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Literature for peptidase A01.023: plasmepsin-2

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, K Knockout, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Syed,S.F., Thakur,P., Patil,M. and Choudhary,S.<br>Physico-Chemical Insights into the Catalytic Inhibition of Plasmodium falciparum Plasmepsin II Activity by Repurposing Fluoroquinolone Drugs<br>J Phys Chem B (2026) 130, 2015-2030. PubMed  Europe PubMed DOI
    2. 2024
  2. Mishra,V., Deshmukh,A., Rathore,I., Chakraborty,S., Patankar,S., Gustchina,A., Wlodawer,A., Yada,R.Y. and Bhaumik,P.<br>Inhibition of Plasmodium falciparum plasmepsins by drugs targeting HIV-1 protease: A way forward for antimalarial drug discovery<br>Curr Res Struct Biol (2024) 7, 100128-100128. PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2023
  3. Meller,A., Bhakat,S., Solieva,S. and Bowman,G.R.<br>Accelerating Cryptic Pocket Discovery Using AlphaFold<br>J Chem Theory Comput (2023) 19, 4355-4363. PubMed  Europe PubMed DOI
    4. 2022
  4. Bhakat,S. and Soderhjelm,P.<br>Flap Dynamics in Pepsin-Like Aspartic Proteases: A Computational Perspective Using Plasmepsin-II and BACE-1 as Model Systems<br>J Chem Inf Model (2022) 62, 914-926. PubMed  Europe PubMed DOI  PMC  EPMC
  5. En-Nahli,F., Baammi,S., Hajji,H., Alaqarbeh,M., Lakhlifi,T. and Bouachrine,M.<br>High-throughput virtual screening approach of natural compounds as target inhibitors of plasmepsin-II<br>J Biomol Struct Dyn (2022) , 1-11. PubMed  Europe PubMed DOI
    6. 2020
  6. Asua,V., Conrad,M.D., Aydemir,O., Duvalsaint,M., Legac,J., Duarte,E., Tumwebaze,P., Chin,D.M., Cooper,R.A., Yeka,A., Kamya,M.R., Dorsey,G., Nsobya,S.L., Bailey,J. and Rosenthal,P.J.<br>Changing Prevalence of Potential Mediators of Aminoquinoline, Antifolate, and Artemisinin Resistance Across Uganda<br>J Infect Dis (2020) PubMed  Europe PubMed DOI  I
  7. Manhas,A., Kumar,S. and Jha,P.C.<br>Identification of the natural compound inhibitors against Plasmodium falciparum plasmepsin-II via common feature based screening and molecular dynamics simulations<br>J Biomol Struct Dyn (2020) , 1-13. PubMed  Europe PubMed DOI
  8. Nasamu,A.S., Polino,A.J., Istvan,E.S. and Goldberg,D.E.<br>Malaria parasite plasmepsins: more than just plain old degradative pepsins<br>J Biol Chem (2020) PubMed  Europe PubMed DOI
    9. 2019
  9. Bobrovs,R., Jaudzems,K. and Jirgensons,A.<br>Exploiting structural dynamics to design open-flap inhibitors of malarial aspartic proteases<br>J Med Chem (2019) 62, 8931-8950. PubMed  Europe PubMed DOI  I
    10. 2018
  10. Inoue,J., Silva,M., Fofana,B., Sanogo,K., Martensson,A., Sagara,I., Bjorkman,A., Veiga,M.I., Ferreira,P.E., Djimde,A. and Gil,J.P.<br>Piperaquine resistance in Plasmodium falciparum, West Africa<br>Emerg Infect Dis (2018) 24 PubMed  Europe PubMed DOI
  11. Kinena,L., Leitis,G., Kanepe-Lapsa,I., Bobrovs,R., Jaudzems,K., Ozola,V., Suna,E. and Jirgensons,A.<br>Azole-based non-peptidomimetic plasmepsin inhibitors<br>Arch Pharm (Weinheim) (2018) 351, e1800151-e1800151. PubMed  Europe PubMed DOI  I
