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Literature for peptidase A01.004: BACE1 g.p. (Homo sapiens)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, R Splicing, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Banoo,R., Nuthakki,V.K., Wadje,B.N., Sharma,A. and Bharate,S.B.
    Design, synthesis, and pharmacological evaluation of indole-piperidine amides as Blood-brain barrier permeable dual cholinesterase and beta-secretase inhibitors
    Eur J Med Chem266, 116131-116131. PubMed  Europe PubMed DOI  I
  2. Coimbra,J.R.M., Resende,R., Custodio,J.B.A., Salvador,J.A.R. and Santos,A.E.
    BACE1 Inhibitors for Alzheimer's Disease: Current Challenges and Future Perspectives
    J Alzheimers Dis101, S53-S78. PubMed  Europe PubMed DOI  V
  3. Gao,F., Zhang,M., Wang,Q., Ni,M., Liu,C., Deng,K., Xie,Q., Wang,S., Shi,J. and Shen,Y.
    Associations of CSF BACE1 with amyloid pathology, neurodegeneration, and cognition in Alzheimer's disease
    Acta Neuropathol147, 97-97. PubMed  Europe PubMed DOI
  4. Jia,T., Wang,H., Chi,W., Zhou,W., Guo,L., Dai,Y., Bian,K., Sun,Z., Ding,X. and Yu,Y.
    Knockdown of BACE1 by a multistage brain-targeting polyion complex improved memory and learning behaviors in APP/PS1 transgenic mouse model
    Int J Pharm650, 123727-123727. PubMed  Europe PubMed DOI
  5. Li,Y., Li,H., Liang,W., Li,Y. and Wang,Z.
    The Large Ectodomain of APP Prevents APP from being Directly Cleaved by gamma-Secretase
    Front Biosci (Landmark Ed)29, 78-78. PubMed  Europe PubMed DOI
  6. Nakamoto,K., Kikuhara,S., Fujimori,H., Saraswat,B., Gao,Z., Vadi Velu,A., Zhang,Z., Tong,Y., Imamichi,S., Nozaki,T., Murakami,Y. and Masutani,M.
    Effect of Functional Inhibition of BACE1 on Sensitization to gamma-Irradiation in Cancer Cells
    Curr Issues Mol Biol46, 450-460. PubMed  Europe PubMed DOI  K
  7. Quang De,T., Nguyen,C.Q., Le Dang,Q., Nguyen Thi,N.Y., Trong Tuan,N., Hoon Suh,D., Chu,J., Bepary,S., Lee,G.H., Kang,N.S., Cho,H., Park,W.K. and Lim,H.J.
    Rational design of novel diaryl ether-linked benzimidazole derivatives as potent and selective BACE1 inhibitors
    Biochem Biophys Res Commun698, 149538-149538. PubMed  Europe PubMed DOI  I
  8. Schmidt,A., Hrupka,B., van Bebber,F., Sunil Kumar,S., Feng,X., Tschirner,S.K., Assfalg,M., Muller,S.A., Hilger,L.S., Hofmann,L.I., Pigoni,M., Jocher,G., Voytyuk,I., Self,E.L., Ito,M., Hyakkoku,K., Yoshimura,A., Horiguchi,N., Feederle,R., De Strooper,B., Schulte-Merker,S., Lammert,E., Moechars,D., Schmid,B. and Lichtenthaler,S.F.
    The Alzheimer's disease-linked protease BACE2 cleaves VEGFR3 and modulates its signaling
    J Clin Invest134, e170550-e170550. PubMed  Europe PubMed DOI
  9. Tutus,B., Kaya,A.Z., Baz,Y., Evren,A.E., Saglik Ozkan,B.N. and Yurttas,L.
    Synthesis of new N-(5,6-methylenedioxybenzothiazole-2-yl)-2-[(substituted)thio/piperazine]acetamide/propanamide derivatives and evaluation of their AChE, BChE, and BACE-1 inhibitory activities
    Drug Dev Res85, e22214-e22214. PubMed  Europe PubMed DOI  I
  10. Wang,Y.R., Zeng,X.Q., Wang,J., Fowler,C.J., Li,Q.X., Bu,X.L., Doecke,J., Maruff,P., Martins,R.N., Rowe,C.C., Masters,C.L., Wang,Y.J. and Liu,Y.H.
