Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-788 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 25 |
LAST_MAM peptidase (Limulus-type) |
22-45 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 27 |
LAST_MAM peptidase (Limulus-type) |
24-45 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 29 |
cathepsin S |
21-44 |
N |
|
MS |
Biniossek et al., 2011 |
| 32 |
unknown peptidase |
|
P |
|
MS |
Mahrus et al., 2008 |
| 44 |
peptidyl-Lys metallopeptidase |
1-788 |
N |
|
MS |
|
| 45 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 52 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 62 |
LAST_MAM peptidase (Limulus-type) |
59-75 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 93 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 100 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 149 |
cathepsin L |
145-158 |
N |
|
MS |
Biniossek et al., 2011 |
| 163 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 166 |
cathepsin L |
164-180 |
N |
|
MS |
Biniossek et al., 2011 |
| 171 |
granzyme B (Homo sapiens-type) |
2-788 |
N |
|
MS |
Van Damme et al., 2010 |
| 180 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 198 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 214 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 228 |
cathepsin S |
215-243 |
N |
|
MS |
Biniossek et al., 2011 |
| 243 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 246 |
cathepsin S |
244-255 |
N |
|
MS |
Biniossek et al., 2011 |
| 255 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 257 |
lysyl endopeptidase (bacteria) |
1-788 |
N |
|
MS |
|
| 275 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 288 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 364 |
cathepsin S |
328-376 |
N |
|
MS |
Biniossek et al., 2011 |
| 426 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 442 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 520 |
granzyme B (Homo sapiens-type) |
2-788 |
N |
|
MS |
Van Damme et al., 2010 |
| 523 |
caspase-3 |
2-788 |
P |
|
MS |
Impens et al., 2010 |
| 572 |
cathepsin L |
548-581 |
N |
|
MS |
Biniossek et al., 2011 |
| 597 |
cathepsin L |
582-609 |
N |
|
MS |
Biniossek et al., 2011 |
| 597 |
cathepsin S |
582-609 |
N |
|
MS |
Biniossek et al., 2011 |
| 600 |
meprin beta subunit |
2-788 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 617 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 626 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 637 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 642 |
peptidyl-Lys metallopeptidase |
1-788 |
N |
|
MS |
|
| 650 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 651 |
peptidyl-Lys metallopeptidase |
1-788 |
N |
|
MS |
|
| 661 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 668 |
granzyme B (Homo sapiens-type) |
2-788 |
N |
|
MS |
Van Damme et al., 2010 |
| 671 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 678 |
granzyme B (Homo sapiens-type) |
2-788 |
N |
|
MS |
Van Damme et al., 2010 |
| 697 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 705 |
astacin |
702-717 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 705 |
meprin beta subunit |
702-717 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 707 |
meprin alpha subunit |
704-717 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 709 |
astacin |
706-717 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 710 |
meprin alpha subunit |
707-717 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 717 |
trypsin 1 |
1-788 |
N |
|
MS |
Schilling & Overall, 2008 |
| 758 |
granzyme B (Homo sapiens-type) |
2-788 |
N |
|
MS |
Van Damme et al., 2010 |
| 770 |
trypsin 1 |
1-788 |
N |
|
|
Van Damme et al., 2009 |