  12. Kumar Singh,A., Rajendran,V., Singh,S., Kumar,P., Kumar,Y., Singh,A., Miller,W., Potemkin,V., Poonam, Grishina,M., Gupta,N., Kempaiah,P., Durvasula,R., Singh,B.K., Dunn,B.M. and Rathi,B.<br>Antiplasmodial activity of hydroxyethylamine analogs: synthesis, biological activity and structure activity relationship of plasmepsin inhibitors<br>Bioorg Med Chem (2018) 26, 3837-3844. PubMed  Europe PubMed DOI  I
  13. Mishra,V., Rathore,I., Arekar,A., Sthanam,L.K., Xiao,H., Kiso,Y., Sen,S., Patankar,S., Gustchina,A., Hidaka,K., Wlodawer,A., Yada,R.Y. and Bhaumik,P.<br>Deciphering the mechanism of potent peptidomimetic inhibitors targeting plasmepsins - biochemical and structural insights<br>FEBS J (2018) 285, 3077-3096. PubMed  Europe PubMed DOI  S  I
  14. Rasina,D., Stakanovs,G., Borysov,O.V., Pantelejevs,T., Bobrovs,R., Kanepe-Lapsa,I., Tars,K., Jaudzems,K. and Jirgensons,A.<br>2-Aminoquinazolin-4(3H)-one based plasmepsin inhibitors with improved hydrophilicity and selectivity<br>Bioorg Med Chem (2018) 26, 2488-2500. PubMed  Europe PubMed DOI  I
  15. Robert,M.G., Foguim Tsombeng,F., Gendrot,M., Mosnier,J., Amalvict,R., Benoit,N., Torrentino-Madamet,M. and Pradines,B.<br>Absence of high level of duplication of the plasmepsin 2 gene in Africa<br>Antimicrob Agents Chemother (2018) 62, e00374-18-e00374-18. PubMed  Europe PubMed DOI
  16. Santos Souza,S., L'Episcopia,M., Severini,C., Udhayakumar,V. and Lucchi,N.W.<br>Photo-Induced Electron Transfer Real-Time PCR for Detection of Plasmodium falciparum plasmepsin 2 gene copy number<br>Antimicrob Agents Chemother (2018) 62, e00317-18-e00317-18. PubMed  Europe PubMed DOI
    17. 2017
  17. Kumar,P., Kaalia,R., Srinivasan,A. and Ghosh,I.<br>Multiple target-based pharmacophore design from active site structures<br>SAR QSAR Environ Res (2017) , 1-19. PubMed  Europe PubMed DOI  I
    18. 2016
  18. Guerra,Y., Valiente,P.A., Pons,T., Berry,C. and Rudino-Pinera,E.<br>Structures of a bi-functional Kunitz-type STI family inhibitor of serine and aspartic proteases: could the aspartic protease inhibition have evolved from a canonical serine protease-binding loop?<br>J Struct Biol (2016) 195, 259-271. PubMed  Europe PubMed DOI  S
  19. Jaafar,A.H., Xiao,H., Dee,D.R., Bryksa,B.C., Bhaumik,P. and Yada,R.Y.<br>The prosegment catalyzes native folding of Plasmodium falciparum plasmepsin II<br>Biochim Biophys Acta (2016) 1864, 1356-1362. PubMed  Europe PubMed DOI
  20. Ponsuwanna,P., Kochakarn,T., Bunditvorapoom,D., Kumpornsin,K., Otto,T.D., Ridenour,C., Chotivanich,K., Wilairat,P., White,N.J., Miotto,O. and Chookajorn,T.<br>Comparative genome-wide analysis and evolutionary history of haemoglobin-processing and haem detoxification enzymes in malarial parasites<br>Malar J (2016) 15, 51-51. PubMed  Europe PubMed DOI  PMC  EPMC
  21. Rasina,D., Otikovs,M., Leitans,J., Recacha,R., Borysov,O.V., Kanepe-Lapsa,I., Domraceva,I., Pantelejevs,T., Tars,K., Blackman,M.J., Jaudzems,K. and Jirgensons,A.<br>Fragment-based discovery of 2-aminoquinazolin-4(3h)-ones as novel class nonpeptidomimetic inhibitors of the plasmepsins I, II, and IV<br>J Med Chem (2016) 59, 374-387. PubMed  Europe PubMed DOI  I
