Substrates for peptidase S60.001: lactoferrin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Hap serine peptidase	P45387	26-1394	peptide-Arg1019+Arg-peptide	P	Val	Arg	Ser	Arg	Arg	Ala	Ala	Arg	Hendrixson et al., 2003	17794
Hap serine peptidase	P45387	26-1394	peptide-Arg1020+Ala-peptide	P	Arg	Ser	Arg	Arg	Ala	Ala	Arg	Ala	Hendrixson et al., 2003	17795
IgA1 protease	P44969	26-1694	peptide-Arg1382+Arg-peptide	P	Arg	Arg	Ser	Arg	Arg	Ser	Val	Arg	Hendrixson et al., 2003	17796
IgA1 protease	P44969	26-1694	peptide-Arg1383+Ser-peptide	P	Arg	Ser	Arg	Arg	Ser	Val	Arg	Ser	Hendrixson et al., 2003	17797
lactoferrin	P24627	20-708	peptide-Arg415+Lys-peptide	P	Ala	Glu	Asn	Arg	Lys	Ser	Ser	Lys	Massucci et al., 2004	17798
lactoferrin	P24627	20-708	peptide-Lys440+Lys-peptide	P	Ala	Val	Val	Lys	Lys	Ala	Asn	Glu	Massucci et al., 2004	17799
Z-Phe-Arg-NHMec			Z-Phe-Arg+NHMec	S	-	Z	Phe	Arg	AMC	-	-	-	Massucci et al., 2004