Structure for peptidase homologue S09.979: acetylcholinesterase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Pharma

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bungarus fasciatus
mature peptidase	2.70 Å	4QWW	4QWW	4QWW	4QWW	4QWW	4QWW	Bourne et al., 2015
Homo sapiens
complex with green mamba venom peptide fasciculin-II	2.76 Å	1B41	1B41	1B41	1B41	1B41	1B41	Kryger et al., 2000
Glu202Gln mutant; complex with green mamba venom peptide fasciculin-II	2.90 Å	1F8U	1F8U	1F8U	1F8U	1F8U	1F8U
theoretical model	0.00 Å	2CLJ	2CLJ	2CLJ	2CLJ	2CLJ	2CLJ
inhibited by aged tabun and complex with fasciculin-ii	2.95 Å	2X8B	2X8B	2X8B	2X8B	2X8B	2X8B
recombinant human acetylcholinesterase	3.20 Å	3LII	3LII	3LII	3LII	3LII	3LII
complex with huprine w and fasciculin 2	3.10 Å	4BDT	4BDT	4BDT	4BDT	4BDT	4BDT
crystal structure of recombinant human acetylcholinesterase in the apostate	2.16 Å	4EY4	4EY4	4EY4	4EY4	4EY4	4EY4
complex with (-)-huperzine a	2.30 Å	4EY5	4EY5	4EY5	4EY5	4EY5	4EY5
complex with (-)-galantamine	2.40 Å	4EY6	4EY6	4EY6	4EY6	4EY6	4EY6
complex with donepezil	2.35 Å	4EY7	4EY7	4EY7	4EY7	4EY7	4EY7
complex with fasciculin-2	2.60 Å	4EY8	4EY8	4EY8	4EY8	4EY8	4EY8
complex with dihydrotanshinone i	2.00 Å	4M0E	4M0E	4M0E	4M0E	4M0E	4M0E
complex with territrem b	2.30 Å	4M0F	4M0F	4M0F	4M0F	4M0F	4M0F
mature peptidase	2.90 Å	4PQE	4PQE	4PQE	4PQE	4PQE	4PQE
structure of homo sapiens acetylcholinesterase phosphonylated by sarin.	2.40 Å	5FPQ	5FPQ	5FPQ	5FPQ	5FPQ	5FPQ
complex with paraoxon in the unaged state (predominant acyl loop conformation)	2.15 Å	5HF5	5HF5	5HF5	5HF5	5HF5	5HF5
complex with paraoxon in the aged state	2.30 Å	5HF6	5HF6	5HF6	5HF6	5HF6	5HF6
complex with paraoxon (alternative acyl loop conformation)	2.80 Å	5HF8	5HF8	5HF8	5HF8	5HF8	5HF8
complex with paraoxon and hi6	2.20 Å	5HF9	5HF9	5HF9	5HF9	5HF9	5HF9
complex with paraoxon and 2-pam	2.20 Å	5HFA	5HFA	5HFA	5HFA	5HFA	5HFA
stable, high-expression variant of human acetylcholinesterase	2.60 Å	5HQ3	5HQ3	5HQ3	5HQ3	5HQ3	5HQ3
crystal structure of recombinant human acetylcholinesterase inhibited by (-) stereoisomer of vx	2.27 Å	6CQT	6CQT	6CQT	6CQT	6CQT	6CQT
crystal structure of recombinant human acetylcholinesterase with reactivator hi-6 ***caveat 6cqu nag a 603 has wrong chirality at atom c1	2.31 Å	6CQU	6CQU	6CQU	6CQU	6CQU	6CQU
complex with vx(+) and hi-6	2.60 Å	6CQV	6CQV	6CQV	6CQV	6CQV	6CQV
complex with vx(-) and hi-6	2.28 Å	6CQW	6CQW	6CQW	6CQW	6CQW	6CQW
crystal structure of recombinant human acetylcholinesterase inhibited by vx(+)	2.40 Å	6CQX	6CQX	6CQX	6CQX	6CQX	6CQX
complex with empa and hi-6	2.45 Å	6CQY	6CQY	6CQY	6CQY	6CQY	6CQY