    Autoantibodies to BACE1 promote Abeta accumulation and neurodegeneration in Alzheimer's disease
    Acta Neuropathol148, 57-57. PubMed  Europe PubMed DOI
  11. Wang,Z., Zhou,J., Zhang,B., Xu,Z., Wang,H., Sun,Q. and Wang,N.
    Inhibitory effects of beta-asarone on lncRNA BACE1-mediated induction of autophagy in a model of Alzheimer's disease
    Behav Brain Res463, 114896-114896. PubMed  Europe PubMed DOI
  12. Wei,X., Fan,J., Hao,Y., Dong,H., Zhang,Y., Zhou,Y. and Xu,M.
    Electrochemiluminescence and electrochemical dual-mode detection of BACE1 activity based on the assembly of peptide and luminol co-functionalized silver nanoparticles induced by cucurbit[8]uril
    Talanta266, 124904-124904. PubMed  Europe PubMed DOI
  13. Zimmer,V.C., Lauer,A.A., Haupenthal,V., Stahlmann,C.P., Mett,J., Grosgen,S., Hundsdorfer,B., Rothhaar,T., Endres,K., Eckhardt,M., Hartmann,T., Grimm,H.S. and Grimm,M.O.W.
    A bidirectional link between sulfatide and Alzheimer's disease
    Cell Chem Biol31, 265-283. PubMed  Europe PubMed DOI
    14. 2023
  14. Abraham,C.B., Xu,L., Pantelopulos,G.A. and Straub,J.E.
    Characterizing the transmembrane domains of ADAM10 and BACE1 and the impact of membrane composition
    Biophys J122, 3999-4010. PubMed  Europe PubMed DOI
  15. Bao,H. and Shen,Y.
    Unmasking BACE1 in aging and age-related diseases
    Trends Mol Med29, 99-111. PubMed  Europe PubMed DOI  V
  16. Benoit,M.R., Darboe,M., Das,B., Ge,Y., Zhou,J., Yao,A., He,W., Yan,R. and Hu,X.
    Postnatal neuronal Bace1 deletion impairs neuroblast and oligodendrocyte maturation
    Hum Mol Genet32, 1193-1207. PubMed  Europe PubMed DOI
  17. Bhatia,S., Singh,M., Sharma,P., Mujwar,S., Singh,V., Mishra,K.K., Singh,T.G., Singh,T. and Ahmad,S.F.
    Scaffold Morphing and In Silico Design of Potential BACE-1 (beta-Secretase) Inhibitors: A Hope for a Newer Dawn in Anti-Alzheimer Therapeutics
    Molecules28, PubMed  Europe PubMed DOI  I
  18. Drozdowska,D., Maliszewski,D., Wrobel,A., Ratkiewicz,A. and Sienkiewicz,M.
    New Benzamides as Multi-Targeted Compounds: A Study on Synthesis, AChE and BACE1 Inhibitory Activity and Molecular Docking
    Int J Mol Sci24, PubMed  Europe PubMed DOI  I
  19. Monteiro,K.L.C., Dos Santos Alcantara,M.G., Freire,N.M.L., Brandao,E.M., do Nascimento,V.L., Dos Santos Viana,L.M., de Aquino,T.M. and da Silva-Junior,E.F.
