Literature for peptidase C19.016: ubiquitin-specific peptidase 7

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, T Target, P Specificity, K Knockout, V Review, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Abulimiti,D., Aihemaiti,S., Wei,K., Zhang,Z., Kan,Y., Tao,S. and Liu,H.
USP7 deletion promotes osteoclastogenesis via stimulating NF-kappaB and attenuating Nrf2/HO-1 signaling pathway
Int Immunopharmacol (2026) 170, 116094-116094. PubMed Europe PubMed DOI
Lulu-Shimron,C., Luo,Z., Brekhman,V., Huang,L., Livneh,I., Kosako,H., Cohen-Kaplan,V. and Ciechanover,A.
Proteasomal proteolysis in p62 condensates directs tumor suppression or growth depending on their subcellular localization
Proc Natl Acad Sci U S A (2026) 123, e2529422123-e2529422123. PubMed Europe PubMed DOI PMC EPMC

2025

Aihemaiti,S., Wei,K., Abulimiti,D., Kan,Y., Zhang,Z., Tao,S., Tan,J. and Liu,H.
USP7 inhibition promotes wound healing by suppressing M1 macrophage polarization via NF-kappaB/MAPK signaling pathway
Int Immunopharmacol (2025) 168, 115791-115791. PubMed Europe PubMed DOI
Ancia,M., Wahni,K., Chakrowf,J., El Aakchioui,A., Claude,E., de Lhoneux,G., Liberelle,M., Janvier,S., Baranova,E., Malo Pueyo,J., Jijon Vergara,A., Papadopoulos,N., Balty,C., Dejeu,J., Decottignies,A., Messens,J. and Frederick,R.
Structural insights into the interaction between testis-specific Y-encoded-like protein 5 and ubiquitin-specific protease 7
Protein Sci (2025) 34, e70116-e70116. PubMed Europe PubMed DOI PMC EPMC
Bai,M., Xu,P., Cheng,R., Li,N., Cao,S., Guo,Q., Wang,X., Li,C., Bai,N., Jiang,B., Wu,X., Song,X., Sun,C., Zhao,M. and Cao,L.
ROS-ATM-CHK2 axis stabilizes HIF-1alpha and promotes tumor angiogenesis in hypoxic microenvironment
Oncogene (2025) PubMed Europe PubMed DOI
Chen,C., Addepalli,K., Soldan,S.S., Castro-Munoz,L.J., Preston-Alp,S., Patel,R.J., Albitz,C.J., Tang,H.Y., Tempera,I. and Lieberman,P.M.
USP7 Inhibitors Destabilize EBNA1 and Suppress Epstein-Barr Virus Tumorigenesis
J Med Virol (2025) 97, e70168-e70168. PubMed Europe PubMed DOI PMC EPMC
Chen,H., Ferguson,C.J., Mitchell,D.C., Risch,I., Titus,A., Paulo,J.A., Hwang,A., Beck,L.K., Lin,T.H., Gu,W., Song,S.K., Yuede,C.M., Yano,H., Griffith,O.L., Griffith,M., Gygi,S.P., Bonni,A. and Kim,A.H.
The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway
Cell Rep (2025) 44, 115231-115231. PubMed Europe PubMed DOI K
Ernst,L.N., Jaag,S.J., Wydra,V.R., Masberg,B., Knappe,C., Gerstenecker,S., Serafim,R.A.M., Liang,X.J., Seidler,N.J., Lammerhofer,M., Gehringer,M. and Boeckler,F.M.
Screening of Covalent Kinase Inhibitors Yields Hits for Cysteine Protease USP7 / HAUSP
Drug Des Devel Ther (2025) 19, 2253-2284. PubMed Europe PubMed DOI PMC EPMC
Hou,D., Hu,Y., Yun,T., Yu,D. and Yang,G.
USP7 promotes PINK1/Parkin-dependent mitophagy to ameliorate cerebral ischemia-reperfusion injury by deubiquitinating and stabilizing SIRT1
Brain Res (2025) 1858, 149638-149638. PubMed Europe PubMed DOI
Iwase,R., Maisonet,I.J., Lee,K., Buhrlage,S.J. and Cole,P.A.
Deubiquitinase processing of a non-natural linkage of ubiquitinated-PTEN
Bioorg Chem (2025) 157, 108223-108223. PubMed Europe PubMed DOI
Jaen Maisonet,I., Sharafi,M., Korchak,E.J., Salazar-Chaparro,A., Bratt,A., Parikh,T., Varca,A.C., Shah,B., Darnowski,M., Chung,M., Teh,W.P., Che,J., Bezsonova,I. and Buhrlage,S.J.
Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Jaen Maisonet,I., Sharafi,M., Korchak,E.J., Salazar-Chaparro,A., Bratt,A.S., Parikh,T., Varca,A.C., Shah,B., Darnowski,M., Chung,M., Teh,W.P., Che,J., Bezsonova,I. and Buhrlage,S.J.
Small-molecule allosteric activator of ubiquitin-specific protease 7 (USP7)
Proc Natl Acad Sci U S A (2025) 122, e2510496122-e2510496122. PubMed Europe PubMed DOI PMC EPMC
Jia,G., Wang,Y., Zhou,W., Huang,X. and Song,Z.
Discovery of o-aminodiphenyl-based USP7 inhibitor for immune activation and antitumor response in colorectal cancer
Int Immunopharmacol (2025) 167, 115732-115732. PubMed Europe PubMed DOI I
Korchak,E.J., Sharafi,M., Maisonet,I.J., Caro,P., Schaaf,C.P., Buhrlage,S.J. and Bezsonova,I.
Functional Spectrum of USP7 Pathogenic Variants in Hao-Fountain Syndrome: Insights into the Enzyme's Activity, Stability, and Allosteric Modulation
bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC
Korchak,E.J., Sharafi,M., Jaen Maisonet,I., Salazar-Chaparro,A., Semenova,I.V., Khan,H., O'Neil,A.L., Caro,P., Schaaf,C.P., Buhrlage,S.J. and Bezsonova,I.
Functional spectrum of USP7 pathogenic variants in Hao-Fountain syndrome: Insights into the enzyme's activity, stability, and allosteric modulation
Proc Natl Acad Sci U S A (2025) 122, e2510252122-e2510252122. PubMed Europe PubMed DOI PMC EPMC
Leng,Y., Liu,Z., Min,J., Ke,Q., Shao,Y., Lai,J. and Zhao,J.
METTL14 Promotes the Osteogenic Differentiation of Human Bone Marrow Stromal Cells via m6A-Dependent Stabilization of USP7 mRNA
Biochem Genet (2025) PubMed Europe PubMed DOI
Liang,A., Liu,J., Zhang,Z., Xiao,J., Liu,D., Dong,Z. and Chen,G.
Usp7 contributes to the tail regeneration of planarians via Islet/Wnt1 axis
J Transl Med (2025) 23, 137-137. PubMed Europe PubMed DOI PMC EPMC
Lin,J., Lin,Y.T., Hsu,K.W., Liu,Y.E., Chen,Y.C., Yeh,Y.L., Huang,H.Y., Hsieh,C.C., Chen,D.R. and Wu,H.T.
Targeting the USP7-CDK1 axis suppresses estrogen receptor-positive breast cancer progression
Cancer Cell Int (2025) 25, 60-60. PubMed Europe PubMed DOI PMC EPMC
Liu,P., Chen,Z., Guo,Y., He,Q. and Pan,C.
Recent advances in small molecule inhibitors of deubiquitinating enzymes
Eur J Med Chem (2025) 287, 117324-117324. PubMed Europe PubMed DOI V
Liu,Y., Ji,Y., Zhang,Y. and Li,Z.
Activation of TRAF1 induced by USP7/SP1 exacerbates the severity of infantile pneumonia
Hereditas (2025) 162, 44-44. PubMed Europe PubMed DOI PMC EPMC
Liu,Z., Shi,X., Ke,T., Yan,Z., Xiong,L. and Tang,F.
USP7 promotes endothelial activation to aggravate sepsis-induced acute lung injury through PDK1/AKT/NF-kappaB signaling pathway
Cell Death Discov (2025) 11, 183-183. PubMed Europe PubMed DOI PMC EPMC K
Lusardi,M., Rapetti,F., Spallarossa,A., Massone,M., Cichero,E. and Brullo,C.
USP7 at the Crossroads of Ubiquitin Signaling, Cell Cycle, and Tumorigenesis
Molecules (2025) 30 PubMed Europe PubMed DOI PMC EPMC
Lusardi,M., Morretta,E., Spallarossa,A., Chiara Monti,M., Rosano,C., Iervasi,E., Ponassi,M., Mori,M., Meneghetti,F. and Brullo,C.
Targeting Ubiquitin-Specific Protease 7 with Novel 5-Amino-Pyrazole Inhibitors: Design, Synthesis, and Biological Evaluation
ChemMedChem (2025) , e2500185-e2500185. PubMed Europe PubMed DOI I
Lv,H., Wu,W., Sima,Y., Guo,Z., Zhu,J., Shen,Y. and Mao,T.
USP7-mediated stabilization of CXCL3 aggravates inflammation in models of acute lung injury
J Thorac Dis (2025) 17, 6673-6688. PubMed Europe PubMed DOI PMC EPMC K
Miao,Y.L., Fan,F., Cheng,Y.J., Jia,L., Song,S.S., Huan,X.J., Bao,X.B., Ding,J., Yu,X. and He,J.X.
USP7 V517F mutation as a mechanism of inhibitor resistance
Nat Commun (2025) 16, 2526-2526. PubMed Europe PubMed DOI PMC EPMC
Miranda,R., Anson,F., Smith,S.T., Ultsch,M., Tenorio,C.A., Rouge,L., Farrell,B., Adaligil,E., Holden,J.K., Harris,S.F. and Dueber,E.C.
Discovery and characterization of potent macrocycle inhibitors of ubiquitin-specific protease-7
Structure (2025) PubMed Europe PubMed DOI I
Peng,F. and Deng,X.
Ubiquitin-specific protease 7 exacerbates acute pancreatitis progression by enhancing ATF4-mediated autophagy
In Vitro Cell Dev Biol Anim (2025) PubMed Europe PubMed DOI K
Ruan,W., Peng,Z., Huang,M., Zhang,H., Li,X., Ma,T., Deng,J., Pan,M., Mai,Z., Meng,X. and Zhang,J.
Cigarette smoke-induced glycerophospholipid DLPC promotes macrophage ferroptosis through the USP7/GPX4 regulatory axis in chronic obstructive pulmonary disease
Chem Biol Interact (2025) 420, 111697-111697. PubMed Europe PubMed DOI K
Saha,G. and Ghosh,M.K.
The key vulnerabilities and therapeutic opportunities in the USP7-p53/MDM2 axis in cancer
Biochim Biophys Acta Mol Cell Res (2025) 1872, 119908-119908. PubMed Europe PubMed DOI
Shi,L., Xu,Z., Chen,X., Meng,Q., Zhou,H., Xiong,B. and Zhang,N.
Sertraline and Astemizole Enhance the Deubiquitinase Activity of USP7 by Binding to Its Switching Loop Region
J Med Chem (2025) PubMed Europe PubMed DOI
Su,L., Wang,D., Purwin,T.J., Ran,S., Yang,Q., Zhang,Q. and Cai,W.
Selective USP7 inhibition synergizes with MEK1/2 inhibitor to enhance immune responses and potentiate anti-PD-1 therapy in NRAS mutant melanoma
J Invest Dermatol (2025) PubMed Europe PubMed DOI I
Wang,J., Chen,M., Jiang,J., Wan,Y., Li,X., Zhang,M., Xiao,F., Zhong,L., Zhong,H., Qin,Z. and Hou,J.
Targeting deubiquitinase USP7-mediated stabilization of XPO1 contributes to the anti-myeloma effects of selinexor
J Transl Med (2025) 23, 62-62. PubMed Europe PubMed DOI PMC EPMC K
Wang,M., Shi,Y., Liang,Z. and Yang,F.
USP7 promotes the malignant progression of osteosarcoma through the KPNA2/PKLR axis
Cell Signal (2025) 132, 111819-111819. PubMed Europe PubMed DOI
Wang,S., Tian,X., Zhong,Y., Xie,X., Gao,M., Zhang,C., Cheng,X., Qi,Y., Zhong,B., Feng,P., Lan,K. and Zhang,J.
Disrupting the OTUD4-USP7 deubiquitinase complex to suppress herpesvirus replication: a novel antiviral strategy
PLoS Pathog (2025) 21, e1013052-e1013052. PubMed Europe PubMed DOI
Wang,Y., Mu,H., Yang,B., Yang,C., Dong,W. and Wang,J.
USP7 - A novel target for controlling periodontal inflammation through modulation of macrophage polarization
Immunol Lett (2025) 273, 106981-106981. PubMed Europe PubMed DOI
Wolf van der Meer,J., Larue,A., van der Knaap,J.A., Chalkley,G.E., Sijm,A., Beikmohammadi,L., Kozhevnikova,E.N., van der Vaart,A., Tilly,B.C., Bezstarosti,K., Dekkers,D.H.W., Doff,W.A.S., Wetering-Tieleman,P.J., Lanko,K., Barakat,T.S., Allertz,T., van Haren,J., Demmers,J.A.A., Atlasi,Y. and Verrijzer,C.P.
Hao-Fountain syndrome protein USP7 controls neuronal differentiation via BCOR-ncPRC1.1
Genes Dev (2025) PubMed Europe PubMed DOI
Xie,J., Ma,C., Zhao,S., Wu,D., Zhang,P., Tang,Q., Ni,T., Yan,W. and Qi,M.
Deubiquitination by USP7 Stabilizes JunD and Activates AIFM2 (FSP1) to Inhibit Ferroptosis in Melanoma
J Invest Dermatol (2025) PubMed Europe PubMed DOI
Xu,W., Hua,Z., Wang,Y., Tang,W., Ge,W., Chen,Y., Wang,Z., Gu,Y., Liu,C.Y. and Du,P.
Redox-Induced Stabilization of AMBRA1 by USP7 Promotes Intestinal Oxidative Stress and Colitis Through Antagonizing DUB3-Mediated NRF2 Deubiquitination
Adv Sci (Weinh) (2025) , e2411320-e2411320. PubMed Europe PubMed DOI
Xue,Y., Xiu,B., Yang,M., Zhang,Y., Yang,C., Zhang,L., Yan,Y., Luo,X., Huang,Y., Mei,H., Li,G., Zhou,L., Chen,Y., Zhang,W., Qian,C., Zhang,P., Liu,J., Liang,A., Zeng,Y. and Yang,J.
Ubiquitin-Specific Protease 7-Mediated Stabilization of Discoidin Domain Receptor 1 Drives Progression of TP53-Mutant Cancers
J Biol Chem (2025) , 110515-110515. PubMed Europe PubMed DOI
Yang,H., Sun,T., Sun,Z., Wang,H., Liu,D., Wu,D., Qin,T. and Zhou,M.
Unravelling the role of ubiquitin-specific proteases in breast carcinoma: insights into tumour progression and immune microenvironment modulation
World J Surg Oncol (2025) 23, 60-60. PubMed Europe PubMed DOI PMC EPMC V
Yang,H., Liu,X., Nie,J., Wu,S., Ma,L., Jiang,Y., Zhou,L., Deng,W., Dong,Q., Xiong,S., Li,S., Zheng,F., Xie,A., Xu,S. and Fu,B.
USP7 promotes chemotherapy resistance and DNA damage response through stabilizing and deubiquitinating KDM4A in bladder cancer
Cell Death Dis (2025) PubMed Europe PubMed DOI
Yang,J., Chen,Z., Hu,W., Zeng,W., Lei,Z., Tong,X., Li,Q., Luo,G., Hu,K., Chen,Z., Liu,Z., Li,C., Xu,C., Ding,C., Zhang,H.T. and Zhao,J.
Acetylation-dependent USP7-TRIM25 axis drives oncogenic progression in non-small cell lung cancer
Cell Death Dis (2025) 16, 695-695. PubMed Europe PubMed DOI PMC EPMC
Zhu,T.C., He,Z.P., Li,S.T., Zheng,L., Zheng,X.Y., Lan,X.L., Qu,C.H., Nie,R.C., Gu,C., Huang,L.N., Cai,X.X., Xiang,Z.C., Xie,D. and Cai,M.Y.
TAOK1 promotes filament formation in HR repair through phosphorylating USP7
Proc Natl Acad Sci U S A (2025) 122, e2422262122-e2422262122. PubMed Europe PubMed DOI
Zhu,Y., Zong,M., Hu,L., Wan,J., Zong,L. and Xu,J.
USP7 deficiency promotes diabetic wound healing by repressing GATA3-mediated pro-inflammatory macrophage polarization
Mol Cell Endocrinol (2025) , 112489-112489. PubMed Europe PubMed DOI K
Ziemniak,M., Budniak,U., Dominiak,P.M. and Wozniak,K.
Computational analysis of energetic features and intermolecular interactions in protein-inhibitor USP7 complexes
Org Biomol Chem (2025) PubMed Europe PubMed DOI

