Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P01034

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
26	unknown peptidase	1-146	P	release of a signal peptide	NT	Zhang & Henzel, 2004
29	prolyl tripeptidyl peptidase	27-146	N			Banbula et al., 1999
31	unknown peptidase	27-146	P		NT	Abrahamson et al., 1998
33	unknown peptidase	27-146	P		NT	Abrahamson et al., 1998
34	gingipain RgpA	27-146	N			Abrahamson et al., 1998
34	matrix metallopeptidase-2	27-146	P		NT	Dean et al., 2007
34	meprin alpha subunit	27-146	N		MS	Becker-Pauly et al., 2011
34	meprin beta subunit	27-146	N		MS	Becker-Pauly et al., 2011
35	meprin alpha subunit	27-146	N		MS	Becker-Pauly et al., 2011
36	elastase-2	27-146	P	normal turnover	NT	Abrahamson et al., 1998
37	glycyl endopeptidase	27-146	N			Popovic et al., 1999
37	cathepsin L	27-146	P	normal turnover		Popovic et al., 1999
37	meprin alpha subunit	27-146	N		MS	Becker-Pauly et al., 2011
37	meprin beta subunit	27-146	N		MS	Becker-Pauly et al., 2011
40	meprin alpha subunit	27-146	N		MS	Becker-Pauly et al., 2011
40	meprin beta subunit	27-146	N		MS	Becker-Pauly et al., 2011
41	meprin alpha subunit	27-146	N		MS	Becker-Pauly et al., 2011
41	meprin beta subunit	27-146	N		MS	Becker-Pauly et al., 2011
55	cathepsin D	27-146	P	normal turnover		Lenarcic et al., 1991
90	cathepsin D	27-146	P	normal turnover		Lenarcic et al., 1991
128	cathepsin D	27-146	P	normal turnover		Lenarcic et al., 1991
138	cathepsin D	27-146	P	normal turnover		Lenarcic et al., 1991