Structure for peptidase homologue S09.979: acetylcholinesterase

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Inhibitors Pharma

TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Bungarus fasciatus
mature peptidase	2.70 Å	4QWW	4QWW	4QWW	4QWW	4QWW	4QWW	Bourne et al., 2015
Homo sapiens
complex with green mamba venom peptide fasciculin-II	2.76 Å	1B41	1B41	1B41	1B41	1B41	1B41	Kryger et al., 2000
Glu202Gln mutant; complex with green mamba venom peptide fasciculin-II	2.90 Å	1F8U	1F8U	1F8U	1F8U	1F8U	1F8U
theoretical model	0.00 Å	2CLJ	2CLJ	2CLJ	2CLJ	2CLJ	2CLJ
inhibited by aged tabun and complex with fasciculin-ii	2.95 Å	2X8B	2X8B	2X8B	2X8B	2X8B	2X8B
recombinant human acetylcholinesterase	3.20 Å	3LII	3LII	3LII	3LII	3LII	3LII
complex with huprine w and fasciculin 2	3.10 Å	4BDT	4BDT	4BDT	4BDT	4BDT	4BDT
crystal structure of recombinant human acetylcholinesterase in the apostate	2.16 Å	4EY4	4EY4	4EY4	4EY4	4EY4	4EY4
complex with (-)-huperzine a	2.30 Å	4EY5	4EY5	4EY5	4EY5	4EY5	4EY5
complex with (-)-galantamine	2.40 Å	4EY6	4EY6	4EY6	4EY6	4EY6	4EY6
complex with donepezil	2.35 Å	4EY7	4EY7	4EY7	4EY7	4EY7	4EY7
complex with fasciculin-2	2.60 Å	4EY8	4EY8	4EY8	4EY8	4EY8	4EY8
complex with dihydrotanshinone i	2.00 Å	4M0E	4M0E	4M0E	4M0E	4M0E	4M0E
complex with territrem b	2.30 Å	4M0F	4M0F	4M0F	4M0F	4M0F	4M0F
mature peptidase	2.90 Å	4PQE	4PQE	4PQE	4PQE	4PQE	4PQE
structure of homo sapiens acetylcholinesterase phosphonylated by sarin.	2.40 Å	5FPQ	5FPQ	5FPQ	5FPQ	5FPQ	5FPQ
complex with paraoxon in the unaged state (predominant acyl loop conformation)	2.15 Å	5HF5	5HF5	5HF5	5HF5	5HF5	5HF5
complex with paraoxon in the aged state	2.30 Å	5HF6	5HF6	5HF6	5HF6	5HF6	5HF6
complex with paraoxon (alternative acyl loop conformation)	2.80 Å	5HF8	5HF8	5HF8	5HF8	5HF8	5HF8
complex with paraoxon and hi6	2.20 Å	5HF9	5HF9	5HF9	5HF9	5HF9	5HF9
complex with paraoxon and 2-pam	2.20 Å	5HFA	5HFA	5HFA	5HFA	5HFA	5HFA
stable, high-expression variant of human acetylcholinesterase	2.60 Å	5HQ3	5HQ3	5HQ3	5HQ3	5HQ3	5HQ3
crystal structure of recombinant human acetylcholinesterase inhibited by (-) stereoisomer of vx	2.27 Å	6CQT	6CQT	6CQT	6CQT	6CQT	6CQT
crystal structure of recombinant human acetylcholinesterase with reactivator hi-6 ***caveat 6cqu nag a 603 has wrong chirality at atom c1	2.31 Å	6CQU	6CQU	6CQU	6CQU	6CQU	6CQU
complex with vx(+) and hi-6	2.60 Å	6CQV	6CQV	6CQV	6CQV	6CQV	6CQV
complex with vx(-) and hi-6	2.28 Å	6CQW	6CQW	6CQW	6CQW	6CQW	6CQW
crystal structure of recombinant human acetylcholinesterase inhibited by vx(+)	2.40 Å	6CQX	6CQX	6CQX	6CQX	6CQX	6CQX
