Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P10493

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
28	unknown peptidase	1-1245	P	release of a signal peptide	NT	Durkin et al., 1988
33	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
62	matrix metallopeptidase-7	29-1245	P			Sires et al., 1993
62	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
110	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
119	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
231	trypsin 1	29-1245	N			Walker et al., 1998
231	plasmin	29-1245	P			Walker et al., 1998
248	matrix metallopeptidase-7	29-1245	P			Mayer et al., 1993
251	trypsin 1	29-1245	N			Walker et al., 1998
264	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
272	trypsin 1	29-1245	N			Walker et al., 1998
303	matrix metallopeptidase-7	29-1245	P			Mayer et al., 1993
325	unknown peptidase	29-1245	P			Sires et al., 1993
328	trypsin 1	29-1245	N			Sires et al., 1993
328	thrombin	29-1245	P			Walker et al., 1998
349	trypsin 1	29-1245	N			Walker et al., 1998
349	plasma kallikrein	29-1245	P			Walker et al., 1998
349	thrombin	29-1245	P			Walker et al., 1998
349	plasmin	29-1245	P			Walker et al., 1998
357	trypsin 1	29-1245	N			Walker et al., 1998
373	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
376	elastase-2	29-1245	P	normal turnover		Walker et al., 1998
378	chymase (Homo sapiens-type)	29-1245	P			Walker et al., 1998
379	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
648	unknown peptidase	29-1245	P			Sires et al., 1993
665	matrix metallopeptidase-7	29-1245	P			Sires et al., 1993
775	matrix metallopeptidase-7	29-1245	P			Sires et al., 1993
808	trypsin 1	29-1245	N			Sires et al., 1993
924	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
927	unknown peptidase	29-1245	P			Walker et al., 1998
953	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
954	trypsin 1	29-1245	N			Walker et al., 1998
978	elastase-2	29-1245	P	normal turnover		Walker et al., 1998
979	elastase-2	29-1245	P			Walker et al., 1998
1002	trypsin 1	29-1245	N			Walker et al., 1998
1002	thrombin	29-1245	N			Sires et al., 1993
1004	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
1004	matrix metallopeptidase-7	29-1245	P			Mayer et al., 1993
1012	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
1017	matrix metallopeptidase-2	29-1245	N		MS	auf dem Keller et al., 2010
1023	matrix metallopeptidase-7	29-1245	P			Mayer et al., 1993
1031	trypsin 1	29-1245	N			Walker et al., 1998
1031	thrombin	29-1245	N			Sires et al., 1993
1032	matrix metallopeptidase-2	29-1245	N		MS	auf dem Keller et al., 2010
1042	trypsin 1	29-1245	N			Walker et al., 1998
1044	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
1046	elastase-2	29-1245	P	normal turnover		Walker et al., 1998
1047	matrix metallopeptidase-7	29-1245	P			Mayer et al., 1993
1054	trypsin 1	29-1245	N			Walker et al., 1998
1055	elastase-2	29-1245	P	normal turnover		Walker et al., 1998
1065	trypsin 1	29-1245	N			Sires et al., 1993
1065	thrombin	29-1245	P	normal turnover		Walker et al., 1998
1066	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
1076	matrix metallopeptidase-2	29-1245	N		MS	auf dem Keller et al., 2010
1087	trypsin 1	29-1245	N			Walker et al., 1998
1089	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
1091	elastase-2	29-1245	P	normal turnover		Walker et al., 1998
1099	trypsin 1	29-1245	N			Walker et al., 1998
1111	matrix metallopeptidase-7	29-1245	P			Mayer et al., 1993
1115	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
1120	matrix metallopeptidase-2	29-1245	N		MS	auf dem Keller et al., 2010
1130	trypsin 1	29-1245	N			Walker et al., 1998
1132	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998
1167	trypsin 1	29-1245	N			Walker et al., 1998
1170	matrix metallopeptidase-3	29-1245	P	normal turnover		Walker et al., 1998
1180	trypsin 1	29-1245	N			Walker et al., 1998
1181	glutamyl endopeptidase I	29-1245	N			Walker et al., 1998