Structure for peptidase C19.016: ubiquitin-specific peptidase 7

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
1NBF	Homo sapiens	2.30 Å	complex with ubiquitin aldehyde
One molecule of the homodimer is shown. Catalytic residues are shown in ball-and-stick representation: Cys223 in yellow, His464 in purple and Asp481 in pink.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
catalytic domain only	2.30 Å	1NB8	1NB8	1NB8	1NB8	1NB8	1NB8	Hu et al., 2002
complex with ubiquitin aldehyde	2.30 Å	1NBF	1NBF	1NBF	1NBF	1NBF	1NBF	Hu et al., 2002
mature peptidase	1.70 Å	1YY6	1YY6	1YY6	1YY6	1YY6	1YY6	Saridakis et al., 2005
mature peptidase	2.00 Å	1YZE	1YZE	1YZE	1YZE	1YZE	1YZE	Saridakis et al., 2005
mature peptidase	1.65 Å	2F1W	2F1W	2F1W	2F1W	2F1W	2F1W	Hu et al., 2006
mature peptidase	2.30 Å	2F1X	2F1X	2F1X	2F1X	2F1X	2F1X	Hu et al., 2006
mature peptidase	1.70 Å	2F1Y	2F1Y	2F1Y	2F1Y	2F1Y	2F1Y	Hu et al., 2006
mature peptidase	3.20 Å	2F1Z	2F1Z	2F1Z	2F1Z	2F1Z	2F1Z	Hu et al., 2006
mature peptidase	1.60 Å	2FOJ	2FOJ	2FOJ	2FOJ	2FOJ	2FOJ	Sheng et al., 2006
mature peptidase	2.20 Å	2FOO	2FOO	2FOO	2FOO	2FOO	2FOO	Sheng et al., 2006
mature peptidase	2.10 Å	2FOP	2FOP	2FOP	2FOP	2FOP	2FOP	Sheng et al., 2006
mature peptidase	0.00 Å	2KVR	2KVR	2KVR	2KVR	2KVR	2KVR
mature peptidase	1.60 Å	2XXN	2XXN	2XXN	2XXN	2XXN	2XXN	Lee et al., 2011
mature peptidase	2.70 Å	2YLM	2YLM	2YLM	2YLM	2YLM	2YLM	Faesen et al., 2011
mature peptidase	1.80 Å	3MQR	3MQR	3MQR	3MQR	3MQR	3MQR
mature peptidase	2.40 Å	3MQS	3MQS	3MQS	3MQS	3MQS	3MQS
mature peptidase	1.95 Å	4JJQ	4JJQ	4JJQ	4JJQ	4JJQ	4JJQ
mature peptidase	1.70 Å	4KG9	4KG9	4KG9	4KG9	4KG9	4KG9	Jagannathan et al., 2014
mature peptidase	2.24 Å	4M5W	4M5W	4M5W	4M5W	4M5W	4M5W	Molland et al., 2014
mature peptidase	2.19 Å	4M5X	4M5X	4M5X	4M5X	4M5X	4M5X	Molland et al., 2014
mature peptidase	2.84 Å	4PYZ	4PYZ	4PYZ	4PYZ	4PYZ	4PYZ
mature peptidase	2.92 Å	4WPH	4WPH	4WPH	4WPH	4WPH	4WPH	Pfoh et al., 2015
mature peptidase	3.40 Å	4WPI	4WPI	4WPI	4WPI	4WPI	4WPI	Pfoh et al., 2015
mature peptidase	2.92 Å	4YOC	4YOC	4YOC	4YOC	4YOC	4YOC	Cheng et al., 2015
structure of usp7 with a novel viral protein	1.02 Å	4YSI	4YSI	4YSI	4YSI	4YSI	4YSI
mature peptidase	2.69 Å	5C56	5C56	5C56	5C56	5C56	5C56	Cheng et al., 2015
mature peptidase	2.29 Å	5C6D	5C6D	5C6D	5C6D	5C6D	5C6D	Zhang et al., 2015
structure of usp7 catalytic domain and three ubl-domains	3.40 Å	5FWI	5FWI	5FWI	5FWI	5FWI	5FWI
molecular understanding of usp7 substrate recognition and c-terminal activation	3.20 Å	5J7T	5J7T	5J7T	5J7T	5J7T	5J7T
usp7cd-ctp in complex with ubiquitin	3.32 Å	5JTJ	5JTJ	5JTJ	5JTJ	5JTJ	5JTJ
usp7cd-ubl45 in complex with ubiquitin	3.31 Å	5JTV	5JTV	5JTV	5JTV	5JTV	5JTV
catalytic domain; Val302Lys mutant	2.20 Å	5KYB	5KYB	5KYB	5KYB	5KYB	5KYB
catalytic domain; Val302Lys mutant; complex with ubiquitin (malonate bound)	1.43 Å	5KYC	5KYC	5KYC	5KYC	5KYC	5KYC
catalytic domain; Val302Lys mutant; complex with ubiquitin	1.62 Å	5KYD	5KYD	5KYD	5KYD	5KYD	5KYD
catalytic domain; His294Glu mutant; complex with ubiquitin	1.97 Å	5KYE	5KYE	5KYE	5KYE	5KYE	5KYE
catalytic domain; Leu299Ala mutant; complex with ubiquitin	1.45 Å	5KYF	5KYF	5KYF	5KYF	5KYF	5KYF
complex with a potent, selective and reversible small-molecule inhibitor	2.23 Å	5N9R	5N9R	5N9R	5N9R	5N9R	5N9R
complex with a potent, selective and reversible small-molecule inhibitor	1.73 Å	5N9T	5N9T	5N9T	5N9T	5N9T	5N9T
complex with the non-covalent inhibitor, ft671	2.35 Å	5NGE	5NGE	5NGE	5NGE	5NGE	5NGE
complex with the covalent inhibitor, ft827	2.33 Å	5NGF	5NGF	5NGF	5NGF	5NGF	5NGF
complex with gne6640 (4-(2-amino-4-ethyl-5-(1h-indazol-5-yl) pyridin-3-yl)phenol)	2.84 Å	5UQV	5UQV	5UQV	5UQV	5UQV	5UQV
structure of dub complex	2.27 Å	5VS6	5VS6	5VS6	5VS6	5VS6	5VS6
structure of dub complex	1.85 Å	5VSB	5VSB	5VSB	5VSB	5VSB	5VSB
structure of dub complex	3.33 Å	5VSK	5VSK	5VSK	5VSK	5VSK	5VSK
usp7 in complex with cpd2 (4-(3-(1-methylpiperidin-4-yl)-1,2,4- oxadiazol-5-yl)phenol)	2.55 Å	5WHC	5WHC	5WHC	5WHC	5WHC	5WHC
complex with a 4-hydroxypiperidine based inhibitor	2.16 Å	6F5H	6F5H	6F5H	6F5H	6F5H	6F5H