PDBe 2x8b

X-ray diffraction
2.95Å resolution

Crystal structure of human acetylcholinesterase inhibited by aged tabun and complexed with fasciculin-II

Released:

Function and Biology Details

Structure analysis Details

Assembly composition:
hetero dimer (preferred)
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fasciculin-2 Chain: B
Molecule details ›
Chain: B
Length: 61 amino acids
Theoretical weight: 6.77 KDa
Source organism: Dendroaspis angusticeps
UniProt:
  • Canonical: P0C1Z0 (Residues: 1-61; Coverage: 100%)
Structure domains: CD59
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 583 amino acids
Theoretical weight: 64.75 KDa
Source organism: Homo sapiens
Expression system: Cricetulus griseus
UniProt:
  • Canonical: P22303 (Residues: 32-614; Coverage: 100%)
Gene name: ACHE
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments


1 modified residue:

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF BEAMLINE ID14-1
Spacegroup: R32
Unit cell:
a: 151.31Å b: 151.31Å c: 247.24Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.187 0.183 0.253
Expression system: Cricetulus griseus