    BACE-1 Inhibitors Targeting Alzheimer's Disease
    Curr Alzheimer Res20, 131-148. PubMed  Europe PubMed DOI  V  I
  20. Munj,S.M. and Patil,P.B.
    Drug Discovery to Drug Development of BACE1 Inhibitor as Antialzheimer's: A Review
    Curr Top Med Chem23, 77-97. PubMed  Europe PubMed DOI  V
  21. Nangare,S. and Patil,P.
    Platinum-alginate-chitosan nanobioconjugate decorated carbon backbone layered biosensor for highly sensitive and selective detection of BACE-1
    Int J Biol Macromol250, 126224-126224. PubMed  Europe PubMed DOI
  22. Pratsch,K., Unemura,C., Ito,M., Lichtenthaler,S.F., Horiguchi,N. and Herms,J.
    New Highly Selective BACE1 Inhibitors and Their Effects on Dendritic Spine Density In Vivo
    Int J Mol Sci24, PubMed  Europe PubMed DOI  I
  23. Rather,H.A., Almousa,S., Kumar,A., Sharma,M., Pennington,I., Kim,S., Su,Y., He,Y., Ghara,A.R., Sai,K.K.S., Navone,N.M., Vander Griend,D.J. and Deep,G.
    The beta-Secretase 1 Enzyme as a Novel Therapeutic Target for Prostate Cancer
    Cancers (Basel)16, PubMed  Europe PubMed DOI
    24. 2022
  24. Bhakat,S. and Soderhjelm,P.
    Flap Dynamics in Pepsin-Like Aspartic Proteases: A Computational Perspective Using Plasmepsin-II and BACE-1 as Model Systems
    J Chem Inf Model62, 914-926. PubMed  Europe PubMed DOI
  25. Choi,J.Y., Park,J.H., Jo,C., Kim,K.C. and Koh,Y.H.
    SARS-CoV-2 spike S1 subunit protein-mediated increase of beta-secretase 1 (BACE1) impairs human brain vessel cells
    Biochem Biophys Res Commun626, 66-71. PubMed  Europe PubMed DOI
  26. Diaz,A., Martin-Jimenez,C., Woo,Y., Merino,P., Torre,E. and Yepes,M.
    Urokinase-Type Plasminogen Activator Triggers Wingless/Int1-Independent Phosphorylation of the Low-Density Lipoprotein Receptor-Related Protein-6 in Cerebral Cortical Neurons
    J Alzheimers Dis89, 877-891. PubMed  Europe PubMed DOI
  27. Ihara,M.
    Endothelial BACE1: Bridging the Gap Between Hypertension and Alzheimer's Disease
    Circ Res130, 1342-1344. PubMed  Europe PubMed DOI
  28. Sayad,A., Najafi,S., Hussen,B.M., Abdullah,S.T., Movahedpour,A., Taheri,M. and Hajiesmaeili,M.
    The Emerging Roles of the beta-Secretase BACE1 and the Long Non-coding RNA BACE1-AS in Human Diseases: A Focus on Neurodegenerative Diseases and Cancer
    Front Aging Neurosci14, 853180-853180. PubMed  Europe PubMed DOI
  29. Singh,N., Benoit,M.R., Zhou,J., Das,B., Davila-Velderrain,J., Kellis,M., Tsai,L.H., Hu,X. and Yan,R.
    BACE-1 inhibition facilitates the transition from homeostatic microglia to DAM-1
    Sci Adv8, eabo1286-eabo1286. PubMed  Europe PubMed DOI
  30. Taoka,B.M., Wu,W.L., Hao,J., Dolmaski,M., Wang,H., Levorse,D., Orth,P., Hyde,L.A., Smith,B., Michener,M.S., Kennedy,M.E., Parker,E.M. and Cumming,J.N.
    Design and discovery of C2-fluoroalkyl iminothiazine dioxides as BACE inhibitors
    Bioorg Med Chem Lett56, 128463-128463. PubMed  Europe PubMed DOI  I
  31. Taylor,H.A., Przemylska,L., Clavane,E.M. and Meakin,P.J.
    BACE1: More than just a beta-secretase
    Obes Reve13430-e13430. PubMed  Europe PubMed DOI  V
  32. Ugbaja,S.C., Lawal,I.A., Abubakar,B.H., Mushebenge,A.G., Lawal,M.M. and Kumalo,H.M.
    Allostery Inhibition of BACE1 by Psychotic and Meroterpenoid Drugs in Alzheimer's Disease Therapy
