Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 23 |
HIV-1 retropepsin |
16-40 |
N |
|
MS |
Schilling & Overall, 2008 |
| 25 |
HIV-1 retropepsin |
16-40 |
N |
|
MS |
Schilling & Overall, 2008 |
| 27 |
cathepsin K |
2-40 |
N |
|
MS |
Schilling & Overall, 2008 |
| 27 |
glutamyl endopeptidase I |
2-40 |
N |
|
MS |
Schilling & Overall, 2008 |
| 40 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 60 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 64 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 65 |
matrix metallopeptidase-2 |
53-83 |
N |
|
MS |
Schilling & Overall, 2008 |
| 67 |
HIV-1 retropepsin |
64-79 |
N |
|
MS |
Schilling & Overall, 2008 |
| 67 |
cathepsin G |
64-79 |
N |
|
MS |
Schilling & Overall, 2008 |
| 79 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 83 |
chymotrypsin A (cattle-type) |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 90 |
glutamyl endopeptidase I |
84-105 |
N |
|
MS |
Schilling & Overall, 2008 |
| 91 |
matrix metallopeptidase-2 |
84-105 |
N |
|
MS |
Schilling & Overall, 2008 |
| 92 |
cathepsin G |
84-105 |
N |
|
MS |
Schilling & Overall, 2008 |
| 93 |
elastase-2 |
84-105 |
N |
|
MS |
Schilling & Overall, 2008 |
| 93 |
cathepsin G |
84-105 |
N |
|
MS |
Schilling & Overall, 2008 |
| 96 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 103 |
chymotrypsin A (cattle-type) |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 105 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 156 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 163 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 199 |
matrix metallopeptidase-2 |
166-214 |
N |
|
MS |
Schilling & Overall, 2008 |
| 202 |
HIV-1 retropepsin |
166-214 |
N |
|
MS |
Schilling & Overall, 2008 |
| 205 |
granzyme B (Homo sapiens-type) |
1-451 |
N |
|
MS |
Van Damme et al., 2010 |
| 214 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 215 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 229 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 243 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 252 |
HIV-1 retropepsin |
243-264 |
N |
|
MS |
Schilling & Overall, 2008 |
| 264 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 269 |
cathepsin G |
264-280 |
N |
|
MS |
Schilling & Overall, 2008 |
| 270 |
matrix metallopeptidase-2 |
264-280 |
N |
|
MS |
Schilling & Overall, 2008 |
| 280 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 286 |
cathepsin G |
280-304 |
N |
|
MS |
Schilling & Overall, 2008 |
| 304 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 311 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 316 |
HIV-1 retropepsin |
311-326 |
N |
|
MS |
Schilling & Overall, 2008 |
| 320 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 326 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 336 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 339 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 342 |
HIV-1 retropepsin |
341-352 |
N |
|
MS |
Schilling & Overall, 2008 |
| 343 |
cathepsin G |
341-352 |
N |
|
MS |
Schilling & Overall, 2008 |
| 352 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 355 |
elastase-2 |
352-370 |
N |
|
MS |
Schilling & Overall, 2008 |
| 370 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 373 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 377 |
matrix metallopeptidase-2 |
373-390 |
N |
|
MS |
Schilling & Overall, 2008 |
| 390 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 394 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 401 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 422 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 430 |
trypsin 1 |
1-451 |
N |
|
MS |
Schilling & Overall, 2008 |
| 437 |
PhTET2 aminopeptidase |
437-450 |
N |
|
|
Dura et al., 2005 |
| 438 |
PhTET2 aminopeptidase |
438-450 |
N |
|
|
Dura et al., 2005 |
| 438 |
granzyme B (Homo sapiens-type) |
1-451 |
N |
|
MS |
Van Damme et al., 2010 |
| 439 |
PhTET2 aminopeptidase |
439-450 |
N |
|
|
Dura et al., 2005 |
| 440 |
PhTET2 aminopeptidase |
440-450 |
N |
|
|
Dura et al., 2005 |
| 441 |
PhTET2 aminopeptidase |
441-450 |
N |
|
|
Dura et al., 2005 |
| 442 |
PhTET2 aminopeptidase |
442-450 |
N |
|
|
Dura et al., 2005 |
| 443 |
PhTET2 aminopeptidase |
443-450 |
N |
|
|
Dura et al., 2005 |
