridinyl hydrazides as potent aspartic protease inhibitors
    Bioorg Med Chem Lett18, 3011-3015. PubMed  Europe PubMed DOI  I
  65. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E.
    Plasmodium food vacuole plasmepsins are activated by falcipains
    J Biol Chem283, 12870-12876. PubMed  Europe PubMed DOI
  66. Friedman,R. and Caflisch,A.
    Pepsinogen-like activation intermediate of plasmepsin II revealed by molecular dynamics analysis
    Proteins73, 814-827. PubMed  Europe PubMed DOI
  67. Hidaka,K., Kimura,T., Ruben,A.J., Uemura,T., Kamiya,M., Kiso,A., Okamoto,T., Tsuchiya,Y., Hayashi,Y., Freire,E. and Kiso,Y.
    Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin
    Bioorg Med Chem16, 10049-10060. PubMed  Europe PubMed DOI  I
  68. Luksch,T., Chan,N.S., Brass,S., Sotriffer,C.A., Klebe,G. and Diederich,W.E.
    Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors
    ChemMedChem3, 1323-1336. PubMed  Europe PubMed DOI  I
  69. Rumsh,L.D., Mikhailova,A.G., Mikhura,I.V., Prudchenko,I.A., Chikin,L.D., Mikhaleva,I.I., Kaliberda,E.N., Dergousova,N.I., Mel'nikov,E.E. and Formanovskii,A.A.
    Selective inhibitors of plasmepsin II of Plasmodium falciparum on the basis of pepstatin
    Russ J Bioorganic Chem34, 660-667. DOI  I
  70. Rumsh,L.D., Mikhailova,A.G., Mikhura,I.V., Prudchenko,I.A., Chikin,L.D., Mikhaleva,I.I., Kaliberda,E.N., Dergousova,N.I., Mel'nikov,E.E. and Formanovskii,A.A.
    [Selective inhibitors of plasmepsin II from Plasmodium falciparum based on pepstatin]
    Bioorg Khim34, 739-746. PubMed  Europe PubMed  I
  71. Zurcher,M., Gottschalk,T., Meyer,S., Bur,D. and Diederich,F.
    Exploring the flap pocket of the antimalarial target plasmepsin II: the "55 % rule" applied to enzymes
    ChemMedChem3, 237-240. PubMed  Europe PubMed DOI
    72. 2007
  72. Bonilla,J.A., Bonilla,T.D., Yowell,C.A., Fujioka,H. and Dame,J.B.
    Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function
    Mol Microbiol65, 64-75. PubMed  Europe PubMed DOI  K
  73. Bonilla,J.A., Moura,P.A., Bonilla,T.D., Yowell,C.A., Fidock,D.A. and Dame,J.B.
    Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum
    Int J Parasitol37, 317-327. PubMed  Europe PubMed DOI  K
  74. Friedman,R. and Caflisch,A.
    The protonation state of the catalytic aspartates in plasmepsin II
    FEBS Lett581, 4120-4124. PubMed  Europe PubMed DOI
  75. Hidaka,K., Kimura,T., Tsuchiya,Y., Kamiya,M., Ruben,A.J., Freire,E., Hayashi,Y. and Kiso,Y.
    Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II
    Bioorg Med Chem Lett17, 3048-3052. PubMed  Europe PubMed DOI  I
  76. Kasam,V., Zimmermann,M., Maass,A., Schwichtenberg,H., Wolf,A., Jacq,N., Breton,V. and Hofmann-Apitius,M.
    Design of new plasmepsin inhibitors: a virtual high throughput screening approach on the EGEE grid
    J Chem Inf Model47, 1818-1828. PubMed  Europe PubMed DOI  I
    77. 2006
  77. Andrews,K.T., Fairlie,D.P., Madala,P.K., Ray,J., Wyatt,D.M., Hilton,P.M., Melville,L.A., Beattie,L., Gardiner,D.L., Reid,R.C., Stoermer,M.J., Skinner-Adams,T., Berry,C. and McCarthy,J.S.
    Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria
    Antimicrob Agents Chemother50, 639-648. PubMed  Europe PubMed DOI  I
  78. [YEAR:27-6-2006]Bjelic,S. and Aqvist,J.
    Catalysis and linear free energy relationships in aspartic proteases
    Biochemistry45, 7709-7723. PubMed  Europe PubMed DOI
  79. Boss,C., Corminboeuf,O., Grisostomi,C., Meyer,S., Jones,A.F., Prade,L., Binkert,C., Fischli,W., Weller,T. and Bur,D.
    Achiral, cheap, and potent inhibitors of plasmepsins I, II, and IV
    ChemMedChem1, 1341-1345. PubMed  Europe PubMed DOI  S  I
  80. [YEAR:14-12-2006]Dell'Agli,M., Parapini,S., Galli,G., Vaiana,N., Taramelli,D., Sparatore,A., Liu,P., Dunn,B.M., Bosisio,E. and Romeo,S.
    High antiplasmodial activity of novel plasmepsins I and II inhibitors
    J Med Chem49, 7440-7449. PubMed  Europe PubMed DOI  I
  81. [YEAR:21-11-2006]Ersmark,K., Nervall,M., Gutierrez-de-Teran,H., Hamelink,E., Janka,L.K., Clemente,J.C., Dunn,B.M., Gogoll,A., Samuelsson,B., Qvist,J. and Hallberg,A.
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