    Molecules27, PubMed  Europe PubMed DOI
  33. Yeap,Y.J., Kandiah,N., Nizetic,D. and Lim,K.L.
    BACE2: A Promising Neuroprotective Candidate for Alzheimer's Disease
    J Alzheimers Dis PubMed  Europe PubMed DOI  V
    34. 2021
  34. Armbrust,F., Bickenbach,K., Marengo,L., Pietrzik,C. and Becker-Pauly,C.
    The Swedish dilemma - the almost exclusive use of APPswe-based mouse models impedes adequate evaluation of alternative beta-secretases
    Biochim Biophys Acta Mol Cell Res119164-119164. PubMed  Europe PubMed DOI
  35. Bhakat,S.
    Pepsin-like aspartic proteases (PAPs) as model systems for combining biomolecular simulation with biophysical experiments
    RSC Adv11, 11026-11047. PubMed  Europe PubMed DOI
  36. Bouza,A.A., Edokobi,N., Hodges,S.L., Pinsky,A.M., Offord,J., Piao,L., Zhao,Y.T., Lopatin,A.N., Lopez-Santiago,L.F. and Isom,L.L.
    Sodium channel beta1 subunits participate in regulated intramembrane proteolysis-excitation coupling
    JCI Insight PubMed  Europe PubMed DOI
  37. Checler,F., Afram,E., Pardossi-Piquard,R. and Lauritzen,I.
    Is gamma-secretase a beneficial inactivating enzyme of the toxic APP C-terminal fragment C99?
    J Biol Chem100489-100489. PubMed  Europe PubMed DOI  V
  38. Fissel,J.A. and Farah,M.H.
    The influence of BACE1 on macrophage recruitment and activity in the injured peripheral nerve
    J Neuroinflammation18, 71-71. PubMed  Europe PubMed DOI  V
  39. Fujimoto,K., Yoshida,S., Tadano,G., Asada,N., Fuchino,K., Suzuki,S., Matsuoka,E., Yamamoto,T., Yamamoto,S., Ando,S., Kanegawa,N., Tonomura,Y., Ito,H., Moechars,D., Rombouts,F.J.R., Gijsen,H.J.M. and Kusakabe,K.I.
    Structure-Based Approaches to Improving Selectivity through Utilizing Explicit Water Molecules: Discovery of Selective beta-Secretase (BACE1) Inhibitors over BACE2
    J Med Chem64, 3075-3085. PubMed  Europe PubMed DOI  I
  40. Gaborit,B., Govers,R., Altie,A., Brunel,J.M., Morange,P. and Peiretti,F.
    The aminosterol Claramine inhibits beta-secretase 1-mediated insulin receptor cleavage
    J Biol Chem100818-100818. PubMed  Europe PubMed DOI
  41. Ma,F., Wang,Q., Xu,Q. and Zhang,C.Y.
    Self-Assembly of Superquenched Gold Nanoparticle Nanosensors for Lighting up BACE-1 in Live Cells
    Anal Chem93, 15124-15132. PubMed  Europe PubMed DOI
  42. McKinzie,D.L., Winneroski,L.L., Green,S.J., Hembre,E.J., Erickson,J.A., Willis,B.A., Monk,S.A., Aluise,C.D., Baker,T.K., Lopez,J.E., Hendle,J., Beck,J.P., Brier,R.A., Boggs,L.N., Borders,A.R., Cocke,P.J., Garcia-Losada,P., Lowe,S.L., Mathes,B.M., May,P.C., Porter,W.J., Stout,S.L., Timm,D.E., Watson,B.M., Yang,Z. and Mergott,D.J.
    Discovery and Early Clinical Development of LY3202626, a Low-Dose, CNS-Penetrant BACE Inhibitor
    J Med Chem64, 8076-8100. PubMed  Europe PubMed DOI  I
  43. Miranda,A., Montiel,E., Ulrich,H. and Paz,C.
    Selective Secretase Targeting for Alzheimer's Disease Therapy
    J Alzheimers Dis PubMed  Europe PubMed DOI  I
  44. Mycroft-West,C.J., Devlin,A.J., Cooper,L.C., Guimond,S.E., Procter,P., Guerrini,M., Miller,G.J., Fernig,D.G., Yates,E.A., Lima,M.A. and Skidmore,M.A.
