Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01236

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
28	unknown peptidase	1-227	P	release of a signal peptide	NT	Jacobs & Niall, 1975
81	matrix metallopeptidase-1	29-227	P			Macotela et al., 2006
81	thrombin	29-227	P		NT	Khurana et al., 1999
139	matrix metallopeptidase-1	29-227	P	normal turnover		Macotela et al., 2006
139	matrix metallopeptidase-2	29-227	P	normal turnover		Macotela et al., 2006
139	matrix metallopeptidase-9	29-227	P	normal turnover		Macotela et al., 2006
139	matrix metallopeptidase-3	29-227	P			Macotela et al., 2006
160	cathepsin D	29-227	P	normal turnover		Piwnica et al., 2004
175	cathepsin D	29-227	P	normal turnover		Piwnica et al., 2004
178	cathepsin D	29-227	P	normal turnover		Piwnica et al., 2004
184	matrix metallopeptidase-1	29-227	P	normal turnover		Macotela et al., 2006
184	matrix metallopeptidase-8	29-227	P			Macotela et al., 2006
184	matrix metallopeptidase-2	29-227	P			Macotela et al., 2006
184	matrix metallopeptidase-9	29-227	P			Macotela et al., 2006
184	matrix metallopeptidase-3	29-227	P			Macotela et al., 2006
184	matrix metallopeptidase-13	29-227	P			Macotela et al., 2006
187	procollagen C-peptidase	29-227	P		NT	Ge et al., 2007