Literature for peptidase A01.009: cathepsin D

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Francisco,C.C., Josafat Marina,E.B., Francisco Javier,C.M., Alonso Alexis,L.Z., Hisila Del Carmen,S.O., Ignacio Alfredo,R.E., Ofelia,R.S. and Jose Luis,C.L.
The Impact of Thermal and pH Variations on the Structure of Cathepsin D in the Hepatopancreas of Japanese Clam (Ruditapes philippinarum)
Curr Protein Pept Sci PubMed Europe PubMed DOI
Haddad,G. and Blaine,J.
miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum
Cells14, PubMed Europe PubMed DOI
Lu,Y., Wang,F.Y., Levine,M.S., Shi,H.R., Wang,Y., Xiong,X., Yang,L.M., Shi,Y.Q., Zou,T., Sessler,J.L., Liang,H. and Huang,K.B.
Oxoisoaporphine Alkaloid Iridium(III) Derivative: An Immunogenic Cell Death Inducer That Engages the Autophagy-Dependent Regulator Cathepsin D
J Am Chem Soc PubMed Europe PubMed DOI
Niu,L., Zhou,X., Li,D., Zheng,Y. and Li,H.
Glycosylation Triggers Cathepsin D Maturation and Secretion to Promote Gastric Cancer Development
Am J Pathol PubMed Europe PubMed DOI
Sulatsky,M.I., Stepanenko,O.V., Stepanenko,O.V., Mikhailova,E.V. and Sulatskaya,A.I.
From protective enzyme to facilitator of amyloid propagation: Cathepsin D-mediated amyloid fibril fragmentation
Int J Biol Macromol140971-140971. PubMed Europe PubMed DOI

2024

Alves,S., Santos-Pereira,C., Oliveira,C.S.F., Preto,A., Chaves,S.R. and Corte-Real,M.
Enhancement of Acetate-Induced Apoptosis of Colorectal Cancer Cells by Cathepsin D Inhibition Depends on Oligomycin A-Sensitive Respiration
Biomolecules14, PubMed Europe PubMed DOI
Desroys du Roure,P., Lajoie,L., Mallavialle,A., Alcaraz,L.B., Mansouri,H., Fenou,L., Garambois,V., Rubio,L., David,T., Coenon,L., Boissiere-Michot,F., Chateau,M.C., Ngo,G., Jarlier,M., Villalba,M., Martineau,P., Laurent-Matha,V., Roger,P., Guiu,S., Chardes,T., Gros,L. and Liaudet-Coopman,E.
A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer
J Immunother Cancer12, PubMed Europe PubMed DOI
Huber,R.J., Kim,W.D. and Wilson-Smillie,M.L.D.M.
Mechanisms regulating the intracellular trafficking and release of CLN5 and CTSD
Traffic25, e12925-e12925. PubMed Europe PubMed DOI
Lee,S.G., Woo,S.M., Seo,S.U., Lee,C.H., Baek,M.C., Jang,S.H., Park,Z.Y., Yook,S., Nam,J.O. and Kwon,T.K.
Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling
Exp Mol Med56, 383-394. PubMed Europe PubMed DOI
Schneider,J., Mitschke,J., Bhat,M., Vogele,D., Schilling,O., Reinheckel,T. and Hess,L.
Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover
Biochimie226, 35-48. PubMed Europe PubMed DOI
Xiong,N., Du,Y., Huang,C., Yan,Q., Zhao,L., Yang,C., Sun,Q., Gao,Z., Wang,C., Zhan,J., Zhang,H., Wang,S., Ye,Y., Li,Y. and Shen,Z.
N-glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer
Adv Sci (Weinh)e2411740-e2411740. PubMed Europe PubMed DOI
Zhao,D., Huang,Z.K., Liang,Y., Li,Z.J., Zhang,X.W., Li,K.H., Wu,H., Zhang,X.D., Li,C.S., An,D., Sun,X., An,M.X., Shi,J.X., Bao,Y.J., Tian,L., Wang,D.F., Wu,A.H., Chen,Y.H. and Zhao,W.D.
Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes
Circ Res134, e17-e17. PubMed Europe PubMed DOI

2023

Chai,Y.L., Liang,N.H.P., Chong,J.R., Venketasubramanian,N., Tan,B.Y., Hilal,S., Chen,C.P. and Lai,M.K.P.
Serum Cathepsin D Is a Potential Biomarker for Alzheimer's Disease Dementia and Cognitive Decline
J Alzheimers Dis91, 989-998. PubMed Europe PubMed DOI
Duarte-Olivenza,C., Moran,G., Hurle,J.M., Lorda-Diez,C.I. and Montero,J.A.
Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death
Cell Death Dis14, 813-813. PubMed Europe PubMed DOI
Ikari,N. and Arakawa,H.
Identification of a mitochondrial targeting sequence in cathepsin D and its localization in mitochondria
Biochem Biophys Res Commun655, 25-34. PubMed Europe PubMed DOI
Kim,H.S., Kong,H., Kim,T., Lim,C., Lee,S., Kim,S.H. and Suh,Y.G.
Structural Congeners of Izenamides Responsible for Cathepsin D Inhibition: Insights from Synthesis-Derived Elucidation
Mar Drugs21, PubMed Europe PubMed DOI
Ma,M., Liu,P., Wang,C., Deng,X., Zhang,L. and Zhang,J.
Oxidation of Cathepsin D by Hydroxy Radical: Its Effect on Enzyme Structure and Activity against Myofibrillar Proteins Extracted from Coregonus peled
Molecules28, PubMed Europe PubMed DOI
Mitsui,S., Yamaguchi,J., Suzuki,C., Uchiyama,Y. and Tanida,I.
TUNEL-positive structures in activated microglia and SQSTM1/p62-positive structures in activated astrocytes in the neurodegenerative brain of a CLN10 mouse model
Glia71, 2753-2769. PubMed Europe PubMed DOI
Ouyang,X., Wani,W.Y., Benavides,G.A., Redmann,M.J., Vo,H., van Groen,T., Darley-Usmar,V.M. and Zhang,J.
Cathepsin D overexpression in the nervous system rescues lethality and Abeta42 accumulation of cathepsin D systemic knockout in vivo
Acta Pharm Sin B13, 4172-4184. PubMed Europe PubMed DOI
Rodriguez-Rios,M., McHugh,B.J., Liang,Z., Megia-Fernandez,A., Lilienkampf,A., Dockrell,D. and Bradley,M.
A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages
Commun Chem6, 237-237. PubMed Europe PubMed DOI
Terron,H.M., Maranan,D.S., Burgard,L.A., LaFerla,F.M., Lane,S. and Leissring,M.A.
A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D
Int J Mol Sci24, PubMed Europe PubMed DOI
Ye,N., Miao,L., Wang,F., Wu,S., Wu,B., Zhou,Y., Wang,C. and Sun,G.
Cathepsin D Attenuates the Proliferation of Vascular Smooth Muscle Cells Induced by the AGE/RAGE Pathway by Suppressing the ERK Signal
Curr Pharm Des29, 2387-2395. PubMed Europe PubMed DOI K
Zhang,Y., Yu,Y., Zhou,H., Zhao,M. and Pan,X.
A novel function by cathepsin D in degradation of nucleic acids
Biochem Biophys Res Commun682, 250-258. PubMed Europe PubMed DOI

2022

Limonte,C.P., Valo,E., Drel,V., Natarajan,L., Darshi,M., Forsblom,C., Henderson,C.M., Hoofnagle,A.N., Ju,W., Kretzler,M., Montemayor,D., Nair,V., Nelson,R.G., O'Toole,J.F., Toto,R.D., Rosas,S.E., Ruzinski,J., Sandholm,N., Schmidt,I.M., Vaisar,T., Waikar,S.S., Zhang,J., Rossing,P., Ahluwalia,T.S., Groop,P.H., Pennathur,S., Snell-Bergeon,J.K., Costacou,T., Orchard,T.J., Sharma,K. and de Boer,I.H.
Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes
Diabetes Care45, 1416-1427. PubMed Europe PubMed DOI K
Pedram,K., Laqtom,N.N., Shon,D.J., Di Spiezio,A., Riley,N.M., Saftig,P., Abu-Remaileh,M. and Bertozzi,C.R.
Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals
Proc Natl Acad Sci U S A119, e2117105119-e2117105119. PubMed Europe PubMed DOI
Skopal,A., Keki,T., Toth,P.A., Csoka,B., Koscso,B., Nemeth,Z.H., Antonioli,L., Ivessa,A., Ciruela,F., Virag,L., Hasko,G. and Kokai,E.
Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling
J Biol Chem298, 101888-101888. PubMed Europe PubMed DOI

2021

Alcaraz,L.B., Mallavialle,A., David,T., Derocq,D., Delolme,F., Dieryckx,C., Mollevi,C., Boissiere-Michot,F., Simony-Lafontaine,J., du Manoir,S., Huesgen,P.F., Overall,C.M., Tartare-Deckert,S., Jacot,W., Chardes,T., Guiu,S., Roger,P., Reinheckel,T., Moali,C. and Liaudet-Coopman,E.
A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment
Theranostics11, 6173-6192. PubMed Europe PubMed DOI
Bassal,M., Liu,J., Jankowiak,W., Saftig,P. and Bartsch,U.
Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease
Cells10, PubMed Europe PubMed DOI
Bunk,J., Prieto Huarcaya,S., Drobny,A., Dobert,J.P., Walther,L., Rose-John,S., Arnold,P. and Zunke,F.
Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified alpha-Synuclein Degradation Properties
Front Cell Dev Biol9, 581805-581805. PubMed Europe PubMed DOI
Carvelli,L., Aguilera,A.C., Zyla,L., Pereyra,L.L., Morales,C.R., Hermo,L. and Sosa,M.A.
Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis
PLoS ONE16, e0250454-e0250454. PubMed Europe PubMed DOI
Caval,T., Hecht,E.S., Tang,W., Uy-Gomez,M., Nichols,A., Kil,Y.J., Sandoval,W., Bern,M. and Heck,A.J.R.
The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies
FEBS J PubMed Europe PubMed DOI
Falkowski,P., Mrozek,P., Miluski,P., Lukaszewski,Z. and Gorodkiewicz,E.
A Comparison of Various Chips Used for the Manufacture of Biosensors Applied in Non-Fluidic Array SPRi, Based on the Example of Determination of Cathepsin D
Biosensors (Basel)12, PubMed Europe PubMed DOI I
Hattersley,K.J., Carosi,J.M., Hein,L.K., Bensalem,J. and Sargeant,T.J.
PICALM regulates cathepsin D processing and lysosomal function
Biochem Biophys Res Commun570, 103-109. PubMed Europe PubMed DOI
Kunnapuu,J., Bokharaie,H. and Jeltsch,M.
Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs
Biology (Basel)10, PubMed Europe PubMed DOI
Liu,L. and Doray,B.
Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway
FEBS Open Bio11, 1695-1703. PubMed Europe PubMed DOI
Liu,Y.J., Zhang,T., Chen,S., Cheng,D., Wu,C., Wang,X., Duan,D., Zhu,L., Lou,H., Gong,Z., Wang,X.D., Ho,M.S. and Duan,S.
The noncanonical role of the protease cathepsin D as a cofilin phosphatase
Cell Res PubMed Europe PubMed DOI
Suire,C.N. and Leissring,M.A.
Cathepsin D: A Candidate Link between Amyloid beta-protein and Tauopathy in Alzheimer Disease
J Exp Neurol2, 10-15. PubMed Europe PubMed V
Wang,X., Zou,Y., Chen,Z., Li,Y., Pan,L., Wang,Y., Liu,M., Yin,C., Wu,J., Yang,C., Zhang,L., Li,C., Huang,Z., Wang,D., Qian,J., Ge,J., Zou,Y. and Gong,H.
Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis
Theranostics11, 1249-1268. PubMed Europe PubMed DOI I
Yang,J., Ding,X., Meng,S., Cai,J. and Zhou,W.
The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease
Mol Genet Genomic Mede1777-e1777. PubMed Europe PubMed DOI