2024

Al-Eidan,A., Draper,B., Wang,S., Coke,B., Skipp,P., Wang,Y. and Ewing,R.M.
Knockdown proteomics reveals USP7 as a regulator of cell-cell adhesion in colorectal cancer via AJUBA
Mol Cell Proteomics (2024) , 100878-100878. PubMed Europe PubMed DOI K
Alhasan,B.A., Morozov,A.V., Guzhova,I.V. and Margulis,B.A.
The ubiquitin-proteasome system in the regulation of tumor dormancy and recurrence
Biochim Biophys Acta Rev Cancer (2024) 1879, 189119-189119. PubMed Europe PubMed DOI V
Amici,D.R., Alhayek,S., Klein,A.T., Wang,Y.Z., Wilen,A.P., Song,W., Zhu,P., Thakkar,A., King,M.A., Steffeck,A.W., Alasady,M.J., Peek,C., Savas,J.N. and Mendillo,M.L.
Tight regulation of a nuclear HAPSTR1-HUWE1 pathway essential for mammalian life
Life Sci Alliance (2024) 7 PubMed Europe PubMed DOI PMC EPMC
Chen,H., Ferguson,C.J., Mitchell,D.C., Titus,A., Paulo,J.A., Hwang,A., Lin,T.H., Yano,H., Gu,W., Song,S.K., Yuede,C.M., Gygi,S.P., Bonni,A. and Kim,A.H.
The Hao-Fountain syndrome protein USP7 regulates neuronal connectivity in the brain via a novel p53-independent ubiquitin signaling pathway
Cell Rep (2024) 44, 115231-115231. PubMed Europe PubMed DOI PMC EPMC
Chen,J., Jiao,Z., Liu,Y., Zhang,M. and Wang,D.
USP7 interacts with and destabilizes oncoprotein SET
Biochem Biophys Res Commun (2024) 709, 149818-149818. PubMed Europe PubMed DOI
Cheng,Y.J., Zhuang,Z., Miao,Y.L., Song,S.S., Bao,X.B., Yang,C.H. and He,J.X.
Identification of YCH2823 as a novel USP7 inhibitor for cancer therapy
Biochem Pharmacol (2024) 222, 116071-116071. PubMed Europe PubMed DOI K I
Gao,A., Zhang,M., Zhu,S.Q., Zou,S., Chen,H., Li,X., He,C., Zhou,L., Mei,Y., Ding,W., Zhou,J., Zhou,Y. and Cao,Y.
DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1alpha
Cell Death Dis (2024) 15, 171-171. PubMed Europe PubMed DOI PMC EPMC K
Gu,J., Xiao,X., Zou,C., Mao,Y., Jin,C., Fu,D., Li,R. and Li,H.
Ubiquitin-specific protease 7 maintains c-Myc stability to support pancreatic cancer glycolysis and tumor growth
J Transl Med (2024) 22, 1135-1135. PubMed Europe PubMed DOI PMC EPMC
Guan,X., Wang,Y., Yu,W., Wei,Y., Lu,Y., Dai,E., Dong,X., Zhao,B., Hu,C., Yuan,L., Luan,X., Miao,K., Chen,B., Cheng,X.D., Zhang,W. and Qin,J.J.
Blocking Ubiquitin-Specific Protease 7 Induces Ferroptosis in Gastric Cancer via Targeting Stearoyl-CoA Desaturase
Adv Sci (Weinh) (2024) , e2307899-e2307899. PubMed Europe PubMed DOI
Guo,N.J., Wang,B., Zhang,Y., Kang,H.Q., Nie,H.Q., Feng,M.K., Zhang,X.Y., Zhao,L.J., Wang,N., Liu,H.M., Zheng,Y.C., Li,W. and Gao,Y.
USP7 as an emerging therapeutic target: A key regulator of protein homeostasis
Int J Biol Macromol (2024) 263, 130309-130309. PubMed Europe PubMed DOI
Hu,H., Lu,J., Xu,M., Wang,J., Zhang,Y., Yang,S., Wang,X., Wang,M., Xie,W., Xu,W. and Lu,H.
PiR-hsa-23533 promotes malignancy in head and neck squamous cell carcinoma via USP7
Transl Oncol (2024) 45, 101990-101990. PubMed Europe PubMed DOI PMC EPMC
Hu,M., Dai,C., Sun,X., Chen,Y., Xu,N., Lin,Z., Xu,S., Cheng,C., Tan,Z., Bian,S. and Zheng,W.
Ubiquitination-specific protease 7 enhances stemness of hepatocellular carcinoma by stabilizing basic transcription factor 3
Funct Integr Genomics (2024) 24, 28-28. PubMed Europe PubMed DOI K I
Huang,B., Cao,D., Yuan,X., Xiong,Y., Chen,B., Wang,Y., Niu,X., Tian,R. and Huang,H.
USP7 deubiquitinates KRAS and promotes non-small cell lung cancer
Cell Rep (2024) 43, 114917-114917. PubMed Europe PubMed DOI
Huang,M.Y., Hu,S.Y., Dong,J., Deng,L., Andriani,L., Ma,X.Y., Zhang,Y.L., Zhang,F.L., Shao,Z.M. and Li,D.Q.
The DRAP1/DR1 Repressor Complex Increases mTOR Activity to Promote Progression and Confer Everolimus Sensitivity in Triple-Negative Breast Cancer
Cancer Res (2024) 84, 2660-2673. PubMed Europe PubMed DOI
Javaid,S., Zadi,S., Awais,M., Wahab,A.T., Zafar,H., Maslennikov,I. and Choudhary,M.I.
Identification of new leads against ubiquitin specific protease-7 (USP7): a step towards the potential treatment of cancers
RSC Adv (2024) 14, 33080-33093. PubMed Europe PubMed DOI PMC EPMC
Jurisic,A., Sung,P.J., Wappett,M., Daubriac,J., Lobb,I.T., Kung,W.W., Crawford,N., Page,N., Cassidy,E., Feutren-Burton,S., Rountree,J.S.S., Helm,M.D., O'Dowd,C.R., Kennedy,R.D., Gavory,G., Cranston,A.N., Longley,D.B., Jacq,X. and Harrison,T.
USP7 inhibitors suppress tumour neoangiogenesis and promote synergy with immune checkpoint inhibitors by downregulating fibroblast VEGF
Clin Transl Med (2024) 14, e1648-e1648. PubMed Europe PubMed DOI PMC EPMC
Keijzer,N., Priyanka,A., Stijf-Bultsma,Y., Fish,A., Gersch,M. and Sixma,T.K.
Variety in the USP deubiquitinase catalytic mechanism
Life Sci Alliance (2024) 7 PubMed Europe PubMed DOI PMC EPMC
Keshri,S., Vicinanza,M., Takla,M. and Rubinsztein,D.C.
USP7 protects TFEB from proteasome-mediated degradation
Cell Rep (2024) 43, 114872-114872. PubMed Europe PubMed DOI
Kim,D.H., Kim,S.L., Singh,V. and Ramakrishna,S.
Usp7 Regulates Glial Lineage Cell-Specific Transcription Factors by Modulating Histone H2B Monoubiquitination
Int J Stem Cells (2024) 17, 427-436. PubMed Europe PubMed DOI
Klett,T., Schwer,M., Ernst,L.N., Engelhardt,M.U., Jaag,S.J., Masberg,B., Knappe,C., Lammerhofer,M., Gehringer,M. and Boeckler,F.M.
Evaluation of a Covalent Library of Diverse Warheads (CovLib) Binding to JNK3, USP7, or p53
Drug Des Devel Ther (2024) 18, 2653-2679. PubMed Europe PubMed DOI PMC EPMC
Lee,S.H. and Chung,K.C.
Correction: USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7
PLoS ONE (2024) 19, e0297970-e0297970. PubMed Europe PubMed DOI PMC EPMC
Li,H., Sun,Y., Yin,H., Zhang,Y., Yu,J., Hou,N., Wang,P., Liang,H., Xie,A., Wang,X., Dong,J. and Xu,X.
Virtual screening of natural products targeting ubiquitin-specific protease 7
J Biomol Struct Dyn (2024) , 1-8. PubMed Europe PubMed DOI I
Li,J., Zhang,B., Feng,Z., An,D., Zhou,Z., Wan,C., Hu,Y., Sun,Y., Wang,Y., Liu,X., Wei,W., Yang,X., Meng,J., Che,M., Sheng,Y., Wu,B., Wen,L., Huang,F., Li,Y. and Yang,K.
Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis
J Exp Clin Cancer Res (2024) 43, 28-28. PubMed Europe PubMed DOI K
Li,W., Shen,Y., Yang,C., Ye,F., Liang,Y., Cheng,Z., Ou,Y., Chen,W., Chen,Z., Zou,L., Liu,Y., Hu,Y., Yan,X. and Jiang,H.
Identification of a novel ferroptosis-inducing micropeptide in bladder cancer
Cancer Lett (2024) 582, 216515-216515. PubMed Europe PubMed DOI
Li,Y., Sun,X. and Huang,Z.
USP7 facilitates deubiquitination of LRRC42 in colorectal cancer to accelerate tumorigenesis and augment Wnt/beta-catenin signaling
Biochim Biophys Acta Mol Cell Res (2024) 1872, 119859-119859. PubMed Europe PubMed DOI
Li,Z., Zhou,G., Li,Q., Jiang,L., He,J. and Ye,C.
USP7 promotes decidualization of ESCs by STAT3/PR axis during early pregnancy
Mol Cell Endocrinol (2024) 580, 112090-112090. PubMed Europe PubMed DOI
Li,Z., Wang,Z., Zhong,C., Zhang,H., Liu,R., An,P., Ma,Z., Lu,J., Pan,C., Zhang,Z., Cao,Z., Hu,J., Xing,D., Fei,Y., Ding,Y. and Lu,B.
P53 upregulation by USP7-engaging molecular glues
Sci Bull (Beijing) (2024) 69, 1936-1953. PubMed Europe PubMed DOI I
Liu,J., Hu,X., Luo,K., Xiong,Y., Chen,L., Wang,Z., Inuzuka,H., Qian,C., Yu,X., Xie,L., Muneer,A., Zhang,D., Paulo,J.A., Chen,X., Jin,J. and Wei,W.
USP7-Based Deubiquitinase-Targeting Chimeras Stabilize AMPK
J Am Chem Soc (2024) PubMed Europe PubMed DOI
Liu,J., Cao,L., Wang,Y., Zou,Y., Guo,Q., Chen,S., Jiang,B., Wu,X., Zheng,L., Zhang,S., Lu,S., Zhou,K., Jiang,P., Xiao,Y., Yang,R., Dong,S., Li,Z., Chen,D., Zhang,Y., Zhang,N., Sun,G., Xing,C., Song,X., Wang,Z. and Cao,L.
The phosphorylation-deubiquitination positive feedback loop of the CHK2-USP7 axis stabilizes p53 under oxidative stress
Cell Rep (2024) 43, 114366-114366. PubMed Europe PubMed DOI
Liu,X., Lu,R., Yang,Q., He,J., Huang,C., Cao,Y., Zhou,Z., Huang,J., Li,L., Chen,R., Wang,Y., Huang,J., Xie,R., Zhao,X. and Yu,J.
USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression
Mol Oncol (2024) 18, 170-189. PubMed Europe PubMed DOI PMC EPMC
Liu,X., Zheng,W., Zhang,L., Cao,Z., Cong,X., Hu,Q., Hou,J., Jin,X., Yuan,Q., Lin,L., Tan,J., Lu,J., Zhang,Y. and Zhang,N.
Arginine methylation-dependent cGAS stability promotes non-small cell lung cancer cell proliferation
Cancer Lett (2024) 586, 216707-216707. PubMed Europe PubMed DOI
Lv,H., Yu,J., Qian,X., Shu,J., Qian,Q., Shen,L., Shi,D., Tao,Z., Fan,G., Zhuang,B. and Lu,B.
USP7 upregulated by TGF-beta1 promotes ferroptosis via inhibiting LATS1-YAP axis in sepsis-induced acute lung injury
iScience (2024) 27, 109667-109667. PubMed Europe PubMed DOI PMC EPMC K
Malla,S., Kumari,K., Garcia-Prieto,C.A., Caroli,J., Nordin,A., Phan,T.T.T., Bhattarai,D.P., Martinez-Gamero,C., Dorafshan,E., Stransky,S., Alvarez-Errico,D., Saiki,P.A., Lai,W., Lyu,C., Lizana,L., Gilthorpe,J.D., Wang,H., Sidoli,S., Mateus,A., Lee,D.F., Cantu,C., Esteller,M., Mattevi,A., Roman,A.C. and Aguilo,F.
The scaffolding function of LSD1 controls DNA methylation in mouse ESCs
Nat Commun (2024) 15, 7758-7758. PubMed Europe PubMed DOI PMC EPMC
Meng,Y., Lin,W., Wang,N., Wei,X., Mei,P., Wang,X., Zhang,C., Huang,Q. and Liao,Y.
USP7-mediated ERbeta stabilization mitigates ROS accumulation and promotes osimertinib resistance by suppressing PRDX3 SUMOylation in non-small cell lung carcinoma
Cancer Lett (2024) 582, 216587-216587. PubMed Europe PubMed DOI
Miao,Y., Zhang,T., Guan,M., Zhao,Q., Zhang,R., Liu,X., Ma,T., Ren,T., Zheng,Z., He,W., Tian,W., Cui,Q., Zhai,X., Zuo,Y., Zhu,H., Zheng,H. and Yuan,Y.
DDX4 enhances antiviral activity of type I interferon by disrupting interaction of USP7/SOCS1 and promoting degradation of SOCS1
MBio (2024) 15, e0321323-e0321323. PubMed Europe PubMed DOI PMC EPMC
Ojedele,O.A., Umar,H.I., Baammi,S., Metouekel,A., Mengistie,A.A., Bin Jardan,Y.A., Shazly,G.A. and Victor,O.
Cheminformatics-aided discovery of potential allosteric site modulators of ubiquitin-specific protease 7
Sci Rep (2024) 14, 24995-24995. PubMed Europe PubMed DOI PMC EPMC
Ryu,E., Yoo,J., Kang,M.S., Ha,N.Y., Jang,Y., Kim,J., Kim,Y., Kim,B.G., Kim,S., Myung,K. and Kang,S.
ATAD5 functions as a regulatory platform for Ub-PCNA deubiquitination
Proc Natl Acad Sci U S A (2024) 121, e2315759121-e2315759121. PubMed Europe PubMed DOI
Shao,Z.Y., Yang,W.D., Qiu,H., He,Z.H., Lu,M.R., Shen,Q., Ding,J., Zheng,J.N. and Bai,J.
The role of USP7-YY1 interaction in promoting colorectal cancer growth and metastasis
Cell Death Dis (2024) 15, 347-347. PubMed Europe PubMed DOI PMC EPMC
Su,C., Zhang,H., Mo,J., Liao,Z., Zhang,B. and Zhu,P.
SP1-activated USP27X-AS1 promotes hepatocellular carcinoma progression via USP7-mediated AKT stabilisation
Clin Transl Med (2024) 14, e1563-e1563. PubMed Europe PubMed DOI PMC EPMC
Sun,L.L., Zhao,L.N., Sun,J., Yuan,H.F., Wang,Y.F., Hou,C.Y., Lv,P., Zhang,H.H., Yang,G., Zhang,N.N., Zhang,X.D. and Lu,W.
Inhibition of USP7 enhances CD8(+) T cell activity in liver cancer by suppressing PRDM1-mediated FGL1 upregulation
Acta Pharmacol Sin (2024) 45, 1686-1700. PubMed Europe PubMed DOI K
Sun,M., Li,Q., Zhang,Y., Cai,Y., Dong,Y., Shu,J., Li,D. and Cai,C.
Identification of Two Variants c.2697A > C and c.3305A > C in USP7 by Analysis of Whole-Exome Sequencing in Chinese Patients with Hao-Fountain Syndrome
Glob Med Genet (2024) 11, 13-19. PubMed Europe PubMed DOI PMC EPMC
Sun,Y.J., Zhang,Q., Cao,S.J., Sun,X.H., Zhang,J.C., Zhang,B.Y., Shang,Z.B., Zhao,C.Y., Cao,Z.Y., Zhang,Q.J., Gao,X.M., Qiu,F. and Kang,N.
Tetrahydrocurcumin targets TRIP13 inhibiting the interaction of TRIP13/USP7/c-FLIP to mediate c-FLIP ubiquitination in triple-negative breast cancer
J Adv Res (2024) PubMed Europe PubMed DOI K
Tang,F., Gong,H., Ke,T., Yang,W., Yang,Y. and Liu,Z.
USP7 Promotes TGF-beta1 Signaling by De-Ubiquitinating Smad2/Smad3 in Pulmonary Fibrosis
Discov Med (2024) 36, 1616-1626. PubMed Europe PubMed DOI K
Tang,K., Yin,T., Deng,B., Wang,M., Ren,Z., Wang,S., Liu,X., Li,H., Wang,J., Du,Y., Zhou,J., Chen,Y. and Wang,Y.
USP7 deubiquitinates epigenetic reader ZMYND8 to promote breast cancer cell migration and invasion
J Biol Chem (2024) , 107672-107672. PubMed Europe PubMed DOI
Tao,R., Liu,Z., Zhang,Z. and Zhang,Z.
USP3 promotes cisplatin resistance in non-small cell lung cancer cells by suppressing ACOT7-regulated ferroptosis
Anticancer Drugs (2024) 35, 483-491. PubMed Europe PubMed DOI
Tu,R., Ma,J., Chen,Y., Kang,Y., Ren,D., Cai,Z., Zhang,R., Pan,Y., Liu,Y., Da,Y., Xu,Y., Yu,Y., Wang,D., Wang,J., Dong,Y., Lu,X. and Zhang,C.
USP7 depletion potentiates HIF2alpha degradation and inhibits clear cell renal cell carcinoma progression
Cell Death Dis (2024) 15, 749-749. PubMed Europe PubMed DOI PMC EPMC
Vasas,A., Ivanschitz,L., Molnar,B., Kiss,A., Baker,L., Fiumana,A., Macias,A., Murray,J.B., Sanders,E., Whitehead,N., Hubbard,R.E., Saunier,C., Monceau,E., Girard,A.M., Rousseau,M., Chanrion,M., Demarles,D., Geneste,O., Weber,C., Lewkowicz,E. and Kotschy,A.
Structure-Guided Discovery of Selective USP7 Inhibitors with In Vivo Activity
J Med Chem (2024) 67, 18993-19009. PubMed Europe PubMed DOI
Vogt,M., Classen,S., Krause,A.K., Peter,N.J., Petersen,C., Rothkamm,K., Borgmann,K. and Meyer,F.
USP7 Deregulation Impairs S Phase Specific DNA Repair after Irradiation in Breast Cancer Cells
Biomedicines (2024) 12 PubMed Europe PubMed DOI PMC EPMC
Wang,L., Li,N., Wang,Y. and Chen,X.
Esculin alleviates lipopolysaccharide (LPS)-induced pneumonia by regulating the USP7/MAPK14 axis
J Appl Toxicol (2024) 44, 1949-1961. PubMed Europe PubMed DOI
Wang,N., Xu,J., Wang,Y., Zhang,X. and Zhang,H.
USP7 promotes cervical cancer progression by stabilizing MTDH expression through deubiquitination
J Cancer Res Clin Oncol (2024) 150, 196-196. PubMed Europe PubMed DOI PMC EPMC K
Wang,S., Tian,X., Zhou,Y., Xie,J., Gao,M., Zhong,Y., Zhang,C., Yu,K., Bai,L., Qin,Q., Zhong,B., Lin,D., Feng,P., Lan,K. and Zhang,J.
Non-canonical regulation of the reactivation of an oncogenic herpesvirus by the OTUD4-USP7 deubiquitinases
PLoS Pathog (2024) 20, e1011943-e1011943. PubMed Europe PubMed DOI PMC EPMC
Wang,Y., Gu,Y.H., Ren,K.W., Xie,X., Wang,S.H., Zhu,X.X., Wang,L., Yang,X.L. and Bi,H.L.
Administration of USP7 inhibitor p22077 alleviates Angiotensin II (Ang II)-induced atrial fibrillation in Mice
Hypertens Res (2024) 47, 1309-1322. PubMed Europe PubMed DOI I
Xu,Q., Kong,F., Zhao,G., Jin,J., Feng,S. and Li,M.
USP7 alleviates neuronal inflammation and apoptosis in spinal cord injury via deubiquitinating NRF1/KLF7 axis
Neurol Res (2024) , 1-10. PubMed Europe PubMed DOI K
Yan,M., Su,L., Wu,K., Mei,Y., Liu,Z., Chen,Y., Zeng,W., Xiao,Y., Zhang,J., Cai,G. and Bai,Y.
USP7 promotes cardiometabolic disorders and mitochondrial homeostasis dysfunction in diabetic mice via stabilizing PGC1beta
Pharmacol Res (2024) 205, 107235-107235. PubMed Europe PubMed DOI
Yan,M., Mei,Y., Zhang,T., Liu,Z., Su,L., Xiao,Y., Zhong,X. and Lu,Y.
USP7 cardiomyocyte specific knockout causes disordered mitochondrial biogenesis and dynamics and early neonatal lethality in mice
Int J Cardiol (2024) 408, 132149-132149. PubMed Europe PubMed DOI
Yang,Z. and Nicholas,J.
Biologically significant interaction of human herpesvirus 8 viral interferon regulatory factor 4 with ubiquitin-specific protease 7
J Virol (2024) , e0025524-e0025524. PubMed Europe PubMed DOI
Yang,Z., Yu,W., Xu,A., Liu,B., Jin,L., Tao,H. and Wang,D.
mTORC1 accelerates osteosarcoma progression via m(6)A-dependent stabilization of USP7 mRNA
Cell Death Discov (2024) 10, 127-127. PubMed Europe PubMed DOI PMC EPMC
Yin,Y., Li,Y., Ma,B., Ren,C., Zhao,S., Li,J., Gong,Y., Yang,H. and Li,J.
Mitochondrial-Derived Peptide MOTS-c Suppresses Ovarian Cancer Progression by Attenuating USP7-Mediated LARS1 Deubiquitination
Adv Sci (Weinh) (2024) , e2405620-e2405620. PubMed Europe PubMed DOI
Yu,T., Zhao,X., Tang,Y., Zhang,Y., Ji,B., Song,W. and Su,J.
Deubiquitylase USP7 plays a crucial role in the lineage differentiation of preimplantation blastocysts
Biol Reprod (2024) 111, 28-42. PubMed Europe PubMed DOI I
Yuan,S., Wang,Z., Yao,S., Wang,Y., Xie,Z., Wang,J., Yu,X., Song,Y., Cui,X., Zhou,J. and Ge,J.
Knocking out USP7 attenuates cardiac fibrosis and endothelial-to-mesenchymal transition by destabilizing SMAD3 in mice with heart failure with preserved ejection fraction
Theranostics (2024) 14, 5793-5808. PubMed Europe PubMed DOI PMC EPMC
Zadi,S., Javaid,S., Atia,T.W., Zafar,H., Awais,M., Maslennikov,I. and Choudhary,M.I.
Repurposing of US-FDA-approved drugs as negative modulators of ubiquitin specific protease-7 (USP7)
Heliyon (2024) 10, e26345-e26345. PubMed Europe PubMed DOI PMC EPMC
Zhang,B., Li,J., Wang,Y., Liu,X., Yang,X., Liao,Z., Deng,S., Deng,Y., Zhou,Z., Tian,Y., Wei,W., Meng,J., Hu,Y., Wan,C., Zhang,Z., Huang,F., Wen,L., Wu,B., Sun,Y., Li,Y. and Yang,K.
Deubiquitinase USP7 stabilizes KDM5B and promotes tumor progression and cisplatin resistance in nasopharyngeal carcinoma through the ZBTB16/TOP2A axis
Cell Death Differ (2024) 31, 309-321. PubMed Europe PubMed DOI PMC EPMC
Zhang,N., Wang,F., Yang,X., Wang,Q., Chang,R., Zhu,L., Feitelson,M.A. and Chen,Z.
TMEM43 promotes the development of hepatocellular carcinoma by activating VDAC1 through USP7 deubiquitination
Transl Gastroenterol Hepatol (2024) 9, 9-9. PubMed Europe PubMed DOI PMC EPMC
Zhang,R., Zhang,D., Han,F., Song,X., Zhang,Y., Zhang,J., Zhu,Q. and Qin,Y.
The deubiquitinase USP7 and E3 ligase TRIM21 regulate vasculogenic mimicry and malignant progression of RMS by balancing SNAI2 homeostasis
J Exp Clin Cancer Res (2024) 43, 135-135. PubMed Europe PubMed DOI PMC EPMC
Zhang,S., Meng,N., Liu,S., Ruan,J., Li,H., Xu,X., Ruan,Q. and Xie,W.
Targeting senescent HDF with the USP7 inhibitor P5091 to enhance DFU wound healing through the p53 pathway
Biochem Biophys Res Commun (2024) 722, 150149-150149. PubMed Europe PubMed DOI I
Zhang,Y., Dou,W., Zhao,Z., Li,G., Li,C., Chen,X. and Mou,L.
Stereo-selectivity of enantiomeric inhibitors to ubiquitin-specific protease 7 (USP7) dissected by molecular docking, molecular dynamics simulations, and binding free energy calculations
Mol Divers (2024) PubMed Europe PubMed DOI
Zhao,B., Xia,Z., Yang,B., Guo,Y., Zhou,R., Gu,M., Liu,M., Li,Q., Bai,W., Huang,J., Zhang,X., Zhu,C., Leung,K.T., Chen,C. and Dong,J.
USP7 promotes IgA class switching through stabilizing RUNX3 for germline transcription activation
Cell Rep (2024) 43, 114194-114194. PubMed Europe PubMed DOI
Zhu,Y., Zhang,X., Gao,M., Huang,Y., Tan,Y., Parnas,A., Wu,S., Zhan,D., Adar,S. and Hu,J.
Coordination of transcription-coupled repair and repair-independent release of lesion-stalled RNA polymerase II
Nat Commun (2024) 15, 7089-7089. PubMed Europe PubMed DOI PMC EPMC
Zhuang,Z., Miao,Y.L., Song,S.S., Leng,G.T., Zhang,X.F., He,Q., Ding,J., He,J.X. and Yang,C.H.
Discovery of pyrrolo[2,3-d]pyrimidin-4-one derivative YCH3124 as a potent USP7 inhibitor for cancer therapy
Eur J Med Chem (2024) 277, 116752-116752. PubMed Europe PubMed DOI I