    22. 2015
  22. Dan,N. and Bhakat,S.<br>New paradigm of an old target: an update on structural biology and current progress in drug design towards plasmepsin II<br>Eur J Med Chem (2015) 95, 324-348. PubMed  Europe PubMed DOI
  23. Karubiu,W., Bhakat,S., McGillewie,L. and Soliman,M.E.<br>Flap dynamics of plasmepsin proteases: insight into proposed parameters and molecular dynamics<br>Mol Biosyst (2015) 11, 1061-1066. PubMed  Europe PubMed DOI  S
  24. McGillewie,L. and Soliman,M.E.<br>Flap flexibility amongst plasmepsins I, II, III, IV, and V: sequence, structural, and molecular dynamics analyses<br>Proteins (2015) 83, 1693-1705. PubMed  Europe PubMed DOI
  25. Recacha,R., Leitans,J., Akopjana,I., Aprupe,L., Trapencieris,P., Jaudzems,K., Jirgensons,A. and Tars,K.<br>Structures of plasmepsin II from Plasmodium falciparum in complex with two hydroxyethylamine-based inhibitors<br>Acta Crystallogr F Struct Biol Commun (2015) 71, 1531-1539. PubMed  Europe PubMed DOI  S  I
  26. Singh,A.K., Rathore,S., Tang,Y., Goldfarb,N.E., Dunn,B.M., Rajendran,V., Ghosh,P.C., Singh,N., Latha,N., Singh,B.K., Rawat,M. and Rathi,B.<br>Hydroxyethylamine based phthalimides as new class of plasmepsin hits: design, synthesis and antimalarial evaluation<br>PLoS ONE (2015) 10, e0139347-e0139347. PubMed  Europe PubMed DOI  PMC  EPMC  I
    27. 2014
  27. Jin,H., Xu,Z., Cui,K., Zhang,T., Lu,W. and Huang,J.<br>Dietary flavonoids fisetin and myricetin: dual inhibitors of Plasmodium falciparum falcipain-2 and plasmepsin II<br>Fitoterapia (2014) 94, 55-61. PubMed  Europe PubMed DOI  I
  28. Lerdsirisuk,P., Maicheen,C. and Ungwitayatorn,J.<br>Antimalarial activity of HIV-1 protease inhibitor in chromone series<br>Bioorg Chem (2014) 57, 142-147. PubMed  Europe PubMed DOI  I
  29. Meyers,M.J., Tortorella,M.D., Xu,J., Qin,L., He,Z., Lang,X., Zeng,W., Xu,W., Qin,L., Prinsen,M.J., Sverdrup,F.M., Eickhoff,C.S., Griggs,D.W., Oliva,J., Ruminski,P.G., Jacobsen,E.J., Campbell,M.A., Wood,D.C., Goldberg,D.E., Liu,X., Lu,Y., Lu,X., Tu,Z., Lu,X., Ding,K. and Chen,X.<br>Evaluation of aminohydantoins as a novel class of antimalarial agents<br>ACS Med Chem Lett (2014) 5, 89-93. PubMed  Europe PubMed DOI  PMC  EPMC  I
  30. Miura,T., Hidaka,K., Azai,Y., Kashimoto,K., Kawasaki,Y., Chen,S.E., de Freitas,R.F., Freire,E. and Kiso,Y.<br>Optimization of plasmepsin inhibitor by focusing on similar structural feature with chloroquine to avoid drug-resistant mechanism of Plasmodium falciparum<br>Bioorg Med Chem Lett (2014) 24, 1698-1701. PubMed  Europe PubMed DOI  I
    31. 2013
  31. Aureggi,V., Ehmke,V., Wieland,J., Schweizer,W.B., Bernet,B., Bur,D., Meyer,S., Rottmann,M., Freymond,C., Brun,R., Breit,B. and Diederich,F.<br>Potent inhibitors of malarial aspartic proteases, the plasmepsins, by hydroformylation of substituted 7-azanorbornenes<br>Chemistry (2013) 19, 155-164. PubMed  Europe PubMed DOI  I
