Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P37840

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	endopeptidase K	1-140	N			Levin etal, 2008
4	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
7	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
7	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
7	endopeptidase K	1-140	N			Levin etal, 2008
9	calpain-1	1-140	P		NT	Dufty et al., 2007
10	trypsin 1	1-140	N			Levin etal, 2008
12	trypsin 1	1-140	N			Levin etal, 2008
18	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
18	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
18	endopeptidase K	1-140	N			Levin etal, 2008
21	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
32	trypsin 1	1-140	N			Levin etal, 2008
41	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
43	trypsin 1	1-140	N			Levin etal, 2008
43	endopeptidase K	1-140	N			Levin etal, 2008
45	trypsin 1	1-140	N		MS	Schilling & Overall, 2008
47	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
53	endopeptidase K	1-140	N			Levin etal, 2008
54	matrix metallopeptidase-3	1-140	P			Sung et al., 2005
54	endopeptidase K	1-140	N			Levin etal, 2008
57	matrix metallopeptidase-3	1-140	P			Sung et al., 2005
58	trypsin 1	1-140	N		MS	Schilling & Overall, 2008
60	trypsin 1	1-140	N		MS	Schilling & Overall, 2008
66	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
70	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
70	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
70	endopeptidase K	1-140	N			Levin etal, 2008
71	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
71	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
73	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
74	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
78	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
78	matrix metallopeptidase-9	1-140	P	normal turnover		Levin etal, 2008
78	matrix metallopeptidase-3	1-140	P			Sung et al., 2005
79	matrix metallopeptidase-3	1-140	P			Sung et al., 2005
80	matrix metallopeptidase-3	1-140	P			Levin etal, 2008
80	trypsin 1	1-140	N		MS	Schilling & Overall, 2008
87	matrix metallopeptidase-3	1-140	P			Levin etal, 2008
89	endopeptidase K	1-140	N			Levin etal, 2008
90	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
90	matrix metallopeptidase-3	1-140	P			Levin etal, 2008
91	matrix metallopeptidase-3	1-140	P			Sung et al., 2005
91	endopeptidase K	1-140	N			Levin etal, 2008
92	endopeptidase K	1-140	N			Levin etal, 2008
93	matrix metallopeptidase-3	1-140	P			Sung et al., 2005
94	matrix metallopeptidase-3	1-140	P			Levin etal, 2008
97	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
97	trypsin 1	1-140	N			Levin etal, 2008
98	matrix metallopeptidase-9	1-140	P			Levin etal, 2008
98	endopeptidase K	1-140	N			Levin etal, 2008
102	matrix metallopeptidase-3	1-140	P			Sung et al., 2005
122	calpain-1	1-140	P			Dufty et al., 2007
123	cathepsin D	1-140	P	normal turnover	NT	Sevlever et al., 2008
133	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008
134	matrix metallopeptidase-1	1-140	P	normal turnover		Levin etal, 2008