Structure for peptidase homologue T01.986: proteasome subunit beta 1

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
20S proteasome	2.60 Å	4R3O	4R3O	4R3O	4R3O	4R3O	4R3O	Harshbarger et al., 2015
20S proteasome; complex with carfilzomib	2.89 Å	4R67	4R67	4R67	4R67	4R67	4R67	Harshbarger et al., 2015
cryo-em reveals the conformation of a substrate analogue in the human 20s proteasome core	3.50 Å	5A0Q	5A0Q	5A0Q	5A0Q	5A0Q	5A0Q
26S proteasome; complex with USP14-UbAl	4.35 Å	5GJQ	5GJQ	5GJQ	5GJQ	5GJQ	5GJQ
26S proteasome	3.50 Å	5GJR	5GJR	5GJR	5GJR	5GJR	5GJR
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133)	2.80 Å	5L5B	5L5B	5L5B	5L5B	5L5B	5L5B
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with onx 0914	2.80 Å	5L5D	5L5D	5L5D	5L5D	5L5D	5L5D
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with carfilzomib	2.90 Å	5L5E	5L5E	5L5E	5L5E	5L5E	5L5E
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with bortezomib	2.50 Å	5L5F	5L5F	5L5F	5L5F	5L5F	5L5F
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with pr-924	2.60 Å	5L5H	5L5H	5L5H	5L5H	5L5H	5L5H
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 9	2.90 Å	5L5I	5L5I	5L5I	5L5I	5L5I	5L5I
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 14	2.90 Å	5L5J	5L5J	5L5J	5L5J	5L5J	5L5J
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 16	2.60 Å	5L5O	5L5O	5L5O	5L5O	5L5O	5L5O
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 17	2.80 Å	5L5P	5L5P	5L5P	5L5P	5L5P	5L5P
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone 18	2.80 Å	5L5Q	5L5Q	5L5Q	5L5Q	5L5Q	5L5Q
yeast 20s proteasome with human beta5i (1-138;v31m) and human beta6 (97-111; 118-133)	2.90 Å	5L5R	5L5R	5L5R	5L5R	5L5R	5L5R
yeast 20s proteasome with human beta5i (1-138; v31m) and human beta6 (97-111; 118-133) in complex with pr-924	2.60 Å	5L5S	5L5S	5L5S	5L5S	5L5S	5L5S
yeast 20s proteasome with human beta5i (1-138; v31m) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 16	2.90 Å	5L5T	5L5T	5L5T	5L5T	5L5T	5L5T
yeast 20s proteasome with human beta5i (1-138; v31m) and human beta6 (97-111; 118-133) in complex with epoxyketone inhibitor 17 *caveat 5l5u 04c h 301 has wrong chirality at atom c27 04c k 301 has *caveat 2 5l5u wrong chirality at atom c27 04c v 301 h	2.60 Å	5L5U	5L5U	5L5U	5L5U	5L5U	5L5U
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133)	2.80 Å	5L5W	5L5W	5L5W	5L5W	5L5W	5L5W
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with onx 0914	2.90 Å	5L5X	5L5X	5L5X	5L5X	5L5X	5L5X
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with carfilzomib	2.70 Å	5L5Y	5L5Y	5L5Y	5L5Y	5L5Y	5L5Y
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with bortezomib	2.70 Å	5L5Z	5L5Z	5L5Z	5L5Z	5L5Z	5L5Z
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with pr-924	2.70 Å	5L60	5L60	5L60	5L60	5L60	5L60
yeast 20s proteasome with human beta5c (1-138) and human beta6 (99- 132) in complex with epoxyketone inhibitor 14	2.80 Å	5L61	5L61	5L61	5L61	5L61	5L61
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 16	2.80 Å	5L62	5L62	5L62	5L62	5L62	5L62
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 17 *caveat 5l63 04c h 301 has wrong chirality at atom c27 04c k 301 has *caveat 2 5l63 wrong chirality at atom c27 04c v 301 has wr	2.70 Å	5L63	5L63	5L63	5L63	5L63	5L63
yeast 20s proteasome with human beta5c (1-138) and human beta6 (97- 111; 118-133) in complex with epoxyketone inhibitor 18	2.70 Å	5L64	5L64	5L64	5L64	5L64	5L64
native human 20s proteasome at 1.8 angstrom ***caveat 5le5 6v1 u 47 has wrong chirality at atom c1	1.80 Å	5LE5	5LE5	5LE5	5LE5	5LE5	5LE5
