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Literature for peptidase C30.003: human coronavirus 229E main peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Jiang,L., Gu,M., Xiao,J., Zhao,Y., Shen,F., Guo,X., Li,H., Guo,D., Li,C., Zhu,Q., Yang,D., Xing,X. and Sun,D.
    Ethyl caffeate as a novel targeted inhibitor of 3CLpro with antiviral activity against porcine epidemic diarrhea virus
    Virology (2025) 604, 110406-110406. PubMed  Europe PubMed DOI  I
  2. Martianez-Vendrell,X., van Kasteren,P.B., Myeni,S.K. and Kikkert,M.
    HCoV-229E Mpro Suppresses RLR-Mediated Innate Immune Signalling Through Cleavage of NEMO and Through Other Mechanisms
    Int J Mol Sci (2025) 26 PubMed  Europe PubMed DOI  PMC  EPMC
    3. 2024
  3. Wang,M., Sun,X., Peng,S., Wang,F., Zhao,K. and Wang,D.
    Deciphering the cleavage sites of 3C-like protease in Gammacoronaviruses and Deltacoronaviruses
    Biochim Biophys Acta Proteins Proteom (2024) 1873, 141057-141057. PubMed  Europe PubMed DOI
  4. Xu,J., Zhu,Q., Li,W., Yin,X. and Li,J.
    Structural basis for the inhibition of the HCoV-NL63 main protease M(pro) by X77
    Biochem Biophys Res Commun (2024) 724, 150231-150231. PubMed  Europe PubMed DOI  I
    5. 2023
  5. Pathak,R.K., Kim,W.I. and Kim,J.M.
    Targeting the PEDV 3CL protease for identification of small molecule inhibitors: an insight from virtual screening, ADMET prediction, molecular dynamics, free energy landscape, and binding energy calculations
    J Biol Eng (2023) 17, 29-29. PubMed  Europe PubMed DOI  PMC  EPMC
    6. 2022
  6. Feng,J., Li,D., Zhang,J., Yin,X. and Li,J.
    Crystal structure of SARS-CoV 3C-like protease with baicalein
    Biochem Biophys Res Commun (2022) 611, 190-194. PubMed  Europe PubMed DOI  PMC  EPMC  I
  7. Zhu,Y., Scholle,F., Kisthardt,S.C. and Xie,D.Y.
    Flavonols and dihydroflavonols inhibit the main protease activity of SARS-CoV-2 and the replication of human coronavirus 229E
    Virology (2022) 571, 21-33. PubMed  Europe PubMed DOI  PMC  EPMC  I
    8. 2021
  8. Gao,H., Zhang,Y., Jiang,H., Hu,X., Zhang,Y., Zhou,X., Zhong,F., Lin,C., Li,J., Luo,J. and Zhang,J.
    Crystal structures of human coronavirus NL63 main protease at different pH values
    Acta Crystallogr F Struct Biol Commun (2021) 77, 348-355. PubMed  Europe PubMed DOI  PMC  EPMC
  9. Hu,Y., Ma,C., Szeto,T., Hurst,B., Tarbet,B. and Wang,J.
    Boceprevir, Calpain Inhibitors II and XII, and GC-376 Have Broad-Spectrum Antiviral Activity against Coronaviruses
    ACS Infect Dis (2021) 7, 586-597. PubMed  Europe PubMed DOI  PMC  EPMC  I
  10. Jang,M., Park,R., Park,Y.I., Cha,Y.E., Yamamoto,A., Lee,J.I. and Park,J.
    EGCG, a green tea polyphenol, inhibits human coronavirus replication in vitro
    Biochem Biophys Res Commun (2021) 547, 23-28. PubMed  Europe PubMed DOI  PMC  EPMC  I
    11. 2020
  11. Grottesi,A., Besker,N., Emerson,A., Manelfi,C., Beccari,A.R., Frigerio,F., Lindahl,E., Cerchia,C. and Talarico,C.
    Computational Studies of SARS-CoV-2 3CLpro: Insights from MD Simulations
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI
  12. Joshi,T., Joshi,T., Pundir,H., Sharma,P., Mathpal,S. and Chandra,S.
    Predictive modeling by deep learning, virtual screening and molecular dynamics study of natural compounds against SARS-CoV-2 main protease
    J Biomol Struct Dyn (2020) , 1-19. PubMed  Europe PubMed DOI
  13. Koulgi,S., Jani,V., Uppuladinne,M., Sonavane,U., Nath,A.K., Darbari,H. and Joshi,R.
    Drug repurposing studies targeting SARS-CoV-2: an ensemble docking approach on drug target 3C-like protease (3CL(pro))
    J Biomol Struct Dyn (2020) , 1-21. PubMed  Europe PubMed DOI
  14. Kozak,J.J., Gray,H.B. and Garza-Lopez,R.A.
    Structural stability of the SARS-CoV-2 main protease: Can metal ions affect function?
    J Inorg Biochem (2020) 211, 111179-111179. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Kumar,N., Sood,D., van der Spek,P.J., Sharma,H.S. and Chandra,R.