crystal structure of recombinant human acetylcholinesterase inhibited by vx	2.22 Å	6CQZ	6CQZ	6CQZ	6CQZ	6CQZ	6CQZ
complex with c35.	3.05 Å	6F25	6F25	6F25	6F25	6F25	6F25
complex with reactivator, hlo7	2.42 Å	6NEA	6NEA	6NEA	6NEA	6NEA	6NEA
binary complex of native hache with donepezil	2.35 Å	6O4W	6O4W	6O4W	6O4W	6O4W	6O4W
binary complex of native hache with 9-aminoacridine	2.30 Å	6O4X	6O4X	6O4X	6O4X	6O4X	6O4X
binary complex of native hache with bw284c51	2.35 Å	6O50	6O50	6O50	6O50	6O50	6O50
room temperature structure of binary complex of native hache with bw284c51	3.20 Å	6O52	6O52	6O52	6O52	6O52	6O52
room temperature structure of binary complex of native hache with oxime reactivator rs-170b	2.80 Å	6O5R	6O5R	6O5R	6O5R	6O5R	6O5R
room temperature structure of vx-phosphonylated hache in complex with oxime reactivator rs-170b	2.80 Å	6O5S	6O5S	6O5S	6O5S	6O5S	6O5S
binary complex of native hache with oxime reactivator rs-170b	2.15 Å	6O5V	6O5V	6O5V	6O5V	6O5V	6O5V
complex with oxime reactivatorrs-170b	2.45 Å	6O66	6O66	6O66	6O66	6O66	6O66
crystal structure of double mutant l380r/f535k of human acetylcholinesterase	2.08 Å	6O69	6O69	6O69	6O69	6O69	6O69
Mus musculus
mature peptidase	4.50 Å	1C2B	1C2B	1C2B	1C2B	1C2B	1C2B	Bourne et al., 1999
mature peptidase	4.20 Å	1C2O	1C2O	1C2O	1C2O	1C2O	1C2O	Bourne et al., 1999
mature peptidase	2.35 Å	1J06	1J06	1J06	1J06	1J06	1J06	Bourne et al., 2003
mature peptidase	2.35 Å	1J07	1J07	1J07	1J07	1J07	1J07	Bourne et al., 2003
mature peptidase	2.50 Å	1KU6	1KU6	1KU6	1KU6	1KU6	1KU6	Bourne et al., 2003
mature peptidase	2.90 Å	1MAA	1MAA	1MAA	1MAA	1MAA	1MAA	Bourne et al., 1999
mature peptidase	3.20 Å	1MAH	1MAH	1MAH	1MAH	1MAH	1MAH	Bourne et al., 1995
mature peptidase	2.20 Å	1N5M	1N5M	1N5M	1N5M	1N5M	1N5M	Bourne et al., 2003
mature peptidase	2.25 Å	1N5R	1N5R	1N5R	1N5R	1N5R	1N5R	Bourne et al., 2003
mature peptidase	2.65 Å	1Q83	1Q83	1Q83	1Q83	1Q83	1Q83	Bourne et al., 2004
mature peptidase	2.45 Å	1Q84	1Q84	1Q84	1Q84	1Q84	1Q84	Bourne et al., 2004
mature peptidase	2.50 Å	2C0P	2C0P	2C0P	2C0P	2C0P	2C0P	Ekstrom et al., 2006
mature peptidase	2.50 Å	2C0Q	2C0Q	2C0Q	2C0Q	2C0Q	2C0Q	Ekstrom et al., 2006
mature peptidase	2.20 Å	2GYU	2GYU	2GYU	2GYU	2GYU	2GYU	Ekstrom et al., 2006
mature peptidase	2.50 Å	2GYV	2GYV	2GYV	2GYV	2GYV	2GYV	Ekstrom et al., 2006
mature peptidase	2.40 Å	2GYW	2GYW	2GYW	2GYW	2GYW	2GYW	Ekstrom et al., 2006
mature peptidase	2.40 Å	2H9Y	2H9Y	2H9Y	2H9Y	2H9Y	2H9Y	Bourne et al., 2006
mature peptidase	2.20 Å	2HA0	2HA0	2HA0	2HA0	2HA0	2HA0	Bourne et al., 2006
mature peptidase	2.05 Å	2HA2	2HA2	2HA2	2HA2	2HA2	2HA2	Bourne et al., 2006