  32. Bhattacharjya Sharma,R. and Chetia,D.<br>Docking studies on quinine analogs for plasmepsin-II of malaria parasite using bioinformatics tools<br>Int J Pharmcy Pharm Sci (2013) 5, 681-685.  I
  33. Chugh,M., Sundararaman,V., Kumar,S., Reddy,V.S., Siddiqui,W.A., Stuart,K.D. and Malhotra,P.<br>Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum<br>Proc Natl Acad Sci U S A (2013) 110, 5392-5397. PubMed  Europe PubMed DOI
  34. de Oliveira,M.E., Cenzi,G., Nunes,R.R., Andrighetti,C.R., de Sousa Valadao,D.M., Dos Reis,C., Simoes,C.M., Nunes,R.J., Junior,M.C., Taranto,A.G., Sanchez,B.A., Viana,G.H. and de Pilla Varotti,F.<br>Antimalarial activity of 4-metoxychalcones: Docking studies as falcipain/plasmepsin inhibitors, ADMET and lipophilic efficiency analysis to identify a putative oral lead candidate<br>Molecules (2013) 18, 15276-15287. PubMed  Europe PubMed DOI  I
  35. Song,Y., Jin,H., Liu,X., Zhu,L., Huang,J. and Li,H.<br>Discovery of non-peptide inhibitors of plasmepsin II by structure-based virtual screening<br>Bioorg Med Chem Lett (2013) 23, 2078-2082. PubMed  Europe PubMed DOI  I
    36. 2012
  36. Berry,C. and Goldberg,D.E.<br>Food vacuole plasmepsins<br>[ISSN:978-0-12-407744-7] (2012) 3, 98-103. DOI
  37. Bhaumik,P., Gustchina,A. and Wlodawer,A.<br>Structural studies of vacuolar plasmepsins<br>Biochim Biophys Acta (2012) 1824, 207-223. PubMed  Europe PubMed DOI  S
  38. Dali,B., Keita,M., Megnassan,E., Frecer,V. and Miertus,S.<br>Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human cathepsin D<br>Chem Biol Drug Des (2012) 79, 411-430. PubMed  Europe PubMed DOI  I
  39. Meyers,M.J. and Goldberg,D.E.<br>Recent advances in plasmepsin medicinal chemistry and implications for future antimalarial drug discovery efforts<br>Curr Top Med Chem (2012) 12, 445-455. PubMed  Europe PubMed DOI  I
  40. Saify,Z.S., Azim,M.K., Ahmad,W., Nisa,M., Goldberg,D.E., Hussain,S.A., Akhtar,S., Akram,A., Arayne,A., Oksman,A. and Khan,I.A.<br>New benzimidazole derivatives as antiplasmodial agents and plasmepsin inhibitors: synthesis and analysis of structure-activity relationships<br>Bioorg Med Chem Lett (2012) 22, 1282-1286. PubMed  Europe PubMed DOI  I
    41. 2011
  41. Chullai,C., Nongrum,E. and Namdeo,R.<br>Proposing de-novo generated, iteratively optimized new lead molecules targeting Plasmodium falciparum plasmepsin-II frederick<br>Int J ChemTech Res (2011) 3, 1538-1547.  I
  42. Gil,L., Valiente,P.A., Pascutti,P.G. and Pons,T.<br>Computational perspectives into plasmepsins structure-function relationship: implications to inhibitors design<br>J Trop Med (2011) 2011, 657483-657483. PubMed  Europe PubMed DOI  PMC  EPMC  V
  43. McKay,P.B., Peters,M.B., Carta,G., Flood,C.T., Dempsey,E., Bell,A., Berry,C., Lloyd,D.G. and Fayne,D.<br>Identification of plasmepsin inhibitors as selective anti-malarial agents using ligand based drug design<br>Bioorg Med Chem Lett (2011) 21, 3335-3341. PubMed  Europe PubMed DOI  I
  44. Ojha,P.K. and Roy,K.<br>Exploring molecular docking and QSAR studies of plasmepsin-II inhibitor di-tertiary amines as potential antimalarial compounds<br>Mol Simul (2011) 37, 779-803. DOI  I
