Substrates for peptidase M27.001: tentoxilysin

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates Pharma

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference	CutDB
cellubrevin	Q15836	2-100	peptide-Gln59+Phe-peptide	N		Gly	Ala	Ser	Gln	Phe	Glu	Thr	Ser	Montecucco, 1998
tetanus toxin	P04958	2-1315	peptide-Ala457+Ser-peptide	P		Asn	Arg	Thr	Ala	Ser	Leu	Thr	Asp		17077
VAMP-1	P23763	1-118	peptide-Gln78+Phe-peptide	N		Gly	Ala	Ser	Gln	Phe	Glu	Ser	Ser	Montecucco, 1998
VAMP-2	P63045	2-116	peptide-Gln76+Phe-peptide	N	LC	Gly	Ala	Ser	Gln	Phe	Glu	Thr	Ser	Cornille et al., 1994