mature peptidase	2.25 Å	2HA3	2HA3	2HA3	2HA3	2HA3	2HA3	Bourne et al., 2006
mature peptidase	2.56 Å	2HA4	2HA4	2HA4	2HA4	2HA4	2HA4	Bourne et al., 2006
mature peptidase	2.15 Å	2HA5	2HA5	2HA5	2HA5	2HA5	2HA5	Bourne et al., 2006
mature peptidase	2.25 Å	2HA6	2HA6	2HA6	2HA6	2HA6	2HA6	Bourne et al., 2006
mature peptidase	2.66 Å	2HA7	2HA7	2HA7	2HA7	2HA7	2HA7	Bourne et al., 2006
mature peptidase	2.70 Å	2JEY	2JEY	2JEY	2JEY	2JEY	2JEY	Ekstrom et al., 2007
mature peptidase	2.60 Å	2JEZ	2JEZ	2JEZ	2JEZ	2JEZ	2JEZ	Ekstrom et al., 2007
mature peptidase	2.50 Å	2JF0	2JF0	2JF0	2JF0	2JF0	2JF0	Ekstrom et al., 2007
mature peptidase	2.60 Å	2JGE	2JGE	2JGE	2JGE	2JGE	2JGE	Hornberg et al., 2007
mature peptidase	2.50 Å	2JGF	2JGF	2JGF	2JGF	2JGF	2JGF	Hornberg et al., 2007
mature peptidase	2.90 Å	2JGI	2JGI	2JGI	2JGI	2JGI	2JGI	Hornberg et al., 2007
mature peptidase	2.50 Å	2JGJ	2JGJ	2JGJ	2JGJ	2JGJ	2JGJ	Hornberg et al., 2007
mature peptidase	2.90 Å	2JGK	2JGK	2JGK	2JGK	2JGK	2JGK	Hornberg et al., 2007
mature peptidase	2.60 Å	2JGL	2JGL	2JGL	2JGL	2JGL	2JGL	Hornberg et al., 2007
mature peptidase	2.90 Å	2JGM	2JGM	2JGM	2JGM	2JGM	2JGM	Hornberg et al., 2007
mature peptidase	2.20 Å	2WHP	2WHP	2WHP	2WHP	2WHP	2WHP	Ekstrom et al., 2009
mature peptidase	2.15 Å	2WHQ	2WHQ	2WHQ	2WHQ	2WHQ	2WHQ	Ekstrom et al., 2009
mature peptidase	2.54 Å	2WHR	2WHR	2WHR	2WHR	2WHR	2WHR	Ekstrom et al., 2009
mature peptidase	2.60 Å	2WLS	2WLS	2WLS	2WLS	2WLS	2WLS	Pang et al., 2009
mature peptidase	2.70 Å	2WU3	2WU3	2WU3	2WU3	2WU3	2WU3	Hornberg et al., 2010
mature peptidase	2.40 Å	2WU4	2WU4	2WU4	2WU4	2WU4	2WU4	Hornberg et al., 2010
mature peptidase	2.65 Å	2XUD	2XUD	2XUD	2XUD	2XUD	2XUD	Bourne et al., 2010
mature peptidase	2.55 Å	2XUF	2XUF	2XUF	2XUF	2XUF	2XUF	Bourne et al., 2010
mature peptidase	2.60 Å	2XUG	2XUG	2XUG	2XUG	2XUG	2XUG	Bourne et al., 2010
mature peptidase	2.65 Å	2XUH	2XUH	2XUH	2XUH	2XUH	2XUH	Bourne et al., 2010
mature peptidase	2.60 Å	2XUI	2XUI	2XUI	2XUI	2XUI	2XUI	Bourne et al., 2010
mature peptidase	2.65 Å	2XUJ	2XUJ	2XUJ	2XUJ	2XUJ	2XUJ	Bourne et al., 2010
mature peptidase	2.75 Å	2XUK	2XUK	2XUK	2XUK	2XUK	2XUK	Bourne et al., 2010
mature peptidase	2.80 Å	2XUO	2XUO	2XUO	2XUO	2XUO	2XUO	Bourne et al., 2010
mature peptidase	2.70 Å	2XUP	2XUP	2XUP	2XUP	2XUP	2XUP	Bourne et al., 2010
mature peptidase	2.70 Å	2XUQ	2XUQ	2XUQ	2XUQ	2XUQ	2XUQ	Bourne et al., 2010
mature peptidase	2.60 Å	2Y2U	2Y2U	2Y2U	2Y2U	2Y2U	2Y2U
mature peptidase	2.45 Å	2Y2V	2Y2V	2Y2V	2Y2V	2Y2V	2Y2V
mature peptidase	2.50 Å	3DL4	3DL4	3DL4	3DL4	3DL4	3DL4	Carletti et al., 2008
mature peptidase	2.50 Å	3DL7	3DL7	3DL7	3DL7	3DL7	3DL7	Carletti et al., 2008