2020

Araujo-Montoya,B.O., Senger,M.R., Gomes,B.F., Harris,G., Owens,R.J. and Silva-Jr,F.P.
Schistosoma mansoni cathepsin D1: biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells
Protein Expr Purif167, 105532-105532. PubMed Europe PubMed DOI
Choi,H., Ko,Y. and Lee,C.Y.
Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study
BMC Cancer20, 825-825. PubMed Europe PubMed DOI
Di,Y.Q., Han,X.L., Kang,X.L., Wang,D., Chen,C.H., Wang,J.X. and Zhao,X.F.
Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis
Autophagy1-23. PubMed Europe PubMed DOI
Ding,L., Houben,T., Oligschlaeger,Y., Bitorina,A.V., Verwer,B.J., Tushuizen,M.E. and Shiri-Sverdlov,R.
Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals
Front Endocrinol (Lausanne)11, 575070-575070. PubMed Europe PubMed DOI
Fu,Q., Yuan,J., Wang,L., Ran,H., Li,F., Liu,F., Zhang,J., Liu,W., Huang,W., Huang,Y. and Xia,X.
Proteomic analysis of murine macrophages mitochondria and lysosomes reveal cathepsin D as a potential broad-spectrum antimicrobial protein
J Proteomics223, 103821-103821. PubMed Europe PubMed DOI
Gomez,L.A., Alvarez,F.I., Molina,R.E., Soto-Shara,R., Daza-Castro,C., Flores,M.R., Leon,Y. and Onate,A.A.
A Zinc-Dependent Metalloproteinase of Brucella abortus Is Required in the Intracellular Adaptation of Macrophages
Front Microbiol11, 1586-1586. PubMed Europe PubMed DOI
Goyal,S., Patel,K.V., Nagare,Y., Raykar,D.B., Raikar,S.S., Dolas,A., Khurana,P., Cyriac,R., Sarak,S., Gangar,M., Agarwal,A.K. and Kulkarni,A.
Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D
Bioorg Med Chem29, 115879-115879. PubMed Europe PubMed DOI I
Henriques,B.S., Gomes,B., Oliveira,P.L., Garcia,E.S., Azambuja,P. and Genta,F.A.
Characterization of the Temporal Pattern of Blood Protein Digestion in Rhodnius prolixus: First Description of Early and Late Gut Cathepsins
Front Physiol11, 509310-509310. PubMed Europe PubMed DOI
Hoes,M.F., Tromp,J., Ouwerkerk,W., Bomer,N., Oberdorf-Maass,S.U., Samani,N.J., Ng,L.L., Lang,C.C., van der Harst,P., Hillege,H., Anker,S.D., Metra,M., van Veldhuisen,D.J., Voors,A.A. and van der Meer,P.
The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach
Eur J Heart Fail22, 2102-2111. PubMed Europe PubMed DOI
Hossain,M.I., Marcus,J.M., Lee,J.H., Garcia,P.L., Singh,V., Shacka,J.J., Zhang,J., Gropen,T.I., Falany,C.N. and Andrabi,S.A.
Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective
Autophagy1-19. PubMed Europe PubMed DOI U
Houstecka,R., Hadzima,M., Fanfrlik,J., Brynda,J., Pallova,L., Hanova,I., Mertlikova-Kaiserova,H., Lepsik,M., Horn,M., Smrcina,M., Majer,P. and Mares,M.
Biomimetic macrocyclic inhibitors of human cathepsin D: structure-activity relationship and binding mode analysis
J Med Chem63, 1576-1596. PubMed Europe PubMed DOI I
Jantas,D., Chwastek,J., Malarz,J., Stojakowska,A. and Lason,W.
Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition
Biomolecules10, PubMed Europe PubMed DOI
Kang,J., Kim,J.W., Heo,H., Lee,J., Park,K.Y., Yoon,J.H. and Chang,J.
Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease
Clin Transl Sci PubMed Europe PubMed DOI
Kang,J., Yu,Y., Jeong,S., Lee,H., Heo,H.J., Park,J.J., Na,H.S., Ko,D.S. and Kim,Y.H.
Prognostic role of high cathepsin D expression in breast cancer: a systematic review and meta-analysis
Ther Adv Med Oncol12, 1758835920927838-1758835920927838. PubMed Europe PubMed DOI
Ketterer,S., Mitschke,J., Ketscher,A., Schlimpert,M., Reichardt,W., Baeuerle,N., Hess,M.E., Metzger,P., Boerries,M., Peters,C., Kammerer,B., Brummer,T., Steinberg,F. and Reinheckel,T.
Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling
Nat Commun11, 5133-5133. PubMed Europe PubMed DOI
Liu,Y.J., Zhang,T., Cheng,D., Yang,J., Chen,S., Wang,X., Li,X., Duan,D., Lou,H., Zhu,L., Luo,J., Ho,M.S., Wang,X.D. and Duan,S.
Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD
Sci Adv6, PubMed Europe PubMed DOI
Maeser,S., Petre,B.A., Ion,L., Rawer,S., Kohlschutter,A., Santorelli,F.M., Simonati,A., Schulz,A. and Przybylski,M.
Enzymatic diagnosis of neuronal lipofuscinoses in dried blood spots using substrates for concomitant tandem mass spectrometry and fluorimetry
J Mass Spectrome4675-e4675. PubMed Europe PubMed DOI
Mahajan,U.M., Goni,E., Langhoff,E., Li,Q., Costello,E., Greenhalf,W., Kruger,S., Ormanns,S., Halloran,C., Ganeh,P., Marron,M., Lammerhirt,F., Zhao,Y., Beyer,G., Weiss,F.U., Sendler,M., Bruns,C.J., Kohlmann,T., Kirchner,T., Werner,J., D'Haese,J.G., von Bergwelt-Baildon,M., Heinemann,V., Neoptolemos,J.P., Buchler,M.W., Belka,C., Boeck,S., Lerch,M.M. and Mayerle,J.
Cathepsin D expression and gemcitabine resistance in pancreatic cancer
JNCI Cancer Spectr4, kz060-kz060. PubMed Europe PubMed DOI
Marques,A.R.A., Di Spiezio,A., Thiessen,N., Schmidt,L., Grotzinger,J., Lullmann-Rauch,R., Damme,M., Storck,S.E., Pietrzik,C.U., Fogh,J., Bar,J., Mikhaylova,M., Glatzel,M., Bassal,M., Bartsch,U. and Saftig,P.
Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis
Autophagy16, 811-825. PubMed Europe PubMed DOI E U
Niu,R., Wang,J., Geng,C., Li,Y., Dong,L., Liu,L., Chang,Y., Shen,J., Nie,Z., Zhang,Y. and Hu,B.
Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy
Aging (Albany NY)12, PubMed Europe PubMed DOI
Singh,M.P., Sharma,C. and Kang,S.C.
Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling
Int Immunopharmacol90, 107234-107234. PubMed Europe PubMed DOI
Suire,C.N., Abdul-Hay,S.O., Sahara,T., Kang,D., Brizuela,M.K., Saftig,P., Dickson,D.W., Rosenberry,T.L. and Leissring,M.A.
Cathepsin D regulates cerebral Abeta42/40 ratios via differential degradation of Abeta42 and Abeta40
Alzheimers Res Ther12, 80-80. PubMed Europe PubMed DOI K
Tam,J.M., Josephson,L., Pilozzi,A.R. and Huang,X.
A novel dual fluorochrome near-infrared imaging probe for potential Alzheimer's enzyme biomarkers-BACE1 and cathepsin D
Molecules25, PubMed Europe PubMed DOI L
Tayebi,N., Lopez,G., Do,J. and Sidransky,E.
Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism
Trends Mol Med26, 913-923. PubMed Europe PubMed DOI
Triebel,J., Schauer,N., Zamora,M., Moreno-Vega,A.I., Escalera,G.M., Clapp,C. and Bertsch,T.
Matrix metalloproteases and cathepsin D in human serum do not cleave prolactin to generate vasoinhibin
Clin Lab66, PubMed Europe PubMed DOI
Wang,Y., Wu,Q., Anand,B.G., Karthivashan,G., Phukan,G., Yang,J., Thinakaran,G., Westaway,D. and Kar,S.
Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against beta-amyloid-toxicity
Neuropathol Appl Neurobiol46, 686-706. PubMed Europe PubMed DOI
Wu,Y., Li,C., Peng,H., Swaidan,A., Riehle,A., Pollmeier,B., Zhang,Y., Gulbins,E. and Grassme,H.
Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D
Cells9, PubMed Europe PubMed DOI
Zhang,T., Cheng,D., Wu,C., Wang,X., Ke,Q., Lou,H., Zhu,L., Wang,X.D., Duan,S. and Liu,Y.J.
Lysosomal hydrolase cathepsin D non-proteolytically modulates dendritic morphology in Drosophila
Neurosci Bull36, 1147-1157. PubMed Europe PubMed DOI
Zheng,W., Chen,Q., Wang,C., Yao,D., Zhu,L., Pan,Y., Zhang,J., Bai,Y. and Shao,C.
Inhibition of cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy
Mol Carcinog59, 651-660. PubMed Europe PubMed DOI T

2019

Ashraf,Y., Mansouri,H., Laurent-Matha,V., Alcaraz,L.B., Roger,P., Guiu,S., Derocq,D., Robin,G., Michaud,H.A., Delpech,H., Jarlier,M., Pugniere,M., Robert,B., Puel,A., Martin,L., Landomiel,F., Bourquard,T., Achour,O., Fruitier-Arnaudin,I., Pichard,A., Deshayes,E., Turtoi,A., Poupon,A., Simony-Lafontaine,J., Boissiere-Michot,F., Pirot,N., Bernex,F., Jacot,W., du Manoir,S., Theillet,C., Pouget,J.P., Navarro-Teulon,I., Bonnefoy,N., Pelegrin,A., Chardes,T., Martineau,P. and Liaudet-Coopman,E.
Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies
J Immunother Cancer7, 29-29. PubMed Europe PubMed DOI
Butler,V.J., Cortopassi,W.A., Argouarch,A.R., Ivry,S.L., Craik,C.S., Jacobson,M.P. and Kao,A.W.
Progranulin stimulates the in vitro maturation of pro-cathepsin D at acidic pH
J Mol Biol431, 1038-1047. PubMed Europe PubMed DOI
Butler,V.J., Cortopassi,W.A., Gururaj,S., Wang,A.L., Pierce,O.M., Jacobson,M.P. and Kao,A.W.
Multi-granulin domain peptides bind to pro-cathepsin D and stimulate its enzymatic activity more effectively than progranulin in vitro
Biochemistry58, 2670-2674. PubMed Europe PubMed DOI
Cui,T., Chi,B., Heidbrink Thompson,J., Kasali,T., Sellick,C. and Turner,R.
Cathepsin D: removal strategy on Protein A chromatography, near real time monitoring and characterisation during monoclonal antibody production
J Biotechnol305, 51-60. PubMed Europe PubMed DOI
Jha,S.K., Rauniyar,K., Chronowska,E., Mattonet,K., Maina,E.W., Koistinen,H., Stenman,U.H., Alitalo,K. and Jeltsch,M.
KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D
elife8, PubMed Europe PubMed DOI
Kang,J.M., Yoo,W.G., Le,H.G., Thai,T.L., Hong,S.J., Sohn,W.M. and Na,B.K.
Partial characterization of two cathepsin D family aspartic peptidases of Clonorchis sinensis
Korean J Parasitol57, 671-680. PubMed Europe PubMed DOI
Khurana,P., Yadati,T., Goyal,S., Dolas,A., Houben,T., Oligschlaeger,Y., Agarwal,A.K., Kulkarni,A. and Shiri-Sverdlov,R.
Inhibiting extracellular cathepsin D reduces hepatic steatosis in Sprague-Dawley rats
Biomolecules9, PubMed Europe PubMed DOI I
Li,X., Qin,L., Li,Y., Yu,H., Zhang,Z., Tao,C., Liu,Y., Xue,Y., Zhang,X., Xu,Z., Wang,Y., Lou,H., Tan,Z., Saftig,P., Chen,Z., Xu,T., Bi,G., Duan,S. and Gao,Z.
Presynaptic endosomal cathepsin D regulates the biogenesis of GABAergic synaptic vesicles
Cell Rep28, 1015-1028. PubMed Europe PubMed DOI
Lim,C.
Total syntheses of cathepsin D inhibitory izenamides A, B, and C and structural confirmation of izenamide B
Molecules24, PubMed Europe PubMed DOI I
Suzuki,C., Tanida,I., Ohmuraya,M., Oliva Trejo,J.A., Kakuta,S., Sunabori,T. and Uchiyama,Y.
Lack of cathepsin D in the renal proximal tubular cells resulted in increased sensitivity against renal ischemia/reperfusion injury
Int J Mol Sci20, PubMed Europe PubMed DOI K
Thottath,J., Vellarikkal,S.K., Jayarajan,R., Verma,A., Manamel,M., Singh,A., Rajendran,V.R., Sivasubbu,S. and Scaria,V.
A novel cathepsin D mutation in 2 siblings with late infantile neuronal ceroid lipofuscinosis
Neurol Genet5, e302-e302. PubMed Europe PubMed DOI M
Vangala,G., Imhoff,F.M., Squires,C.M.L., Cridge,A.G. and Baird,S.K.
Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D
Exp Cell Res383, 111494-111494. PubMed Europe PubMed DOI
Zoia,M.A.P., Azevedo,F.V.P., Vecchi,L., Mota,S.T.S., Rodovalho,V.R., Cordeiro,A.O., Correia,L.I.V., Silva,A.C.A., Avila,V.M.R., Araujo,T.G. and Goulart,L.R.
Inhibition of triple-negative breast cancer cell aggressiveness by cathepsin D blockage: role of annexin A1
Int J Mol Sci20, PubMed Europe PubMed DOI I

