Structure for peptidase A01.011: penicillopepsin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1BXO	Penicillium janthinellum	0.95 Å	complex with ethyl cyclo[(2S)-2-[[(1R)-1-(N-(l-N-(3-methylbutanoyl)valyl-L-aspartyl)amino)-3-methylbutyl]hydroxyphosphinyloxy]-3-(3-aminomethyl)phenylpropanoate
Active site residues are shown in ball-and-stick representation: Asp33 and Asp213 in pink, Tyr75 in green. Carbohydrates are shown as CPK spheres in yellow. Bound inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Penicillium janthinellum
complex with isoval-Val-Val-Lysta-O-Et	1.80 Å	1APT	1APT	1APT	1APT	1APT	1APT
complex with isoval-Val-Val-Sta-O-Et	1.80 Å	1APU	1APU	1APU	1APU	1APU	1APU
complex with isoval-Val-Val-hydrated difluorostatone-N-methylamide	1.80 Å	1APV	1APV	1APV	1APV	1APV	1APV	James et al., 1992
complex with isoval-Val-Val-difluorostatone-N-methylamide	1.80 Å	1APW	1APW	1APW	1APW	1APW	1APW	James et al., 1992
complex with ethyl cyclo[(2S)-2-[[(1R)-1-(N-(l-N-(3-methylbutanoyl)valyl-L-aspartyl)amino)-3-methylbutyl]hydroxyphosphinyloxy]-3-(3-aminomethyl)phenylpropanoate	0.95 Å	1BXO	1BXO	1BXO	1BXO	1BXO	1BXO	Khan et al., 1998
complex with phosphonate inhibitor	1.41 Å	1BXQ	1BXQ	1BXQ	1BXQ	1BXQ	1BXQ	Khan et al., 1998
complex with isoval-Val-Val-Sta(P)-O-Et	1.80 Å	1PPK	1PPK	1PPK	1PPK	1PPK	1PPK	Fraser et al., 1992
complex with isoval-Val-Val-Leu(P)-O(Phe)-OME	1.70 Å	1PPL	1PPL	1PPL	1PPL	1PPL	1PPL	Fraser et al., 1992
complex with CBZ-Ala-Ala-Leu(P)-(O)Phe-OME	1.70 Å	1PPM	1PPM	1PPM	1PPM	1PPM	1PPM	Fraser et al., 1992
complex with phosphonate inhibitor methyl[cyclo-7[(2R)-((N-valyl)amino)-2-(hydroxyl-(1S)-1-methyloxycarbonyl-2-phenylethoxy)phosphinyloxy-ethyl]-1-naphthaleneacetamide]	1.25 Å	2WEA	2WEA	2WEA	2WEA	2WEA	2WEA	Ding et al., 1998
complex with phosphonate inhibitor methyl (2S)-[1-((N-formyl)-l-valyl)amino-2-(2-naphthyl)ethyl)hydroxyphosphinyloxy]-3-phenyl propanoate	1.50 Å	2WEB	2WEB	2WEB	2WEB	2WEB	2WEB	Ding et al., 1998
complex with phosphonate inhibitor methyl (2S)-[1-((N-(naphthaleneacetyl))-L-valyl)aminomethyl)hydroxyphosphinyloxy]-3-phenyl propanoate	1.50 Å	2WEC	2WEC	2WEC	2WEC	2WEC	2WEC	Ding et al., 1998
complex with phosphonate macrocyclic inhibitor	1.50 Å	2WED	2WED	2WED	2WED	2WED	2WED	Ding et al., 1998
mature peptidase	1.80 Å	3APP	3APP	3APP	3APP	3APP	3APP	James & Sielecki, 1983