mature peptidase	2.60 Å	3ZLT	3ZLT	3ZLT	3ZLT	3ZLT	3ZLT	Artursson et al., 2013
mature peptidase	2.60 Å	3ZLU	3ZLU	3ZLU	3ZLU	3ZLU	3ZLU	Artursson et al., 2013
mature peptidase	2.50 Å	3ZLV	3ZLV	3ZLV	3ZLV	3ZLV	3ZLV	Artursson et al., 2013
mature peptidase	2.65 Å	4A16	4A16	4A16	4A16	4A16	4A16	Ronco et al., 2012
mature peptidase	2.40 Å	4A23	4A23	4A23	4A23	4A23	4A23	Berg et al., 2011
mature peptidase	2.50 Å	4ARA	4ARA	4ARA	4ARA	4ARA	4ARA	Berg et al., 2012
mature peptidase	2.25 Å	4ARB	4ARB	4ARB	4ARB	4ARB	4ARB	Berg et al., 2012
mature peptidase	2.30 Å	4B7Z	4B7Z	4B7Z	4B7Z	4B7Z	4B7Z	Andersson et al., 2013
mature peptidase	2.50 Å	4B80	4B80	4B80	4B80	4B80	4B80	Andersson et al., 2013
mature peptidase	2.80 Å	4B81	4B81	4B81	4B81	4B81	4B81	Andersson et al., 2013
mature peptidase	2.10 Å	4B82	4B82	4B82	4B82	4B82	4B82	Andersson et al., 2013
mature peptidase	2.40 Å	4B83	4B83	4B83	4B83	4B83	4B83	Andersson et al., 2013
mature peptidase	2.60 Å	4B84	4B84	4B84	4B84	4B84	4B84	Andersson et al., 2013
mature peptidase	2.10 Å	4B85	4B85	4B85	4B85	4B85	4B85	Andersson et al., 2013
mature peptidase	3.35 Å	4BC0	4BC0	4BC0	4BC0	4BC0	4BC0	Carletti et al., 2013
mature peptidase	2.95 Å	4BC1	4BC1	4BC1	4BC1	4BC1	4BC1	Carletti et al., 2013
mature peptidase	2.50 Å	4BTL	4BTL	4BTL	4BTL	4BTL	4BTL	Andersson et al., 2013
mature peptidase	2.40 Å	5DTG	5DTG	5DTG	5DTG	5DTG	5DTG	Katz et al., 2015
mature peptidase	2.00 Å	5DTI	5DTI	5DTI	5DTI	5DTI	5DTI	Katz et al., 2015
mature peptidase	2.71 Å	5DTJ	5DTJ	5DTJ	5DTJ	5DTJ	5DTJ	Katz et al., 2015
mache-syn tz2pa5 complex	2.60 Å	5EHN	5EHN	5EHN	5EHN	5EHN	5EHN
mache-anti tz2pa5 complex	2.50 Å	5EHQ	5EHQ	5EHQ	5EHQ	5EHQ	5EHQ
mache-syn tz2pa5 complex from an equimolar mixture of the syn/anti isomers	2.50 Å	5EHZ	5EHZ	5EHZ	5EHZ	5EHZ	5EHZ
mache-anti tz2pa5 complex from a 1:6 mixture of the syn/anti isomers	2.70 Å	5EIA	5EIA	5EIA	5EIA	5EIA	5EIA
mache-tz2 complex	2.10 Å	5EIE	5EIE	5EIE	5EIE	5EIE	5EIE
mache-tz2/pa5 complex	2.70 Å	5EIH	5EIH	5EIH	5EIH	5EIH	5EIH
complex with c-547,an alkyl ammonium derivative of 6-methyl uracil	3.13 Å	5FKJ	5FKJ	5FKJ	5FKJ	5FKJ	5FKJ
structure of a pre-reaction ternary complex between sarin- acetylcholinesterase and hi-6	2.40 Å	5FPP	5FPP	5FPP	5FPP	5FPP	5FPP
mus musculus acetylcholinesterase in complex with al200	2.50 Å	5FUM	5FUM	5FUM	5FUM	5FUM	5FUM
inhibited by DFP	2.42 Å	5HCU	5HCU	5HCU	5HCU	5HCU	5HCU
complex with crystal violet	2.40 Å	5OV9	5OV9	5OV9	5OV9	5OV9	5OV9
mus musculus acetylcholinesterase in complex with 2-(4-biphenylyloxy)-n-[3-(1-piperidinyl)propyl]-acetamide hydrochloride (10)	2.70 Å	6FSD	6FSD	6FSD	6FSD	6FSD	6FSD