Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P10126

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
58	cathepsin D	1-462	P		MS	Impens et al., 2010
58	cathepsin E	1-462	P		MS	Impens et al., 2010
77	matrix metallopeptidase-2	1-462	N		MS	auf dem Keller et al., 2010
114	cathepsin D	1-462	P		MS	Impens et al., 2010
114	cathepsin E	1-462	P		MS	Impens et al., 2010
122	matrix metallopeptidase-2	1-462	N		MS	auf dem Keller et al., 2010
147	matrix metallopeptidase-2	1-462	N		MS	Kleifeld et al., 2010
148	cathepsin D	1-462	P		MS	Impens et al., 2010
252	granzyme B (Homo sapiens-type)	1-462	N			Van Damme et al., 2009
252	granzyme B, rodent-type	1-462	P	normal turnover		Van Damme et al., 2009
254	cathepsin D	1-462	P		MS	Impens et al., 2010
254	cathepsin E	1-462	P		MS	Impens et al., 2010
266	matrix metallopeptidase-2	1-462	N		MS	Kleifeld et al., 2010
266	trypsin 1	1-462	N			Van Damme et al., 2009
284	matrix metallopeptidase-2	1-462	N		MS	Kleifeld et al., 2010
352	matrix metallopeptidase-2	1-462	N		MS	Kleifeld et al., 2010
393	matrix metallopeptidase-2	1-462	N		MS	Prudova et al., 2010
393	matrix metallopeptidase-9	1-462	N		MS	Prudova et al., 2010
400	matrix metallopeptidase-2	1-462	N		MS	auf dem Keller et al., 2010
413	unknown peptidase	1-462	P			Van Damme et al., 2009
414	cathepsin D	1-462	P		MS	Impens et al., 2010
423	trypsin 1	1-462	N			Van Damme et al., 2009
437	matrix metallopeptidase-2	1-462	N		MS	Kleifeld et al., 2010