Structure for peptidase S08.129: Tk-subtilisin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
2Z57_A	Thermococcus kodakarensis	1.80 Å	Ser324Alamutant; complex with Gly56Glu-propeptide mutant
Catalytic residues are shown in ball-and-stick representation: Asp139 in pink, His177 in purple, Asn288 in dark pink and Ser348 (engineered to Ala) in orange. The structural zinc atoms are shown as light grey CPK spheres, with calcium shown as yellow CPK spheres. The propeptide is shown in grey ribbon representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Thermococcus kodakarensis
precursor	2.30 Å	2E1P	2E1P	2E1P	2E1P	2E1P	2E1P	Tanaka et al., 2007
mature form peptidase	1.70 Å	2Z2X	2Z2X	2Z2X	2Z2X	2Z2X	2Z2X	Tanaka et al., 2007
autoprocessed form	1.89 Å	2Z2Y	2Z2Y	2Z2Y	2Z2Y	2Z2Y	2Z2Y	Tanaka et al., 2007
unautoprocessed form soaked by 10mm CaCL2	1.87 Å	2Z2Z	2Z2Z	2Z2Z	2Z2Z	2Z2Z	2Z2Z	Tanaka et al., 2007
complex with Tk-propeptide	1.65 Å	2Z30	2Z30	2Z30	2Z30	2Z30	2Z30	Tanaka et al., 2007
Ser324Alamutant; complex with Gly56Ser-propeptide mutant	1.90 Å	2Z56	2Z56	2Z56	2Z56	2Z56	2Z56	Pulido et al., 2007
Ser324Alamutant; complex with Gly56Glu-propeptide mutant	1.80 Å	2Z57	2Z57	2Z57	2Z57	2Z57	2Z57	Pulido et al., 2007
Ser324Alamutant; complex with Gly56Trp-propeptide mutant	1.88 Å	2Z58	2Z58	2Z58	2Z58	2Z58	2Z58	Pulido et al., 2007
Ser324Ala mutant	2.16 Å	2ZRQ	2ZRQ	2ZRQ	2ZRQ	2ZRQ	2ZRQ	Tanaka et al., 2008
mature peptidase	2.07 Å	2ZWO	2ZWO	2ZWO	2ZWO	2ZWO	2ZWO	Takeuchi et al., 2009
mature peptidase	2.40 Å	2ZWP	2ZWP	2ZWP	2ZWP	2ZWP	2ZWP	Takeuchi et al., 2009
mature peptidase	2.20 Å	3A3N	3A3N	3A3N	3A3N	3A3N	3A3N	Tanaka et al., 2009
mature peptidase	1.90 Å	3A3O	3A3O	3A3O	3A3O	3A3O	3A3O	Tanaka et al., 2009
mature peptidase	1.90 Å	3A3P	3A3P	3A3P	3A3P	3A3P	3A3P	Tanaka et al., 2009
mature peptidase	2.15 Å	3VHQ	3VHQ	3VHQ	3VHQ	3VHQ	3VHQ	Uehara et al., 2012
mature peptidase	1.83 Å	3VV2	3VV2	3VV2	3VV2	3VV2	3VV2	Uehara et al., 2013
mature peptidase	1.80 Å	3WIU	3WIU	3WIU	3WIU	3WIU	3WIU
mature peptidase	1.90 Å	3WIV	3WIV	3WIV	3WIV	3WIV	3WIV
mature peptidase	2.21 Å	4JP8	4JP8	4JP8	4JP8	4JP8	4JP8	Yuzaki et al., 2013