2023

Barbeito,P., Martin-Morales,R., Palencia-Campos,A., Cerrolaza,J., Rivas-Santos,C., Gallego-Colastra,L., Caparros-Martin,J.A., Martin-Bravo,C., Martin-Hurtado,A., Sanchez-Bellver,L., Marfany,G., Ruiz-Perez,V.L. and Garcia-Gonzalo,F.R.
EVC-EVC2 complex stability and ciliary targeting are regulated by modification with ubiquitin and SUMO
Front Cell Dev Biol (2023) 11, 1190258-1190258. PubMed Europe PubMed DOI PMC EPMC
Carreira,L.D., Oliveira,R.I., Moreira,V.M. and Salvador,J.A.R.
Ubiquitin-specific protease 7 (USP7): an emerging drug target for cancer treatment
Expert Opin Ther Targets (2023) 27, 1043-1058. PubMed Europe PubMed DOI
Chang,Y., Chen,L., Tang,J., Chen,G., Ji,J. and Xu,M.
USP7-mediated JUND suppresses RCAN2 transcription and elevates NFATC1 to enhance stem cell property in colorectal cancer
Cell Biol Toxicol (2023) 39, 3121-3140. PubMed Europe PubMed DOI K
Chang,Y.C., Lin,K., Baxley,R.M., Durrett,W., Wang,L., Stojkova,O., Billmann,M., Ward,H., Myers,C.L. and Bielinsky,A.K.
RNF4 and USP7 cooperate in ubiquitin-regulated steps of DNA replication
Open Biol (2023) 13, 230068-230068. PubMed Europe PubMed DOI PMC EPMC
Ghoreshi,Z.A., Molaei,H.R. and Arefinia,N.
The Role of DNA Viruses in Human Cancer
Cancer Inform (2023) 22, 11769351231154186-11769351231154186. PubMed Europe PubMed DOI PMC EPMC V
He,Y., Jiang,S., Zhong,Y., Wang,X., Cui,Y., Liang,J., Sun,Y., Zhu,Z., Huang,Z. and Mao,X.
USP7 promotes non-small-cell lung cancer cell glycolysis and survival by stabilizing and activating c-Abl
Clin Transl Med (2023) 13, e1509-e1509. PubMed Europe PubMed DOI PMC EPMC K
Kumagai,J., Kiuchi,M., Kokubo,K., Yagyu,H., Nemoto,M., Tsuji,K., Nagahata,K., Sasaki,A., Hishiya,T., Onoue,M., Shinmi,R., Sonobe,Y., Iinuma,T., Yonekura,S., Shinga,J., Hanazawa,T., Koseki,H., Nakayama,T., Yokote,K. and Hirahara,K.
The USP7-STAT3-granzyme-Par-1 axis regulates allergic inflammation by promoting differentiation of IL-5-producing Th2 cells
Proc Natl Acad Sci U S A (2023) 120, e2302903120-e2302903120. PubMed Europe PubMed DOI PMC EPMC
Le Clorennec,C., Lee,K., Huo,Y. and Zage,P.E.
USP7 Inhibition Suppresses Neuroblastoma Growth via Induction of p53-Mediated Apoptosis and EZH2 and N-Myc Downregulation
Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Lee,S.H. and Chung,K.C.
USP7 attenuates endoplasmic reticulum stress-induced apoptotic cell death through deubiquitination and stabilization of FBXO7
PLoS ONE (2023) 18, e0290371-e0290371. PubMed Europe PubMed DOI PMC EPMC
Li,X., Yang,F., He,N., Zhang,M., Lv,Y., Yu,Y., Dong,Q., Hou,X., Hao,Y., An,Z., Zhang,H., Yang,Z., Zhai,H., Guo,D., Cao,Z., Jiang,V.C. and Chen,Y.
YM155 inhibits neuroblastoma growth through degradation of MYCN: A new role as a USP7 inhibitor
Eur J Pharm Sci (2023) 181, 106343-106343. PubMed Europe PubMed DOI
Lin,Y.C., Zheng,G., Liu,H.T., Wang,P., Yuan,W.Q., Zhang,Y.H., Peng,X.S., Li,G.J., Wu,Y.F. and Shen,H.Y.
USP7 promotes the osteoclast differentiation of CD14+ human peripheral blood monocytes in osteoporosis via HMGB1 deubiquitination
J Orthop Translat (2023) 40, 80-91. PubMed Europe PubMed DOI PMC EPMC K I
Liu,C., Sun,L., Tan,Y., Wang,Q., Luo,T., Li,C., Yao,N., Xie,Y., Yi,X., Zhu,Y., Guo,T. and Ji,J.
USP7 represses lineage differentiation genes in mouse embryonic stem cells by both catalytic and noncatalytic activities
Sci Adv (2023) 9, eade3888-eade3888. PubMed Europe PubMed DOI PMC EPMC
Liu,J., Zhou,T., Dong,X., Guo,Q., Zheng,L., Wang,X., Zhang,N., Li,D., Ren,L., Yi,F., Zhang,Y., Li,Z., Wang,X., Deng,C., Li,C., Xu,H., Guan,Y., Li,X., Yu,Y., Guo,W., Wang,Z., Jiang,B., Wu,X., Bai,N., Feng,Y., Ma,M., Kong,Q., Wei,J., Wang,Z., Li,H., Lu,S., Cao,L., Xiao,Y., Song,X., Wang,Z., Xing,C. and Cao,L.
De-ubiquitination of SAMHD1 by USP7 promotes DNA damage repair to overcome oncogenic stress and affect chemotherapy sensitivity
Oncogene (2023) 42, 1843-1856. PubMed Europe PubMed DOI PMC EPMC
Liu,N., Lin,M.M. and Wang,Y.
The Emerging Roles of E3 Ligases and DUBs in Neurodegenerative Diseases
Mol Neurobiol (2023) 60, 247-263. PubMed Europe PubMed DOI PMC EPMC V
Manea,T., Nelson,J.K., Garrone,C.M., Hansson,K., Evans,I., Behrens,A. and Sancho,R.
USP7 controls NGN3 stability and pancreatic endocrine lineage development
Nat Commun (2023) 14, 2457-2457. PubMed Europe PubMed DOI PMC EPMC
Morretta,E., Brullo,C., Belvedere,R., Petrella,A., Spallarossa,A. and Monti,M.C.
Targeting USP-7 by a Novel Fluorinated 5-Pyrazolyl-Urea Derivative
Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Park,H.B. and Baek,K.H.
Current and future directions of USP7 interactome in cancer study
Biochim Biophys Acta Rev Cancer (2023) 1878, 188992-188992. PubMed Europe PubMed DOI V
Park,H.B., Min,Y., Hwang,S. and Baek,K.H.
Suppression of USP7 negatively regulates the stability of ETS proto-oncogene 2 protein
Biomed Pharmacother (2023) 162, 114700-114700. PubMed Europe PubMed DOI
Peng,Q., Shi,X., Li,D., Guo,J., Zhang,X., Zhang,X. and Chen,Q.
SCML2 contributes to tumor cell resistance to DNA damage through regulating p53 and CHK1 stability
Cell Death Differ (2023) 30, 1849-1867. PubMed Europe PubMed DOI PMC EPMC
Peng,Y., Tang,R., Ding,L., Zheng,R., Liu,Y., Yin,L., Fu,Y., Deng,T. and Li,X.
Diosgenin inhibits prostate cancer progression by inducing UHRF1 protein degradation
Eur J Pharmacol (2023) 942, 175522-175522. PubMed Europe PubMed DOI
Saha,G., Roy,S., Basu,M. and Ghosh,M.K.
USP7 - a crucial regulator of cancer hallmarks
Biochim Biophys Acta Rev Cancer (2023) 1878, 188903-188903. PubMed Europe PubMed DOI V
Wang,C., Zhu,Y., Zhu,X., Chen,R., Zhang,X. and Lian,N.
USP7 regulates HMOX-1 via deubiquitination to suppress ferroptosis and ameliorate spinal cord injury in rats
Neurochem Int (2023) 168, 105554-105554. PubMed Europe PubMed DOI
Wang,N., Li,T., Liu,W., Lin,J., Zhang,K., Li,Z., Huang,Y., Shi,Y., Xu,M. and Liu,X.
USP7- and PRMT5-dependent G3BP2 stabilization drives de novo lipogenesis and tumorigenesis of HNSC
Cell Death Dis (2023) 14, 182-182. PubMed Europe PubMed DOI PMC EPMC
Wang,X., Zou,C., Hou,C., Bian,Z., Jiang,W., Li,M. and Zhu,L.
Extracellular vesicles from bone marrow mesenchymal stem cells alleviate osteoporosis in mice through USP7-mediated YAP1 protein stability and the Wnt/beta-catenin pathway
Biochem Pharmacol (2023) 217, 115829-115829. PubMed Europe PubMed DOI
Wang,Y., Luo,X., Wu,N., Liao,Q. and Wang,J.
USP7 mediates TRAF4 deubiquitination to facilitate the malignant phenotype of ovarian cancer via the RSK4/PI3K/AKT axis
J Cancer Res Ther (2023) 19, 97-107. PubMed Europe PubMed DOI K
Xia,C., Xiao,C., Luk,H.Y., Chan,P.K.S. and Boon,S.S.
The ubiquitin specific protease 7 stabilizes HPV16E7 to promote HPV-mediated carcinogenesis
Cell Mol Life Sci (2023) 80, 278-278. PubMed Europe PubMed DOI
Xie,Z., Wu,Y., Shen,Y., Guo,J., Yuan,P., Ma,Q., Wang,S., Jie,Z., Zhou,H., Fan,S. and Chen,S.
USP7 Inhibits Osteoclastogenesis via Dual Effects of Attenuating TRAF6/TAK1 Axis and Stimulating STING Signaling
Aging Dis (2023) 14, 2267-2283. PubMed Europe PubMed DOI
Xu,J., Wang,Y., Zhang,J., Abdelmoneim,A.A., Liang,Z., Wang,L., Jin,J., Dai,Q. and Ye,F.
Elastic network models and molecular dynamic simulations reveal the molecular basis of allosteric regulation in ubiquitin-specific protease 7 (USP7)
Comput Biol Med (2023) 162, 107068-107068. PubMed Europe PubMed DOI
Yi,J., Li,H., Chu,B., Kon,N., Hu,X., Hu,J., Xiong,Y., Kaniskan,H.U., Jin,J. and Gu,W.
Inhibition of USP7 induces p53-independent tumor growth suppression in triple-negative breast cancers by destabilizing FOXM1
Cell Death Differ (2023) 30, 1799-1810. PubMed Europe PubMed DOI PMC EPMC K
Zhang,K., Sun,T., Li,W., Guo,Y., Li,A., Hsieh,M., Wang,J., Wu,J., Arvanitis,L. and Raz,D.J.
Inhibition of USP7 upregulates USP22 and activates its downstream cancer-related signaling pathways in human cancer cells
Cell Commun Signal (2023) 21, 319-319. PubMed Europe PubMed DOI PMC EPMC K
Zhang,S.Y., Ruan,J.J., Jin,D.M., Chen,N., Xie,W.G. and Ruan,Q.F.
[Pan-cancer analysis of ubiquitin-specific protease 7 and its expression changes in the carcinogenesis of scar ulcer]
Zhonghua Shao Shang Za Zhi (2023) 39, 518-526. PubMed Europe PubMed DOI
Zhang,X., Xie,X.F., Li,A., Song,W., Li,C., Li,F., Li,X.Z., Fan,X.Y., Zhou,C.Y., Wang,G., Sun,Q.Y. and Ou,X.H.
USP7 reduction leads to developmental failure of mouse early embryos
Exp Cell Res (2023) 427, 113605-113605. PubMed Europe PubMed DOI K
Zhou,H., Feng,W., Yu,J., Shafiq,T.A., Paulo,J.A., Zhang,J., Luo,Z., Gygi,S.P. and Moazed,D.
SENP3 and USP7 regulate Polycomb-rixosome interactions and silencing functions
Cell Rep (2023) 42, 112339-112339. PubMed Europe PubMed DOI
Zhou,M., Gao,Y., Wu,S., Chen,J., Ding,J., Wang,Y. and Yang,J.
Ubiquitin-specific protease 7 prevents recurrent spontaneous abortion by targeting enhancer of zeste homolog 2 to regulate trophoblast proliferation, apoptosis, migration, and invasion through the Wnt/beta-catenin pathwaydagger
Biol Reprod (2023) 109, 204-214. PubMed Europe PubMed DOI K I