2018

Aghdassi,A.A., John,D.S., Sendler,M., Weiss,F.U., Reinheckel,T., Mayerle,J. and Lerch,M.M.
Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis
J Biol Chem293, 1018-1029. PubMed Europe PubMed DOI
Arodola,O.A. and Soliman,M.E.
Hybrid 2D/3D-quantitative structure-activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors
Future Med Chem10, 5-26. PubMed Europe PubMed DOI I
Cornelio,V.E., de Moraes,M.C., Domingues,V.C., Fernandes,J.B., da Silva,M.F.D.G.F., Cass,Q.B. and Vieira,P.C.
Cathepsin D immobilized capillary reactors for on-flow screening assays
J Pharm Biomed Anal151, 252-259. PubMed Europe PubMed DOI A
Guo,D.Z., Xiao,L., Liu,Y.J., Shen,C., Lou,H.F., Lv,Y. and Pan,S.Y.
Cathepsin D deficiency delays central nervous system myelination by inhibiting proteolipid protein trafficking from late endosome/lysosome to plasma membrane
Exp Mol Med50, e457-e457. PubMed Europe PubMed DOI
Hanova,I., Brynda,J., Houstecka,R., Alam,N., Sojka,D., Kopacek,P., Maresova,L., Vondrasek,J., Horn,M., Schueler-Furman,O. and Mares,M.
Novel structural mechanism of allosteric regulation of aspartic peptidases via an evolutionarily conserved exosite
Cell Chem Biol25, 318-329. PubMed Europe PubMed DOI
Kettwig,M., Ohlenbusch,A., Jung,K., Steinfeld,R. and Gartner,J.
Cathepsin D polymorphism C224T in childhood-onset neurodegenerative disorders: no impact for childhood dementia
J Pediatr Genet7, 14-18. PubMed Europe PubMed DOI M
Leyria,J., Fruttero,L.L., Ligabue-Braun,R., Defferrari,M.S., Arrese,E.L., Soulages,J.L., Settembrini,B.P., Carlini,C.R. and Canavoso,L.E.
DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima (Hemiptera: Reduviidae): purification, bioinformatic analyses and the significance of its interaction with lipophorin in the internalization by developing oocytes
J Insect Physiol105, 28-39. PubMed Europe PubMed DOI
Ning,M., Yuan,M., Liu,M., Gao,Q., Wei,P., Gu,W., Wang,W. and Meng,Q.
Characterization of cathepsin D from Eriocheir sinensis involved in Spiroplasma eriocheiris infection
Dev Comp Immunol86, 1-8. PubMed Europe PubMed DOI
Rodriguez-Siordia,I., Rojo-Arreola,L., Navarrete Del Toro,M.L.A. and Garcia-Carreno,F.
American lobster cathepsin D, an aspartic peptidase resistant to proteolysis and active in organic solvents, non-ionic detergents and salts
Int J Biol Macromol107, 1501-1509. PubMed Europe PubMed DOI
Snir,J.A., Suchy,M., Bindseil,G.A., Kovacs,M., Chronik,B.A., Hudson,R.H.E., Pasternak,S.H. and Bartha,R.
An aspartyl cathepsin targeted PET agent: application in an Alzheimer's disease mouse model
J Alzheimers Dis61, 1241-1252. PubMed Europe PubMed DOI L
Xu,X., Zheng,Y., Huang,Y., Chen,J., Gong,Z., Li,Y., Lu,C., Lai,W. and Xu,Q.
Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging
J Dermatol Sci90, 263-275. PubMed Europe PubMed DOI

2017

Al-Awadhi,F.H., Law,B.K., Paul,V.J. and Luesch,H.
Grassystatins D-F, potent aspartic protease inhibitors from marine cyanobacteria as potential antimetastatic agents targeting invasive breast cancer
J Nat Prod80, 2969-2986. PubMed Europe PubMed DOI I
Aufschnaiter,A., Kohler,V. and Buttner,S.
Taking out the garbage: cathepsin D and calcineurin in neurodegeneration
Neural Regen Res12, 1776-1779. PubMed Europe PubMed DOI
Carcel-Trullols,J., Kovacs,A.D. and Pearce,D.A.
Role of the lysosomal membrane protein, CLN3, in the regulation of cathepsin D activity
J Cell Biochem118, 3883-3890. PubMed Europe PubMed DOI
Cheng,S., Wani,W.Y., Hottman,D.A., Jeong,A., Cao,D., LeBlanc,K.J., Saftig,P., Zhang,J. and Li,L.
Haplodeficiency of cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice
J Neurochem142, 297-304. PubMed Europe PubMed DOI
Dubey,V. and Luqman,S.
Cathepsin D as a promising target for the discovery of novel anticancer agents
Curr Cancer Drug Targets17, 404-422. PubMed Europe PubMed DOI T
Ellis,C.R., Tsai,C.C., Lin,F.Y. and Shen,J.
Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor
J Comput Chem38, 1260-1269. PubMed Europe PubMed DOI I
Kang,T., Jin,R., Zhang,Y., Wan,H., Lee,K.S., Jin,B.R. and Li,J.
Functional characterization of the aspartic proteinase cathepsin D in the beet armyworm (Spodoptera exigua)
Gene617, 1-7. PubMed Europe PubMed DOI
Koike,M., Shibata,M., Sunabori,T., Yamaguchi,J., Sakimura,K., Komatsu,M., Tanaka,K. and Uchiyama,Y.
Purkinje cells are more vulnerable to the specific depletion of cathepsin D than to that of Atg7
Am J Pathol187, 1586-1600. PubMed Europe PubMed DOI K
Li,Y., Chang,Y., Ye,N., Dai,D., Chen,Y., Zhang,N., Sun,G. and Sun,Y.
Advanced glycation end products inhibit the proliferation of human umbilical vein endothelial cells by inhibiting cathepsin D
Int J Mol Sci18, PubMed Europe PubMed DOI
Martinez-Alarcon,D., Saborowski,R., Rojo-Arreola,L. and Garcia-Carreno,F.
Is digestive cathepsin D the rule in decapod crustaceans?
Comp Biochem Physiol B Biochem Mol Biol215, 31-38. PubMed Europe PubMed DOI
Pimentel,A.C., Fuzita,F.J., Palmisano,G., Ferreira,C. and Terra,W.R.
Role of cathepsins D in the midgut of Dysdercus peruvianus
Comp Biochem Physiol B Biochem Mol Biol204, 45-52. PubMed Europe PubMed DOI
Pranjol,M.Z.I., Gutowski,N.J., Hannemann,M. and Whatmore,J.L.
Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways
Biochim Biophys Acta1865, 25-33. PubMed Europe PubMed DOI
Wu,P., Yuan,X., Li,F., Zhang,J., Zhu,W., Wei,M., Li,J. and Wang,X.
Myocardial upregulation of cathepsin D by ischemic heart disease promotes autophagic flux and protects against cardiac remodeling and heart failure
Circ Heart Fail10, PubMed Europe PubMed DOI
Xu,H., Bao,K., Tang,S., Ai,J., Hu,H. and Zhang,W.
Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors
J Pept Sci23, 701-706. PubMed Europe PubMed DOI I
Yu,C., Cha,Y., Wu,F., Xu,X., Qin,L. and Du,M.
Molecular cloning and functional characterization of cathepsin D from sea cucumber Apostichopus japonicus
Fish Shellfish Immunol70, 553-559. PubMed Europe PubMed DOI
Zhou,X., Paushter,D.H., Feng,T., Pardon,C.M., Mendoza,C.S. and Hu,F.
Regulation of cathepsin D activity by the FTLD protein progranulin
Acta Neuropathol134, 151-153. PubMed Europe PubMed DOI

2016

Al-Awadhi,F.H., Ratnayake,R., Paul,V.J. and Luesch,H.
Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium
Bioorg Med Chem24, 3276-3282. PubMed Europe PubMed DOI I
Anantaraju,H.S., Battu,M.B., Viswanadha,S., Sriram,D. and Yogeeswari,P.
Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: molecular docking and bioevaluation against triple-negative and triple-positive breast cancers
Mol Divers20, 521-535. PubMed Europe PubMed DOI I
Arodola,O.A. and Soliman,M.E.
Molecular dynamics simulations of ligand-induced flap conformational changes in cathepsin-D- a comparative study
J Cell Biochem117, 2643-2657. PubMed Europe PubMed DOI
Boonen,M., Staudt,C., Gilis,F., Oorschot,V., Klumperman,J. and Jadot,M.
Cathepsin D and its newly identified transport receptor Sez6l2 can modulate neurite outgrowth
J Cell Sci129, 557-568. PubMed Europe PubMed DOI
Castro-Gomes,T., Corrotte,M., Tam,C. and Andrews,N.W.
Plasma membrane repair is regulated extracellularly by proteases released from lysosomes
PLoS ONE11, e0152583-e0152583. PubMed Europe PubMed DOI
Cocchiaro,P., Fox,C., Tregidgo,N.W., Howarth,R., Wood,K.M., Situmorang,G.R., Pavone,L.M., Sheerin,N.S. and Moles,A.
Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury
Sci Rep6, 27112-27112. PubMed Europe PubMed DOI I
Di Domenico,F., Tramutola,A. and Perluigi,M.
Cathepsin D as a therapeutic target in Alzheimer's disease
Expert Opin Ther Targets20, 1393-1395. PubMed Europe PubMed DOI T
Fritsch,J., Fickers,R., Klawitter,J., Sarchen,V., Zingler,P., Adam,D., Janssen,O., Krause,E. and Schutze,S.
TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death
Oncotarget7, 75774-75789. PubMed Europe PubMed DOI
Jancekova,B., Ondrouskova,E., Knopfova,L., Smarda,J. and Benes,P.
Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL
Tumour Biol37, 10685-10696. PubMed Europe PubMed DOI
Ketscher,A., Ketterer,S., Dollwet-Mack,S., Reif,U. and Reinheckel,T.
Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10
Biochimie122, 219-226. PubMed Europe PubMed DOI K
Macias-Vidal,J., Guerrero-Hernandez,M., Estanyol,J.M., Aguado,C., Knecht,E., Coll,M.J. and Bachs,O.
Identification of lysosomal Npc1-binding proteins: cathepsin D activity is regulated by NPC1
Proteomics16, 150-158. PubMed Europe PubMed DOI
Mehanna,S., Suzuki,C., Shibata,M., Sunabori,T., Imanaka,T., Araki,K., Yamamura,K., Uchiyama,Y. and Ohmuraya,M.
Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity
Biochem Biophys Res Commun469, 405-411. PubMed Europe PubMed DOI
Morrow,G., Kim,H.J., Pellerito,O., Bourrelle-Langlois,M., Le Pecheur,M., Groebe,K. and Tanguay,R.M.
Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a mitochondrial localization for cathepsin D
Mech Ageing Dev155, 36-47. PubMed Europe PubMed DOI
Vidoni,C., Follo,C., Savino,M., Melone,M.A. and Isidoro,C.
The role of cathepsin D in the pathogenesis of human neurodegenerative disorders
Med Res Rev36, 845-870. PubMed Europe PubMed DOI
Zhou,Y., Wynia-Smith,S.L., Couvertier,S.M., Kalous,K.S., Marletta,M.A., Smith,B.C. and Weerapana,E.
Chemoproteomic strategy to quantitatively monitor transnitrosation uncovers functionally relevant S-nitrosation sites on cathepsin D and HADH2
Cell Chem Biol23, 727-737. PubMed Europe PubMed DOI
Zuhl,A.M., Nolan,C.E., Brodney,M.A., Niessen,S., Atchison,K., Houle,C., Karanian,D.A., Ambroise,C., Brulet,J.W., Beck,E.M., Doran,S.D., O'Neill,B.T., Am Ende,C.W., Chang,C., Geoghegan,K.F., West,G.M., Judkins,J.C., Hou,X., Riddell,D.R. and Johnson,D.S.
Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of beta-secretase inhibitors
Nat Commun7, 13042-13042. PubMed Europe PubMed DOI I