    Molecular Binding Mechanism and Pharmacology Comparative Analysis of Noscapine for Repurposing against SARS-CoV-2 Protease
    J Proteome Res (2020) PubMed  Europe PubMed DOI
  16. Sharma,P., Vijayan,V., Pant,P., Sharma,M., Vikram,N., Kaur,P., Singh,T.P. and Sharma,S.
    Identification of potential drug candidates to combat COVID-19: a structural study using the main protease (mpro) of SARS-CoV-2
    J Biomol Struct Dyn (2020) , 1-11. PubMed  Europe PubMed DOI  T  I
    17. 2019
  17. Zhou,J., Fang,L., Yang,Z., Xu,S., Lv,M., Sun,Z., Chen,J., Wang,D., Gao,J. and Xiao,S.
    Identification of novel proteolytically inactive mutations in coronavirus 3C-like protease using a combined approach
    FASEB J (2019) 33, 14575-14587. PubMed  Europe PubMed DOI
    18. 2017
  18. Jaru-Ampornpan,P., Jengarn,J., Wanitchang,A. and Jongkaewwattana,A.
    Porcine epidemic diarrhea virus (PEDV) 3C-Like protease-mediated nucleocapsid processing: a possible link to viral cell-culture adaptability
    J Virol (2017) 91, e01660-16-e01660-16. PubMed  Europe PubMed DOI
  19. Wang,F., Chen,C., Yang,K., Xu,Y., Liu,X., Gao,F., Liu,H., Chen,X., Zhao,Q., Liu,X., Cai,Y. and Yang,H.
    Michael acceptor-based peptidomimetic inhibitor of main protease from porcine epidemic diarrhea virus
    J Med Chem (2017) 60, 3212-3216. PubMed  Europe PubMed DOI  S  I
    20. 2016
  20. St John,S.E., Anson,B.J. and Mesecar,A.D.
    X-Ray structure and inhibition of 3C-like protease from porcine epidemic diarrhea virus
    Sci Rep (2016) 6, 25961-25961. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  21. Wang,D., Fang,L., Shi,Y., Zhang,H., Gao,L., Peng,G., Chen,H., Li,K. and Xiao,S.
    Porcine epidemic diarrhea virus 3C-like protease regulates its interferon antagonism by cleaving NEMO
    J Virol (2016) 90, 2090-2101. PubMed  Europe PubMed DOI
  22. Wang,F., Chen,C., Tan,W., Yang,K. and Yang,H.
    Structure of main protease from human coronavirus NL63: insights for wide spectrum anti-coronavirus drug design
    Sci Rep (2016) 6, 22677-22677. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  23. Ye,G., Deng,F., Shen,Z., Luo,R., Zhao,L., Xiao,S., Fu,Z.F. and Peng,G.
    Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease
    Virology (2016) 494, 225-235. PubMed  Europe PubMed DOI  S
    24. 2015
  24. Berry,M., Fielding,B. and Gamieldien,J.
    Human coronavirus OC43 3CL protease and the potential of ML188 as a broad-spectrum lead compound: Homology modelling and molecular dynamic studies
    BMC Struct Biol (2015) 15, 8- PubMed  Europe PubMed DOI  PMC  EPMC  I
    25. 2014
  25. Tan,Y., Wang,F., Chen,X., Wang,J., Zhao,Q., Li,S., Wang,Z., Fu,S., Chen,C. and Yang,H.
    Crystallization and preliminary crystallographic study of porcine epidemic diarrhea virus main protease in complex with an inhibitor
    Acta Crystallogr F Struct Biol Commun (2014) 70, 1608-1611. PubMed  Europe PubMed DOI  I
  26. Wang,F., Tan,Y., Li,H., Chen,X., Wang,J., Li,S., Fu,S., Zhao,Q., Chen,C., Su,D. and Yang,H.
    Crystallization and preliminary crystallographic study of human coronavirus NL63 main protease in complex with an inhibitor
    Acta Crystallogr F Struct Biol Commun (2014) 70, 1068-1071. PubMed  Europe PubMed DOI
    27. 2012
  27. Stobart,C.C. and Denison,M.R.
    Coronavirus picornain-like cysteine proteinase
    [ISSN:978-0-12-407743-0] (2012) 3, 2436-2441. DOI
    28. 2004
  28. Denison,M.R.
    Coronavirus picornain-like cysteine proteinase
    [ISSN:0-12-079610-4] (2004) 2, 1382-1385.  V
    29. 2003
  29. [YEAR:13-6-2003]Anand,K., Ziebuhr,J., Wadhwani,P., Mesters,J.R. and Hilgenfeld,R.
    Coronavirus main proteinase (3CLpro) structure: basis for design of anti-SARS drugs
    Science (13-6-2003) 300, 1763-1767. PubMed  Europe PubMed DOI  S
    30. 2001
  30. Kocherhans,R., Bridgen,A., Ackermann,M. and Tobler,K.
    Completion of the porcine epidemic diarrhoea coronavirus (PEDV) genome sequence
    Virus Genes (2001) 23, 137-144. PubMed  Europe PubMed DOI
    31. 1998
  31. Collins,A.R. and Grubb,A.
    Cystatin D, a natural salivary cysteine protease inhibitor, inhibits coronavirus replication at its physiologic concentration
    Oral Microbiol Immunol (1998) 13, 59-61. PubMed  Europe PubMed
  32. Ziebuhr,J., Heusipp,G., Seybert,A. and Siddell,S.G.
    Substrate specificity of the human coronavirus 229E 3C-like proteinase
    Adv Exp Med Biol (1998) 440, 115-120. PubMed  Europe PubMed
    33. 1997
  33. Ziebuhr,J., Heusipp,G. and Siddell,S.G.
    Biosynthesis, purification, and characterization of the human coronavirus 229E 3C-like proteinase
    J Virol (1997) 71, 3992-3997. PubMed  Europe PubMed  PMC  EPMC

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