2022

Dong,B., Ding,C., Xiang,H., Zheng,J., Li,X., Xue,W. and Li,Y.
USP7 accelerates FMR1-mediated ferroptosis by facilitating TBK1 ubiquitination and DNMT1 deubiquitination after renal ischemia-reperfusion injury
Inflamm Res (2022) 71, 1519-1533. PubMed Europe PubMed DOI K
Dong,X., Yang,C., Luo,Y., Dong,W., Xu,X., Wu,Y. and Wang,J.
USP7 Attenuates Endoplasmic Reticulum Stress and NF-kappaB Signaling to Modulate Chondrocyte Proliferation, Apoptosis, and Inflammatory Response under Inflammation
Oxid Med Cell Longev (2022) 2022, 1835900-1835900. PubMed Europe PubMed DOI PMC EPMC K
Gao,M., Qi,Z., Deng,M., Huang,H., Xu,Z., Guo,G., Jing,J., Huang,X., Xu,M., Kloeber,J.A., Liu,S., Huang,J., Lou,Z. and Han,J.
The deubiquitinase USP7 regulates oxidative stress through stabilization of HO-1
Oncogene (2022) 41, 4018-4027. PubMed Europe PubMed DOI
Gong,X., Li,Y., He,Y. and Zhou,F.
USP7-SOX9-miR-96-5p-NLRP3 Network Regulates Myocardial Injury and Cardiomyocyte Pyroptosis in Sepsis
Hum Gene Ther (2022) , 1-18. PubMed Europe PubMed DOI
Gu,Y.H., Ren,K.W., Wang,Y., Wang,S.H., Yu,X.H., Xu,L.W., Li,H.H. and Bi,H.L.
Administration of USP7 inhibitor P22077 inhibited cardiac hypertrophy and remodeling in Ang II-induced hypertensive mice
Front Pharmacol (2022) 13, 1021361-1021361. PubMed Europe PubMed DOI PMC EPMC I
Huang,Q., Qin,D., Pei,D., Vermeulen,M. and Zhang,X.
UBE2O and USP7 co-regulate RECQL4 ubiquitinylation and homologous recombination-mediated DNA repair
FASEB J (2022) 36, e22112-e22112. PubMed Europe PubMed DOI
Kordon,M.M., Arron,S., Cleaver,J.E., Bezrookove,V., Karentz,D., Lu,B., Perr,E., Chang,D. and Pederson,T.
The UVSSA protein is part of a genome integrity homeostasis network with links to transcription-coupled DNA repair and ATM signaling
Proc Natl Acad Sci U S A (2022) 119, e2116254119-e2116254119. PubMed Europe PubMed DOI PMC EPMC
Korenev,G., Yakukhnov,S., Druk,A., Golovina,A., Chasov,V., Mirgayazova,R., Ivanov,R. and Bulatov,E.
USP7 Inhibitors in Cancer Immunotherapy: Current Status and Perspective
Cancers (Basel) (2022) 14 PubMed Europe PubMed DOI PMC EPMC V
Li,J., Dai,Y., Ge,H., Guo,S., Zhang,W., Wang,Y., Liu,L., Cheng,J. and Jiang,H.
The deubiquitinase USP7 promotes HNSCC progression via deubiquitinating and stabilizing TAZ
Cell Death Dis (2022) 13, 677-677. PubMed Europe PubMed DOI PMC EPMC K
Li,N., Geng,F., Liang,S.M. and Qin,X.
USP7 inhibits TIMP2 by up-regulating the expression of EZH2 to activate the NF-kappaB/PD-L1 axis to promote the development of cervical cancer
Cell Signal (2022) 96, 110351-110351. PubMed Europe PubMed DOI
Li,P., Liu,Y. and Liu,H.M.
A patent review of ubiquitin-specific protease 7 (USP7) inhibitors (2014-present)
Expert Opin Ther Pat (2022) 32, 753-767. PubMed Europe PubMed DOI
Li,Y.C., Cai,S.W., Shu,Y.B., Chen,M.W. and Shi,Z.
USP15 in Cancer and Other Diseases: From Diverse Functionsto Therapeutic Targets
Biomedicines (2022) 10 PubMed Europe PubMed DOI PMC EPMC
Lin,Y.T., Lin,J., Liu,Y.E., Chen,Y.C., Liu,S.T., Hsu,K.W., Chen,D.R. and Wu,H.T.
USP7 Induces Chemoresistance in Triple-Negative Breast Cancer via Deubiquitination and Stabilization of ABCB1
Cells (2022) 11 PubMed Europe PubMed DOI PMC EPMC K
Nie,L., Wang,C., Liu,X., Teng,H., Li,S., Huang,M., Feng,X., Pei,G., Hang,Q., Zhao,Z., Gan,B., Ma,L. and Chen,J.
USP7 substrates identified by proteomics analysis reveal the specificity of USP7
Genes Dev (2022) 36, 1016-1030. PubMed Europe PubMed DOI PMC EPMC
Niu,H., Zhu,Y., Wang,J., Wang,T., Wang,X. and Yan,L.
Effects of USP7 on radiation sensitivity through p53 pathway in laryngeal squamous cell carcinoma
Transl Oncol (2022) 22, 101466-101466. PubMed Europe PubMed DOI PMC EPMC K
Park,H.B., Hwang,S. and Baek,K.H.
USP7 regulates the ERK1/2 signaling pathway through deubiquitinating Raf-1 in lung adenocarcinoma
Cell Death Dis (2022) 13, 698-698. PubMed Europe PubMed DOI PMC EPMC
Pei,Y., Fu,J., Shi,Y., Zhang,M., Luo,G., Luo,X., Song,N., Mi,T., Yang,Y., Li,J., Zhou,Y. and Zhou,B.
Discovery of a Potent and Selective Degrader for USP7
Angew Chem Int Ed Engl (2022) 61, e202204395-e202204395. PubMed Europe PubMed DOI
Pereira,T., Abbasi,M., Oliveira,R.I., Guedes,R.A., Salvador,J.A.R. and Arrais,J.P.
Deep generative model for therapeutic targets using transcriptomic disease-associated data-USP7 case study
Brief Bioinform (2022) 23 PubMed Europe PubMed DOI
Qiao,H., Tian,Y., Huo,Y. and Man,H.Y.
Role of the DUB enzyme USP7 in dendritic arborization, neuronal migration, and autistic-like behaviors in mice
iScience (2022) 25, 104595-104595. PubMed Europe PubMed DOI PMC EPMC K
Qin,W., Steinek,C., Kolobynina,K., Forne,I., Imhof,A., Cardoso,M.C. and Leonhardt,H.
Probing protein ubiquitination in live cells
Nucleic Acids Res (2022) 50, e125-e125. PubMed Europe PubMed DOI PMC EPMC
Saha,G., Sarkar,S., Mohanta,P.S., Kumar,K., Chakrabarti,S., Basu,M. and Ghosh,M.K.
USP7 targets XIAP for cancer progression: Establishment of a p53-independent therapeutic avenue for glioma
Oncogene (2022) 41, 5061-5075. PubMed Europe PubMed DOI
Sharma,S.S., Pledger,W.J. and Kondaiah,P.
The deubiquitylase USP7 is a novel cyclin F-interacting protein and regulates cyclin F protein stability
Aging (Albany NY) (2022) 14, 8645-8660. PubMed Europe PubMed DOI PMC EPMC
Sijm,A., Atlasi,Y., van der Knaap,J.A., Wolf van der Meer,J., Chalkley,G.E., Bezstarosti,K., Dekkers,D.H.W., Doff,W.A.S., Ozgur,Z., van IJcken,W.F.J., Demmers,J.A.A. and Verrijzer,C.P.
USP7 regulates the ncPRC1 Polycomb axis to stimulate genomic H2AK119ub1 deposition uncoupled from H3K27me3
Sci Adv (2022) 8, eabq7598-eabq7598. PubMed Europe PubMed DOI PMC EPMC
Valles,G., Pozhidaeva,A., Korzhnev,D.M. and Bezsonova,I.
Backbone and ILV side-chain NMR resonance assignments of the catalytic domain of human deubiquitinating enzyme USP7
Biomol NMR Assign (2022) PubMed Europe PubMed DOI
Wu,Y., Gu,H., Bao,Y., Lin,T., Wang,Z., Gu,D., Shen,H., Xian,H., Fan,Y. and Mao,R.
USP7 sustains an active epigenetic program via stabilizing MLL2 and WDR5 in diffuse large B-cell lymphoma
Cell Biochem Funct (2022) 40, 379-390. PubMed Europe PubMed DOI
Xu,Q., Liu,M., Gu,J., Ling,S., Liu,X., Luo,Z., Jin,Y., Chai,R., Ou,W., Liu,S. and Liu,N.
Ubiquitin-specific protease 7 regulates myocardial ischemia/reperfusion injury by stabilizing Keap1
Cell Death Discov (2022) 8, 291-291. PubMed Europe PubMed DOI PMC EPMC
Zhang,N., Wang,F., Zhang,G., Zhang,Q., Liu,Y., Wang,Q., Elsharkawy,M.S., Zheng,M., Wen,J., Zhao,G. and Li,Q.
USP7 Promotes deubiquitination and stabilization of MyD88 to enhance immune responses
Front Immunol (2022) 13, 900243-900243. PubMed Europe PubMed DOI PMC EPMC K
Zhang,S., Wang,Y., Liu,L., Zhao,G., Sun,Y., Wang,J., Liu,F., Wang,P. and Xu,X.
Virtual Screening Inhibitors of Ubiquitin-specific Protease 7 combining Pharmacophore Modeling and Molecular Docking
Mol Inform (2022) , e2100273-e2100273. PubMed Europe PubMed DOI I
Zhuang,H., Ren,Y., Mao,C., Zhong,Y., Zhang,Z., Cao,B., Zhang,Y., Huang,J., Xu,G., Huang,Z., Xu,Y. and Mao,X.
Induction of zinc finger protein RNF6 auto-ubiquitination for the treatment of myeloma and chronic myeloid leukemia
J Biol Chem (2022) 298, 102314-102314. PubMed Europe PubMed DOI PMC EPMC

2021

Cheng,X., Zhang,B., Guo,F., Wu,H. and Jin,X.
Deubiquitination of FBP1 by USP7 blocks FBP1-DNMT1 interaction and decreases the sensitivity of pancreatic cancer cells to PARP inhibitors
Mol Oncol (2021) PubMed Europe PubMed DOI
Galarreta,A., Valledor,P., Ubieto-Capella,P., Lafarga,V., Zarzuela,E., Munoz,J., Malumbres,M., Lecona,E. and Fernandez-Capetillo,O.
USP7 limits CDK1 activity throughout the cell cycle
EMBO J (2021) , e99692-e99692. PubMed Europe PubMed DOI
Han,J.J., Ho,D.V., Kim,H.M., Lee,J.Y., Jeon,Y.S. and Chan,J.Y.
The deubiquitinating enzyme USP7 regulates the transcription factor Nrf1 by modulating its stability in response to toxic metal exposure
J Biol Chem (2021) , 100732-100732. PubMed Europe PubMed DOI
Huang,Y.T., Cheng,A.C., Tang,H.C., Huang,G.C., Cai,L., Lin,T.H., Wu,K.J., Tseng,P.H., Wang,G.G. and Chen,W.Y.
USP7 facilitates SMAD3 autoregulation to repress cancer progression in p53-deficient lung cancer
Cell Death Dis (2021) 12, 880-880. PubMed Europe PubMed DOI PMC EPMC
Li,N., Zhao,Z., Liu,P., Zheng,Y., Cai,S., Sun,Y. and Wang,B.
Upregulation of deubiquitinase USP7 by transcription factor FOXO6 promotes EC progression via targeting the JMJD3/CLU axis
Mol Ther Oncolytics (2021) 20, 583-595. PubMed Europe PubMed DOI PMC EPMC
Li,P., Liu,Y., Yang,H. and Liu,H.M.
Design, synthesis, biological evaluation and structure-activity relationship study of quinazolin-4(3H)-one derivatives as novel USP7 inhibitors
Eur J Med Chem (2021) 216, 113291-113291. PubMed Europe PubMed DOI I
Lu,J., Zhao,H., Yu,C., Kang,Y. and Yang,X.
Targeting Ubiquitin-Specific Protease 7 (USP7) in Cancer: A New Insight to Overcome Drug Resistance
Front Pharmacol (2021) 12, 648491-648491. PubMed Europe PubMed DOI PMC EPMC V
Pan,T., Li,X., Li,Y., Tao,Z., Yao,H., Wu,Y., Chen,G., Zhang,K., Zhou,Y. and Huang,Y.
USP7 inhibition induces apoptosis in glioblastoma by enhancing ubiquitination of ARF4
Cancer Cell Int (2021) 21, 508-508. PubMed Europe PubMed DOI PMC EPMC
Perry,M., Biegert,M., Kollala,S.S., Mallard,H., Su,G., Kodavati,M., Kreiling,N., Holbrook,A. and Ghosal,G.
USP11 mediates repair of DNA-protein crosslinks by deubiquitinating SPRTN metalloprotease
J Biol Chem (2021) , 100396-100396. PubMed Europe PubMed DOI
Su,D., Wang,W., Hou,Y., Wang,L., Yi,X., Cao,C., Wang,Y., Gao,H., Wang,Y., Yang,C., Liu,B., Chen,X., Wu,X., Wu,J., Yan,D., Wei,S., Han,L., Liu,S., Wang,Q., Shi,L. and Shan,L.
Bimodal regulation of the PRC2 complex by USP7 underlies tumorigenesis
Nucleic Acids Res (2021) 49, 4421-4440. PubMed Europe PubMed DOI PMC EPMC
Tang,L.J., Zhou,Y.J., Xiong,X.M., Li,N.S., Zhang,J.J., Luo,X.J. and Peng,J.
Ubiquitin-specific protease 7 promotes ferroptosis via activation of the p53/TfR1 pathway in the rat hearts after ischemia/reperfusion
Free Radic Biol Med (2021) 162, 339-352. PubMed Europe PubMed DOI K
Valles,G.J., Ashton,N.W., Jaiswal,N., Woodgate,R. and Bezsonova,I.
Nuclear magnetic resonance spectral data of the USP7 TRAF and UBL1-2 domains in complex with DNA polymerase iota peptides
Data Brief (2021) 34, 106680-106680. PubMed Europe PubMed DOI PMC EPMC
Wang,Z., Kang,W., Li,O., Qi,F., Wang,J., You,Y., He,P., Suo,Z., Zheng,Y. and Liu,H.M.
Abrogation of USP7 is an alternative strategy to downregulate PD-L1 and sensitize gastric cancer cells to T cells killing
Acta Pharm Sin B (2021) 11, 694-707. PubMed Europe PubMed DOI PMC EPMC
Xue,Q., Yang,D., Zhang,J., Gan,P., Lin,C., Lu,Y., Zhang,W., Zhang,L. and Guang,X.
USP7, negatively regulated by miR-409-5p, aggravates hypoxia-induced cardiomyocyte injury
APMIS (2021) 129, 152-162. PubMed Europe PubMed DOI
Yan,G., Liu,N., Tian,J., Fu,Y., Wei,W., Zou,J., Li,S., Wang,Q., Li,K. and Wang,J.
Deubiquitylation and stabilization of ARMC5 by ubiquitin-specific processing protease 7 (USP7) are critical for RCC proliferation
J Cell Mol Med (2021) PubMed Europe PubMed DOI K
Zhang,F., Zhang,B., Tang,R., Jiang,H., Ji,Z., Chen,Y. and Feng,H.
The occurrence of lupus nephritis is regulated by USP7-mediated JMJD3 stabilization
Immunol Lett (2021) PubMed Europe PubMed DOI
Zhao,S., Kieser,A., Li,H.Y., Reinking,H.K., Weickert,P., Euteneuer,S., Yaneva,D., Acampora,A.C., Gotz,M.J., Feederle,R. and Stingele,J.
A ubiquitin switch controls autocatalytic inactivation of the DNA-protein crosslink repair protease SPRTN
Nucleic Acids Res (2021) 49, 902-915. PubMed Europe PubMed DOI
Zhao,Y., Li,X., Tian,G., Zhao,X., Wong,J., Shen,Y. and Wu,J.
Ubiquitin-Specific-Processing Protease 7 Regulates Female Germline Stem Cell Self-Renewal Through DNA Methylation
Stem Cell Rev Rep (2021) 17, 938-951. PubMed Europe PubMed DOI K
Zhu,Y., Zhang,Q., Yan,X., Liu,L., Zhai,C., Wang,Q., Chai,L. and Li,M.
Ubiquitin-specific protease 7 mediates platelet-derived growth factor-induced pulmonary arterial smooth muscle cells proliferation
Pulm Circ (2021) 11, 20458940211046131-20458940211046131. PubMed Europe PubMed DOI PMC EPMC K

