Substrates for peptidase M16.005: nardilysin

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
Alpha-neoendorphin	P06300	166-175	peptide-Arg171+Lys-Tyr-Pro-Leu	P		Gly	Phe	Leu	Arg	Lys	Tyr	Pro	Lys	Chesneau et al., 1994
atrial natriuretic factor	P01160	124-151	Ser-Leu-Arg+Arg-peptide	N		-	Ser	Leu	Arg	Arg	Ser	Ser	Cys	Chesneau et al., 2004
Dynorphin A(1-17)	P06300	202-218	peptide-Arg207+Arg-peptide	P		Gly	Phe	Leu	Arg	Arg	Ile	Arg	Pro	Chesneau et al., 1994
glucagon	P55095	53-81	peptide-Ser68+Arg-peptide	P	NT	Tyr	Leu	Asp	Ser	Arg	Arg	Ala	Gln	Fontés et al., 2005
preproneurotensin-(154-170)			peptide-Lys164+Arg-peptide	N		Tyr	Ile	Leu	Lys	Arg	Asp	Ser	Tyr	Chesneau et al., 2004
Rimorphin	P06300	221-233	peptide-Arg226+Arg-peptide	P		Gly	Phe	Leu	Arg	Arg	Gln	Phe	Lys	Chesneau et al., 1994
somatostatin-28	P61278	89-116	peptide-Arg13+Lys-peptide	N		Pro	Arg	Glu	Arg	Lys	Ala	Gly	Cys	Chesneau et al., 2004	17044