Structure for peptidase C30.003: human coronavirus 229E main peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

 

PDB Organism Resolution Comment
1P9S_A human coronavirus 2.54 Å mature
One molecule of the homodimer is shown. Catalytic residues are shown in ball-and-stick representation: His3006 in purple and Cys3109 in yellow.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
human coronavirus
mature  peptidase 2.54 Å 1P9S 1P9S 1P9S 1P9S 1P9S 1P9S Anand et al., 2003
mature  peptidase 2.37 Å 1P9U 1P9U 1P9U 1P9U 1P9U 1P9U Anand et al., 2003
complex with epdtc 1.80 Å 2ZU2 2ZU2 2ZU2 2ZU2 2ZU2 2ZU2
complex with the alpha-ketoamide tert-butyl ((s)-4-(benzylamino)-3,4-dioxo-1-((s)-2- oxopyrrolidin-3-yl)b- utan-2-yl)carbamate (tert-butyl -glnlactam-co- co-nh-benzyl) 2.35 Å 5NH0 5NH0 5NH0 5NH0 5NH0 5NH0
complex with the alpha-ketoamide (s)-n-((s)-4-(benzylamino)-3,4-dioxo-1-((s)-2- oxopyrrolidin-3-yl)butan-2-yl)-2-cinnamamido-4-methylpentanamide (cinnamoyl-leucine-glnlactam-co-co-nh-benzyl) 2.30 Å 6FV1 6FV1 6FV1 6FV1 6FV1 6FV1
complex with the alpha-ketoamide (s)-n-benzyl-3-((s)-2-cinnamamido-3- phenylpropanamido)-2-oxo-4-((s)-2-oxopyrrolidin-3-yl)butanamide (cinnamoyl-phenylalanine-glnlactam-co-co-nh-benzyl) 2.95 Å 6FV2 6FV2 6FV2 6FV2 6FV2 6FV2
porcine epidemic diarrhea virus
mature  peptidase 1.65 Å 4XFQ 4XFQ 4XFQ 4XFQ 4XFQ 4XFQ
Cys144Ala mutant complex with a peptide substrate. 2.39 Å 4ZUH 4ZUH 4ZUH 4ZUH 4ZUH 4ZUH