2020

Ashton,N.W., Valles,G.J., Jaiswal,N., Bezsonova,I. and Woodgate,R.
DNA polymerase iota interacts with both the TRAF-like and UBL1-2 domains of USP7
J Mol Biol (2020) , 166733-166733. PubMed Europe PubMed DOI
Bojagora,A. and Saridakis,V.
USP7 manipulation by viral proteins
Virus Res (2020) 286, 198076-198076. PubMed Europe PubMed DOI
Cartel,M., Mouchel,P.L., Gotanegre,M., David,L., Bertoli,S., Mas,V.M., Besson,A., Sarry,J.E., Manenti,S. and Didier,C.
Inhibition of ubiquitin-specific protease 7 sensitizes acute myeloid leukemia to chemotherapy
Leukemia (2020) PubMed Europe PubMed DOI PMC EPMC I
Chen,F., Zhang,W., Xie,D., Gao,T., Dong,Z. and Lu,X.
Histone chaperone FACT represses retrotransposon MERVL and MERVL-derived cryptic promoters
Nucleic Acids Res (2020) 48, 10211-10225. PubMed Europe PubMed DOI PMC EPMC
Choi,H.S., Pei,C.Z., Park,J.H., Kim,S.Y., Song,S.Y., Shin,G.J. and Baek,K.H.
Protein Stability of Pyruvate Kinase Isozyme M2 Is Mediated by HAUSP
Cancers (Basel) (2020) 12 PubMed Europe PubMed DOI PMC EPMC
Das,S., Chandrasekaran,A.P., Jo,K.S., Ko,N.R., Oh,S.J., Kim,K.S. and Ramakrishna,S.
HAUSP stabilizes Cdc25A and protects cervical cancer cells from DNA damage response
Biochim Biophys Acta Mol Cell Res (2020) 1867, 118835-118835. PubMed Europe PubMed DOI
Dong,X., Xu,X., Yang,C., Luo,Y., Wu,Y. and Wang,J.
USP7 regulates the proliferation and differentiation of ATDC5 cells through the Sox9-PTHrP-PTH1R axis
Bone (2020) 143, 115714-115714. PubMed Europe PubMed DOI K
Han,Y. and Yun,C.C.
Ubiquitin-specific peptidase 7 (USP7) and USP10 mediate deubiquitination of human NHE3 regulating its expression and activity
FASEB J (2020) PubMed Europe PubMed DOI K
Hayal,T.B., Dogan,A., SISlI,H.B., Kiratli,B. and SahIn,F.
Ubiquitin-specific protease 7 downregulation suppresses breast cancer in vitro
Turk J Biol (2020) 44, 145-157. PubMed Europe PubMed DOI PMC EPMC K I
He,Y., Wang,S., Tong,J., Jiang,S., Yang,Y., Zhang,Z., Xu,Y., Zeng,Y., Cao,B., Moran,M.F. and Mao,X.
The deubiquitinase USP7 stabilizes Maf proteins to promote myeloma cell survival
J Biol Chem (2020) 295, 2084-2096. PubMed Europe PubMed DOI
Huang,X.Y., Quan,Y.F., Yan,L.L. and Zhao,L.
[Expression of ubiquitin-specific protease 7 in lung tissue of preterm rats after hyperoxia exposure]
Zhongguo Dang Dai Er Ke Za Zhi (2020) 22, 1331-1337. PubMed Europe PubMed PMC EPMC I
Kanan,D., Kanan,T., Dogan,B., Orhan,M.D., Avsar,T. and Durdagi,S.
An Integrated In Silico Approach and In Vitro Study for the Discovery of USP7 Small Molecule Inhibitors as Potential Cancer Therapies
ChemMedChem (2020) PubMed Europe PubMed DOI
Lee,J.E., Park,C.M. and Kim,J.H.
USP7 deubiquitinates and stabilizes EZH2 in prostate cancer cells
Genet Mol Biol (2020) 43, e20190338-e20190338. PubMed Europe PubMed DOI
Li,J., Wang,R., Jin,J., Han,M., Chen,Z., Gao,Y., Hu,X., Zhu,H., Gao,H., Lu,K., Shao,Y., Lyu,C., Lai,W., Li,P., Hu,G., Li,J., Li,D., Wang,H., Wu,Q. and Wong,J.
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment
Cell Discov (2020) 6, 58-58. PubMed Europe PubMed DOI PMC EPMC
Li,J., Wang,R., Jin,J., Han,M., Chen,Z., Gao,Y., Hu,X., Zhu,H., Gao,H., Lu,K., Shao,Y., Lyu,C., Lai,W., Li,P., Hu,G., Li,J., Li,D., Wang,H., Wu,Q. and Wong,J.
USP7 negatively controls global DNA methylation by attenuating ubiquitinated histone-dependent DNMT1 recruitment
Cell Discov (2020) 6, 58-58. PubMed Europe PubMed DOI
Li,P. and Liu,H.M.
Recent advances in the development of ubiquitin-specific-processing protease 7 (USP7) inhibitors
Eur J Med Chem (2020) 191, 112107-112107. PubMed Europe PubMed DOI I
Li,X., Kong,L., Yang,Q., Duan,A., Ju,X., Cai,B., Chen,L., An,T. and Li,Y.
Parthenolide inhibits ubiquitin-specific peptidase 7 (USP7), Wnt signaling, and colorectal cancer cell growth
J Biol Chem (2020) 295, 3576-3589. PubMed Europe PubMed DOI I
Liu,G., Liu,Q., Yan,B., Zhu,Z. and Xu,Y.
USP7 Inhibition Alleviates H2O2-Induced Injury in Chondrocytes via Inhibiting NOX4/NLRP3 Pathway
Front Pharmacol (2020) 11, 617270-617270. PubMed Europe PubMed DOI PMC EPMC
Ni,W., Lin,S., Bian,S., Zheng,W., Qu,L., Fan,Y., Lu,C., Xiao,M. and Zhou,P.
USP7 mediates pathological hepatic de novo lipogenesis through promoting stabilization and transcription of ZNF638
Cell Death Dis (2020) 11, 843-843. PubMed Europe PubMed DOI PMC EPMC
Nininahazwe,L., Liu,B., He,C., Zhang,H. and Chen,Z.S.
The emerging nature of Ubiquitin-specific protease 7 (USP7): a new target in cancer therapy
Drug Discov Today (2020) PubMed Europe PubMed DOI V
Ohol,Y.M., Sun,M.T., Cutler,G., Leger,P.R., Hu,D.X., Biannic,B., Rana,P., Cho,C., Jacobson,S., Wong,S.T., Sanchez,J., Shah,N., Pookot,D., Abraham,B., Young,K., Suthram,S., Marshall,L.A., Bradford,D., Kozon,N., Han,X., Okano,A., Maung,J., Colas,C., Schwarz,J., Wustrow,D., Brockstedt,D.G. and Kassner,P.D.
Novel, Selective Inhibitors of USP7 Uncover Multiple Mechanisms of Antitumor Activity in Vitro and in Vivo
Mol Cancer Ther (2020) PubMed Europe PubMed DOI T
Pluciennik,A., Liu,Y., Molotsky,E., Marsh,G.B., Ranxhi,B., Arnold,F.J., St-Cyr,S., Davidson,B.L., Pourshafie,N., Lieberman,A.P., Gu,W., Todi,S.V. and Merry,D.E.
Deubiquitinase USP7 contributes to the pathogenicity of spinal and bulbar muscular atrophy
J Clin Invest (2020) PubMed Europe PubMed DOI K
Qi,S.M., Cheng,G., Cheng,X.D., Xu,Z., Xu,B., Zhang,W.D. and Qin,J.J.
Targeting USP7-mediated deubiquitination of MDM2/MDMX-p53 pathway for cancer therapy: are we there yet?
Front Cell Dev Biol (2020) 8, 233-233. PubMed Europe PubMed DOI PMC EPMC
Rasaei,R., Sarodaya,N., Kim,K.S., Ramakrishna,S. and Hong,S.H.
Importance of Deubiquitination in Macrophage-Mediated Viral Response and Inflammation
Int J Mol Sci (2020) 21 PubMed Europe PubMed DOI PMC EPMC V
Schauer,N.J., Liu,X., Magin,R.S., Doherty,L.M., Chan,W.C., Ficarro,S.B., Hu,W., Roberts,R.M., Iacob,R.E., Stolte,B., Giacomelli,A.O., Perera,S., McKay,K., Boswell,S.A., Weisberg,E.L., Ray,A., Chauhan,D., Dhe-Paganon,S., Anderson,K.C., Griffin,J.D., Li,J., Hahn,W.C., Sorger,P.K., Engen,J.R., Stegmaier,K., Marto,J.A. and Buhrlage,S.J.
Selective USP7 inhibition elicits cancer cell killing through a p53-dependent mechanism
Sci Rep (2020) 10, 5324-5324. PubMed Europe PubMed DOI PMC EPMC I
Valles,G.J., Bezsonova,I., Woodgate,R. and Ashton,N.W.
USP7 Is a Master Regulator of Genome Stability
Front Cell Dev Biol (2020) 8, 717-717. PubMed Europe PubMed DOI PMC EPMC V
Wang,Q.Q., Wang,X.D., Wu,L.Z., Fang,Q.Q., Liu,Y.N., Jiang,K., Qu,S.J. and Tan,C.H.
Polyprenylated acylphloroglucinols as deubiquitinating protease USP7 inhibitors from Hypericum hookerianum
Fitoterapia (2020) 146, 104678-104678. PubMed Europe PubMed DOI
Wang,Z., Wang,X., Kang,Y., Zhong,H., Shen,C., Yao,X., Cao,D. and Hou,T.
Binding affinity and dissociation pathway predictions for a series of USP7 inhibitors with pyrimidinone scaffold by multiple computational methods
Phys Chem Chem Phys (2020) 22, 5487-5499. PubMed Europe PubMed DOI I
Xiao,Y., Huang,Q., Wu,Z. and Chen,W.
Roles of protein ubiquitination in inflammatory bowel disease
Immunobiology (2020) 225, 152026-152026. PubMed Europe PubMed DOI V
Zhang,Q., Cao,C., Gong,W., Bao,K., Wang,Q., Wang,Y., Bi,L., Ma,S., Zhao,J., Liu,L., Tian,S., Zhang,K., Yang,J., Yao,Z., Song,N. and Shi,L.
A feedforward circuit shaped by ECT2 and USP7 contributes to breast carcinogenesis
Theranostics (2020) 10, 10769-10790. PubMed Europe PubMed DOI PMC EPMC
Zhang,T., Periz,G., Lu,Y.N. and Wang,J.
USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway
Proc Natl Acad Sci U S A (2020) 117, 28114-28125. PubMed Europe PubMed DOI
Zhang,W., Zhang,J., Xu,C., Zhang,S., Bian,S., Jiang,F., Ni,W., Qu,L., Lu,C., Ni,R., Fan,Y., Xiao,M. and Liu,J.
Ubiquitin-specific protease 7 is a drug-able target that promotes hepatocellular carcinoma and chemoresistance
Cancer Cell Int (2020) 20, 28-28. PubMed Europe PubMed DOI PMC EPMC I
Zhu,Q., Ding,N., Wei,S., Li,P., Wani,G., He,J. and Wani,A.A.
USP7-mediated deubiquitination differentially regulates CSB but not UVSSA upon UV radiation-induced DNA damage
Cell Cycle (2020) 19, 124-141. PubMed Europe PubMed DOI

2019

Gjonaj,L., Sapmaz,A., Gonzalez-Prieto,R., Vertegaal,A.C.O., Flierman,D. and Ovaa,H.
USP7: combining tools towards selectivity
Chem Commun (Camb) (2019) 55, 5075-5078. PubMed Europe PubMed DOI L I
Hu,T., Zhang,J., Sha,B., Li,M., Wang,L., Zhang,Y., Liu,X., Dong,Z., Liu,Z., Li,P. and Chen,P.
Targeting the overexpressed USP7 inhibits esophageal squamous cell carcinoma cell growth by inducing NOXA-Mediated Apoptosis
Mol Carcinog (2019) 58, 42-54. PubMed Europe PubMed DOI
Ji,L., Lu,B., Zamponi,R., Charlat,O., Aversa,R., Yang,Z., Sigoillot,F., Zhu,X., Hu,T., Reece-Hoyes,J.S., Russ,C., Michaud,G., Tchorz,J.S., Jiang,X. and Cong,F.
USP7 inhibits Wnt/beta-catenin signaling through promoting stabilization of Axin
Nat Commun (2019) 10, 4184-4184. PubMed Europe PubMed DOI PMC EPMC
Kim,R.Q., Geurink,P.P., Mulder,M.P.C., Fish,A., Ekkebus,R., El Oualid,F., van Dijk,W.J., van Dalen,D., Ovaa,H., van Ingen,H. and Sixma,T.K.
Kinetic analysis of multistep USP7 mechanism shows critical role for target protein in activity
Nat Commun (2019) 10, 231-231. PubMed Europe PubMed DOI PMC EPMC
Masuda,Y., Kanao,R., Kawai,H., Kukimoto,I. and Masutani,C.
Preferential digestion of PCNA-ubiquitin and p53-ubiquitin linkages by USP7 to remove polyubiquitin chains from substrates
J Biol Chem (2019) 294, 4177-4187. PubMed Europe PubMed DOI P
Peng,Y., Liu,Y., Gao,Y., Yuan,B., Qi,X., Fu,Y., Zhu,Q., Cao,T., Zhang,S., Yin,L. and Li,X.
USP7 is a novel deubiquitinase sustaining PLK1 protein stability and regulating chromosome alignment in mitosis
J Exp Clin Cancer Res (2019) 38, 468-468. PubMed Europe PubMed DOI PMC EPMC I
Pozhidaeva,A. and Bezsonova,I.
USP7: Structure, substrate specificity, and inhibition
DNA Repair (Amst) (2019) 76, 30-39. PubMed Europe PubMed DOI I
Rawat,R., Starczynowski,D.T. and Ntziachristos,P.
Nuclear deubiquitination in the spotlight: the multifaceted nature of USP7 biology in disease
Curr Opin Cell Biol (2019) 58, 85-94. PubMed Europe PubMed DOI
Sun,X., Ding,Y., Zhan,M., Li,Y., Gao,D., Wang,G., Gao,Y., Li,Y., Wu,S., Lu,L., Liu,Q. and Zhou,Z.
Usp7 regulates Hippo pathway through deubiquitinating the transcriptional coactivator Yorkie
Nat Commun (2019) 10, 411-411. PubMed Europe PubMed DOI PMC EPMC
Vamisetti,G.B., Meledin,R., Gopinath,P. and Brik,A.
Halogen substituents in the isoquinoline scaffold switches the selectivity of inhibition between USP2 and USP7
Chembiochem (2019) 20, 282-286. PubMed Europe PubMed DOI I
Wang,Z., Kang,W., You,Y., Pang,J., Ren,H., Suo,Z., Liu,H. and Zheng,Y.
USP7: Novel drug target in cancer therapy
Front Pharmacol (2019) 10, 427-427. PubMed Europe PubMed DOI PMC EPMC
Wei,X., Guo,J., Li,Q., Jia,Q., Jing,Q., Li,Y., Zhou,B., Chen,J., Gao,S., Zhang,X., Jia,M., Niu,C., Yang,W., Zhi,X., Wang,X., Yu,D., Bai,L., Wang,L., Na,J., Zou,Y., Zhang,J., Zhang,S. and Meng,D.
Bach1 regulates self-renewal and impedes mesendodermal differentiation of human embryonic stem cells
Sci Adv (2019) 5, eaau7887-eaau7887. PubMed Europe PubMed DOI PMC EPMC
Wertz,I.E. and Murray,J.M.
Structurally-defined deubiquitinase inhibitors provide opportunities to investigate disease mechanisms
Drug Discov Today Technol (2019) 31, 109-123. PubMed Europe PubMed DOI V I
Xia,X., Liao,Y., Huang,C., Liu,Y., He,J., Shao,Z., Jiang,L., Dou,Q.P., Liu,J. and Huang,H.
Deubiquitination and stabilization of estrogen receptor alpha by ubiquitin-specific protease 7 promotes breast tumorigenesis
Cancer Lett (2019) 465, 118-128. PubMed Europe PubMed DOI
Zeng,Q., Li,Z., Zhao,X., Guo,L., Yu,C., Qin,J., Zhang,S., Zhang,Y. and Yang,X.
Ubiquitin-specific protease 7 promotes osteosarcoma cell metastasis by inducing epithelial-mesenchymal transition
Oncol Rep (2019) 41, 543-551. PubMed Europe PubMed DOI