complex with empa and hi-6	2.45 Å	6CQY	6CQY	6CQY	6CQY	6CQY	6CQY
crystal structure of recombinant human acetylcholinesterase inhibited by vx	2.22 Å	6CQZ	6CQZ	6CQZ	6CQZ	6CQZ	6CQZ
complex with c35.	3.05 Å	6F25	6F25	6F25	6F25	6F25	6F25
complex with reactivator, hlo7	2.42 Å	6NEA	6NEA	6NEA	6NEA	6NEA	6NEA
binary complex of native hache with donepezil	2.35 Å	6O4W	6O4W	6O4W	6O4W	6O4W	6O4W
binary complex of native hache with 9-aminoacridine	2.30 Å	6O4X	6O4X	6O4X	6O4X	6O4X	6O4X
binary complex of native hache with bw284c51	2.35 Å	6O50	6O50	6O50	6O50	6O50	6O50
room temperature structure of binary complex of native hache with bw284c51	3.20 Å	6O52	6O52	6O52	6O52	6O52	6O52
room temperature structure of binary complex of native hache with oxime reactivator rs-170b	2.80 Å	6O5R	6O5R	6O5R	6O5R	6O5R	6O5R
room temperature structure of vx-phosphonylated hache in complex with oxime reactivator rs-170b	2.80 Å	6O5S	6O5S	6O5S	6O5S	6O5S	6O5S
binary complex of native hache with oxime reactivator rs-170b	2.15 Å	6O5V	6O5V	6O5V	6O5V	6O5V	6O5V
complex with oxime reactivatorrs-170b	2.45 Å	6O66	6O66	6O66	6O66	6O66	6O66
crystal structure of double mutant l380r/f535k of human acetylcholinesterase	2.08 Å	6O69	6O69	6O69	6O69	6O69	6O69
Mus musculus
mature peptidase	4.50 Å	1C2B	1C2B	1C2B	1C2B	1C2B	1C2B	Bourne et al., 1999
mature peptidase	4.20 Å	1C2O	1C2O	1C2O	1C2O	1C2O	1C2O	Bourne et al., 1999
mature peptidase	2.35 Å	1J06	1J06	1J06	1J06	1J06	1J06	Bourne et al., 2003
mature peptidase	2.35 Å	1J07	1J07	1J07	1J07	1J07	1J07	Bourne et al., 2003
mature peptidase	2.50 Å	1KU6	1KU6	1KU6	1KU6	1KU6	1KU6	Bourne et al., 2003
mature peptidase	2.90 Å	1MAA	1MAA	1MAA	1MAA	1MAA	1MAA	Bourne et al., 1999
mature peptidase	3.20 Å	1MAH	1MAH	1MAH	1MAH	1MAH	1MAH	Bourne et al., 1995
mature peptidase	2.20 Å	1N5M	1N5M	1N5M	1N5M	1N5M	1N5M	Bourne et al., 2003
mature peptidase	2.25 Å	1N5R	1N5R	1N5R	1N5R	1N5R	1N5R	Bourne et al., 2003
mature peptidase	2.65 Å	1Q83	1Q83	1Q83	1Q83	1Q83	1Q83	Bourne et al., 2004
mature peptidase	2.45 Å	1Q84	1Q84	1Q84	1Q84	1Q84	1Q84	Bourne et al., 2004
mature peptidase	2.50 Å	2C0P	2C0P	2C0P	2C0P	2C0P	2C0P	Ekstrom et al., 2006
mature peptidase	2.50 Å	2C0Q	2C0Q	2C0Q	2C0Q	2C0Q	2C0Q	Ekstrom et al., 2006
mature peptidase	2.20 Å	2GYU	2GYU	2GYU	2GYU	2GYU	2GYU	Ekstrom et al., 2006
mature peptidase	2.50 Å	2GYV	2GYV	2GYV	2GYV	2GYV	2GYV	Ekstrom et al., 2006
mature peptidase	2.40 Å	2GYW	2GYW	2GYW	2GYW	2GYW	2GYW	Ekstrom et al., 2006
mature peptidase	2.40 Å	2H9Y	2H9Y	2H9Y	2H9Y	2H9Y	2H9Y	Bourne et al., 2006
mature peptidase	2.20 Å	2HA0	2HA0	2HA0	2HA0	2HA0	2HA0	Bourne et al., 2006
mature peptidase	2.05 Å	2HA2	2HA2	2HA2	2HA2	2HA2	2HA2	Bourne et al., 2006
