Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-381 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 11 |
cathepsin L |
2-22 |
N |
|
MS |
Biniossek et al., 2011 |
| 17 |
LAST_MAM peptidase (Limulus-type) |
14-32 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 18 |
meprin beta subunit |
15-32 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 18 |
LAST_MAM peptidase (Limulus-type) |
15-32 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 19 |
meprin beta subunit |
16-32 |
N |
|
MS |
Becker-Pauly et al., 2011 |
| 28 |
matrix metallopeptidase-2 |
22-37 |
N |
|
MS |
Schilling & Overall, 2008 |
| 31 |
peptidyl-Lys metallopeptidase |
1-381 |
N |
|
MS |
|
| 32 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 37 |
glutamyl endopeptidase I |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 43 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 44 |
peptidyl-Lys metallopeptidase |
1-381 |
N |
|
MS |
|
| 58 |
cathepsin L |
46-68 |
N |
|
MS |
Biniossek et al., 2011 |
| 58 |
cathepsin S |
46-68 |
N |
|
MS |
Biniossek et al., 2011 |
| 70 |
HIV-1 retropepsin |
69-86 |
N |
|
MS |
Schilling & Overall, 2008 |
| 72 |
elastase-2 |
69-86 |
N |
|
MS |
Schilling & Overall, 2008 |
| 73 |
cathepsin S |
46-86 |
N |
|
MS |
Biniossek et al., 2011 |
| 76 |
cathepsin L |
46-86 |
N |
|
MS |
Biniossek et al., 2011 |
| 83 |
glutamyl endopeptidase I |
45-96 |
N |
|
MS |
Schilling & Overall, 2008 |
| 85 |
elastase-2 |
45-96 |
N |
|
MS |
Schilling & Overall, 2008 |
| 85 |
cathepsin G |
45-96 |
N |
|
MS |
Schilling & Overall, 2008 |
| 86 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 96 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 98 |
cathepsin L |
97-108 |
N |
|
MS |
Biniossek et al., 2011 |
| 105 |
glutamyl endopeptidase I |
96-130 |
N |
|
MS |
Schilling & Overall, 2008 |
| 114 |
matrix metallopeptidase-2 |
107-130 |
N |
|
MS |
Schilling & Overall, 2008 |
| 130 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 138 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 148 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 156 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 160 |
cathepsin L |
157-172 |
N |
|
MS |
Biniossek et al., 2011 |
| 160 |
glutamyl endopeptidase I |
156-172 |
N |
|
MS |
Schilling & Overall, 2008 |
| 161 |
matrix metallopeptidase-2 |
156-172 |
N |
|
MS |
Schilling & Overall, 2008 |
| 164 |
matrix metallopeptidase-2 |
160-181 |
N |
|
MS |
Schilling & Overall, 2008 |
| 172 |
matrix metallopeptidase-2 |
168-181 |
N |
|
MS |
Schilling & Overall, 2008 |
| 172 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 176 |
peptidyl-Lys metallopeptidase |
1-381 |
N |
|
MS |
|
| 181 |
glutamyl endopeptidase I |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 183 |
glutamyl endopeptidase I |
182-209 |
N |
|
MS |
Schilling & Overall, 2008 |
| 193 |
HIV-1 retropepsin |
177-209 |
N |
|
MS |
Schilling & Overall, 2008 |
| 195 |
peptidyl-Lys metallopeptidase |
1-381 |
N |
|
MS |
|
| 200 |
matrix metallopeptidase-2 |
177-209 |
N |
|
MS |
Schilling & Overall, 2008 |
| 209 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 223 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 226 |
cathepsin L |
224-236 |
N |
|
MS |
Biniossek et al., 2011 |
| 226 |
cathepsin G |
224-236 |
N |
|
MS |
Schilling & Overall, 2008 |
| 227 |
elastase-2 |
224-236 |
N |
|
MS |
Schilling & Overall, 2008 |
| 236 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 238 |
cathepsin L |
224-238 |
N |
|
MS |
Biniossek et al., 2011 |
| 252 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 258 |
cathepsin L |
253-265 |
N |
|
MS |
Biniossek et al., 2011 |
| 265 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 298 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 304 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 320 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 330 |
elastase-2 |
320-341 |
N |
|
MS |
Schilling & Overall, 2008 |
| 331 |
cathepsin L |
321-341 |
N |
|
MS |
Biniossek et al., 2011 |
| 331 |
cathepsin S |
321-341 |
N |
|
MS |
Biniossek et al., 2011 |
| 331 |
cathepsin B |
321-341 |
N |
|
MS |
Biniossek et al., 2011 |
| 341 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 348 |
HIV-1 retropepsin |
341-358 |
N |
|
MS |
Schilling & Overall, 2008 |
| 348 |
glutamyl endopeptidase I |
341-358 |
N |
|
MS |
Schilling & Overall, 2008 |
| 349 |
HIV-1 retropepsin |
341-358 |
N |
|
MS |
Schilling & Overall, 2008 |
| 349 |
cathepsin G |
341-358 |
N |
|
MS |
Schilling & Overall, 2008 |
| 358 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 366 |
trypsin 1 |
2-381 |
N |
|
MS |
Schilling & Overall, 2008 |
| 370 |
cathepsin S |
367-381 |
N |
|
MS |
Biniossek et al., 2011 |