  45. Saify,Z.S., Nisa,M., Azhar,K.F., Azim,M.K., Rasheed,H., Mushtaq,N., Arain,M.A., Haider,S., Khanum,M. and Ahmed,W.<br>Characterisation of Plasmodium falciparum aspartic protease inhibition by piperidine derivatives<br>Nat Prod Res (2011) 25, 1965-1968. PubMed  Europe PubMed DOI  I
  46. Steiner,D., Oostenbrink,C., Diederich,F., Zurcher,M. and van Gunsteren,W.F.<br>Calculation of binding free energies of inhibitors to plasmepsin II<br>J Comput Chem (2011) 32, 1801-1812. PubMed  Europe PubMed DOI  I
  47. Xiao,H., Dee,D. and Yada,R.Y.<br>The native conformation of plasmepsin II is kinetically trapped at neutral pH<br>Arch Biochem Biophys (2011) 513, 102-109. PubMed  Europe PubMed DOI
    48. 2010
  48. Ahmed,W., Rani,M., Khan,I.A., Iqbal,A., Khan,K.M., Haleem,M.A. and Azim,M.K.<br>Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors<br>J Enzyme Inhib Med Chem (2010) 25, 673-678. PubMed  Europe PubMed DOI  I
  49. Friedman,R. and Caflisch,A.<br>On the orientation of the catalytic dyad in aspartic proteases<br>Proteins (2010) 78, 1575-1582. PubMed  Europe PubMed DOI  S
  50. Gupta,D., Yedidi,R.S., Varghese,S., Kovari,L.C. and Woster,P.M.<br>Mechanism-based inhibitors of the aspartyl protease plasmepsin II as potential antimalarial agents<br>J Med Chem (2010) 53, 4234-4247. PubMed  Europe PubMed DOI  I
  51. Luksch,T., Blum,A., Klee,N., Diederich,W.E., Sotriffer,C.A. and Klebe,G.<br>Pyrrolidine derivatives as plasmepsin inhibitors: binding mode analysis assisted by molecular dynamics simulations of a highly flexible protein<br>ChemMedChem (2010) 5, 443-454. PubMed  Europe PubMed DOI  I
  52. Miura,T., Hidaka,K., Uemura,T., Kashimoto,K., Hori,Y., Kawasaki,Y., Ruben,A.J., Freire,E., Kimura,T. and Kiso,Y.<br>Improvement of both plasmepsin inhibitory activity and antimalarial activity by 2-aminoethylamino substitution<br>Bioorg Med Chem Lett (2010) 20, 4836-4839. PubMed  Europe PubMed DOI  I
  53. Mohapatra,S.C., Tiwari,H.K., Singla,M., Rathi,B., Sharma,A., Mahiya,K., Kumar,M., Sinha,S. and Chauhan,S.S.<br>Antimalarial evaluation of copper(II) nanohybrid solids: inhibition of plasmepsin II, a hemoglobin-degrading malarial aspartic protease from Plasmodium falciparum<br>J Biol Inorg Chem (2010) 15, 373-385. PubMed  Europe PubMed DOI  I
  54. Parr-Vasquez,C.L. and Yada,R.Y.<br>Functional chimera of porcine pepsin prosegment and Plasmodium falciparum plasmepsin II<br>Protein Eng Des Sel (2010) 23, 19-26. PubMed  Europe PubMed DOI
  55. Valiente,P.A., Gil,A., Batista,P.R., Caffarena,E.R., Pons,T. and Pascutti,P.G.<br>New parameterization approaches of the LIE method to improve free energy calculations of PlmII-inhibitors complexes<br>J Comput Chem (2010) 31, 2723-2734. PubMed  Europe PubMed DOI  I
    56. 2009
  56. Degliesposti,G., Kasam,V., Da Costa,A., Kang,H.K., Kim,N., Kim,D.W., Breton,V., Kim,D. and Rastelli,G.<br>Design and discovery of plasmepsin II inhibitors using an automated workflow on large-scale grids<br>ChemMedChem (2009) 4, 1164-1173. PubMed  Europe PubMed DOI  I