mature peptidase	2.25 Å	2HA3	2HA3	2HA3	2HA3	2HA3	2HA3	Bourne et al., 2006
mature peptidase	2.56 Å	2HA4	2HA4	2HA4	2HA4	2HA4	2HA4	Bourne et al., 2006
mature peptidase	2.15 Å	2HA5	2HA5	2HA5	2HA5	2HA5	2HA5	Bourne et al., 2006
mature peptidase	2.25 Å	2HA6	2HA6	2HA6	2HA6	2HA6	2HA6	Bourne et al., 2006
mature peptidase	2.66 Å	2HA7	2HA7	2HA7	2HA7	2HA7	2HA7	Bourne et al., 2006
mature peptidase	2.70 Å	2JEY	2JEY	2JEY	2JEY	2JEY	2JEY	Ekstrom et al., 2007
mature peptidase	2.60 Å	2JEZ	2JEZ	2JEZ	2JEZ	2JEZ	2JEZ	Ekstrom et al., 2007
mature peptidase	2.50 Å	2JF0	2JF0	2JF0	2JF0	2JF0	2JF0	Ekstrom et al., 2007
mature peptidase	2.60 Å	2JGE	2JGE	2JGE	2JGE	2JGE	2JGE	Hornberg et al., 2007
mature peptidase	2.50 Å	2JGF	2JGF	2JGF	2JGF	2JGF	2JGF	Hornberg et al., 2007
mature peptidase	2.90 Å	2JGI	2JGI	2JGI	2JGI	2JGI	2JGI	Hornberg et al., 2007
mature peptidase	2.50 Å	2JGJ	2JGJ	2JGJ	2JGJ	2JGJ	2JGJ	Hornberg et al., 2007
mature peptidase	2.90 Å	2JGK	2JGK	2JGK	2JGK	2JGK	2JGK	Hornberg et al., 2007
mature peptidase	2.60 Å	2JGL	2JGL	2JGL	2JGL	2JGL	2JGL	Hornberg et al., 2007
mature peptidase	2.90 Å	2JGM	2JGM	2JGM	2JGM	2JGM	2JGM	Hornberg et al., 2007
mature peptidase	2.20 Å	2WHP	2WHP	2WHP	2WHP	2WHP	2WHP	Ekstrom et al., 2009
mature peptidase	2.15 Å	2WHQ	2WHQ	2WHQ	2WHQ	2WHQ	2WHQ	Ekstrom et al., 2009
mature peptidase	2.54 Å	2WHR	2WHR	2WHR	2WHR	2WHR	2WHR	Ekstrom et al., 2009
mature peptidase	2.60 Å	2WLS	2WLS	2WLS	2WLS	2WLS	2WLS	Pang et al., 2009
mature peptidase	2.70 Å	2WU3	2WU3	2WU3	2WU3	2WU3	2WU3	Hornberg et al., 2010
mature peptidase	2.40 Å	2WU4	2WU4	2WU4	2WU4	2WU4	2WU4	Hornberg et al., 2010
mature peptidase	2.65 Å	2XUD	2XUD	2XUD	2XUD	2XUD	2XUD	Bourne et al., 2010
mature peptidase	2.55 Å	2XUF	2XUF	2XUF	2XUF	2XUF	2XUF	Bourne et al., 2010
mature peptidase	2.60 Å	2XUG	2XUG	2XUG	2XUG	2XUG	2XUG	Bourne et al., 2010
mature peptidase	2.65 Å	2XUH	2XUH	2XUH	2XUH	2XUH	2XUH	Bourne et al., 2010
mature peptidase	2.60 Å	2XUI	2XUI	2XUI	2XUI	2XUI	2XUI	Bourne et al., 2010
mature peptidase	2.65 Å	2XUJ	2XUJ	2XUJ	2XUJ	2XUJ	2XUJ	Bourne et al., 2010
mature peptidase	2.75 Å	2XUK	2XUK	2XUK	2XUK	2XUK	2XUK	Bourne et al., 2010
mature peptidase	2.80 Å	2XUO	2XUO	2XUO	2XUO	2XUO	2XUO	Bourne et al., 2010
mature peptidase	2.70 Å	2XUP	2XUP	2XUP	2XUP	2XUP	2XUP	Bourne et al., 2010
mature peptidase	2.70 Å	2XUQ	2XUQ	2XUQ	2XUQ	2XUQ	2XUQ	Bourne et al., 2010
mature peptidase	2.60 Å	2Y2U	2Y2U	2Y2U	2Y2U	2Y2U	2Y2U
mature peptidase	2.45 Å	2Y2V	2Y2V	2Y2V	2Y2V	2Y2V	2Y2V
mature peptidase	2.50 Å	3DL4	3DL4	3DL4	3DL4	3DL4	3DL4	Carletti et al., 2008
mature peptidase	2.50 Å	3DL7	3DL7	3DL7	3DL7	3DL7	3DL7	Carletti et al., 2008