    Glycosaminoglycans from Litopenaeus vannamei Inhibit the Alzheimer's Disease beta Secretase, BACE1
    Mar Drugs19, PubMed  Europe PubMed DOI  I
  45. Pont,C., Ginex,T., Grinan-Ferre,C., Scheiner,M., Mattellone,A., Martinez,N., Arce,E.M., Soriano-Fernandez,Y., Naldi,M., De Simone,A., Barenys,M., Gomez-Catalan,J., Perez,B., Sabate,R., Andrisano,V., Loza,M.I., Brea,J., Bartolini,M., Bolognesi,M.L., Decker,M., Pallas,M., Luque,F.J. and Munoz-Torrero,D.
    From virtual screening hits targeting a cryptic pocket in BACE-1 to a nontoxic brain permeable multitarget anti-Alzheimer lead with disease-modifying and cognition-enhancing effects
    Eur J Med Chem225, 113779-113779. PubMed  Europe PubMed DOI
  46. Ugbaja,S., Lawal,I., Kumalo,H. and Lawal,M.
    Alzheimer's Disease and beta-Secretase Inhibition: An Update With a Focus on Computer-Aided Inhibitor Design
    Curr Drug Targets PubMed  Europe PubMed DOI  V
  47. Vishal,P.K., Oh,J.M., Khames,A., Abdelgawad,M.A., Nair,A.S., Nath,L.R., Gambacorta,N., Ciriaco,F., Nicolotti,O., Kim,H. and Mathew,B.
    Trimethoxylated Halogenated Chalcones as Dual Inhibitors of MAO-B and BACE-1 for the Treatment of Neurodegenerative Disorders
    Pharmaceutics13, PubMed  Europe PubMed DOI  I
  48. Xia,Y., Wang,Z.H., Zhang,Z., Liu,X., Yu,S.P., Wang,J.Z., Wang,X.C. and Ye,K.
    Delta- and beta- secretases crosstalk amplifies the amyloidogenic pathway in Alzheimer's disease
    Prog Neurobiol102113-102113. PubMed  Europe PubMed DOI
    49. 2020

  49. Correction for Bao et al., BACE1 SUMOylation increases its stability and escalates the protease activity in Alzheimer's disease
    Proc Natl Acad Sci U S A117, 28528-28530. PubMed  Europe PubMed DOI
  50. Ali,S., Asad,M.H.H.B., Khan,F., Murtaza,G., Rizvanov,A.A., Iqbal,J., Babak,B. and Hussain,I.
    Biological evaluation of newly synthesized biaryl guanidine derivatives to arrest beta-secretase enzymatic activity involved in Alzheimer's disease
    Biomed Res Int2020, 8934289-8934289. PubMed  Europe PubMed DOI  I
  51. Arakawa,R., Takano,A., Stenkrona,P., Stepanov,V., Nag,S., Jahan,M., Gryback,P., Bolin,M., Chen,L., Zhang,L., He,P., Villalobos,A., McCarthy,T.J., Halldin,C. and Varrone,A.
    PET imaging of beta-secretase 1 in the human brain: radiation dosimetry, quantification, and test-retest examination of [(18)F]PF-06684511
    Eur J Nucl Med Mol Imaging47, 2429-2439. PubMed  Europe PubMed DOI  L
  52. Durrant,C.S., Ruscher,K., Sheppard,O., Coleman,M.P. and Ozen,I.
    Beta secretase 1-dependent amyloid precursor protein processing promotes excessive vascular sprouting through NOTCH3 signalling
    Cell Death Dis11, 98-98. PubMed  Europe PubMed DOI  I
  53. Escamilla-Ayala,A.A., Sannerud,R., Mondin,M., Poersch,K., Vermeire,W., Paparelli,L., Berlage,C., Koenig,M., Chavez-Gutierrez,L., Ulbrich,M.H., Munck,S., Mizuno,H. and Annaert,W.