native human 20s proteasome in mg-acetate at 2.2 angstrom ***caveat 5lex 6v1 u 47 has wrong chirality at atom c1	2.20 Å	5LEX	5LEX	5LEX	5LEX	5LEX	5LEX
20s proteasome; complex with oprozomib	1.90 Å	5LEY	5LEY	5LEY	5LEY	5LEY	5LEY
20s proteasome; complex with oprozomib in mg-acetate	2.19 Å	5LEZ	5LEZ	5LEZ	5LEZ	5LEZ	5LEZ
human 20s proteasome complex with epoxomicin at 2.4 angstrom *caveat 5lf0 6v1 u 47 has wrong chirality at atom c1 iml c 2 has wrong caveat 2 5lf0 chirality at atom cb iml d 2 has wrong chirality at atom ca **caveat 3 5lf0 iml d 2 has wrong chirality	2.41 Å	5LF0	5LF0	5LF0	5LF0	5LF0	5LF0
human 20s proteasome complex with dihydroeponemycin at 2.0 angstrom ***caveat 5lf1 6v1 u 47 has wrong chirality at atom c1	2.00 Å	5LF1	5LF1	5LF1	5LF1	5LF1	5LF1
human 20s proteasome complex with bortezomib at 2.1 angstrom ***caveat 5lf3 6v1 u 47 has wrong chirality at atom c1	2.10 Å	5LF3	5LF3	5LF3	5LF3	5LF3	5LF3
human 20s proteasome complex with delanzomib at 2.0 angstrom *caveat 5lf4 6v1 u 47 has wrong chirality at atom c1 6v7 n 307 has wrong caveat 2 5lf4 chirality at atom c9 6v7 y 306 has wrong chirality at atom **caveat 3 5lf4 c9	1.99 Å	5LF4	5LF4	5LF4	5LF4	5LF4	5LF4
human 20s proteasome complex with z-lly-ketoaldehyde at 2.1 angstrom ***caveat 5lf6 6v1 u 47 has wrong chirality at atom c1	2.07 Å	5LF6	5LF6	5LF6	5LF6	5LF6	5LF6
human 20s proteasome complex with ixazomib at 2.0 angstrom ***caveat 5lf7 6v1 u 47 has wrong chirality at atom c1	2.00 Å	5LF7	5LF7	5LF7	5LF7	5LF7	5LF7
the human 26s proteasome at 6.8 ang. *caveat 5ln3 pro h 311 has wrong chirality at atom ca thr n 752 has wrong *caveat 2 5ln3 chirality at atom ca	6.80 Å	5LN3	5LN3	5LN3	5LN3	5LN3	5LN3
yeast 20s proteasome with human beta5i (1-138) and human beta6 (97- 111; 118-133) in complex with thiazole based inhibitor ro19	2.70 Å	5M2B	5M2B	5M2B	5M2B	5M2B	5M2B
26s proteasome; complex with oprozomib	3.80 Å	5M32	5M32	5M32	5M32	5M32	5M32
structural basis for dynamic regulation of the human 26s proteasome ***caveat 5t0g entry contains improper peptide linkages.	4.40 Å	5T0G	5T0G	5T0G	5T0G	5T0G	5T0G
structural basis for dynamic regulation of the human 26s proteasome ***caveat 5t0h entry contains improper peptide linkages.	6.80 Å	5T0H	5T0H	5T0H	5T0H	5T0H	5T0H
structural basis for dynamic regulation of the human 26s proteasome *caveat 5t0i entry contains improper peptide linkages. residue arg k 20 *caveat 2 5t0i is incorrectly modeled.	8.00 Å	5T0I	5T0I	5T0I	5T0I	5T0I	5T0I
structural basis for dynamic regulation of the human 26s proteasome ***caveat 5t0j entry contains improper peptide linkages.	8.00 Å	5T0J	5T0J	5T0J	5T0J	5T0J	5T0J
nucleotide-driven triple-state remodeling of the aaa-atpase channel inthe activated human 26s proteasome	3.50 Å	5VFO	5VFO	5VFO	5VFO	5VFO	5VFO
nucleotide-driven triple-state remodeling of the aaa-atpase channel inthe activated human 26s proteasome	4.90 Å	5VFR	5VFR	5VFR	5VFR	5VFR	5VFR
nucleotide-driven triple-state remodeling of the aaa-atpase channel inthe activated human 26s proteasome	7.00 Å	5VFT	5VFT	5VFT	5VFT	5VFT	5VFT
cryo-em structure of human immunoproteasome with a novel noncompetitive inhibitor that selectively inhibits activated lymphocytes	3.80 Å	6AVO	6AVO	6AVO	6AVO	6AVO	6AVO
endogeneous native human 20s proteasome	3.50 Å	6R70	6R70	6R70	6R70	6R70	6R70
Rattus norvegicus
ground state 26s proteasome (gs2)	12.30 Å	6EPC	6EPC	6EPC	6EPC	6EPC	6EPC
substrate processing state 26s proteasome (sps1) ***caveat 6epd pro 2 231 has wrong chirality at atom ca	15.40 Å	6EPD	6EPD	6EPD	6EPD	6EPD	6EPD
substrate processing state 26s proteasome (sps2)	12.80 Å	6EPE	6EPE	6EPE	6EPE	6EPE	6EPE
ground state 26s proteasome (gs1)	11.80 Å	6EPF	6EPF	6EPF	6EPF	6EPF	6EPF