mature peptidase	2.60 Å	3ZLT	3ZLT	3ZLT	3ZLT	3ZLT	3ZLT	Artursson et al., 2013
mature peptidase	2.60 Å	3ZLU	3ZLU	3ZLU	3ZLU	3ZLU	3ZLU	Artursson et al., 2013
mature peptidase	2.50 Å	3ZLV	3ZLV	3ZLV	3ZLV	3ZLV	3ZLV	Artursson et al., 2013
mature peptidase	2.65 Å	4A16	4A16	4A16	4A16	4A16	4A16	Ronco et al., 2012
mature peptidase	2.40 Å	4A23	4A23	4A23	4A23	4A23	4A23	Berg et al., 2011
mature peptidase	2.50 Å	4ARA	4ARA	4ARA	4ARA	4ARA	4ARA	Berg et al., 2012
mature peptidase	2.25 Å	4ARB	4ARB	4ARB	4ARB	4ARB	4ARB	Berg et al., 2012
mature peptidase	2.30 Å	4B7Z	4B7Z	4B7Z	4B7Z	4B7Z	4B7Z	Andersson et al., 2013
mature peptidase	2.50 Å	4B80	4B80	4B80	4B80	4B80	4B80	Andersson et al., 2013
mature peptidase	2.80 Å	4B81	4B81	4B81	4B81	4B81	4B81	Andersson et al., 2013
mature peptidase	2.10 Å	4B82	4B82	4B82	4B82	4B82	4B82	Andersson et al., 2013
mature peptidase	2.40 Å	4B83	4B83	4B83	4B83	4B83	4B83	Andersson et al., 2013
mature peptidase	2.60 Å	4B84	4B84	4B84	4B84	4B84	4B84	Andersson et al., 2013
mature peptidase	2.10 Å	4B85	4B85	4B85	4B85	4B85	4B85	Andersson et al., 2013
mature peptidase	3.35 Å	4BC0	4BC0	4BC0	4BC0	4BC0	4BC0	Carletti et al., 2013
mature peptidase	2.95 Å	4BC1	4BC1	4BC1	4BC1	4BC1	4BC1	Carletti et al., 2013
mature peptidase	2.50 Å	4BTL	4BTL	4BTL	4BTL	4BTL	4BTL	Andersson et al., 2013
mature peptidase	2.40 Å	5DTG	5DTG	5DTG	5DTG	5DTG	5DTG	Katz et al., 2015
mature peptidase	2.00 Å	5DTI	5DTI	5DTI	5DTI	5DTI	5DTI	Katz et al., 2015
mature peptidase	2.71 Å	5DTJ	5DTJ	5DTJ	5DTJ	5DTJ	5DTJ	Katz et al., 2015
mache-syn tz2pa5 complex	2.60 Å	5EHN	5EHN	5EHN	5EHN	5EHN	5EHN
mache-anti tz2pa5 complex	2.50 Å	5EHQ	5EHQ	5EHQ	5EHQ	5EHQ	5EHQ
mache-syn tz2pa5 complex from an equimolar mixture of the syn/anti isomers	2.50 Å	5EHZ	5EHZ	5EHZ	5EHZ	5EHZ	5EHZ
mache-anti tz2pa5 complex from a 1:6 mixture of the syn/anti isomers	2.70 Å	5EIA	5EIA	5EIA	5EIA	5EIA	5EIA
mache-tz2 complex	2.10 Å	5EIE	5EIE	5EIE	5EIE	5EIE	5EIE
mache-tz2/pa5 complex	2.70 Å	5EIH	5EIH	5EIH	5EIH	5EIH	5EIH
complex with c-547,an alkyl ammonium derivative of 6-methyl uracil	3.13 Å	5FKJ	5FKJ	5FKJ	5FKJ	5FKJ	5FKJ
structure of a pre-reaction ternary complex between sarin- acetylcholinesterase and hi-6	2.40 Å	5FPP	5FPP	5FPP	5FPP	5FPP	5FPP
mus musculus acetylcholinesterase in complex with al200	2.50 Å	5FUM	5FUM	5FUM	5FUM	5FUM	5FUM
inhibited by DFP	2.42 Å	5HCU	5HCU	5HCU	5HCU	5HCU	5HCU
complex with crystal violet	2.40 Å	5OV9	5OV9	5OV9	5OV9	5OV9	5OV9
mus musculus acetylcholinesterase in complex with 2-(4-biphenylyloxy)-n-[3-(1-piperidinyl)propyl]-acetamide hydrochloride (10)	2.70 Å	6FSD	6FSD	6FSD	6FSD	6FSD	6FSD