Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P22392

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-152	P		NT	<%Agarwal et al., 2012[]%>
6	LAST peptidase (Limulus-type)	3-18	N		MS	Becker-Pauly et al., 2011
6	LAST_MAM peptidase (Limulus-type)	3-18	N		MS	Becker-Pauly et al., 2011
6	trypsin 1	1-152	N		MS	Schilling & Overall, 2008
9	cathepsin L	2-23	N		MS	Biniossek et al., 2011
9	cathepsin S	7-18	N		MS	Biniossek et al., 2011
9	elastase-2	6-18	N		MS	Schilling & Overall, 2008
18	trypsin 1	1-152	N		MS	Schilling & Overall, 2008
26	trypsin 1	1-152	N		MS	Schilling & Overall, 2008
27	trypsin 1	1-152	N		MS	Schilling & Overall, 2008
38	peptidyl-Lys metallopeptidase	1-152	N		MS
48	peptidyl-Lys metallopeptidase	1-152	N		MS
75	cathepsin B	67-85	N		MS	Biniossek et al., 2011
76	cathepsin B	67-85	N		MS	Biniossek et al., 2011
91	HIV-1 retropepsin	88-105	N		MS	Schilling & Overall, 2008
91	meprin beta subunit	88-105	N		MS	Becker-Pauly et al., 2011
91	elastase-2	88-105	N		MS	Schilling & Overall, 2008
91	cathepsin G	88-105	N		MS	Schilling & Overall, 2008
92	cathepsin L	67-105	N		MS	Biniossek et al., 2011
92	cathepsin S	89-105	N		MS	Biniossek et al., 2011
92	meprin beta subunit	89-105	N		MS	Becker-Pauly et al., 2011
105	trypsin 1	1-152	N		MS	Schilling & Overall, 2008
113	cathepsin S	106-124	N		MS	Biniossek et al., 2011
114	trypsin 1	1-152	N		MS	Schilling & Overall, 2008
118	cathepsin L	115-128	N		MS	Biniossek et al., 2011
127	peptidyl-Lys metallopeptidase	1-152	N		MS
133	meprin alpha subunit	130-143	N		MS	Becker-Pauly et al., 2011
134	cathepsin L	129-143	N		MS	Biniossek et al., 2011
134	meprin alpha subunit	131-143	N		MS	Becker-Pauly et al., 2011
142	peptidyl-Lys metallopeptidase	1-152	N		MS