2018

Bhattacharya,S., Chakraborty,D., Basu,M. and Ghosh,M.K.
Emerging insights into HAUSP (USP7) in physiology, cancer and other diseases
Signal Transduct Target Ther (2018) 3, 17-17. PubMed Europe PubMed DOI PMC EPMC V
Gavory,G., O'Dowd,C.R., Helm,M.D., Flasz,J., Arkoudis,E., Dossang,A., Hughes,C., Cassidy,E., McClelland,K., Odrzywol,E., Page,N., Barker,O., Miel,H. and Harrison,T.
Discovery and characterization of highly potent and selective allosteric USP7 inhibitors
Nat Chem Biol (2018) 14, 118-125. PubMed Europe PubMed DOI S I
Georges,A., Marcon,E., Greenblatt,J. and Frappier,L.
Identification and characterization of USP7 targets in cancer cells
Sci Rep (2018) 8, 15833-15833. PubMed Europe PubMed DOI PMC EPMC
Inoue,M., Hitora,Y., Kato,H., Losung,F., Mangindaan,R.E.P. and Tsukamoto,S.
New geranyl flavonoids from the leaves of Artocarpus communis
J Nat Med (2018) 72, 632-640. PubMed Europe PubMed DOI I
Jing,B., Liu,M., Yang,L., Cai,H.Y., Chen,J.B., Li,Z.X., Kou,X., Wu,Y.Z., Qin,D.J., Zhou,L., Jin,J., Lei,H., Xu,H.Z., Wang,W.W. and Wu,Y.L.
Characterization of naturally occurring pentacyclic triterpenes as novel inhibitors of deubiquitinating protease USP7 with anticancer activity in vitro
Acta Pharmacol Sin (2018) 39, 492-498. PubMed Europe PubMed DOI I
O'Dowd,C.R., Helm,M.D., Rountree,J.S.S., Flasz,J.T., Arkoudis,E., Miel,H., Hewitt,P.R., Jordan,L., Barker,O., Hughes,C., Rozycka,E., Cassidy,E., McClelland,K., Odrzywol,E., Page,N., Feutren-Burton,S., Dvorkin,S., Gavory,G. and Harrison,T.
Identification and structure-guided development of pyrimidinone based USP7 inhibitors
ACS Med Chem Lett (2018) 9, 238-243. PubMed Europe PubMed DOI PMC EPMC I
Ozen,A., Rouge,L., Bashore,C., Hearn,B.R., Skelton,N.J. and Dueber,E.C.
Selectively modulating conformational states of USP7 catalytic domain for activation
Structure (2018) 26, 72-84. PubMed Europe PubMed DOI
Palazon-Riquelme,P., Worboys,J.D., Green,J., Valera,A., Martin-Sanchez,F., Pellegrini,C., Brough,D. and Lopez-Castejon,G.
USP7 and USP47 deubiquitinases regulate NLRP3 inflammasome activation
EMBO Rep (2018) 19, e44766-e44766. PubMed Europe PubMed DOI
Shan,H., Li,X., Xiao,X., Dai,Y., Huang,J., Song,J., Liu,M., Yang,L., Lei,H., Tong,Y., Zhou,L., Xu,H. and Wu,Y.
USP7 deubiquitinates and stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia
Signal Transduct Target Ther (2018) 3, 29-29. PubMed Europe PubMed DOI PMC EPMC
Srivastava,M., Suri,C., Singh,M., Mathur,R. and Asthana,S.
Molecular dynamics simulation reveals the possible druggable hot-spots of USP7
Oncotarget (2018) 9, 34289-34305. PubMed Europe PubMed DOI PMC EPMC I
Tavana,O., Sun,H. and Gu,W.
Targeting HAUSP in both p53 wildtype and p53-mutant tumors
Cell Cycle (2018) 17, 823-828. PubMed Europe PubMed DOI I
Wu,J., Kumar,S., Wang,F., Wang,H., Chen,L., Arsenault,P., Mattern,M. and Weinstock,J.
Chemical approaches to intervening in ubiquitin specific protease 7 (USP7) function for oncology and immune oncology therapies
J Med Chem (2018) 61, 422-443. PubMed Europe PubMed DOI I
Yeasmin Khusbu,F., Chen,F.Z. and Chen,H.C.
Targeting ubiquitin specific protease 7 in cancer: a deubiquitinase with great prospects
Cell Biochem Funct (2018) 36, 244-254. PubMed Europe PubMed DOI
Zhou,J., Wang,J., Chen,C., Yuan,H., Wen,X. and Sun,H.
USP7: Target validation and drug discovery for cancer therapy
Med Chem (2018) 14, 3-18. PubMed Europe PubMed DOI V

2017

Identified selective USP7 inhibitors compete with ubiquitin binding
Cancer Discov (2017) DOI S I
Agathanggelou,A., Smith,E., Davies,N.J., Kwok,M., Zlatanou,A., Oldreive,C.E., Mao,J., da Costa,D., Yadollahi,S., Perry,T., Kearns,P., Skowronska,A., Yates,E., Parry,H., Hillmen,P., Reverdy,C., Delansorne,R., Paneesha,S., Pratt,G., Moss,P., Taylor,A.M.R., Stewart,G.S. and Stankovic,T.
USP7 inhibition alters homologous recombination repair and targets CLL cells independently of ATM/p53 functional status
Blood (2017) 130, 156-166. PubMed Europe PubMed DOI
Ali,A., Raja,R., Farooqui,S.R., Ahmad,S. and Banerjea,A.C.
USP7 deubiquitinase controls HIV-1 production by stabilizing Tat protein
Biochem J (2017) 474, 1653-1668. PubMed Europe PubMed DOI I
Chen,C., Song,J., Wang,J., Xu,C., Chen,C., Gu,W., Sun,H. and Wen,X.
Synthesis and biological evaluation of thiazole derivatives as novel USP7 inhibitors
Bioorg Med Chem Lett (2017) 27, 845-849. PubMed Europe PubMed DOI I
Desroses,M. and Altun,M.
The next step forward in ubiquitin-specific protease 7 selective inhibition
Cell Chem Biol (2017) 24, 1429-1431. PubMed Europe PubMed DOI I
Di Lello,P., Pastor,R., Murray,J.M., Blake,R.A., Cohen,F., Crawford,T.D., Drobnick,J., Drummond,J., Kategaya,L., Kleinheinz,T., Maurer,T., Rouge,L., Zhao,X., Wertz,I., Ndubaku,C. and Tsui,V.
Discovery of small-molecule inhibitors of ubiquitin specific protease 7 (USP7) using integrated NMR and in silico techniques
J Med Chem (2017) 60, 10056-10070. PubMed Europe PubMed DOI I
El-Desoky,A.H., Kato,H. and Tsukamoto,S.
Ceylonins G-I: spongian diterpenes from the marine sponge Spongia ceylonensis
J Nat Med (2017) 71, 765-769. PubMed Europe PubMed DOI I
Hernandez-Perez,S., Cabrera,E., Salido,E., Lim,M., Reid,L., Lakhani,S.R., Khanna,K.K., Saunus,J.M. and Freire,R.
DUB3 and USP7 de-ubiquitinating enzymes control replication inhibitor geminin: molecular characterization and associations with breast cancer
Oncogene (2017) 36, 4802-4809. PubMed Europe PubMed DOI
Jiang,L., Xiong,J., Zhan,J., Yuan,F., Tang,M., Zhang,C., Cao,Z., Chen,Y., Lu,X., Li,Y., Wang,H., Wang,L., Wang,J., Zhu,W.G. and Wang,H.
Ubiquitin-specific peptidase 7 (USP7)-mediated deubiquitination of the histone deacetylase SIRT7 regulates gluconeogenesis
J Biol Chem (2017) 292, 13296-13311. PubMed Europe PubMed DOI
Kategaya,L., Di Lello,P., Rouge,L., Pastor,R., Clark,K.R., Drummond,J., Kleinheinz,T., Lin,E., Upton,J.P., Prakash,S., Heideker,J., McCleland,M., Ritorto,M.S., Alessi,D.R., Trost,M., Bainbridge,T.W., Kwok,M.C.M., Ma,T.P., Stiffler,Z., Brasher,B., Tang,Y., Jaishankar,P., Hearn,B.R., Renslo,A.R., Arkin,M.R., Cohen,F., Yu,K., Peale,F., Gnad,F., Chang,M.T., Klijn,C., Blackwood,E., Martin,S.E., Forrest,W.F., Ernst,J.A., Ndubaku,C., Wang,X., Beresini,M.H., Tsui,V., Schwerdtfeger,C., Blake,R.A., Murray,J., Maurer,T. and Wertz,I.E.
USP7 small-molecule inhibitors interfere with ubiquitin binding
Nature (2017) 550, 534-538. PubMed Europe PubMed DOI I
Kim,R.Q. and Sixma,T.K.
Regulation of USP7: a high incidence of E3 complexes
J Mol Biol (2017) 429, 3395-3408. PubMed Europe PubMed DOI
Lamberto,I., Liu,X., Seo,H.S., Schauer,N.J., Iacob,R.E., Hu,W., Das,D., Mikhailova,T., Weisberg,E.L., Engen,J.R., Anderson,K.C., Chauhan,D., Dhe-Paganon,S. and Buhrlage,S.J.
Structure-guided development of a potent and selective non-covalent active-site inhibitor of USP7
Cell Chem Biol (2017) 24, 1490-1500. PubMed Europe PubMed DOI S I
Tavana,O. and Gu,W.
Modulation of the p53/MDM2 interplay by HAUSP inhibitors
J Mol Cell Biol (2017) 9, 45-52. PubMed Europe PubMed DOI I
Turnbull,A.P., Ioannidis,S., Krajewski,W.W., Pinto-Fernandez,A., Heride,C., Martin,A.C.L., Tonkin,L.M., Townsend,E.C., Buker,S.M., Lancia,D.R., Caravella,J.A., Toms,A.V., Charlton,T.M., Lahdenranta,J., Wilker,E., Follows,B.C., Evans,N.J., Stead,L., Alli,C., Zarayskiy,V.V., Talbot,A.C., Buckmelter,A.J., Wang,M., McKinnon,C.L., Saab,F., McGouran,J.F., Century,H., Gersch,M., Pittman,M.S., Marshall,C.G., Raynham,T.M., Simcox,M., Stewart,L.M.D., McLoughlin,S.B., Escobedo,J.A., Bair,K.W., Dinsmore,C.J., Hammonds,T.R., Kim,S., Urbe,S., Clague,M.J., Kessler,B.M. and Komander,D.
Molecular basis of USP7 inhibition by selective small-molecule inhibitors
Nature (2017) 550, 481-486. PubMed Europe PubMed DOI S I
Wang,F., Wang,L., Wu,J., Sokirniy,I., Nguyen,P., Bregnard,T., Weinstock,J., Mattern,M., Bezsonova,I., Hancock,W.W. and Kumar,S.
Active site-targeted covalent irreversible inhibitors of USP7 impair the functions of Foxp3+ T-regulatory cells by promoting ubiquitination of Tip60
PLoS ONE (2017) 12, e0189744-e0189744. PubMed Europe PubMed DOI I
Yamaguchi,L., Nishiyama,A., Misaki,T., Johmura,Y., Ueda,J., Arita,K., Nagao,K., Obuse,C. and Nakanishi,M.
Usp7-dependent histone H3 deubiquitylation regulates maintenance of DNA methylation
Sci Rep (2017) 7, 55-55. PubMed Europe PubMed DOI
Zhang,W., Sartori,M.A., Makhnevych,T., Federowicz,K.E., Dong,X., Liu,L., Nim,S., Dong,A., Yang,J., Li,Y., Haddad,D., Ernst,A., Heerding,D., Tong,Y., Moffat,J. and Sidhu,S.S.
Generation and validation of intracellular ubiquitin variant inhibitors for USP7 and USP10
J Mol Biol (2017) 429, 3546-3560. PubMed Europe PubMed DOI S I

2016

Carra,G., Panuzzo,C., Crivellaro,S., Morena,D., Taulli,R., Guerrasio,A., Saglio,G. and Morotti,A.
The targetable role of herpes virus-associated ubiquitin-specific protease (HAUSP) in p190 BCR-ABL leukemia
Oncol Lett (2016) 12, 3123-3126. PubMed Europe PubMed DOI T I
Chavoshi,S., Egorova,O., Lacdao,I.K., Farhadi,S., Sheng,Y. and Saridakis,V.
Identification of Kaposi sarcoma herpesvirus (KSHV) vIRF1 protein as a novel interaction partner of human deubiquitinase USP7
J Biol Chem (2016) 291, 6281-6291. PubMed Europe PubMed DOI
Di Lello,P., Rouge,L., Pan,B. and Maurer,T.
(1)H, (13)C and (15)N backbone resonance assignment for the 40.5 kDa catalytic domain of ubiquitin specific protease 7 (USP7)
Biomol NMR Assign (2016) 10, 345-349. PubMed Europe PubMed DOI S
Hirano,A., Nakagawa,T., Yoshitane,H., Oyama,M., Kozuka-Hata,H., Lanjakornsiripan,D. and Fukada,Y.
USP7 and TDP-43: pleiotropic regulation of cryptochrome protein stability paces the oscillation of the mammalian circadian clock
PLoS ONE (2016) 11, e0154263-e0154263. PubMed Europe PubMed DOI
Kim,R.Q., van Dijk,W.J. and Sixma,T.K.
Structure of USP7 catalytic domain and three Ubl-domains reveals a connector alpha-helix with regulatory role
J Struct Biol (2016) 195, 11-18. PubMed Europe PubMed DOI S
Lecona,E., Rodriguez-Acebes,S., Specks,J., Lopez-Contreras,A.J., Ruppen,I., Murga,M., Munoz,J., Mendez,J. and Fernandez-Capetillo,O.
USP7 is a SUMO deubiquitinase essential for DNA replication
Nat Struct Mol Biol (2016) 23, 270-277. PubMed Europe PubMed DOI
Lecona,E. and Fernandez-Capetillo,O.
A SUMO and ubiquitin code coordinates protein traffic at replication factories
Bioessays (2016) 38, 1209-1217. PubMed Europe PubMed DOI
Lee,G., Oh,T.I., Um,K.B., Yoon,H., Son,J., Kim,B.M., Kim,H.I., Kim,H., Kim,Y.J., Lee,C.S. and Lim,J.H.
Small-molecule inhibitors of USP7 induce apoptosis through oxidative and endoplasmic reticulum stress in cancer cells
Biochem Biophys Res Commun (2016) 470, 181-186. PubMed Europe PubMed DOI I
Qin,D., Wang,W., Lei,H., Luo,H., Cai,H., Tang,C., Wu,Y., Wang,Y., Jin,J., Xiao,W., Wang,T., Ma,C., Xu,H., Zhang,J., Gao,F. and Wu,Y.L.
CDDO-Me reveals USP7 as a novel target in ovarian cancer cells
Oncotarget (2016) 7, 77096-77109. PubMed Europe PubMed DOI T I
Ronau,J.A., Beckmann,J.F. and Hochstrasser,M.
Substrate specificity of the ubiquitin and Ubl proteases
Cell Res (2016) 26, 441-456. PubMed Europe PubMed DOI
Rouge,L., Bainbridge,T.W., Kwok,M., Tong,R., Di Lello,P., Wertz,I.E., Maurer,T., Ernst,J.A. and Murray,J.
Molecular understanding of USP7 substrate recognition and C-terminal activation
Structure (2016) 24, 1335-1345. PubMed Europe PubMed DOI
Smits,V.A. and Freire,R.
USP7/HAUSP: a SUMO deubiquitinase at the heart of DNA replication
Bioessays (2016) 38, 863-868. PubMed Europe PubMed DOI
Tavana,O., Li,D., Dai,C., Lopez,G., Banerjee,D., Kon,N., Chen,C., Califano,A., Yamashiro,D.J., Sun,H. and Gu,W.
HAUSP deubiquitinates and stabilizes N-Myc in neuroblastoma
Nat Med (2016) 22, 1180-1186. PubMed Europe PubMed DOI T
Wang,L., Kumar,S., Dahiya,S., Wang,F., Wu,J., Newick,K., Han,R., Samanta,A., Beier,U.H., Akimova,T., Bhatti,T.R., Nicholson,B., Kodrasov,M.P., Agarwal,S., Sterner,D.E., Gu,W., Weinstock,J., Butt,T.R., Albelda,S.M. and Hancock,W.W.
Ubiquitin-specific protease-7 inhibition impairs Tip60-dependent Foxp3+ T-regulatory cell function and promotes antitumor immunity
EBioMedicine (2016) 13, 99-112. PubMed Europe PubMed DOI I
Yi,L., Cui,Y., Xu,Q. and Jiang,Y.
Stabilization of LSD1 by deubiquitinating enzyme USP7 promotes glioblastoma cell tumorigenesis and metastasis through suppression of the p53 signaling pathway
Oncol Rep (2016) 36, 2935-2945. PubMed Europe PubMed DOI
Zhang,C., Lu,J., Zhang,Q.W., Zhao,W., Guo,J.H., Liu,S.L., Wu,Y.L., Jiang,B. and Gao,F.H.
USP7 promotes cell proliferation through the stabilization of Ki-67 protein in non-small cell lung cancer cells
Int J Biochem Cell Biol (2016) 79, 209-221. PubMed Europe PubMed DOI T
Zlatanou,A., Sabbioneda,S., Miller,E.S., Greenwalt,A., Aggathanggelou,A., Maurice,M.M., Lehmann,A.R., Stankovic,T., Reverdy,C., Colland,F., Vaziri,C. and Stewart,G.S.
USP7 is essential for maintaining Rad18 stability and DNA damage tolerance
Oncogene (2016) 35, 965-976. PubMed Europe PubMed DOI

