Substrates for peptidase M42.004: PhTET2 aminopeptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
AIT-Ad2 1-9 Ala+Ile-peptide N - - - Ala Ile Thr Ile Gly Dura et al., 2005
AIT-Ad2 2-9 Ala+Ile-peptide N - - - Ile Thr Ile Gly Asn Dura et al., 2005
AIT-Ad2 3-9 Ala+Ile-peptide N - - - Thr Ile Gly Asn Lys Dura et al., 2005
Ala-Ala-Ala-NHPhNO2 Ala+Ala-Ala-NHPhNO2 S - - - Ala Ala Ala NAN - Dura et al., 2005
Ala-Ala-NHPhNO2 Ala+Ala-NHPhNO2 S - - - Ala Ala NAN - - Dura et al., 2005
Ala-Ala-Phe-NHMec Ala+Ala-Phe-NHMec S - - - Ala Ala Phe AMC - Dura et al., 2005
Ala-NHPhNO2 Ala+NHPhNO2 S - - - Ala NAN - - - Dura et al., 2005
C12L 1-12 Cys+Gly-peptide N - - - Cys Gly Ala Thr Pro Dura et al., 2005
Gln-NHMec Gln+NHMec S - - - Gln AMC - - - Dura et al., 2005
Ile-NHPhNO2 Ile+NHPhNO2 S - - - Ile NAN - - - Dura et al., 2005
Leu-NHPhNO2 Leu+NHPhNO2 S - - - Leu NAN - - - Dura et al., 2005
mannose-binding protein C P11226 196-205 Val+Asp-Leu-Thr-Gly-Asn-Arg-Leu-Thr-Tyr N - - - Val Asp Leu Thr Gly Dura et al., 2005
Met-NHPhNO2 Met+NHPhNO2 S - - - Met NAN - - - Dura et al., 2005
Ser-NHMec Ser+NHMec S - - - Ser AMC - - - Dura et al., 2005
Thr-NHMec Thr+NHMec S - - - Thr AMC - - - Dura et al., 2005
tubulin alpha-1B chain P68363 440-450 Val+Glu-Gly-Glu-Gly-Glu-Glu-Glu-Gly-Glu-Glu N - - - Val Glu Gly Glu Gly Dura et al., 2005
tubulin alpha-1B chain P68363 437-450 Val+Asp-Ser-Val-Glu-Gly-Glu-Gly-Glu-Glu-Glu-Gly-Glu-Glu N - - - Val Asp Ser Val Glu Dura et al., 2005
tubulin alpha-1B chain P68363 438-450 Asp+Ser-Val-Glu-Gly-Glu-Gly-Glu-Glu-Glu-Gly-Glu-Glu N - - - Asp Ser Val Glu Gly Dura et al., 2005
tubulin alpha-1B chain P68363 439-450 Ser+Val-Glu-Gly-Glu-Gly-Glu-Glu-Glu-Gly-Glu-Glu N - - - Ser Val Glu Gly Glu Dura et al., 2005
tubulin alpha-1B chain P68363 441-450 Glu+Gly-Glu-Gly-Glu-Glu-Glu-Gly-Glu-Glu N - - - Glu Gly Glu Gly Glu Dura et al., 2005
tubulin alpha-1B chain P68363 442-450 Gly+Glu-Gly-Glu-Glu-Glu-Gly-Glu-Glu N - - - Gly Glu Gly Glu Glu Dura et al., 2005
tubulin alpha-1B chain P68363 443-450 Glu+Gly-Glu-Glu-Glu-Gly-Glu-Glu N - - - Glu Gly Glu Glu Glu Dura et al., 2005
Val-NHMec Val+NHMec S - - - Val AMC - - - Dura et al., 2005