2015

Bae,E.J., Yang,N.Y., Lee,C., Kim,S., Lee,H.J. and Lee,S.J.
Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of alpha-synuclein aggregates
Cell Death Dis6, e1901-e1901. PubMed Europe PubMed DOI K
Bennett,N.R., Zwick,D.B., Courtney,A.H. and Kiessling,L.L.
Multivalent antigens for promoting B and T cell activation
ACS Chem Biol10, 1817-1824. PubMed Europe PubMed DOI
Carcel-Trullols,J., Kovacs,A.D. and Pearce,D.A.
Cell biology of the NCL proteins: what they do and don't do
Biochim Biophys Acta1852, 2242-2255. PubMed Europe PubMed DOI
Fernandez-Montoya,J. and Perez,M.
Cathepsin D in a murine model of frontotemporal dementia with Parkinsonism-linked to chromosome 17
J Alzheimers Dis45, 1-14. PubMed Europe PubMed DOI
Hu,H.Y., Lim,N.H., Ding-Pfennigdorff,D., Saas,J., Wendt,K.U., Ritzeler,O., Nagase,H., Plettenburg,O., Schultz,C. and Nazare,M.
DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis
Bioconjug Chem26, 383-388. PubMed Europe PubMed DOI I
Okada,R., Wu,Z., Zhu,A., Ni,J., Zhang,J., Yoshimine,Y., Peters,C., Saftig,P. and Nakanishi,H.
Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier
Mol Cell Neurosci64C, 51-60. PubMed Europe PubMed DOI K
Oliveira,C.S., Pereira,H., Alves,S., Castro,L., Baltazar,F., Chaves,S.R., Preto,A. and Corte-Real,M.
Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria
Cell Death Dis6, e1788-e1788. PubMed Europe PubMed DOI T I
Paz-Y-Mino,C.A., Garcia-Cardenas,J.M., Lopez-Cortes,A., Salazar,C., Serrano,M. and Leone,P.E.
Positive association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease
Am J Med Sci350, 296-301. PubMed Europe PubMed DOI M
Snir,J.A., Suchy,M., Lawrence,K.S., Hudson,R.H., Pasternak,S.H. and Bartha,R.
Prolonged in vivo retention of a cathepsin D targeted optical contrast agent in a mouse model of Alzheimer's disease
J Alzheimers Dis48, 73-87. PubMed Europe PubMed DOI L
Xiao,R., Zhang,Z., Wang,H., Han,Y., Gou,M., Li,B., Duan,D., Wang,J., Liu,X. and Li,Q.
Identification and characterization of a cathepsin D homologue from lampreys (Lampetra japonica)
Dev Comp Immunol49, 149-156. PubMed Europe PubMed DOI
Zeleznik,T.Z., Kadin,A., Turk,V. and Dolenc,I.
Aspartic cathepsin D degrades the cytosolic cysteine cathepsin inhibitor stefin B in the cells
Biochem Biophys Res Commun465, 213-217. PubMed Europe PubMed DOI
Zheng,Y., Chen,H., Lai,W., Xu,Q., Liu,C., Wu,L. and Maibach,H.I.
Cathepsin D repairing role in photodamaged skin barrier
Skin Pharmacol Physiol28, 97-102. PubMed Europe PubMed DOI U
Zhou,R., Lu,Y., Han,Y., Li,X., Lou,H., Zhu,L., Zhen,X. and Duan,S.
Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression
Prog Neuropsychopharmacol Biol Psychiatry63, 110-118. PubMed Europe PubMed DOI K

2014

Authier,F. and Desbuquois,B.
Assessment of insulin proteolysis in rat liver endosomes: its relationship to intracellular insulin signaling
Methods Enzymol535, 3-23. PubMed Europe PubMed DOI
Azizan,S., Wan,K.-L. and Mohd-Adnan,A.
Molecular characterisation and expression analysis of cathepsin D from the Asian seabass Lates calcarifer
Sains Malays43, 1139-1148.
Choi,K.M., Shim,S.H., An,C.M., Nam,B.H., Kim,Y.O., Kim,J.W. and Park,C.I.
Cloning, characterisation, and expression analysis of the cathepsin D gene from rock bream (Oplegnathus fasciatus)
Fish Shellfish Immunol40, 253-258. PubMed Europe PubMed DOI
Dougall,A.M., Skwarczynski,M., Khoshnejad,M., Chandrudu,S., Daly,N.L., Toth,I. and Loukas,A.
Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine
Hum Vaccin Immunother10, 399-409. PubMed Europe PubMed DOI
Gradler,U., Czodrowski,P., Tsaklakidis,C., Klein,M., Werkmann,D., Lindemann,S., Maskos,K. and Leuthner,B.
Structure-based optimization of non-peptidic cathepsin D inhibitors
Bioorg Med Chem Lett24, 4141-4150. PubMed Europe PubMed DOI I
Hersheson,J., Burke,D., Clayton,R., Anderson,G., Jacques,T.S., Mills,P., Wood,N.W., Gissen,P., Clayton,P., Fearnley,J., Mole,S.E. and Houlden,H.
Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology
Neurology83, 1873-1875. PubMed Europe PubMed DOI M
Ishida,M., Maehara,M., Watanabe,T., Yanagisawa,Y., Takata,Y., Nakajima,R., Suzuki,M. and Harigaya,T.
Vasoinhibins, N-terminal mouse prolactin fragments, participate in mammary gland involution
J Mol Endocrinol52, 279-287. PubMed Europe PubMed DOI
Jiao,Y., Li,C.H., Lu,X.J. and Chen,J.
Characterization and expression of sweetfish (Pleco glossus altivelis) cathepsin D
Dongwuxue Yanjiu35, 294-299. PubMed Europe PubMed DOI
Khalkhali-Ellis,Z. and Hendrix,M.J.C.
Two faces of cathepsin D: physiological guardian angel and pathological demon
Biol Med6, 206- PubMed Europe PubMed DOI V
Khalkhali-Ellis,Z., Goossens,W., Margaryan,N.V. and Hendrix,M.J.
Cleavage of histone 3 by cathepsin D in the involuting mammary gland
PLoS ONE9, e103230-e103230. PubMed Europe PubMed DOI
Mo,C., Peng,Q., Sui,J., Wang,J., Deng,Y., Xie,L., Li,T., He,Y., Qin,X. and Li,S.
Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis
BMC Neurol14, 13-13. PubMed Europe PubMed DOI M
Sayad,A., Noruzinia,M., Zamani,M., Harirchian,M.H. and Kazemnejad,A.
Association study of cathepsin D gene polymorphism in Iranian patients with sporadic late-onset Alzheimer's disease
Dementia Geriatr Cogn Disord37, 257-264. PubMed Europe PubMed DOI M
Tian,L., Zhang,K., Tian,Z.-Y., Wang,T., Shang,D.-S., Li,B., Liu,D.-X., Fang,W.-G., Wang,Z.-Y. and Chen,Y.-H.
Decreased expression of cathepsin D in monocytes is related to the defective degradation of amyloid-beta in Alzheimer's disease
J Alzheimer's Dis42, 511-520. PubMed Europe PubMed DOI
Venugopal,A. and Siva Kumar,N.
Biochemical characterization of cathepsin D from the mussel Lamellidens corrianus
Comp Biochem Physiol B Biochem Mol Biol169, 25-30. PubMed Europe PubMed DOI
Yu,J., Wu,F.Y., Zou,F.M., Cai,X.Y., Yu,H.Y., Liu,Y.W., Fang,Y., Ren,Z.X., Jia,J.Q., Zhang,G.Z., Guo,X.J., Jin,B.R. and Gui,Z.Z.
Identification and functional analysis of the cathepsin D gene promoter of Bombyx mori
Mol Biol Rep41, 1623-1630. PubMed Europe PubMed DOI

2013

Achour,O., Bridiau,N., Kacem,M., Delatouche,R., Bordenave-Juchereau,S., Sannier,F., Thiery,V., Piot,J.M., Maugard,T. and Arnaudin,I.
Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel cathepsin D substrate for simultaneous cancer diagnosis and therapy
Biochimie95, 2010-2017. PubMed Europe PubMed DOI
Amritraj,A., Wang,Y., Revett,T.J., Vergote,D., Westaway,D. and Kar,S.
Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis
J Biol Chem288, 3136-3152. PubMed Europe PubMed DOI
Ehling,R., Noskova,L., Stranecky,V., Hartmannova,H., Pristoupilova,A., Hodanova,K., Benke,T., Kovacs,G.G., Strobel,T., Niedermuller,U., Wagner,M., Nachbauer,W., Janecke,A., Budka,H., Boesch,S. and Kmoch,S.
Cerebellar dysfunction in a family harboring the PSEN1 mutation co-segregating with a cathepsin D variant p.A58V
J Neurol Sci326, 75-82. PubMed Europe PubMed DOI M
Follo,C., Ozzano,M., Montalenti,C., Santoro,M.M. and Isidoro,C.
Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy
Biosci Rep33, e00034-e00034. PubMed Europe PubMed DOI K
Follo,C., Ozzano,M., Montalenti,C., Ekkapongpisit,M. and Isidoro,C.
Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-cathepsin D: functional implications
Int J Biochem Cell Biol45, 273-282. PubMed Europe PubMed DOI
Frost,L.S., Lopes,V.S., Stefano,F.P., Bragin,A., Williams,D.S., Mitchell,C.H. and Boesze-Battaglia,K.
Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium
Vis Neurosci30, 55-64. PubMed Europe PubMed DOI
Kim,S.J., Kim,K.H., Ahn,E.R., Yoo,B.C. and Kim,S.Y.
Depletion of cathepsin D by transglutaminase 2 through protein cross-linking promotes cell survival
Amino Acids44, 73-80. PubMed Europe PubMed DOI
Koch,S., Scifo,E., Rokka,A., Trippner,P., Lindfors,M., Korhonen,R., Corthals,G.L., Virtanen,I., Lalowski,M. and Tyynela,J.
Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain
Neurobiol Dis50, 107-119. PubMed Europe PubMed DOI K
Mahmood,W., Viberg,L.T., Fischer,K., Walton,S.F. and Holt,D.C.
An aspartic protease of the scabies mite Sarcoptes scabiei is involved in the digestion of host skin and blood macromolecules
PLoS Negl Trop Dis7, e2525-e2525. PubMed Europe PubMed DOI
Maynadier,M., Vezenkov,L.L., Amblard,M., Martin,V., Gandreuil,C., Vaillant,O., Gary-Bobo,M., Basile,I., Hernandez,J.F., Garcia,M. and Martinez,J.
Dipeptide mimic oligomer transporter mediates intracellular delivery of cathepsin D inhibitors: a potential target for cancer therapy
J Control Release171, 251-257. PubMed Europe PubMed DOI I
Maynadier,M., Farnoud,R., Lamy,P.J., Laurent-Matha,V., Garcia,M. and Rochefort,H.
Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment
Int J Oncol43, 1683-1690. PubMed Europe PubMed DOI
Pulliero,A., Marengo,B., Longobardi,M., Fazzi,E., Orcesi,S., Olivieri,I., Cereda,C., Domenicotti,C., Balottin,U. and Izzotti,A.
Inhibition of the de-myelinating properties of Aicardi-Goutieres Syndrome lymphocytes by cathepsin D silencing
Biochem Biophys Res Commun430, 957-962. PubMed Europe PubMed DOI K
Rojo,L., Garcia-Carreno,F. and de Los Angeles Navarrete Del Toro
Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization
Mar Biotechnol (NY)15, 87-96. PubMed Europe PubMed DOI
Sheng,Q., Cao,D., Zhou,Y., Lei,Q., Han,H., Li,F., Lu,Y. and Wang,C.
Detection of SNPs in the cathepsin D gene and their association with yolk traits in chickens
PLoS ONE8, e56656-e56656. PubMed Europe PubMed DOI M
Sun,H., Lou,X., Shan,Q., Zhang,J., Zhu,X., Zhang,J., Wang,Y., Xie,Y., Xu,N. and Liu,S.
Proteolytic characteristics of cathepsin D related to the recognition and cleavage of its target proteins
PLoS ONE8, e65733-e65733. PubMed Europe PubMed DOI P
Ta,R., Suchy,M., Tam,J.H., Li,A.X., Martinez-Santiesteban,F.S., Scholl,T.J., Hudson,R.H., Bartha,R. and Pasternak,S.H.
A dual magnetic resonance imaging/fluorescent contrast agent for cathepsin-D detection
Contrast Media Mol Imaging8, 127-139. PubMed Europe PubMed DOI L