  57. Dell'Agli,M., Galli,G.V., Corbett,Y., Taramelli,D., Lucantoni,L., Habluetzel,A., Maschi,O., Caruso,D., Giavarini,F., Romeo,S., Bhattacharya,D. and Bosisio,E.<br>Antiplasmodial activity of Punica granatum L. fruit rind<br>J Ethnopharmacol (2009) 125, 279-285. PubMed  Europe PubMed DOI  I
  58. Fah,C., Hardegger,L.A., Baitsch,L., Schweizer,W.B., Meyer,S., Bur,D. and Diederich,F.<br>New organofluorine building blocks: inhibition of the malarial aspartic proteases plasmepsin II and IV by alicyclic alpha,alpha-difluoroketone hydrates<br>Org Biomol Chem (2009) 7, 3947-3957. PubMed  Europe PubMed DOI  I
  59. Friedman,R. and Caflisch,A.<br>Discovery of plasmepsin inhibitors by fragment-based docking and consensus scoring<br>ChemMedChem (2009) 4, 1317-1326. PubMed  Europe PubMed DOI  I
  60. Moura,P.A., Dame,J.B. and Fidock,D.A.<br>Role of Plasmodium falciparum digestive vacuole plasmepsins in the specificity and antimalarial mode of action of cysteine and aspartic protease inhibitors<br>Antimicrobial Agents Chemother (2009) 53, 4968-4978. PubMed  Europe PubMed DOI  I
  61. Orrling,K.M., Marzahn,M.R., Gutierrez-de-Teran,H., Aqvist,J., Dunn,B.M. and Larhed,M.<br>alpha-Substituted norstatines as the transition-state mimic in inhibitors of multiple digestive vacuole malaria aspartic proteases<br>Bioorg Med Chem (2009) 17, 5933-5949. PubMed  Europe PubMed DOI  I
  62. Ramirez,A.R., Guerra,Y., Otero,A., Garcia,B., Berry,C., Mendiola,J., Hernandez-Zanui,A. and Chavez,M.<br>Generation of an affinity matrix useful in the purification of natural inhibitors of plasmepsin II, an antimalarial-drug target<br>Biotechnol Appl Biochem (2009) 52, 149-157. PubMed  Europe PubMed DOI  I
  63. Robbins,A.H., Dunn,B.M., Agbandje-McKenna,M. and McKenna,R.<br>Crystallographic evidence for noncoplanar catalytic aspartic acids in plasmepsin II resides in the Protein Data Bank<br>Acta Crystallogr D Biol Crystallogr (2009) 65, 294-296. PubMed  Europe PubMed DOI  S
    64. 2008
  64. Aberathne,P., Mahabaduge,J. and Silva,S.J.<br>Computer aided docking of small molecules to the active site of the malarial aspartic protease, plasmepsin II<br>J Natl Sci Found Sri Lanka (2008) 36, 171-178.  I
  65. Azim,M.K., Ahmed,W., Khan,I.A., Rao,N.A. and Khan,K.M.<br>Identification of acridinyl hydrazides as potent aspartic protease inhibitors<br>Bioorg Med Chem Lett (2008) 18, 3011-3015. PubMed  Europe PubMed DOI  I
  66. Drew,M.E., Banerjee,R., Uffman,E.W., Gilbertson,S., Rosenthal,P.J. and Goldberg,D.E.<br>Plasmodium food vacuole plasmepsins are activated by falcipains<br>J Biol Chem (2008) 283, 12870-12876. PubMed  Europe PubMed DOI  PMC  EPMC
  67. Friedman,R. and Caflisch,A.<br>Pepsinogen-like activation intermediate of plasmepsin II revealed by molecular dynamics analysis<br>Proteins (2008) 73, 814-827. PubMed  Europe PubMed DOI