2015

Cai,J.B., Shi,G.M., Dong,Z.R., Ke,A.W., Ma,H.H., Gao,Q., Shen,Z.Z., Huang,X.Y., Chen,H., Yu,D.D., Liu,L.X., Zhang,P.F., Zhang,C., Hu,M.Y., Yang,L.X., Shi,Y.H., Wang,X.Y., Ding,Z.B., Qiu,S.J., Sun,H.C., Zhou,J., Shi,Y.G. and Fan,J.
Ubiquitin-specific protease 7 accelerates p14(ARF) degradation by deubiquitinating thyroid hormone receptor-interacting protein 12 and promotes hepatocellular carcinoma progression
Hepatology (2015) 61, 1603-1614. PubMed Europe PubMed DOI
Chen,S.T., Okada,M., Nakato,R., Izumi,K., Bando,M. and Shirahige,K.
The deubiquitinating enzyme USP7 regulates androgen receptor activity by modulating its binding to chromatin
J Biol Chem (2015) 290, 21713-21723. PubMed Europe PubMed DOI
Cheng,J., Yang,H., Fang,J., Ma,L., Gong,R., Wang,P., Li,Z. and Xu,Y.
Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation
Nat Commun (2015) 6, 7023- PubMed Europe PubMed DOI S
Cheng,J., Li,Z., Gong,R., Fang,J., Yang,Y., Sun,C., Yang,H. and Xu,Y.
Molecular mechanism for the substrate recognition of USP7
Protein Cell (2015) 6, 849-852. PubMed Europe PubMed DOI
Hao,Y.H., Fountain MD Jr, Fon Tacer,K., Xia,F., Bi,W., Kang,S.H., Patel,A., Rosenfeld,J.A., Le Caignec,C., Isidor,B., Krantz,I.D., Noon,S.E., Pfotenhauer,J.P., Morgan,T.M., Moran,R., Pedersen,R.C., Saenz,M.S., Schaaf,C.P. and Potts,P.R.
USP7 acts as a molecular rheostat to promote WASH-dependent endosomal protein recycling and is mutated in a human neurodevelopmental disorder
Mol Cell (2015) 59, 956-969. PubMed Europe PubMed DOI PMC EPMC
Lecona,E., Narendra,V. and Reinberg,D.
USP7 cooperates with SCML2 to regulate the activity of PRC1
Mol Cell Biol (2015) 35, 1157-1168. PubMed Europe PubMed DOI
Lim,K.H., Park,J.J., Gu,B.H., Kim,J.O., Park,S.G. and Baek,K.H.
HAUSP-nucleolin interaction is regulated by p53-Mdm2 complex in response to DNA damage response
Sci Rep (2015) 5, 12793-12793. PubMed Europe PubMed DOI PMC EPMC
Pandita,T.K.
USP7 saves RIDDLE for the end
Cell Cycle (2015) 14, 1999- PubMed Europe PubMed DOI
Pfoh,R., Lacdao,I.K. and Saridakis,V.
Deubiquitinases and the new therapeutic opportunities offered to cancer
Endocr Relat Cancer (2015) 22, T35-T54. PubMed Europe PubMed DOI V T
Pfoh,R., Lacdao,I.K., Georges,A.A., Capar,A., Zheng,H., Frappier,L. and Saridakis,V.
Crystal structure of USP7 ubiquitin-like domains with an ICP0 peptide reveals a novel mechanism used by viral and cellular proteins to target USP7
PLoS Pathog (2015) 11, e1004950-e1004950. PubMed Europe PubMed DOI PMC EPMC
Pozhidaeva,A.K., Mohni,K.N., Dhe-Paganon,S., Arrowsmith,C.H., Weller,S.K., Korzhnev,D.M. and Bezsonova,I.
Structural characterization of interaction between human ubiquitin-specific protease 7 and immediate-early protein ICP0 of herpes simplex virus-1
J Biol Chem (2015) 290, 22907-22918. PubMed Europe PubMed DOI
Qian,J., Pentz,K., Zhu,Q., Wang,Q., He,J., Srivastava,A.K. and Wani,A.A.
USP7 modulates UV-induced PCNA monoubiquitination by regulating DNA polymerase eta stability
Oncogene (2015) 34, 4791-4796. PubMed Europe PubMed DOI
Ye,M., Tang,Y., Tang,S., Liu,J., Wu,K., Yao,S., Sun,Y., Zhou,L., Deng,T., Chen,Y., Huang,C. and Tan,W.
STIP is a critical nuclear scaffolding protein linking USP7 to p53-Mdm2 pathway regulation
Oncotarget (2015) 6, 34718-34731. PubMed Europe PubMed DOI
Zhang,Z.M., Rothbart,S.B., Allison,D.F., Cai,Q., Harrison,J.S., Li,L., Wang,Y., Strahl,B.D., Wang,G.G. and Song,J.
An allosteric interaction links USP7 to deubiquitination and chromatin targeting of UHRF1
Cell Rep (2015) 12, 1400-1406. PubMed Europe PubMed DOI PMC EPMC
Zhao,Y., Majid,M.C., Soll,J.M., Brickner,J.R., Dango,S. and Mosammaparast,N.
Noncanonical regulation of alkylation damage resistance by the OTUD4 deubiquitinase
EMBO J (2015) 34, 1687-1703. PubMed Europe PubMed DOI
Zhou,Z., Yao,X., Li,S., Xiong,Y., Dong,X., Zhao,Y., Jiang,J. and Zhang,Q.
Deubiquitination of Ci/Gli by Usp7/HAUSP regulates Hedgehog signaling
Dev Cell (2015) 34, 58-72. PubMed Europe PubMed DOI

2014

Alonso-de Vega,I., Martin,Y. and Smits,V.A.
USP7 controls Chk1 protein stability by direct deubiquitination
Cell Cycle (2014) 13, 3921-3926. PubMed Europe PubMed DOI
Bhattacharya,S. and Ghosh,M.K.
HAUSP, a novel deubiquitinase for Rb - MDM2 the critical regulator
FEBS J (2014) 281, 3061-3078. PubMed Europe PubMed DOI
Giovinazzi,S., Sirleto,P., Aksenova,V., Morozov,V.M., Zori,R., Reinhold,W.C. and Ishov,A.M.
Usp7 protects genomic stability by regulating Bub3
Oncotarget (2014) 5, 3728-3742. PubMed Europe PubMed
He,J., Zhu,Q., Wani,G., Sharma,N., Han,C., Qian,J., Pentz,K., Wang,Q.E. and Wani,A.A.
Ubiquitin-specific protease 7 regulates nucleotide excision repair through deubiquitinating XPC protein and preventing XPC protein from undergoing ultraviolet light-induced and VCP/p97 protein-regulated proteolysis
J Biol Chem (2014) 289, 27278-27289. PubMed Europe PubMed DOI
Jagannathan,M., Nguyen,T., Gallo,D., Luthra,N., Brown,G.W., Saridakis,V. and Frappier,L.
A role for USP7 in DNA replication
Mol Cell Biol (2014) 34, 132-145. PubMed Europe PubMed DOI
Kessler,B.M.
Selective and reversible inhibitors of ubiquitin-specific protease 7: a patent evaluation (WO2013030218)
Expert Opin Ther Pat (2014) 24, 597-602. PubMed Europe PubMed DOI I
Molland,K., Zhou,Q. and Mesecar,A.D.
A 2.2 A resolution structure of the USP7 catalytic domain in a new space group elaborates upon structural rearrangements resulting from ubiquitin binding
Acta Crystallogr F Struct Biol Commun (2014) 70, 283-287. PubMed Europe PubMed DOI S
Zemp,I. and Lingner,J.
The shelterin component TPP1 is a binding partner and substrate for the deubiquitinating enzyme USP7
J Biol Chem (2014) 289, 28595-28606. PubMed Europe PubMed DOI

2013

Ching,W., Koyuncu,E., Singh,S., Arbelo-Roman,C., Hartl,B., Kremmer,E., Speiseder,T., Meier,C. and Dobner,T.
A ubiquitin-specific protease possesses a decisive role for adenovirus replication and oncogene-mediated transformation
PLoS Pathog (2013) 9, e1003273-e1003273. PubMed Europe PubMed DOI PMC EPMC I
Colleran,A., Collins,P.E., O'Carroll,C., Ahmed,A., Mao,X., McManus,B., Kiely,P.A., Burstein,E. and Carmody,R.J.
Deubiquitination of NF-kappaB by ubiquitin-specific protease-7 promotes transcription
Proc Natl Acad Sci U S A (2013) 110, 618-623. PubMed Europe PubMed DOI
Dar,A., Shibata,E. and Dutta,A.
Deubiquitination of Tip60 by USP7 Determines the Activity of the p53-Dependent Apoptotic Pathway
Mol Cell Biol (2013) 33, 3309-3320. PubMed Europe PubMed DOI I
Gao,Y., Koppen,A., Rakhshandehroo,M., Tasdelen,I., van de Graaf,S.F., van Loosdregt,J., van Beekum,O., Hamers,N., van Leenen,D., Berkers,C.R., Berger,R., Holstege,F.C., Coffer,P.J., Brenkman,A.B., Ovaa,H. and Kalkhoven,E.
Early adipogenesis is regulated through USP7-mediated deubiquitination of the histone acetyltransferase TIP60
Nat Commun (2013) 4, 2656-2656. PubMed Europe PubMed DOI
Huang,O.W. and Cochran,A.G.
Regulation of deubiquitinase proteolytic activity
Curr Opin Struct Biol (2013) 23, 806-811. PubMed Europe PubMed DOI S
Khoronenkova,S.V. and Dianov,G.L.
USP7S-dependent inactivation of Mule regulates DNA damage signalling and repair
Nucleic Acids Res (2013) 41, 1750-1756. PubMed Europe PubMed DOI
Lee,K.W., Cho,J.G., Kim,C.M., Kang,A.Y., Kim,M., Ahn,B.Y., Chung,S.S., Lim,K.H., Baek,K.H., Sung,J.H., Park,K.S. and Park,S.G.
Herpesvirus-associated ubiquitin-specific protease (HAUSP) modulates peroxisome proliferator-activated receptor gamma (PPARgamma) stability through its deubiquitinating activity
J Biol Chem (2013) 288, 32886-32896. PubMed Europe PubMed DOI
Noguera,N.I., Song,M.S., Divona,M., Catalano,G., Calvo,K.L., Garcia,F., Ottone,T., Florenzano,F., Faraoni,I., Battistini,L., Colombo,E., Amadori,S., Pandolfi,P.P. and Lo-Coco,F.
Nucleophosmin/B26 regulates PTEN through interaction with HAUSP in acute myeloid leukemia
Leukemia (2013) 27, 1037-1043. PubMed Europe PubMed DOI
Sarkari,F., Wheaton,K., La Delfa,A., Mohamed,M., Shaikh,F., Khatun,R., Arrowsmith,C.H., Frappier,L., Saridakis,V. and Sheng,Y.
Ubiquitin-specific protease 7 is a regulator of ubiquitin-conjugating enzyme UbE2E1
J Biol Chem (2013) 288, 16975-16985. PubMed Europe PubMed DOI
Yamaguchi,M., Miyazaki,M., Kodrasov,M.P., Rotinsulu,H., Losung,F., Mangindaan,R.E., de Voogd,N.J., Yokosawa,H., Nicholson,B. and Tsukamoto,S.
Spongiacidin C, a pyrrole alkaloid from the marine sponge Stylissa massa, functions as a USP7 inhibitor
Bioorg Med Chem Lett (2013) 23, 3884-3886. PubMed Europe PubMed DOI I
Zhang,Y., Zhou,L., Rouge,L., Phillips,A.H., Lam,C., Liu,P., Sandoval,W., Helgason,E., Murray,J.M., Wertz,I.E. and Corn,J.E.
Conformational stabilization of ubiquitin yields potent and selective inhibitors of USP7
Nat Chem Biol (2013) 9, 51-58. PubMed Europe PubMed DOI

2012

Chauhan,D., Tian,Z., Nicholson,B., Kumar,K.G., Zhou,B., Carrasco,R., McDermott,J.L., Leach,C.A., Fulcinniti,M., Kodrasov,M.P., Weinstock,J., Kingsbury,W.D., Hideshima,T., Shah,P.K., Minvielle,S., Altun,M., Kessler,B.M., Orlowski,R., Richardson,P., Munshi,N. and Anderson,K.C.
A small molecule inhibitor of ubiquitin-specific protease-7 induces apoptosis in multiple myeloma cells and overcomes bortezomib resistance
Cancer Cell (2012) 22, 345-358. PubMed Europe PubMed DOI I
Faesen,A., Sixma,T.K. and Everett,R.D.
Ubiquitin-specific protease USP7
[ISSN:978-0-12-407743-0] (2012) 3, 2057-2062. DOI
Faesen,A.C., Luna-Vargas,M.P. and Sixma,T.K.
The role of UBL domains in ubiquitin-specific proteases
Biochem Soc Trans (2012) 40, 539-545. PubMed Europe PubMed DOI
Iphofer,A., Kummer,A., Nimtz,M., Ritter,A., Arnold,T., Frank,R., van den Heuvel,J., Kessler,B.M., Jansch,L. and Franke,R.
Profiling ubiquitin linkage specificities of deubiquitinating enzymes with branched ubiquitin isopeptide probes
Chembiochem (2012) 13, 1416-1420. PubMed Europe PubMed DOI P
Jager,W., Santag,S., Weidner-Glunde,M., Gellermann,E., Kati,S., Pietrek,M., Viejo-Borbolla,A. and Schulz,T.F.
The ubiquitin-specific protease USP7 modulates the replication of Kaposi's sarcoma-associated herpesvirus latent episomal DNA
J Virol (2012) 86, 6745-6757. PubMed Europe PubMed DOI
Kalamvoki,M., Gu,H. and Roizman,B.
Overexpression of the ubiquitin-specific protease 7 resulting from transfection or mutations in the ICP0 binding site accelerates rather than depresses herpes simplex virus 1 gene expression
J Virol (2012) 86, 12871-12878. PubMed Europe PubMed DOI
Menard,R. and Sulea,T.
Selective Inhibition of USP7
Chem Biol (2012) 19, 437-438. PubMed Europe PubMed DOI I
Reverdy,C., Conrath,S., Lopez,R., Planquette,C., Atmanene,C., Collura,V., Harpon,J., Battaglia,V., Vivat,V., Sippl,W. and Colland,F.
Discovery of specific inhibitors of human USP7/HAUSP deubiquitinating enzyme
Chem Biol (2012) 19, 467-477. PubMed Europe PubMed DOI I
Weinstock,J., Wu,J., Cao,P., Kingsbury,W.D., McDermott,J.L., Kodrasov,M.P., McKelvey,D.M., Suresh Kumar,K.G., Goldenberg,S.J., Mattern,M.R. and Nicholson,B.
Selective dual inhibitors of the cancer-related deubiquitylating proteases USP7 and USP47
ACS Med Chem Lett (2012) 3, 789-792. PubMed Europe PubMed DOI I

2011

Altun,M., Kramer,H.B., Willems,L.I., McDermott,J.L., Leach,C.A., Goldenberg,S.J., Kumar,K.G., Konietzny,R., Fischer,R., Kogan,E., Mackeen,M.M., McGouran,J., Khoronenkova,S.V., Parsons,J.L., Dianov,G.L., Nicholson,B. and Kessler,B.M.
Activity-based chemical proteomics accelerates inhibitor development for deubiquitylating enzymes
Chem Biol (2011) 18, 1401-1412. PubMed Europe PubMed DOI I
Epping,M.T., Meijer,L.A., Krijgsman,O., Bos,J.L., Pandolfi,P.P. and Bernards,R.
TSPYL5 suppresses p53 levels and function by physical interaction with USP7
Nat Cell Biol (2011) 13, 102-108. PubMed Europe PubMed DOI
Faesen,A.C., Dirac,A.M., Shanmugham,A., Ovaa,H., Perrakis,A. and Sixma,T.K.
Mechanism of USP7/HAUSP activation by its C-terminal ubiquitin-like domain and allosteric regulation by GMP-synthetase
Mol Cell (2011) 44, 147-159. PubMed Europe PubMed DOI S
Faesen,A.C., Luna-Vargas,M.P., Geurink,P.P., Clerici,M., Merkx,R., van Dijk,W.J., Hameed,D.S., El Oualid,F., Ovaa,H. and Sixma,T.K.
The differential modulation of USP activity by internal regulatory domains, interactors and eight ubiquitin chain types
Chem Biol (2011) 18, 1550-1561. PubMed Europe PubMed DOI
Kon,N., Zhong,J., Kobayashi,Y., Li,M., Szabolcs,M., Ludwig,T., Canoll,P.D. and Gu,W.
Roles of HAUSP-mediated p53 regulation in central nervous system development
Cell Death Differ (2011) 18, 1366-1375. PubMed Europe PubMed DOI
Lee,H.R., Choi,W.C., Lee,S., Hwang,J., Hwang,E., Guchhait,K., Haas,J., Toth,Z., Jeon,Y.H., Oh,T.K., Kim,M.H. and Jung,J.U.
Bilateral inhibition of HAUSP deubiquitinase by a viral interferon regulatory factor protein
Nat Struct Mol Biol (2011) 18, 1336-1344. PubMed Europe PubMed DOI S I
Nicholson,B. and Suresh Kumar,K.G.
The multifaceted roles of USP7: new therapeutic opportunities
Cell Biochem Biophys (2011) 60, 61-68. PubMed Europe PubMed DOI T I
Qing,P., Han,L., Bin,L., Yan,L. and Ping,W.X.
USP7 regulates the stability and function of HLTF through deubiquitination
J Cell Biochem (2011) 112, 3856-3862. PubMed Europe PubMed DOI
Sarkari,F., Wang,X., Nguyen,T. and Frappier,L.
The herpesvirus associated ubiquitin specific protease, USP7, is a negative regulator of PML proteins and PML nuclear bodies
PLoS ONE (2011) 6, e16598-e16598. PubMed Europe PubMed DOI PMC EPMC
Wrigley,J.D., Eckersley,K., Hardern,I.M., Millard,L., Walters,M., Peters,S.W., Mott,R., Nowak,T., Ward,R.A., Simpson,P.B. and Hudson,K.
Enzymatic characterisation of USP7 deubiquitinating activity and inhibition
Cell Biochem Biophys (2011) 60, 99-111. PubMed Europe PubMed DOI A

