Substrates for peptidase S09.017: prolyl tripeptidyl peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Ala-Arg-Pro-Ala-D-Lys-amide Ala-Arg-Pro+Ala-D-Lys-amide N - Ala Arg Pro Ala DLy NH2 - Banbula et al., 1999
Ala-Phe-Pro-NHPhNO2 Ala-Phe-Pro+NHPhNO2 N - Ala Phe Pro NAN - - - Banbula et al., 1999
Arg-Gly-Pro-Phe-Pro-Ile Arg-Gly-Pro+Phe-Pro-Ile N - Arg Gly Pro Phe Pro Lys - Banbula et al., 1999
Arg-His-Pro-Lys-Tyr-Lys-Thr-Glu-Leu Arg-His-Pro+Lys-Tyr-Lys-Thr-Glu-Leu N - Arg His Pro Lys Tyr Lys Thr Banbula et al., 1999
Arg-Pro-Pro-Gly-Phe Arg-Pro-Pro+Gly-Phe N - Arg Pro Pro Gly Phe - - Banbula et al., 1999
Arg-Pro-Pro-Gly-Phe-Ser-Pro-Phe-Arg Arg-Pro-Pro+Gly-Phe-Ser-Pro-Phe-Arg N - Arg Pro Pro Gly Phe Ser Pro Banbula et al., 1999
cystatin C P01034 27-146 Ser-Ser+Gly-peptide N - Ser Ser Pro Gly Lys Pro Pro Banbula et al., 1999
Gly-Val-Pro-Lys-Thr-His-Leu-Glu-Leu Gly-Val-Pro+Lys-Thr-His-Leu-Glu-Leu N - Gly Val Pro Lys Thr His Leu Banbula et al., 1999
interleukin-6 P05231 30-212 Val-Pro+Gly-peptide N - Val Pro Pro Gly Glu Asp Ser Banbula et al., 1999
Pro-Asn-Pro-Asn-Gln-Gly-Asn-Phe-Ile Pro-Asn-Pro+Asn-Gln-Gly-Asn-Phe-Ile N - Pro Asn Pro Asn Gln Gly Asn Banbula et al., 1999
Val-Glu-Pro-Ile-Pro-Tyr Val-Glu-Pro+Ile-Pro-Tyr N - Val Glu Pro Ile Pro Tyr - Banbula et al., 1999
Val-Pro-Pro-Gly-Glu-Asp-Ser-Lys Val-Pro-Pro+Gly-Glu-Asp-Ser-Lys N - Val Pro Pro Gly Glu Asp Ser Banbula et al., 1999
Val-Pro-Pro-Gly-Glu-Asp-Ser-Lys-Glu-Val-Ala-Ala-Pro-His-Arg-Gln Val-Pro-Pro+Gly-Glu-Asp-Ser-Lys-Glu-Val-Ala-Ala-Pro-His-Arg-Gln N - Val Pro Pro Gly Glu Asp Ser Banbula et al., 1999