    Super-resolution microscopy reveals majorly mono- and dimeric presenilin1/gamma-secretase at the cell surface
    elife9, PubMed  Europe PubMed DOI
  54. Hampel,H., Vassar,R., De Strooper,B., Hardy,J., Willem,M., Singh,N., Zhou,J., Yan,R., Vanmechelen,E., de Vos,A., Nistico,R., Corbo,M., Imbimbo,B.P., Streffer,J., Voytyuk,I., Timmers,M., Tahami Monfared,A.A., Irizarry,M., Albala,B., Koyama,A., Watanabe,N., Kimura,T., Yarenis,L., Lista,S., Kramer,L. and Vergallo,A.
    The beta-secretase BACE1 in Alzheimer's disease
    Biol Psychiatry PubMed  Europe PubMed DOI
  55. Jagtap,A.D., Kondekar,N.B., Hung,P.Y., Hsieh,C.E., Yang,C.R., Chen,G.S. and Chern,J.W.
    4-Substituted 2-amino-3,4-dihydroquinazolines with a 3-hairpin turn side chain as novel inhibitors of BACE-1
    Bioorg Chem95, 103135-103135. PubMed  Europe PubMed DOI  I
  56. Jain,P., Wadhwa,P.K. and Jadhav,H.R.
    Design, Synthesis and Evaluation of 2,4,6-substituted Pyrimidine Derivatives as BACE-1 inhibitor: Plausible lead for Alzheimer's Disease
    Med Chem PubMed  Europe PubMed DOI  I
  57. Jepsen,W.M., De Both,M., Siniard,A.L., Ramsey,K., Piras,I.S., Naymik,M., Henderson,A. and Huentelman,M.J.
    Adenosine triphosphate Binding Cassette subfamily C member 1 (ABCC1) overexpression reduces APP processing and increases alpha- versus beta-secretase activity, in vitro
    Biol Open PubMed  Europe PubMed DOI
  58. Kumar,V., Ojha,P.K., Saha,A. and Roy,K.
    Exploring 2D-QSAR for prediction of beta-secretase 1 (BACE1) inhibitory activity against Alzheimer's disease
    SAR QSAR Environ Res31, 87-133. PubMed  Europe PubMed DOI  I
  59. Mori,T., Koyama,N., Yokoo,T., Segawa,T., Maeda,M., Sawmiller,D., Tan,J. and Town,T.
    Gallic Acid is a Dual alpha/beta-Secretase Modulator that Reverses Cognitive Impairment and Remediates Pathology in Alzheimer Mice
    J Biol Chem PubMed  Europe PubMed DOI
  60. Mouchlis,V.D., Melagraki,G., Zacharia,L.C. and Afantitis,A.
    Computer-aided drug design of beta-secretase, gamma-secretase and anti-tau inhibitors for the discovery of novel Alzheimer's therapeutics
    Int J Mol Sci21, PubMed  Europe PubMed DOI  I
  61. Mycroft-West,C.J., Devlin,A.J., Cooper,L.C., Procter,P., Miller,G.J., Fernig,D.G., Guerrini,M., Guimond,S.E., Lima,M.A., Yates,E.A. and Skidmore,M.A.
    Inhibition of BACE1, the beta-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus
    Neural Regen Res15, 1546-1553. PubMed  Europe PubMed DOI  I
  62. Ovsepian,S.V., Horacek,J., O'Leary,V.B. and Hoschl,C.
    The Ups and Downs of BACE1: Walking a Fine Line between Neurocognitive and Other Psychiatric Symptoms of Alzheimer's Disease
    Neuroscientist1073858420940943-1073858420940943. PubMed  Europe PubMed DOI
  63. Perrin,F., Papadopoulos,N., Suelves,N., Opsomer,R., Vadukul,D.M., Vrancx,C., Smith,S.O., Vertommen,D., Kienlen-Campard,P. and Constantinescu,S.N.