2010

de Bie,P., Zaaroor-Regev,D. and Ciechanover,A.
Regulation of the Polycomb protein RING1B ubiquitination by USP7
Biochem Biophys Res Commun (2010) 400, 389-395. PubMed Europe PubMed DOI
Kon,N., Kobayashi,Y., Li,M., Brooks,C.L., Ludwig,T. and Gu,W.
Inactivation of HAUSP in vivo modulates p53 function
Oncogene (2010) 29, 1270-1279. PubMed Europe PubMed DOI PMC EPMC
Ma,J., Martin,J.D., Xue,Y., Lor,L.A., Kennedy-Wilson,K.M., Sinnamon,R.H., Ho,T.F., Zhang,G., Schwartz,B., Tummino,P.J. and Lai,Z.
C-terminal region of USP7/HAUSP is critical for deubiquitination activity and contains a second mdm2/p53 binding site
Arch Biochem Biophys (2010) 503, 207-212. PubMed Europe PubMed DOI
Maertens,G.N., El Messaoudi-Aubert,S., Elderkin,S., Hiom,K. and Peters,G.
Ubiquitin-specific proteases 7 and 11 modulate Polycomb regulation of the INK4a tumour suppressor
EMBO J (2010) 29, 2553-2565. PubMed Europe PubMed DOI
Sarkari,F., La Delfa,A., Arrowsmith,C.H., Frappier,L., Sheng,Y. and Saridakis,V.
Further insight into substrate recognition by USP7: structural and biochemical analysis of the HdmX and Hdm2 interactions with USP7
J Mol Biol (2010) 402, 825-837. PubMed Europe PubMed DOI
Sarkari,F., Sheng,Y. and Frappier,L.
USP7/HAUSP promotes the sequence-specific DNA binding activity of p53
PLoS ONE (2010) 5, e13040-e13040. PubMed Europe PubMed DOI PMC EPMC
Tang,J., Qu,L., Pang,M. and Yang,X.
Daxx is reciprocally regulated by Mdm2 and Hausp
Biochem Biophys Res Commun (2010) 393, 542-545. PubMed Europe PubMed DOI PMC EPMC
van der Knaap,J.A., Kozhevnikova,E., Langenberg,K., Moshkin,Y.M. and Verrijzer,C.P.
Biosynthetic enzyme GMP synthetase cooperates with ubiquitin-specific protease 7 in transcriptional regulation of ecdysteroid target genes
Mol Cell Biol (2010) 30, 736-744. PubMed Europe PubMed DOI

2009

Colland,F., Formstecher,E., Jacq,X., Reverdy,C., Planquette,C., Conrath,S., Trouplin,V., Bianchi,J., Aushev,V.N., Camonis,J., Calabrese,A., Borg-Capra,C., Sippl,W., Collura,V., Boissy,G., Rain,J.C., Guedat,P., Delansorne,R. and Daviet,L.
Small-molecule inhibitor of USP7/HAUSP ubiquitin protease stabilizes and activates p53 in cells
Mol Cancer Ther (2009) 8, 2286-2295. PubMed Europe PubMed DOI I
Lee,E.W., Lee,M.S., Camus,S., Ghim,J., Yang,M.R., Oh,W., Ha,N.C., Lane,D.P. and Song,J.
Differential regulation of p53 and p21 by MKRN1 E3 ligase controls cell cycle arrest and apoptosis
EMBO J (2009) 28, 2100-2113. PubMed Europe PubMed DOI PMC EPMC
Sarkari,F., Sanchez-Alcaraz,T., Wang,S., Holowaty,M.N., Sheng,Y. and Frappier,L.
EBNA1-mediated recruitment of a histone H2B deubiquitylating complex to the Epstein-Barr virus latent origin of DNA replication
PLoS Pathog (2009) 5, e1000624-e1000624. PubMed Europe PubMed DOI PMC EPMC

2008

Antrobus,R. and Boutell,C.
Identification of a novel higher molecular weight isoform of USP7/HAUSP that interacts with the Herpes simplex virus type-1 immediate early protein ICP0
Virus Res (2008) 137, 64-71. PubMed Europe PubMed DOI
Becker,K., Marchenko,N.D., Palacios,G. and Moll,U.M.
A role of HAUSP in tumor suppression in a human colon carcinoma xenograft model
Cell Cycle (2008) 7, 1205-1213. PubMed Europe PubMed
Nathan,J.A., Sengupta,S., Wood,S.A., Admon,A., Markson,G., Sanderson,C. and Lehner,P.J.
The ubiquitin E3 ligase MARCH7 is differentially regulated by the deubiquitylating enzymes USP7 and USP9X
Traffic (2008) 9, 1130-1145. PubMed Europe PubMed DOI
Song,M.S., Salmena,L., Carracedo,A., Egia,A., Lo-Coco,F., Teruya-Feldstein,J. and Pandolfi,P.P.
The deubiquitinylation and localization of PTEN are regulated by a HAUSP-PML network
Nature (2008) 455, 813-817. PubMed Europe PubMed DOI
Yang,W., Dicker,D.T., Chen,J. and El-Deiry,W.S.
CARPs enhance p53 turnover by degrading 14-3-3sigma and stabilizing MDM2
Cell Cycle (2008) 7, 670-682. PubMed Europe PubMed

2007

Brooks,C.L., Li,M., Hu,M., Shi,Y. and Gu,W.
The p53-Mdm2-HAUSP complex is involved in p53 stabilization by HAUSP
Oncogene (2007) 26, 7262-7266. PubMed Europe PubMed DOI
Fernandez-Montalvan,A., Bouwmeester,T., Joberty,G., Mader,R., Mahnke,M., Pierrat,B., Schlaeppi,J.M., Worpenberg,S. and Gerhartz,B.
Biochemical characterization of USP7 reveals post-translational modification sites and structural requirements for substrate processing and subcellular localization
FEBS J (2007) 274, 4256-4270. PubMed Europe PubMed DOI
Kessler,B.M., Fortunati,E., Melis,M., Pals,C.E., Clevers,H. and Maurice,M.M.
Proteome changes induced by knock-down of the deubiquitylating enzyme HAUSP/USP7
J Proteome Res (2007) 6, 4163-4172. PubMed Europe PubMed DOI K
Oh,Y.M., Yoo,S.J. and Seol,J.H.
Deubiquitination of Chfr, a checkpoint protein, by USP7/HAUSP regulates its stability and activity
Biochem Biophys Res Commun (2007) 357, 615-619. PubMed Europe PubMed DOI

2006

Baek,K.H., Lee,H.J., Kim,M.S., Kim,Y.S., Seong,M., Lee,E.J. and Lee,M.Y.
Molecular cloning of rHAUSP encoding a deubiquitinating enzyme in rat testis
Oncol Rep (2006) 15, 173-177. PubMed Europe PubMed
Cheon,K.W. and Baek,K.H.
HAUSP as a therapeutic target for hematopoietic tumors (review)
Int J Oncol (2006) 28, 1209-1215. PubMed Europe PubMed V
[YEAR:17-1-2006]Hu,M., Gu,L., Li,M., Jeffrey,P.D., Gu,W. and Shi,Y.
Structural basis of competitive recognition of p53 and MDM2 by HAUSP/USP7: implications for the regulation of the p53-MDM2 pathway
PLoS Biol (17-1-2006) 4, e27-e27. PubMed Europe PubMed DOI PMC EPMC S
Kwon,J.E., La,M., Oh,K.H., Oh,Y.M., Kim,G.R., Seol,J.H., Baek,S.H., Chiba,T., Tanaka,K., Bang,O.S., Joe,C.O. and Chung,C.H.
BTB domain-containing speckle-type POZ protein (SPOP) serves as an adaptor of Daxx for ubiquitination by Cul3-based ubiquitin ligase
J Biol Chem (2006) 281, 12664-12672. PubMed Europe PubMed DOI
Masuya,D., Huang,C., Liu,D., Nakashima,T., Yokomise,H., Ueno,M., Nakashima,N. and Sumitomo,S.
The HAUSP gene plays an important role in non-small cell lung carcinogenesis through p53-dependent pathways
J Pathol (2006) 208, 724-732. PubMed Europe PubMed DOI
[YEAR:12-2-2006]Sheng,Y., Saridakis,V., Sarkari,F., Duan,S., Wu,T., Arrowsmith,C.H. and Frappier,L.
Molecular recognition of p53 and MDM2 by USP7/HAUSP
Nat Struct Mol Biol (12-2-2006) 13, 285-291. PubMed Europe PubMed DOI
[YEAR:10-9-2006]van der Horst,A., de Vries-Smits,A.M., Brenkman,A.B., van Triest,M.H., van den Broek,N., Colland,F., Maurice,M.M. and Burgering,B.M.
FOXO4 transcriptional activity is regulated by monoubiquitination and USP7/HAUSP
Nat Cell Biol (10-9-2006) 8, 1064-1073. PubMed Europe PubMed DOI

2005

Boutell,C., Canning,M., Orr,A. and Everett,R.D.
Reciprocal activities between herpes simplex virus type 1 regulatory protein ICP0, a ubiquitin E3 ligase, and ubiquitin-specific protease USP7
J Virol (2005) 79, 12342-12354. PubMed Europe PubMed DOI PMC EPMC
[YEAR:29-8-2005]Lee,H.J., Kim,M.S., Kim,Y.K., Oh,Y.K. and Baek,K.H.
HAUSP, a deubiquitinating enzyme for p53, is polyubiquitinated, polyneddylated, and dimerized
FEBS Lett (29-8-2005) 579, 4867-4872. PubMed Europe PubMed DOI
[YEAR:27-5-2005]Meulmeester,E., Maurice,M.M., Boutell,C., Teunisse,A.F., Ovaa,H., Abraham,T.E., Dirks,R.W. and Jochemsen,A.G.
Loss of HAUSP-mediated deubiquitination contributes to DNA damage-induced destabilization of Hdmx and Hdm2
Mol Cell (27-5-2005) 18, 565-576. PubMed Europe PubMed DOI
Saridakis,V., Sheng,Y., Sarkari,F., Holowaty,M.N., Shire,K., Nguyen,T., Zhang,R.G., Liao,J., Lee,W., Edwards,A.M., Arrowsmith,C.H. and Frappier,L.
Structure of the p53 binding domain of HAUSP/USP7 bound to Epstein-Barr nuclear antigen 1 implications for EBV-mediated immortalization
Mol Cell (2005) 18, 25-36. PubMed Europe PubMed DOI S
[YEAR:4-3-2005]van der Knaap,J.A., Kumar,B.R., Moshkin,Y.M., Langenberg,K., Krijgsveld,J., Heck,A.J., Karch,F. and Verrijzer,C.P.
GMP synthetase stimulates histone H2B deubiquitylation by the epigenetic silencer USP7
Mol Cell (4-3-2005) 17, 695-707. PubMed Europe PubMed DOI
Yoo,K.J., Lee,H.J., Lee,H., Lee,K.Y., Lee,S.H., Chung,H.M. and Baek,K.H.
Expression and functional analyses of mHAUSP regulating apoptosis of cervical adenocarcinoma cells
Int J Oncol (2005) 27, 97-104. PubMed Europe PubMed

2004

[YEAR:6-7-2004]Canning,M., Boutell,C., Parkinson,J. and Everett,R.D.
A RING finger ubiquitin ligase is protected from autocatalyzed ubiquitination and degradation by binding to ubiquitin-specific protease USP7
J Biol Chem (6-7-2004) 279, 38160-38168. PubMed Europe PubMed DOI
Cummins,J.M., Rago,C., Kohli,M., Kinzler,K.W., Lengauer,C. and Vogelstein,B.
Tumour suppression: disruption of HAUSP gene stabilizes p53
Nature (2004) 428, 1-1. PubMed Europe PubMed DOI
Cummins,J.M. and Vogelstein,B.
HAUSP is required for p53 destabilization
Cell Cycle (2004) 3, 689-692. PubMed Europe PubMed
Everett,R.D.
Ubiquitin-specific protease 7
[ISSN:0-12-079610-4] (2004) 2, 1236-1238. V
[YEAR:8-8-2004]Krishna,S.S. and Grishin,N.V.
The finger domain of the human deubiquitinating enzyme HAUSP is a zinc ribbon
Cell Cycle (8-8-2004) 3, 1046-1049. PubMed Europe PubMed

2003

[YEAR:8-8-2003]Holowaty,M.N., Zeghouf,M., Wu,H., Tellam,J., Athanasopoulos,V., Greenblatt,J. and Frappier,L.
Protein profiling with Epstein-Barr nuclear antigen-1 reveals an interaction with the herpesvirus-associated ubiquitin-specific protease HAUSP/USP7
J Biol Chem (8-8-2003) 278, 29987-29994. PubMed Europe PubMed DOI
Holowaty,M.N., Sheng,Y., Nguyen,T., Arrowsmith,C. and Frappier,L.
Protein interaction domains of the ubiquitin-specific protease, USP7/HAUSP
J Biol Chem (2003) 278, 47753-47761. PubMed Europe PubMed DOI

2002

Hong,S., Kim,S.J., Ka,S., Choi,I. and Kang,S.
USP7, a ubiquitin-specific protease, interacts with ataxin-1, the SCA1 gene product
Mol Cell Neurosci (2002) 20, 298-306. PubMed Europe PubMed DOI
[YEAR:27-12-2002]Hu,M., Li,P., Li,M., Li,W., Yao,T., Wu,J.W., Gu,W., Cohen,R.E. and Shi,Y.
Crystal structure of a UBP-family deubiquitinating enzyme in isolation and in complex with ubiquitin aldehyde
Cell (27-12-2002) 111, 1041-1054. PubMed Europe PubMed DOI S I
[YEAR:11-4-2002]Li,M., Chen,D., Shiloh,A., Luo,J., Nikolaev,A.Y., Qin,J. and Gu,W.
Deubiquitination of p53 by HAUSP is an important pathway for p53 stabilization
Nature (11-4-2002) 416, 648-653. PubMed Europe PubMed DOI

1999

Everett,R.D., Meredith,M. and Orr,A.
The ability of herpes simplex virus type 1 immediate-early protein Vmw110 to bind to a ubiquitin-specific protease contributes to its roles in the activation of gene expression and stimulation of virus replication
J Virol (1999) 73, 417-426. PubMed Europe PubMed PMC EPMC
[YEAR:1-10-1999]Layfield,R., Franklin,K., Landon,M., Walker,G., Wang,P., Ramage,R., Brown,A., Love,S., Urquhart,K., Muir,T., Baker,R. and Mayer,R.J.
Chemically synthesized ubiquitin extension proteins detect distinct catalytic capacities of deubiquitinating enzymes
Anal Biochem (1-10-1999) 274, 40-49. PubMed Europe PubMed DOI

1998

Everett,R.D., Freemont,P., Saitoh,H., Dasso,M., Orr,A., Kathoria,M. and Parkinson,J.
The disruption of ND10 during herpes simplex virus infection correlates with the Vmw110- and proteasome-dependent loss of several PML isoforms
J Virol (1998) 72, 6581-6591. PubMed Europe PubMed PMC EPMC
Robinson,P.A., Lomonte,P., Leek, Markham,A.F. and Everett,R.D.
Assignment of herpesvirus-associated ubiquitin-specific protease gene HAUSP to human chromosome band 16p13.3 by in situ hybridization
Cytogenet Cell Genet (1998) 83, 100-100. PubMed Europe PubMed

1997

Everett,R.D., Meredith,M., Orr,A., Cross,A., Kathoria,M. and Parkinson,J.
A novel ubiquitin-specific protease is dynamically associated with the PML nuclear domain and binds to a herpesvirus regulatory protein
EMBO J (1997) 16, 1519-1530. PubMed Europe PubMed DOI PMC EPMC
[YEAR:15-12-1997]Kashuba,V.I., Gizatullin,R.Z., Protopopov,A.I., Allikmets,R., Korolev,S., Li,J., Boldog,F., Tory,K., Zabarovska,V., Marcsek,Z., Sumegi,J., Klein,G., Zabarovsky,E.R. and Kisselev,L.
NotI linking/jumping clones of human chromosome 3: mapping of the TFRC, RAB7 and HAUSP genes to regions rearranged in leukemia and deleted in solid tumors
FEBS Lett (15-12-1997) 419, 181-185. PubMed Europe PubMed DOI