Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence O15355

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
115	cathepsin L	113-130	N		MS	Biniossek et al., 2011
115	cathepsin S	113-130	N		MS	Biniossek et al., 2011
116	cathepsin B	113-130	N		MS	Biniossek et al., 2011
116	matrix metallopeptidase-2	112-128	N		MS	Schilling & Overall, 2008
118	cathepsin L	113-130	N		MS	Biniossek et al., 2011
128	trypsin 1	1-546	N		MS	Schilling & Overall, 2008
130	trypsin 1	1-546	N		MS	Schilling & Overall, 2008
147	granzyme B (Homo sapiens-type)	1-546	N		MS	Plasman et al., 2011
237	LAST_MAM peptidase (Limulus-type)	234-250	N		MS	Becker-Pauly et al., 2011
242	cathepsin S	221-250	N		MS	Biniossek et al., 2011
326	granzyme B (Homo sapiens-type)	1-546	N		MS	Van Damme et al., 2010
335	matrix metallopeptidase-2	326-355	N		MS	Schilling & Overall, 2008
349	granzyme B (Homo sapiens-type)	1-546	N		MS	Van Damme et al., 2010
355	glutamyl endopeptidase I	1-546	N		MS	Schilling & Overall, 2008
358	trypsin 1	1-546	N		MS	Schilling & Overall, 2008
365	cathepsin L	359-376	N		MS	Biniossek et al., 2011
376	trypsin 1	1-546	N		MS	Schilling & Overall, 2008
387	granzyme B (Homo sapiens-type)	1-546	N		MS	Van Damme et al., 2010