2012

Appelqvist,H., Johansson,A.C., Linderoth,E., Johansson,U., Antonsson,B., Steinfeld,R., Kagedal,K. and Ollinger,K.
Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183
Ann Clin Lab Sci42, 231-242. PubMed Europe PubMed P
Conus,S., Pop,C., Snipas,S.J., Salvesen,G.S. and Simon,H.U.
Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis
J Biol Chem287, 21142-21151. PubMed Europe PubMed DOI
Dali,B., Keita,M., Megnassan,E., Frecer,V. and Miertus,S.
Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human cathepsin D
Chem Biol Drug Des79, 411-430. PubMed Europe PubMed DOI I
Dong,Z.D., Zhang,J., Ji,X.S., Zhou,F.N., Fu,Y., Chen,W., Zeng,Y.Q., Li,T.M. and Wang,H.
Molecular cloning, characterization and expression of cathepsin D from grass carp (Ctenopharyngodon idella)
Fish Shellfish Immunol33, 1207-1214. PubMed Europe PubMed DOI
Fan,C., Lin,X. and Wang,E.
Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study
Tumour Biol33, 1045-1052. PubMed Europe PubMed DOI
Fusek,M., Mares,M. and Vetvicka,V.
Cathepsin D
[ISSN:978-0-12-407744-7]3, 54-63. DOI
Hah,Y.S., Noh,H.S., Ha,J.H., Ahn,J.S., Hahm,J.R., Cho,H.Y. and Kim,D.R.
Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells
Cancer Lett323, 208-214. PubMed Europe PubMed DOI
Huber-Lang,M., Denk,S., Fulda,S., Erler,E., Kalbitz,M., Weckbach,S., Schneider,E.M., Weiss,M., Kanse,S.M. and Perl,M.
Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro
Mol Immunol50, 60-65. PubMed Europe PubMed DOI
Karwowska,A., Lapinski,R., Gacko,M., Grzegorczyk,E., Zurawska,J. and Karczewski,J.K.
Effect of heavy metal cations on the activity of cathepsin D (in vitro study)
Folia Histochem Cytobiol50, 432-435. PubMed Europe PubMed DOI I
Laurent-Matha,V., Huesgen,P.F., Masson,O., Derocq,D., Prebois,C., Gary-Bobo,M., Lecaille,F., Rebiere,B., Meurice,G., Orear,C., Hollingsworth,R.E., Abrahamson,M., Lalmanach,G., Overall,C.M. and Liaudet-Coopman,E.
Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment
FASEB J26, 5172-5181. PubMed Europe PubMed DOI
Liu,X., Shi,G., Cui,D., Wang,R. and Xu,T.
Molecular cloning and comprehensive characterization of cathepsin D in the Miiuy croaker Miichthys miiuy
Fish Shellfish Immunol32, 464-468. PubMed Europe PubMed DOI
Mahapatra,C. and Mahapatra,P.K.
Immunohistochemical localization of cathepsin D and a possible role of melanocytes during tail resorption in tadpoles of a tropical toad
J Morphol273, 791-800. PubMed Europe PubMed DOI
McConnell,R.M., Inapudi,K., Kadasala,N., Yarlagadda,K., Velusamy,P., McConnell,M.S., Green,A., Trana,C., Sayyar,K. and McConnell,J.S.
New cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines
Med Chem8, 1146-1154. PubMed Europe PubMed I
Melzer,I.M., Fernandez,S.B., Bosser,S., Lohrig,K., Lewandrowski,U., Wolters,D., Kehrloesser,S., Brezniceanu,M.L., Theos,A.C., Irusta,P.M., Impens,F., Gevaert,K. and Zornig,M.
The Apaf-1-binding protein Aven is cleaved by cathepsin D to unleash its anti-apoptotic potential
Cell Death Differ19, 1435-1445. PubMed Europe PubMed DOI
Sakkiah,S., Thangapandian,S. and Lee,K.W.
Ligand-based virtual screening and molecular docking studies to identify the critical chemical features of potent cathepsin D inhibitors
Chem Biol Drug Des80, 64-79. PubMed Europe PubMed DOI I
Shacka,J.J.
Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics
Brain Res Bull88, 43-57. PubMed Europe PubMed DOI M

2011

Bewley,M.A., Marriott,H.M., Tulone,C., Francis,S.E., Mitchell,T.J., Read,R.C., Chain,B., Kroemer,G., Whyte,M.K. and Dockrell,D.H.
A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci
PLoS Pathog7, e1001262-e1001262. PubMed Europe PubMed DOI K
Buchold,C., Hemberger,Y., Heindl,C., Welker,A., Degel,B., Pfeuffer,T., Staib,P., Schneider,S., Rosenthal,P.J., Gut,J., Morschhauser,J., Bringmann,G. and Schirmeister,T.
New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors
ChemMedChem6, 141-152. PubMed Europe PubMed DOI I
Chen,L., Zhang,M. and Sun,L.
Identification and expressional analysis of two cathepsins from half-smooth tongue sole (Cynoglossus semilaevis)
Fish Shellfish Immunol31, 1270-1277. PubMed Europe PubMed DOI
Devosse,T., Dutoit,R., Migeotte,I., De Nadai,P., Imbault,V., Communi,D., Salmon,I. and Parmentier,M.
Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3
J Immunol187, 1475-1485. PubMed Europe PubMed DOI P
Feng,T., Zhang,H., Liu,H., Zhou,Z., Niu,D., Wong,L., Kucuktas,H., Liu,X., Peatman,E. and Liu,Z.
Molecular characterization and expression analysis of the channel catfish cathepsin D genes
Fish Shellfish Immunol31, 164-169. PubMed Europe PubMed DOI
Follo,C., Ozzano,M., Mugoni,V., Castino,R., Santoro,M. and Isidoro,C.
Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish
PLoS ONE6, e21908-e21908. PubMed Europe PubMed DOI K
Jeong,B.H., Lee,K.H., Lee,Y.J., Yun,J., Park,Y.J., Kim,Y.H., Cho,Y.S., Choi,E.K., Carp,R.I. and Kim,Y.S.
Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia
Acta Neurol Scand123, 419-423. PubMed Europe PubMed DOI M
Koch,S., Molchanova,S.M., Wright,A.K., Edwards,A., Cooper,J.D., Taira,T., Gillingwater,T.H. and Tyynela,J.
Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis
J Neuropathol Exp Neurol70, 1089-1096. PubMed Europe PubMed DOI K
Liang,Q., Ouyang,X., Schneider,L. and Zhang,J.
Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons
Mol Neurodegener6, 37-37. PubMed Europe PubMed DOI U
Mahapatra,C. and Mahapatra,P.K.
Involvement of cathepsin D during tail regression in tadpoles of the common Indian tree frog, Polypedates maculatus (Anura: Rhacophoridae)
Acta Histochem113, 756-762. PubMed Europe PubMed DOI
Malik,M., Fenko,M.D., Sheikh,A.M., Wen,G. and Li,X.
A Novel Approach for Characterization of Cathepsin D Protease and Its Effect on Tau and beta-Amyloid Proteins
Neurochem Res36, 754-760. PubMed Europe PubMed DOI
Masson,O., Prebois,C., Derocq,D., Meulle,A., Dray,C., Daviaud,D., Quilliot,D., Valet,P., Muller,C. and Liaudet-Coopman,E.
Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis
PLoS ONE6, e16452-e16452. PubMed Europe PubMed DOI
Nakken,B., Varga,T., Szatmari,I., Szeles,L., Gyongyosi,A., Illarionov,P.A., Dezso,B., Gogolak,P., Rajnavolgyi,E. and Nagy,L.
Peroxisome proliferator-activated receptor gamma-regulated cathepsin D is required for lipid antigen presentation by dendritic cells
J Immunol187, 240-247. PubMed Europe PubMed DOI
Pike,L.S., Tannous,B.A., Deliolanis,N.C., Hsich,G., Morse,D., Tung,C.H., Sena-Esteves,M. and Breakefield,X.O.
Imaging gene delivery in a mouse model of congenital neuronal ceroid lipofuscinosis
Gene Ther18, 1173-1178. PubMed Europe PubMed DOI M U
Schuur,M., Ikram,M.A., van Swieten,J.C., Isaacs,A., Vergeer-Drop,J.M., Hofman,A., Oostra,B.A., Breteler,M.M. and van Duijn,C.M.
Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis
Neurobiol Aging32, 1607-1614. PubMed Europe PubMed DOI
Tulone,C., Sponaas,A.M., Raiber,E.A., Tabor,A.B., Langhorne,J. and Chain,B.M.
Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1
PLoS ONE6, e24886-e24886. PubMed Europe PubMed DOI
Zebrakovska,I., Masa,M., Srp,J., Horn,M., Vavrova,K. and Mares,M.
Complex modulation of peptidolytic activity of cathepsin D by sphingolipids
Biochim Biophys Acta1811, 1097-1104. PubMed Europe PubMed DOI

