PDBe 1b41

X-ray diffraction
2.76Å resolution

HUMAN ACETYLCHOLINESTERASE COMPLEXED WITH FASCICULIN-II, GLYCOSYLATED PROTEIN

Released:

Function and Biology Details

Structure analysis Details

Assemblies composition:
hetero dimer (preferred)
hetero tetramer
Entry contents:
2 distinct polypeptide molecules
Macromolecules (2 distinct):
Fasciculin-2 Chain: B
Molecule details ›
Chain: B
Length: 61 amino acids
Theoretical weight: 6.77 KDa
Source organism: Dendroaspis angusticeps
UniProt:
  • Canonical: P0C1Z0 (Residues: 1-61; Coverage: 100%)
Structure domains: CD59
Acetylcholinesterase Chain: A
Molecule details ›
Chain: A
Length: 539 amino acids
Theoretical weight: 59.1 KDa
Source organism: Homo sapiens
Expression system: Homo sapiens
UniProt:
  • Canonical: P22303 (Residues: 36-574; Coverage: 93%)
Gene name: ACHE
Sequence domains:
Structure domains: Rossmann fold

Ligands and Environments

3 bound ligands:

No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: NSLS BEAMLINE X12C
Spacegroup: R32
Unit cell:
a: 148.99Å b: 148.99Å c: 247.01Å
α: 90° β: 90° γ: 120°
R-values:
R R work R free
0.219 0.219 0.265
Expression system: Homo sapiens