Substrates for peptidase S08.049: furin-2 (insect)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
neuroendocrine protein 7B2	P12961	27-212	peptide-Arg181+Ser-peptide	N	CS	Arg	Lys	Arg	Arg	Ser	Val	Asn	Pro	De Bie et al., 1995
pro-opiomelanocortin	P01193	27-235	peptide-Arg123+Ser-peptide	N		Glu	Gly	Lys	Arg	Ser	Tyr	Ser	Met	De Bie et al., 1995
pro-opiomelanocortin	P01193	27-235	peptide-Arg164+Glu-peptide	N		Glu	Phe	Lys	Arg	Glu	Leu	Glu	Gly	De Bie et al., 1995
proenkephalin-B	P06300	22-248	peptide-Arg234+Ser-peptide	N		Val	Val	Thr	Arg	Ser	Gln	Glu	Asn	De Bie et al., 1995