Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q6P2Q9

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-2335	P		NT	<%Agarwal et al., 2012[]%>
23	granzyme B (Homo sapiens-type)	2-2335	N		MS	Van Damme et al., 2010
868	cathepsin L	862-880	N		MS	Biniossek et al., 2011
868	cathepsin S	862-880	N		MS	Biniossek et al., 2011
1075	cathepsin L	1058-1086	N		MS	Biniossek et al., 2011
1873	glutamyl endopeptidase I	1866-1885	N		MS	Schilling & Overall, 2008
1885	trypsin 1	1-2335	N		MS	Schilling & Overall, 2008
2177	matrix metallopeptidase-2	2170-2198	N		MS	Schilling & Overall, 2008
2188	LAST_MAM peptidase (Limulus-type)	2185-2198	N		MS	Becker-Pauly et al., 2011
2198	trypsin 1	1-2335	N		MS	Schilling & Overall, 2008