2010

Ahmed,W., Rani,M., Khan,I.A., Iqbal,A., Khan,K.M., Haleem,M.A. and Azim,M.K.
Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors
J Enzyme Inhib Med Chem25, 673-678. PubMed Europe PubMed DOI I
Albayrak,O., Tirniceriu,A., Riemenschneider,M., Kurz,A., Scherag,A. and Egensperger,R.
The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men
J Gerontol A Biol Sci Med Sci65, 219-224. PubMed Europe PubMed DOI M
Balti,R., Hmidet,N., Jellouli,K., Nedjar-Arroume,N., Guillochon,D. and Nasri,M.
Cathepsin D from the hepatopancreas of the cuttlefish (Sepia officinalis): purification and characterization
J Agric Food Chem58, 10623-10630. PubMed Europe PubMed DOI
Beaujouin,M., Prebois,C., Derocq,D., Laurent-Matha,V., Masson,O., Pattingre,S., Coopman,P., Bettache,N., Grossfield,J., Hollingsworth,R.E., Zhang,H., Yao,Z., Hyman,B.T., van der Geer,P., Smith,G.K. and Liaudet-Coopman,E.
Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth
J Cell Sci123, 3336-3346. PubMed Europe PubMed DOI
Chahory,S., Keller,N., Martin,E., Omri,B., Crisanti,P. and Torriglia,A.
Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D
Neurochem Int57, 278-287. PubMed Europe PubMed DOI
Fontanesi,L., Speroni,C., Buttazzoni,L., Scotti,E., Dall'Olio,S., Nanni Costa,L., Davoli,R. and Russo,V.
The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism
J Anim Sci88, 2235-2245. PubMed Europe PubMed DOI M
Kovacs,G.G., Sanchez-Juan,P., Strobel,T., Schuur,M., Poleggi,A., Nocentini,S., Giannattasio,C., Belay,G., Bishop,M., Capellari,S., Parchi,P., Gelpi,E., Gal,A., Bakos,A., Molnar,M.J., Heinemann,U., Zerr,I., Knight,R.S., Mitrova,E., van Duijn,C. and Budka,H.
Cathepsin D (C224T) polymorphism in sporadic and genetic Creutzfeldt-Jakob disease
Alzheimer Dis Assoc Disord24, 104-107. PubMed Europe PubMed DOI M
Li,C., Zhang,H., Li,L. and Song,L.
Identification of a cathepsin D potentially involved in H2A cleavage from scallop Chlamys farreri
Mol Biol Rep37, 1451-1460. PubMed Europe PubMed DOI
Margaryan,N.V., Kirschmann,D.A., Lipavsky,A., Bailey,C.M., Hendrix,M.J.C. and Khalkhali-Ellis,Z.
New insights into cathepsin D in mammary tissue development and remodeling
Cancer Biol Ther10, 457-466. PubMed Europe PubMed DOI
Masson,O., Bach,A.S., Derocq,D., Prebois,C., Laurent-Matha,V., Pattingre,S. and Liaudet-Coopman,E.
Pathophysiological functions of cathepsin D: targeting its catalytic activity versus its protein binding activity?
Biochimie92, 1635-1643. PubMed Europe PubMed DOI
Mutka,A.L., Haapanen,A., Kakela,R., Lindfors,M., Wright,A.K., Inkinen,T., Hermansson,M., Rokka,A., Corthals,G., Jauhiainen,M., Gillingwater,T.H., Ikonen,E. and Tyynela,J.
Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain
J Neurochem112, 193-203. PubMed Europe PubMed DOI K
Nicotra,G., Castino,R., Follo,C., Peracchio,C., Valente,G. and Isidoro,C.
The dilemma: does tissue expression of cathepsin D reflect tumor malignancy? The question: does the assay truly mirror cathepsin D mis-function in the tumor?
Cancer Biomark7, 47-64. PubMed Europe PubMed DOI
Nicotra,G., Manfroi,F., Follo,C., Castino,R., Fusco,N., Peracchio,C., Kerim,S., Valente,G. and Isidoro,C.
High expression of cathepsin D in non-Hodgkin's lymphomas negatively impacts on clinical outcome
Dis Markers28, 167-183. PubMed Europe PubMed DOI
Nussbaumerova,M., Srp,J., Masa,M., Hradilek,M., Sanda,M., Reinis,M., Horn,M. and Mares,M.
Single- and double-headed chemical probes for detection of active cathepsin D in a cancer cell proteome
Chembiochem11, 1538-1541. PubMed Europe PubMed DOI
Rojo,L., Muhlia-Almazan,A., Saborowski,R. and Garcia-Carreno,F.
Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus
Mar Biotechnol (NY)12, 696-707. PubMed Europe PubMed DOI
Rojo,L., Sotelo-Mundo,R., Garcia-Carreno,F. and Graf,L.
Isolation, biochemical characterization, and molecular modeling of American lobster digestive cathepsin D1
Comp Biochem Physiol B Biochem Mol Biol157, 394-400. PubMed Europe PubMed DOI
Shevtsova,Z., Garrido,M., Weishaupt,J., Saftig,P., Bahr,M., Luhder,F. and Kugler,S.
CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis
Am J Pathol177, 271-279. PubMed Europe PubMed DOI K
Suchy,M., Ta,R., Li,A.X., Wojciechowski,F., Pasternak,S.H., Bartha,R. and Hudson,R.H.
A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies
Org Biomol Chem8, 2560-2566. PubMed Europe PubMed DOI L

2009

Ahn,J.E. and Zhu-Salzman,K.
CmCatD, a cathepsin D-like protease has a potential role in insect defense against a phytocystatin
J Insect Physiol55, 678-685. PubMed Europe PubMed DOI
Beckman,M., Freeman,C., Parish,C.R. and Small,D.H.
Activation of cathepsin D by glycosaminoglycans
FEBS J276, 7343-7352. PubMed Europe PubMed DOI
Byun,H.O., Han,N.K., Lee,H.J., Kim,K.B., Ko,Y.G., Yoon,G., Lee,Y.S., Hong,S.I. and Lee,J.S.
Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence
Cancer Res69, 4638-4647. PubMed Europe PubMed DOI
Carrasco-Marin,E., Madrazo-Toca,F., de los Toyos,J.R., Cacho-Alonso,E., Tobes,R., Pareja,E., Paradela,A., Albar,J.P., Chen,W., Gomez-Lopez,M.T. and Alvarez-Dominguez,C.
The innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O
Mol Microbiol72, 668-682. PubMed Europe PubMed DOI P
Castino,R., Peracchio,C., Salini,A., Nicotra,G., Trincheri,N.F., Demoz,M., Valente,G. and Isidoro,C.
Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-bax activation loop
J Cell Mol Med13, 1096-1109. PubMed Europe PubMed DOI
Cruz-Soto,M.E., Cosio,G., Jeziorski,M.C., Vargas-Barroso,V., Aguilar,M.B., Carabez,A., Berger,P., Saftig,P., Arnold,E., Thebault,S., Martinez de la Escalera,G. and Clapp,C.
Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules
Endocrinology150, 5446-5454. PubMed Europe PubMed DOI
Cullen,V., Lindfors,M., Ng,J., Paetau,A., Swinton,E., Kolodziej,P., Boston,H., Saftig,P., Woulfe,J., Feany,M.B., Myllykangas,L., Schlossmacher,M.G. and Tyynela,J.
Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo
Mol Brain2, 5-5. PubMed Europe PubMed DOI U
De Luca,V., Maria,G., De Mauro,G., Catara,G., Carginale,V., Ruggiero,G., Capasso,A., Parisi,E., Brier,S., Engen,J.R. and Capasso,C.
Aspartic proteinases in Antarctic fish
Mar Genomics2, 1-10. PubMed Europe PubMed DOI
Fritchie,K., Siintola,E., Armao,D., Lehesjoki,A.E., Marino,T., Powell,C., Tennison,M., Booker,J.M., Koch,S., Partanen,S., Suzuki,K., Tyynela,J. and Thorne,L.B.
Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10)
Acta Neuropathol117, 201-208. PubMed Europe PubMed DOI M
Jia,A. and Zhang,X.H.
Molecular cloning, characterization and expression analysis of cathepsin D gene from turbot Scophthalmus maximus
Fish Shellfish Immunol26, 606-613. PubMed Europe PubMed DOI
Kuronen,M., Talvitie,M., Lehesjoki,A.E. and Myllykangas,L.
Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis
Neurobiol Dis36, 488-493. PubMed Europe PubMed DOI K
Matsumoto,I., Asakura,T., Ohmori,T., Tamura,T. and Abe,K.
Cathepsin D-like aspartic proteinase occurring in a maize weevil, Sitophilus zeamais, as a candidate digestive enzyme
Biosci Biotechnol Biochem73, 2338-2340. PubMed Europe PubMed DOI
Minarowska,A., Karwowska,A. and Gacko,M.
Quantitative determination and localization of cathepsin D and its inhibitors
Folia Histochem Cytobiol47, 153-177. PubMed Europe PubMed DOI V
Padilha,M.H., Pimentel,A.C., Ribeiro,A.F. and Terra,W.R.
Sequence and function of lysosomal and digestive cathepsin D-like proteinases of Musca domestica midgut
Insect Biochem Mol Biol39, 782-791. PubMed Europe PubMed DOI
Park,E.M., Kim,Y.O., Nam,B.H., Kong,H.J., Kim,W.J., Lee,S.J. and Kim,K.K.
Cloning and expression analysis of cathepsin D in the olive flounder Paralichthys olivaceus
Biosci Biotechnol Biochem73, 1856-1859. PubMed Europe PubMed DOI
Suttiprapa,S., Mulvenna,J., Huong,N.T., Pearson,M.S., Brindley,P.J., Laha,T., Wongkham,S., Kaewkes,S., Sripa,B. and Loukas,A.
Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity
Int J Biochem Cell Biol41, 1148-1156. PubMed Europe PubMed DOI
van der Hilst,J.C., Kluve-Beckerman,B., van der Meer,J.W. and Simon,A.
Cathepsin D activity protects against development of type AA amyloid fibrils
Eur J Clin Invest39, 412-416. PubMed Europe PubMed DOI
Vetvicka,V., Ohri,S.S. and Vetvicka,V.
Pleiotropic effects of cathepsin D
Endocr Metab Immune Disord Drug Targets9, 385-391. PubMed Europe PubMed DOI
Zaragoza,R., Torres,L., Garcia,C., Eroles,P., Corrales,F., Bosch,A., Lluch,A., Garcia-Trevijano,E.R. and Vina,J.R.
Nitration of cathepsin D enhances its proteolytic activity during mammary gland remodelling after lactation
Biochem J419, 279-288. PubMed Europe PubMed DOI

2008

Azim,M.K., Ahmed,W., Khan,I.A., Rao,N.A. and Khan,K.M.
Identification of acridinyl hydrazides as potent aspartic protease inhibitors
Bioorg Med Chem Lett18, 3011-3015. PubMed Europe PubMed DOI I
Beaujouin,M. and Liaudet-Coopman,E.
Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity
Adv Exp Med Biol617, 453-461. PubMed Europe PubMed DOI
Benes,P., Vetvicka,V. and Fusek,M.
Cathepsin D - many functions of one aspartic protease
Crit Rev Oncol Hematol68, 12-28. PubMed Europe PubMed DOI V
Bishop,M.T., Kovacs,G.G., Sanchez-Juan,P. and Knight,R.S.
Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease
BMC Med Genet9, 31-31. PubMed Europe PubMed DOI M
Bretschneider,N., Kangaspeska,S., Seifert,M., Reid,G., Gannon,F. and Denger,S.
E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements
Mol Oncol2, 182-190. PubMed Europe PubMed DOI
Conus,S., Perozzo,R., Reinheckel,T., Peters,C., Scapozza,L., Yousefi,S. and Simon,H.U.
Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation
J Exp Med205, 685-698. PubMed Europe PubMed DOI
Jabs,S., Quitsch,A., Kakela,R., Koch,B., Tyynela,J., Brade,H., Glatzel,M., Walkley,S., Saftig,P., Vanier,M.T. and Braulke,T.
Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis
J Neurochem106, 1415-1425. PubMed Europe PubMed DOI K
Mei,Y., Chen,Y., Li,J., Gao,P., Wang,C., Zhang,H., Ling,F., Li,Y., Xie,S., Li,S. and Zhang,G.
Sequence identification, tissue distribution and polymorphism of the porcine cathepsin D (CTSD) gene
Anim Biotechnol19, 144-158. PubMed Europe PubMed DOI
Minarowska,A., Gacko,M., Karwowska,A. and Minarowski,L.
Human cathepsin D
Folia Histochem Cytobiol46, 23-38. PubMed Europe PubMed DOI V
Morales,M.E., Rinaldi,G., Gobert,G.N., Kines,K.J., Tort,J.F. and Brindley,P.J.
RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade
Mol Biochem Parasitol157, 160-168. PubMed Europe PubMed DOI T
Ohri,S.S., Vashishta,A., Proctor,M., Fusek,M. and Vetvicka,V.
The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells
Int J Oncol32, 491-498. PubMed Europe PubMed
Padron-Barthe,L., Courta,J., Lepretre,C., Nagbou,A. and Torriglia,A.
Leukocyte elastase inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation
Biochim Biophys Acta1783, 1755-1766. PubMed Europe PubMed DOI
Partanen,S., Haapanen,A., Kielar,C., Pontikis,C., Alexander,N., Inkinen,T., Saftig,P., Gillingwater,T.H., Cooper,J.D. and Tyynela,J.
Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis
J Neuropathol Exp Neurol67, 16-29. PubMed Europe PubMed DOI K
Prince,L.R., Bianchi,S.M., Vaughan,K.M., Bewley,M.A., Marriott,H.M., Walmsley,S.R., Taylor,G.W., Buttle,D.J., Sabroe,I., Dockrell,D.H. and Whyte,M.K.
Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin
J Immunol180, 3502-3511. PubMed Europe PubMed
Qiao,L., Hamamichi,S., Caldwell,K.A., Caldwell,G.A., Yacoubian,T.A., Wilson,S., Xie,Z.L., Speake,L.D., Parks,R., Crabtree,D., Liang,Q., Crimmins,S., Schneider,L., Uchiyama,Y., Iwatsubo,T., Zhou,Y., Peng,L., Lu,Y., Standaert,D.G., Walls,K.C., Shacka,J.J., Roth,K.A. and Zhang,J.
Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity
Mol Brain1, 17-17. PubMed Europe PubMed DOI
Rosochacki,S.J., Juszczuk-Kubiak,E., Barton,L., Sakowski,T., PoLoszynowicz,J., Baranowski,A. and Matejczyk,M.
Preliminary observations upon relation between the G77A polymorphism in CATD gene and lysosomal proteinases activity and sensory traits of meat from bulls of three breeds
Anim Sci Pap Rep26, 25-35. M
Sagulenko,V., Muth,D., Sagulenko,E., Paffhausen,T., Schwab,M. and Westermann,F.
Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death
Carcinogenesis29, 1869-1877. PubMed Europe PubMed DOI
Schechter,I. and Ziv,E.
Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s)
Biol Chem389, 313-320. PubMed Europe PubMed DOI
Sevlever,D., Jiang,P. and Yen,S.H.
Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species
Biochemistry47, 9678-9687. PubMed Europe PubMed DOI
Sojka,D., Franta,Z., Horn,M., Hajdusek,O., Caffrey,C.R., Mares,M. and Kopacek,P.
Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases
Parasit Vectors1, 7-7. PubMed Europe PubMed DOI
Tufet,M.
Apoptosis: killing neutrophils the cathepsin way
Nat Rev Immunol8, 244- DOI
Urbanelli,L., Emiliani,C., Massini,C., Persichetti,E., Orlacchio,A., Pelicci,G., Sorbi,S., Hasilik,A., Bernardi,G. and Orlacchio,A.
Cathepsin D expression is decreased in Alzheimer's disease fibroblasts
Neurobiol Aging29, 12-22. PubMed Europe PubMed DOI
Zaidi,N., Maurer,A., Nieke,S. and Kalbacher,H.
Cathepsin D: a cellular roadmap
Biochem Biophys Res Commun376, 5-9. PubMed Europe PubMed DOI V

