Substrates for peptidase C19.016: ubiquitin-specific peptidase 7

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
polyubiquitinated death domain-associated protein 6	P0CG47/Q9UER7	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Tang et al., 2010
polyubiquitinated E3 ubiquitin-protein ligase ICP0	P0CG47/P08393	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Antrobus & Boutell, 2008
polyubiquitinated E3 ubiquitin-protein ligase Mdm2	P0CG47/Q00987	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Yang et al., 2008
UBICEP52	P0CG47	1-76	peptide-Gly76+Ile1-peptide	N	Leu	Arg	Gly	Gly	Ile	Ile	Glu	Pro	Layfield et al., 1999
UBICEP52	P0CG47	1-76	peptide-Gly76+Ile1-peptide	N	Leu	Arg	Gly	Gly	Ile	Ile	Glu	Pro	Layfield et al., 1999
ubiquitin-beta-galactosidase fusion protein	P0CG47	1-76	peptide-Gly76+Met1-peptide	N	Leu	Arg	Gly	Gly	Met	His	Gly	Ser	Everett, 2004	16274
ubiquitin-Cellular tumor antigen p53 complex	P0CG47/P04637	1-76/1-393	peptide-Gly76+Lys291-peptide	P	Leu	Arg	Gly	Gly	Lys	Lys	Gly	Glu	Li et al., 2002
ubiquitin-Cellular tumor antigen p53 complex	P0CG47/P04637	1-76/1-393	peptide-Gly76+Lys292-peptide	P	Leu	Arg	Gly	Gly	Lys	Gly	Glu	Pro	Li et al., 2002
ubiquitin-NF-kappa-B p65 fusion protein	P0CG47	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	Colleran et al., 2013
ubiquitinated forkhead box protein O4	P0CG47/P98177	1-76	peptide-Gly76+Lys-peptide	P	Leu	Arg	Gly	Gly	Lys	Xaa	Xaa	Xaa	van der Horst et al., 2006
ubiquitinated phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	P0CG47/P60484	1-76	peptide-Gly76+Lys13-peptide	P	Leu	Arg	Gly	Gly	Lys	Arg	Arg	Tyr	Song et al., 2008
ubiquitinated phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN	P0CG47/P60484	1-76	peptide-Gly76+Lys289-peptide	P	Leu	Arg	Gly	Gly	Lys	Val	Glu	Asn	Song et al., 2008