Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P04958

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-1315	P		NT	<%Agarwal et al., 2012[]%>
446	papain	2-457; 458-1315	N			Krieglstein et al., 1991
447	papain	2-457; 458-1315	N			Krieglstein et al., 1991
449	trypsin 1	2-457; 458-1315	N			Krieglstein et al., 1991
450	glutamyl endopeptidase I	2-457; 458-1315	N			Krieglstein et al., 1991
453	chymotrypsin A (cattle-type)	2-457; 458-1315	N			Krieglstein et al., 1991
455	trypsin 1	2-457; 458-1315	N			Krieglstein et al., 1991
457	tentoxilysin	2-1315	P
460	papain	2-457; 458-1315	N			Krieglstein et al., 1991
461	papain	2-457; 458-1315	N			Krieglstein et al., 1991
864	papain	2-457; 458-1315	N			Krieglstein et al., 1991
873	legumain, animal-type	864-1315	P	normal turnover		Chen et al., 2004
903	legumain, animal-type	900-907	N		NT	Dando et al., 1999
950	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
954	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
972	legumain, animal-type	969-976	N		NT	Dando et al., 1999
998	legumain, animal-type	995-1002	N		NT	Dando et al., 1999
1038	legumain, animal-type	1035-1042	N		NT	Dando et al., 1999
1068	legumain, animal-type	1065-1072	N		NT	Dando et al., 1999
1113	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1125	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1128	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1128	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1142	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1144	legumain, animal-type	1141-1148	N		NT	Dando et al., 1999
1148	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1148	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1149	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1149	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1150	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1165	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1165	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1171	legumain, animal-type	1168-1175	N		NT	Dando et al., 1999
1175	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1175	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1184	legumain, animal-type	864-1315	P	normal turnover		Moss et al., 2005
1188	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1189	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1189	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1219	legumain, animal-type	864-1315	P	normal turnover		Moss et al., 2005
1221	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1225	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1237	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1242	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1252	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1252	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1254	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1257	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1257	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1267	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1267	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1272	legumain, animal-type	1269-1276	N		NT	Dando et al., 1999
1284	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1284	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1289	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1289	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1299	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1300	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1303	cathepsin D	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1303	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997
1304	cathepsin E	2-457; 458-1315	P	normal turnover		Hewitt et al., 1997