2007

Castino,R., Bellio,N., Nicotra,G., Follo,C., Trincheri,N.F. and Isidoro,C.
Cathepsin D-Bax death pathway in oxidative stressed neuroblastoma cells
Free Radic Biol Med42, 1305-1316. PubMed Europe PubMed DOI
Follo,C., Castino,R., Nicotra,G., Trincheri,N.F. and Isidoro,C.
Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form
Int J Biochem Cell Biol39, 638-649. PubMed Europe PubMed DOI
Haapanen,A., Ramadan,U.A., Autti,T., Joensuu,R. and Tyynela,J.
In vivo MRI reveals the dynamics of pathological changes in the brains of cathepsin D-deficient mice and correlates changes in manganese-enhanced MRI with microglial activation
Magn Reson Imaging25, 1024-1031. PubMed Europe PubMed DOI K
[YEAR:9-2-2007]Hilfiker-Kleiner,D., Kaminski,K., Podewski,E., Bonda,T., Schaefer,A., Sliwa,K., Forster,O., Quint,A., Landmesser,U., Doerries,C., Luchtefeld,M., Poli,V., Schneider,M.D., Balligand,J.L., Desjardins,F., Ansari,A., Struman,I., Nguyen,N.Q., Zschemisch,N.H., Klein,G., Heusch,G., Schulz,R., Hilfiker,A. and Drexler,H.
A cathepsin D-cleaved 16 KDa form of prolactin mediates postpartum cardiomyopathy
Cell128, 589-600. PubMed Europe PubMed DOI
Kim,S., Ock,J., Kim,A.K., Lee,H.W., Cho,J.Y., Kim,D.R., Park,J.Y. and Suk,K.
Neurotoxicity of microglial cathepsin D revealed by secretome analysis
J Neurochem103, 2640-2650. PubMed Europe PubMed DOI T
Minarowska,A., Minarowski,L., Karwowska,A. and Gacko,M.
Regulatory role of cathepsin D in apoptosis
Folia Histochem Cytobiol45, 159-163. PubMed Europe PubMed
Schestkowa,O., Geisel,D., Jacob,R. and Hasilik,A.
The catalytically inactive precursor of cathepsin D induces apoptosis in human fibroblasts and HeLa cells
J Cell Biochem101, 1558-1566. PubMed Europe PubMed DOI
Shacka,J.J. and Roth,K.A.
Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis
Autophagy3, 474-476. PubMed Europe PubMed
Shacka,J.J., Klocke,B.J., Young,C., Shibata,M., Olney,J.W., Uchiyama,Y., Saftig,P. and Roth,K.A.
Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
J Neurosci27, 2081-2090. PubMed Europe PubMed DOI K M
Trincheri,N.F., Nicotra,G., Follo,C., Castino,R. and Isidoro,C.
Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D
Carcinogenesis28, 922-931. PubMed Europe PubMed DOI I
Tulone,C., Uchiyama,Y., Novelli,M., Grosvenor,N., Saftig,P. and Chain,B.M.
Haematopoietic development and immunological function in the absence of cathepsin D
BMC Immunol8, 22-22. PubMed Europe PubMed DOI K
Vashishta,A., Saraswat Ohri,S., Vetvickova,J., Fusek,M., Ulrichova,J. and Vetvicka,V.
Procathepsin D secreted by HaCaT keratinocyte cells - a novel regulator of keratinocyte growth
Eur J Cell Biol86, 303-313. PubMed Europe PubMed DOI
Vashishta,A., Ohri,S.S., Proctor,M., Fusek,M. and Vetvicka,V.
Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy
Int J Oncol30, 1223-1230. PubMed Europe PubMed T
[YEAR:11-5-2007]Walls,K.C., Klocke,B.J., Saftig,P., Shibata,M., Uchiyama,Y., Roth,K.A. and Shacka,J.J.
Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain
Autophagy3, 222-229. PubMed Europe PubMed K
Wang,P.A., Stenvik,J., Larsen,R., Maehre,H. and Olsen,R.L.
Cathepsin D from Atlantic cod (Gadus morhua L.) liver. Isolation and comparative studies
Comp Biochem Physiol B Biochem Mol Biol147, 504-511. PubMed Europe PubMed DOI
Zaidi,N., Herrmann,T., Baechle,D., Schleicher,S., Gogel,J., Driessen,C., Voelter,W. and Kalbacher,H.
A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles
FEBS J274, 3138-3149. PubMed Europe PubMed DOI A
Zou,J., Henderson,L., Thomas,V., Swan,P., Turner,A.N. and Phelps,R.G.
Presentation of the Goodpasture autoantigen requires proteolytic unlocking steps that destroy prominent T cell epitopes
J Am Soc Nephrol18, 771-779. PubMed Europe PubMed DOI

2006

[YEAR:28-12-2006]Awano,T., Katz,M.L., O'Brien,D.P., Taylor,J.F., Evans,J., Khan,S., Sohar,I., Lobel,P. and Johnson,G.S.
A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis
Mol Genet Metab87, 341-348. PubMed Europe PubMed DOI M
[YEAR:14-12-2006]Baechle,D., Flad,T., Cansier,A., Steffen,H., Schittek,B., Tolson,J., Herrmann,T., Dihazi,H., Beck,A., Mueller,G.A., Mueller,M., Stevanovic,S., Garbe,C., Mueller,C.A. and Kalbacher,H.
Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L
J Biol Chem281, 5406-5415. PubMed Europe PubMed DOI
[YEAR:5-12-2006]Beaujouin,M., Baghdiguian,S., Glondu-Lassis,M., Berchem,G. and Liaudet-Coopman,E.
Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity
Oncogene25, 1967-1973. PubMed Europe PubMed DOI
[YEAR:27-6-2006]Bjelic,S. and Aqvist,J.
Catalysis and linear free energy relationships in aspartic proteases
Biochemistry45, 7709-7723. PubMed Europe PubMed DOI
Davidson,Y., Gibbons,L., Pritchard,A., Hardicre,J., Wren,J., Tian,J., Shi,J., Stopford,C., Julien,C., Thompson,J., Payton,A., Thaker,U., Hayes,A.J., Iwatsubo,T., Pickering-Brown,S.M., Pendleton,N., Horan,M.A., Burns,A., Purandare,N., Lendon,C.L., Neary,D., Snowden,J.S. and Mann,D.M.
Genetic associations between cathepsin D exon 2 C - >T polymorphism and Alzheimer's disease, and pathological correlations with genotype
J Neurol Neurosurg Psychiatry77, 515-517. PubMed Europe PubMed DOI
[YEAR:1-2-2006]del Cerro-Vadillo,E., Madrazo-Toca,F., Carrasco-Marin,E., Fernandez-Prieto,L., Beck,C., Leyva-Cobian,F., Saftig,P. and Alvarez-Dominguez,C.
Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth
J Immunol176, 1321-1325. PubMed Europe PubMed K
[YEAR:19-8-2006]Demoz,M., Castino,R., Follo,C., Hasilik,A., Sloane,B.F. and Isidoro,C.
High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells
Protein Expr Purif45, 157-167. PubMed Europe PubMed DOI E
Gui,Z.Z., Lee,K.S., Kim,B.Y., Choi,Y.S., Wei,Y.D., Choo,Y.M., Kang,P.D., Yoon,H.J., Kim,I., Je,Y.H., Seo,S.J., Lee,S.M., Guo,X., Sohn,H.D. and Jin,B.R.
Functional role of aspartic proteinase cathepsin D in insect metamorphosis
BMC Dev Biol6, 49-49. PubMed Europe PubMed DOI
Haidar,B., Kiss,R.S., Sarov-Blat,L., Brunet,R., Harder,C., McPherson,R. and Marcel,Y.L.
Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux
J Biol Chem281, 39971-39981. PubMed Europe PubMed DOI
Laurent-Matha,V., Derocq,D., Prebois,C., Katunuma,N. and Liaudet-Coopman,E.
Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B
J Biochem139, 363-371. PubMed Europe PubMed DOI
[YEAR:18-7-2006]Liaudet-Coopman,E., Beaujouin,M., Derocq,D., Garcia,M., Glondu-Lassis,M., Laurent-Matha,V., Prebois,C., Rochefort,H. and Vignon,F.
Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis
Cancer Lett237, 167-179. PubMed Europe PubMed DOI
[YEAR:26-12-2006]Masa,M., Maresova,L., Vondrasek,J., Horn,M., Jezek,J. and Mares,M.
Cathepsin D propeptide: mechanism and regulation of its interaction with the catalytic core
Biochemistry45, 15474-15482. PubMed Europe PubMed DOI
McConnell,R.M., Green,A.W., Trana,C.J., McConnell,M.S., Lindley,J.F., Sayyar,K., Godwin,W.E. and Hatfield,S.E.
New cathepsin D inhibitors with hydroxyethylamine isosteres: preparation and characterization
Med Chem2, 27-38. PubMed Europe PubMed DOI I
Navarrete del Toro,M., Garcia-Carreno,F., Lopez,M.D., Celis-Guerrero,L. and Saborowski,R.
Aspartic proteinases in the digestive tract of marine decapod crustaceans
J Exp Zoolog Part A Comp Exp Biol305, 645-654. PubMed Europe PubMed DOI
Payton,A., van den Boogerd,E., Davidson,Y., Gibbons,L., Ollier,W., Rabbitt,P., Worthington,J., Horan,M. and Pendleton,N.
Influence and interactions of cathepsin D, HLA-DRB1 and APOE on cognitive abilities in an older non-demented population
Genes Brain Behav5 Suppl 1, 23-31. PubMed Europe PubMed DOI
Piwnica,D., Fernandez,I., Binart,N., Touraine,P., Kelly,P.A. and Goffin,V.
A new mechanism for prolactin processing into 16K PRL by secreted cathepsin D
Mol Endocrinol20, 3263-3278. PubMed Europe PubMed DOI
[YEAR:1-5-2006]Riemenschneider,M., Blennow,K., Wagenpfeil,S., Andreasen,N., Prince,J.A., Laws,S.M., Forstl,H. and Kurz,A.
The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease
Hum Mutat27, 532-537. PubMed Europe PubMed DOI M
[YEAR:14-8-2006]Sato,Y., Suzuki,Y., Ito,E., Shimazaki,S., Ishida,M., Yamamoto,T., Yamamoto,H., Toda,T., Suzuki,M., Suzuki,A. and Endo,T.
Identification and characterization of an increased glycoprotein in aging: age-associated translocation of cathepsin D
Mech Ageing Dev127, 771-778. PubMed Europe PubMed DOI
[YEAR:2-5-2006]Siintola,E., Partanen,S., Stromme,P., Haapanen,A., Haltia,M., Maehlen,J., Lehesjoki,A.E. and Tyynela,J.
Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis
Brain129, 1438-1445. PubMed Europe PubMed DOI M
Steinfeld,R., Reinhardt,K., Schreiber,K., Hillebrand,M., Kraetzner,R., Bruck,W., Saftig,P. and Gartner,J.
Cathepsin D deficiency is associated with a human neurodegenerative disorder
Am J Hum Genet78, 988-998. PubMed Europe PubMed DOI M
[YEAR:21-9-2006]Zhou,W., Scott,S.A., Shelton,S.B. and Crutcher,K.A.
Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease
Neuroscience143, 689-701. PubMed Europe PubMed DOI