    Dimeric Transmembrane Orientations of APP/C99 Regulate gamma-Secretase Processing Line Impacting Signaling and Oligomerization
    iScience23, 101887-101887. PubMed  Europe PubMed DOI
  64. Peschiulli,A., Oehlrich,D., Rombouts,F., Vos,A. and Gijsen,H.J.
    3,3-Difluoro-3,4,5,6-tetrahydropyridin-2-amines: potent and permeable BACE-1 inhibitors
    Bioorg Med Chem Lett126999-126999. PubMed  Europe PubMed DOI  I
  65. Promyo,K., Iqbal,F., Chaidee,N. and Chetsawang,B.
    Aluminum chloride-induced amyloid beta accumulation and endoplasmic reticulum stress in rat brain are averted by melatonin
    Food Chem Toxicol146, 111829-111829. PubMed  Europe PubMed DOI  I
  66. Rahman,S.O., Kaundal,M., Salman,M., Shrivastava,A., Parvez,S., Panda,B.P., Akhter,M., Akhtar,M. and Najmi,A.K.
    Alogliptin reversed hippocampal insulin resistance in an amyloid-beta fibrils induced animal model of Alzheimer's disease
    Eur J Pharmacol173522-173522. PubMed  Europe PubMed DOI  I
  67. Resuello,D.L., Lirio,S.B., Porto,A.E., Macabeo,A.P.G., Huang,H.Y., Corpuz,M.J.T. and Villaflores,O.B.
    beta-Secretase 1 inhibitory activity and AMP-activated protein kinase activation of Callyspongia samarensis extracts
    Nat Prod Res34, 525-529. PubMed  Europe PubMed DOI  I
  68. Rudan Njavro,J., Klotz,J., Dislich,B., Wanngren,J., Shmueli,M.D., Herber,J., Kuhn,P.H., Kumar,R., Koeglsperger,T., Conrad,M., Wurst,W., Feederle,R., Vlachos,A., Michalakis,S., Jedlicka,P., Muller,S.A. and Lichtenthaler,S.F.
    Mouse brain proteomics establishes MDGA1 and CACHD1 as in vivo substrates of the Alzheimer protease BACE1
    FASEB J34, 2465-2482. PubMed  Europe PubMed DOI  P
  69. Sekine,Y., Lindborg,J.A. and Strittmatter,S.M.
    A proteolytic C-terminal fragment of Nogo-A (reticulon-4A) is released in exosomes and potently inhibits axon regeneration
    J Biol Chem295, 2175-2183. PubMed  Europe PubMed DOI
  70. Shah,H., Patel,A., Parikh,V., Nagani,A., Bhimani,B., Shah,U. and Bambharoliya,T.
    The beta-secretase enzyme BACE1: a biochemical enigma for Alzheimer's disease
    CNS Neurol Disord Drug Targets19, 184-194. PubMed  Europe PubMed DOI
  71. Sho,M., Ichiyanagi,N., Imaizumi,K., Ishikawa,M., Morimoto,S., Watanabe,H. and Okano,H.
    A combinational treatment of carotenoids decreases Abeta secretion in human neurons via beta-secretase inhibition
    Neurosci Res158, 47-55. PubMed  Europe PubMed DOI  I
  72. Tam,J.M., Josephson,L., Pilozzi,A.R. and Huang,X.
    A novel dual fluorochrome near-infrared imaging probe for potential Alzheimer's enzyme biomarkers-BACE1 and cathepsin D
    Molecules25, PubMed  Europe PubMed DOI  L
  73. Wang,B. and Ng,H.L.
    Deep neural network affinity model for BACE inhibitors in D3R Grand Challenge 4
    J Comput Aided Mol Des34, 201-217. PubMed  Europe PubMed DOI  I
  74. Wang,Y., Yang,J.Q., Hong,T.T., Sun,Y.H., Huang,H.L., Chen,F., Chen,X.J., Chen,H.Y., Dong,S.S., Cui,L.L. and Yang,T.L.
    RTN4B-mediated suppression of Sirtuin 2 activity ameliorates beta-amyloid pathology and cognitive impairment in Alzheimer's disease mouse model
    Aging Celle13194-e13194. PubMed  Europe PubMed DOI
    75. 2019
  75. Aathi,M. and Piramanayagam,S.
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