  68. Hidaka,K., Kimura,T., Ruben,A.J., Uemura,T., Kamiya,M., Kiso,A., Okamoto,T., Tsuchiya,Y., Hayashi,Y., Freire,E. and Kiso,Y.<br>Antimalarial activity enhancement in hydroxymethylcarbonyl (HMC) isostere-based dipeptidomimetics targeting malarial aspartic protease plasmepsin<br>Bioorg Med Chem (2008) 16, 10049-10060. PubMed  Europe PubMed DOI  I
  69. Luksch,T., Chan,N.S., Brass,S., Sotriffer,C.A., Klebe,G. and Diederich,W.E.<br>Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors<br>ChemMedChem (2008) 3, 1323-1336. PubMed  Europe PubMed DOI  I
  70. Rumsh,L.D., Mikhailova,A.G., Mikhura,I.V., Prudchenko,I.A., Chikin,L.D., Mikhaleva,I.I., Kaliberda,E.N., Dergousova,N.I., Mel'nikov,E.E. and Formanovskii,A.A.<br>[Selective inhibitors of plasmepsin II from Plasmodium falciparum based on pepstatin]<br>Bioorg Khim (2008) 34, 739-746. PubMed  Europe PubMed  I
  71. Rumsh,L.D., Mikhailova,A.G., Mikhura,I.V., Prudchenko,I.A., Chikin,L.D., Mikhaleva,I.I., Kaliberda,E.N., Dergousova,N.I., Mel'nikov,E.E. and Formanovskii,A.A.<br>Selective inhibitors of plasmepsin II of Plasmodium falciparum on the basis of pepstatin<br>Russ J Bioorganic Chem (2008) 34, 660-667. DOI  I
  72. Zurcher,M., Gottschalk,T., Meyer,S., Bur,D. and Diederich,F.<br>Exploring the flap pocket of the antimalarial target plasmepsin II: the "55 % rule" applied to enzymes<br>ChemMedChem (2008) 3, 237-240. PubMed  Europe PubMed DOI
    73. 2007
  73. Bonilla,J.A., Moura,P.A., Bonilla,T.D., Yowell,C.A., Fidock,D.A. and Dame,J.B.<br>Effects on growth, hemoglobin metabolism and paralogous gene expression resulting from disruption of genes encoding the digestive vacuole plasmepsins of Plasmodium falciparum<br>Int J Parasitol (2007) 37, 317-327. PubMed  Europe PubMed DOI  K
  74. Bonilla,J.A., Bonilla,T.D., Yowell,C.A., Fujioka,H. and Dame,J.B.<br>Critical roles for the digestive vacuole plasmepsins of Plasmodium falciparum in vacuolar function<br>Mol Microbiol (2007) 65, 64-75. PubMed  Europe PubMed DOI  K
  75. Friedman,R. and Caflisch,A.<br>The protonation state of the catalytic aspartates in plasmepsin II<br>FEBS Lett (2007) 581, 4120-4124. PubMed  Europe PubMed DOI
  76. Hidaka,K., Kimura,T., Tsuchiya,Y., Kamiya,M., Ruben,A.J., Freire,E., Hayashi,Y. and Kiso,Y.<br>Additional interaction of allophenylnorstatine-containing tripeptidomimetics with malarial aspartic protease plasmepsin II<br>Bioorg Med Chem Lett (2007) 17, 3048-3052. PubMed  Europe PubMed DOI  I
  77. Kasam,V., Zimmermann,M., Maass,A., Schwichtenberg,H., Wolf,A., Jacq,N., Breton,V. and Hofmann-Apitius,M.<br>Design of new plasmepsin inhibitors: a virtual high throughput screening approach on the EGEE grid<br>J Chem Inf Model (2007) 47, 1818-1828. PubMed  Europe PubMed DOI  I
    78. 2006
  78. Andrews,K.T., Fairlie,D.P., Madala,P.K., Ray,J., Wyatt,D.M., Hilton,P.M., Melville,L.A., Beattie,L., Gardiner,D.L., Reid,R.C., Stoermer,M.J., Skinner-Adams,T., Berry,C. and McCarthy,J.S.<br>Potencies of human immunodeficiency virus protease inhibitors in vitro against Plasmodium falciparum and in vivo against murine malaria<br>Antimicrob Agents Chemother (2006) 50, 639-648. PubMed  Europe PubMed DOI  PMC  EPMC  I
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