Structure for peptidase S60.001: lactoferrin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1LCT	Homo sapiens	2.00 Å	N-terminal half molecule
The N-terminal domain is shown. Catalytic residues are shown in ball-and-stick representation: Ser279 in orange and Lys93 in purple. The structural ferric ion is shown as a red CPK sphere.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bos taurus
mature peptidase	2.80 Å	1BLF	1BLF	1BLF	1BLF	1BLF	1BLF	Moore et al., 1997
Bubalus bubalis
mature peptidase	2.50 Å	1CE2	1CE2	1CE2	1CE2	1CE2	1CE2	Karthikeyan et al., 1999
Camelus dromedarius
mature peptidase	2.65 Å	1DTZ	1DTZ	1DTZ	1DTZ	1DTZ	1DTZ	Khan et al., 2001
mature peptidase	2.70 Å	1I6Q	1I6Q	1I6Q	1I6Q	1I6Q	1I6Q	Khan et al., 2001
complex with Escherichia coli OmpC	2.99 Å	2J4U	2J4U	2J4U	2J4U	2J4U	2J4U
Capra hircus
mature peptidase	4.00 Å	1JW1	1JW1	1JW1	1JW1	1JW1	1JW1
mature peptidase	4.00 Å	1JW1	1JW1	1JW1	1JW1	1JW1	1JW1
Equus caballus
structure of diferric mare lactoferrin at 2.62a resolution	2.62 Å	1B1X	1B1X	1B1X	1B1X	1B1X	1B1X	Sharma et al., 1999
structure of mare apolactoferrin: the n and c lobes are in the closed form	3.80 Å	1B7U	1B7U	1B7U	1B7U	1B7U	1B7U	Sharma et al., 1999
structure of oxalate substituted diferric mare lactoferrin from colostrum	2.70 Å	1B7Z	1B7Z	1B7Z	1B7Z	1B7Z	1B7Z	Sharma & Singh, 1999
melanin protein interaction: x-ray structure of the complex of mare lactoferrin with melanin monomers	2.70 Å	1F9B	1F9B	1F9B	1F9B	1F9B	1F9B	Sharma et al., 2001
apolactoferrin	3.20 Å	1I6B	1I6B	1I6B	1I6B	1I6B	1I6B	Kumar et al., 2002
complex with a lanthanide ion (Sm3+)	3.40 Å	1QJM	1QJM	1QJM	1QJM	1QJM	1QJM	Sharma & Singh, 1999
complex with 6- (hydroxymethyl)oxane-2,3,4,5-tetrol	3.49 Å	3CR9	3CR9	3CR9	3CR9	3CR9	3CR9
Homo sapiens
diferric form	2.20 Å	1B0L	1B0L	1B0L	1B0L	1B0L	1B0L	Sun et al., 1999
oxalate substituted diferric form	2.40 Å	1BKA	1BKA	1BKA	1BKA	1BKA	1BKA	Baker et al., 1996
apo form	2.00 Å	1CB6	1CB6	1CB6	1CB6	1CB6	1CB6	Jameson et al., 1998
N-terminal half molecule; Asp60Ser mutant	2.05 Å	1DSN	1DSN	1DSN	1DSN	1DSN	1DSN	Faber et al., 1996
Arg210Lys mutant; N-terminal lobe	2.00 Å	1EH3	1EH3	1EH3	1EH3	1EH3	1EH3	Peterson et al., 2000
diceric form	2.20 Å	1FCK	1FCK	1FCK	1FCK	1FCK	1FCK	Baker et al., 2000
Arg210Glu mutant; N-terminal lobe	2.20 Å	1H43	1H43	1H43	1H43	1H43	1H43	Peterson et al., 2002
Arg210Ile mutant; N-terminal lobe	2.00 Å	1H44	1H44	1H44	1H44	1H44	1H44	Peterson et al., 2002
Arg210Gly mutant; N-terminal lobe	1.95 Å	1H45	1H45	1H45	1H45	1H45	1H45	Peterson et al., 2002
N-terminal half molecule; His253Met mutant	2.20 Å	1HSE	1HSE	1HSE	1HSE	1HSE	1HSE	Nicholson et al., 1997
domain-opened mutant (Arg121Asp); N-terminal lobe	3.00 Å	1L5T	1L5T	1L5T	1L5T	1L5T	1L5T	Jameson et al., 2002
copper form	2.00 Å	1LCF	1LCF	1LCF	1LCF	1LCF	1LCF	Smith et al., 1994
N-terminal half molecule	2.00 Å	1LCT	1LCT	1LCT	1LCT	1LCT	1LCT	Day et al., 1993
diferric form	2.20 Å	1LFG	1LFG	1LFG	1LFG	1LFG	1LFG	Norris et al., 1991
apo form	2.80 Å	1LFH	1LFH	1LFH	1LFH	1LFH	1LFH	Norris et al., 1991
copper form	2.10 Å	1LFI	1LFI	1LFI	1LFI	1LFI	1LFI	Smith et al., 1992
N2 fragment; complex with legume isolectin II	3.30 Å	1LGB	1LGB	1LGB	1LGB	1LGB	1LGB	Bourne et al., 1994
mature peptidase	3.40 Å	1N76	1N76	1N76	1N76	1N76	1N76
N-terminal half molecule; Arg121Glu mutant	2.30 Å	1VFD	1VFD	1VFD	1VFD	1VFD	1VFD	Faber et al., 1996
N-terminal half molecule; Arg121Ser mutant	2.30 Å	1VFE	1VFE	1VFE	1VFE	1VFE	1VFE	Faber et al., 1996
recombinant form	2.40 Å	2BJJ	2BJJ	2BJJ	2BJJ	2BJJ	2BJJ	Thomassen et al., 2005