Substrates for peptidase C30.003: human coronavirus 229E main peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
nF-kappa-B essential modulator Q9Y6K9 1-419 peptide-Gln231+Val-peptide P MS Ala Gln Leu Gln Val Ala Tyr His Koudelka et al., 2020
optineurin Q96CV9 1-577 peptide-Gln151+Ala-peptide P MS Val Arg Leu Gln Ala Glu Lys Ala Koudelka et al., 2020
optineurin Q96CV9 1-577 peptide-Gln165+Leu-peptide P MS Ser Glu Leu Gln Leu Lys Leu Asn Koudelka et al., 2020
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln2965+Ala-peptide P MU Ser Thr Leu Gln Ala Gly Leu Arg Ziebuhr & Siddell, 1999
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln3267+Ser-peptide P MU Val Asn Leu Gln Ser Gly Lys Thr Ziebuhr & Siddell, 1999
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln3546+Ser-peptide P MU Ser Thr Val Gln Ser Lys Leu Thr Ziebuhr & Siddell, 1999
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln3629+Ser-peptide P MU Ser Ile Leu Gln Ser Val Ala Ser Ziebuhr & Siddell, 1999
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln3824+Asn-peptide P MU Val Lys Leu Gln Asn Asn Glu Ile Ziebuhr & Siddell, 1999
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln3933+Ala-peptide P MU Val Arg Leu Gln Ala Gly Lys Gln Ziebuhr & Siddell, 1999
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln4068+Ser-peptide P MU Thr Ala Ile Gln Ser Phe Asp Asn
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln4995+Ala-peptide P MU Thr Val Leu Gln Ala Ala Gly Leu
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln5592+Ser-peptide P MU Thr Asp Leu Gln Ser Glu Ser Ser
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln6110+Gly-peptide P MU Val Asn Leu Gln Gly Leu Glu Asn
replicase polyprotein 1ab P0C6X1 1-6758 peptide-Gln6458+Ser-peptide P MU Pro Gln Leu Gln Ser Ala Glu Trp