PDBe 4ey8

X-ray diffraction
2.6Å resolution

Crystal structure of recombinant human acetylcholinesterase in complex with fasciculin-2


Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 542 amino acids
Theoretical weight: 59.45 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
  • Canonical: P22303 (Residues: 33-574; Coverage: 93%)
Gene name: ACHE
Sequence domains: Carboxylesterase family
Structure domains: Rossmann fold
Fasciculin-2 Chain: B
Molecule details ›
Chain: B
Length: 61 amino acids
Theoretical weight: 6.77 KDa
Source organism: Dendroaspis angusticeps
  • Canonical: P0C1Z0 (Residues: 1-61; Coverage: 100%)
Structure domains: CD59

Ligands and Environments

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X4C
Spacegroup: R32
Unit cell:
a: 151.705Å b: 151.705Å c: 247.862Å
α: 90° β: 90° γ: 120°
R R work R free
0.196 0.194 0.244
Expression system: Homo sapiens