2005

[YEAR:11-10-2005]Baechle,D., Cansier,A., Fischer,R., Brandenburg,J., Burster,T., Driessen,C. and Kalbacher,H.
Biotinylated fluorescent peptide substrates for the sensitive and specific determination of cathepsin D activity
J Pept Sci11, 166-174. PubMed Europe PubMed DOI
Caffrey,C.R., Placha,L., Barinka,C., Hradilek,M., Dostal,J., Sajid,M., McKerrow,J.H., Majer,P., Konvalinka,J. and Vondrasek,J.
Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors
Biol Chem386, 339-349. PubMed Europe PubMed DOI
Capurso,C., Solfrizzi,V., D'Introno,A., Colacicco,A.M., Capurso,S.A., Mastroianni,F., Liaci,M., Vendemiale,G., Capurso,A. and Panza,F.
The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in european populations
J Gerontol A Biol Sci Med Sci60, 991-996. PubMed Europe PubMed
Emert-Sedlak,L., Shangary,S., Rabinovitz,A., Miranda,M.B., Delach,S.M. and Johnson,D.E.
Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death
Mol Cancer Ther4, 733-742. PubMed Europe PubMed DOI
[YEAR:15-6-2005]Fukuda,M.E., Iwadate,Y., Machida,T., Hiwasa,T., Nimura,Y., Nagai,Y., Takiguchi,M., Tanzawa,H., Yamaura,A. and Seki,N.
Cathepsin D is a potential serum marker for poor prognosis in glioma patients
Cancer Res65, 5190-5194. PubMed Europe PubMed DOI
Fusek,M. and Vetvicka,V.
Dual role of cathepsin D: ligand and protease
Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub149, 43-50. PubMed Europe PubMed
[YEAR:6-12-2005]Goldfarb,N.E., Lam,M.T., Bose,A.K., Patel,A.M., Duckworth,A.J. and Dunn,B.M.
Electrostatic Switches That Mediate the pH-Dependent Conformational Change of "Short" Recombinant Human Pseudocathepsin D
Biochemistry44, 15725-15733. PubMed Europe PubMed DOI
Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y.
Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease)
Am J Pathol167, 1713-1728. PubMed Europe PubMed DOI K
[YEAR:31-1-2005]Laurent-Matha,V., Maruani-Herrmann,S., Prebois,C., Beaujouin,M., Glondu,M., Noel,A., Alvarez-Gonzalez,M.L., Blacher,S., Coopman,P., Baghdiguian,S., Gilles,C., Loncarek,J., Freiss,G., Vignon,F. and Liaudet-Coopman,E.
Catalytically inactive human cathepsin D triggers fibroblast invasive growth
J Cell Biol168, 489-499. PubMed Europe PubMed DOI
[YEAR:24-6-2005]Matsumoto,N., Jo,O.D., Shih,R.N. and Yanagawa,N.
Altered cathepsin D metabolism in PHEX antisense human osteoblast cells
Biochem Biophys Res Commun332, 248-253. PubMed Europe PubMed DOI
Merlen,C., Fayol-Messaoudi,D., Fabrega,S., El Hage,T., Servin,A. and Authier,F.
Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D
FEBS J272, 4385-4397. PubMed Europe PubMed DOI
[YEAR:31-10-2005]Moss,C.X., Villadangos,J.A. and Watts,C.
Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing
Eur J Immunol35, 3442-3451. PubMed Europe PubMed DOI
Myllykangas,L., Tyynela,J., Page-McCaw,A., Rubin,G.M., Haltia,M.J. and Feany,M.B.
Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses
Neurobiol Dis19, 194-199. PubMed Europe PubMed DOI K
Naseem,R.H., Hedegard,W., Henry,T.D., Lessard,J., Sutter,K. and Katz,S.A.
Plasma cathepsin D isoforms and their active metabolites increase after myocardial infarction and contribute to plasma renin activity
Basic Res Cardiol100, 139-146. PubMed Europe PubMed DOI
[YEAR:21-1-2005]Schulmeister,A., Heyers,O., Morales,M.E., Brindley,P.J., Lucius,R., Meusel,G. and Kalinna,B.H.
Organization and functional analysis of the Schistosoma mansoni cathepsin D-like aspartic protease gene promoter
Biochim Biophys Acta1727, 27-34. PubMed Europe PubMed DOI
[YEAR:30-6-2005]Shimizu,T., Hayashi,Y., Yamasaki,R., Yamada,J., Zhang,J., Ukai,K., Koike,M., Mine,K., von Figura,K., Peters,C., Saftig,P., Fukuda,T., Uchiyama,Y. and Nakanishi,H.
Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice
J Neurochem94, 680-690. PubMed Europe PubMed DOI K
[YEAR:4-8-2005]Steet,R., Lee,W.S. and Kornfeld,S.
Identification of the minimal lysosomal enzyme recognition domain in cathepsin D
J Biol Chem280, 33318-33323. PubMed Europe PubMed DOI
Sun,Y., Shi,J.J., Zhang,S.Z., Tang,M.N., Han,H.Y., Guo,Y.B., Ma,C., Liu,X.H. and Li,T.
[The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese]
Yi Chuan27, 190-194. PubMed Europe PubMed M
Wohlke,A., Distl,O. and Drogemuller,C.
The canine CTSD gene as a candidate for late-onset neuronal ceroid lipofuscinosis
Anim Genet36, 530-532. PubMed Europe PubMed DOI M

2004

Alexov,E.
Calculating proton uptake/release and binding free energy taking into account ionization and conformation changes induced by protein-inhibitor association: application to plasmepsin, cathepsin D and endothiapepsin-pepstatin complexes
Proteins56, 572-584. PubMed Europe PubMed DOI I
Brunelle,F., Cloutier,C. and Michaud,D.
Colorado potato beetles compensate for tomato cathepsin D inhibitor expressed in transgenic potato
Arch Insect Biochem Physiol55, 103-113. PubMed Europe PubMed DOI
Conner,G.E.
Cathepsin D
[ISSN:0-12-079610-4]2, 43-52. V
[YEAR:1-6-2004]Egberts,F., Heinrich,M., Jensen,J.M., Winoto-Morbach,S., Pfeiffer,S., Wickel,M., Schunck,M., Steude,J., Saftig,P., Proksch,E. and Schutze,S.
Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation
J Cell Sci117, 2295-2307. PubMed Europe PubMed DOI
Faridi,J.S., Mohan,S. and De Leon,D.D.
Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells
Growth Factors22, 169-177. PubMed Europe PubMed DOI
[YEAR:1-11-2004]Gopalakrishnan,M.M., Grosch,H.W., Locatelli-Hoops,S., Werth,N., Smolenova,E., Nettersheim,M., Sandhoff,K. and Hasilik,A.
Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation
Biochem J383, 507-515. PubMed Europe PubMed DOI
Igarashi,S., Takizawa,T., Takizawa,T., Yasuda,Y., Uchiwa,H., Hayashi,S., Brysk,H., Robinson,J.M., Yamamoto,K., Brysk,M.M. and Horikoshi,T.
Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation
Br J Dermatol151, 355-361. PubMed Europe PubMed DOI
Komai,T., Kawabata,C., Amano,M., Lee,B.R. and Ichishima,E.
Todarepsin, a new cathepsin D from hepatopancreas of Japanese common squid (Todarodes pacificus)
Comp Biochem Physiol B Biochem Mol Biol137, 373-382. PubMed Europe PubMed DOI
[YEAR:20-2-2004]Li,X., Rayford,H., Shu,R., Zhuang,J. and Uhal,B.D.
Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells
Am J Physiol Lung Cell Mol Physiol287, L46-L51. PubMed Europe PubMed DOI
Mommsen,T.P.
Salmon spawning migration and muscle protein metabolism: the August Krogh principle at work
Comp Biochem Physiol B Biochem Mol Biol139, 383-400. PubMed Europe PubMed DOI
[YEAR:18-8-2004]Morales,M.E., Kalinna,B.H., Heyers,O., Mann,V.H., Schulmeister,A., Copeland,C.S., Loukas,A. and Brindley,P.J.
Genomic organization of the Schistosoma mansoni aspartic protease gene, a platyhelminth orthologue of mammalian lysosomal cathepsin D
Gene338, 99-109. PubMed Europe PubMed DOI
[YEAR:15-3-2004]Ntais,C., Polycarpou,A. and Ioannidis,J.P.
Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review
Am J Epidemiol159, 527-536. PubMed Europe PubMed DOI M
[YEAR:10-6-2004]Piwnica,D., Touraine,P., Struman,I., Tabruyn,S., Bolbach,G., Clapp,C., Martial,J.A., Kelly,P.A. and Goffin,V.
Cathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: study of their antiangiogenic properties and physiological relevance
Mol Endocrinol18, 2522-2542. PubMed Europe PubMed DOI
Vetvicka,V., Vetvickova,J. and Benes,P.
Role of enzymatically inactive procathepsin D in lung cancer
Anticancer Res24, 2739-2743. PubMed Europe PubMed
Wille,A., Gerber,A., Heimburg,A., Reisenauer,A., Peters,C., Saftig,P., Reinheckel,T., Welte,T. and Buhling,F.
Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells
Biol Chem385, 665-670. PubMed Europe PubMed DOI

2003

Bidere,N., Lorenzo,H.K., Carmona,S., Laforge,M., Harper,F., Dumont,C. and Senik,A.
Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis
J Biol Chem278, 31401-31411. PubMed Europe PubMed DOI
Carnevali,O. and Maradonna,F.
Exposure to xenobiotic compounds: looking for new biomarkers
Gen Comp Endocrinol131, 203-208. PubMed Europe PubMed DOI
Johansson,A.C., Steen,H., Ollinger,K. and Roberg,K.
Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine
Cell Death Differ10, 1253-1259. PubMed Europe PubMed DOI
Koike,M., Shibata,M., Ohsawa,Y., Nakanishi,H., Koga,T., Kametaka,S., Waguri,S., Momoi,T., Kominami,E., Peters,C., Figura,K., Saftig,P. and Uchiyama,Y.
Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice
Mol Cell Neurosci22, 146-161. PubMed Europe PubMed DOI K
[YEAR:1-1-2003]Partanen,S., Storch,S., Loffler,H.G., Hasilik,A., Tyynela,J. and Braulke,T.
A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells
Biochem J369, 55-62. PubMed Europe PubMed DOI
[YEAR:11-9-2003]Perchick,G.B. and Jabbour,H.N.
Cyclooxygenase-2 overexpression inhibits cathepsin D-mediated cleavage of plasminogen to the potent antiangiogenic factor angiostatin
Endocrinology144, 5322-5328. PubMed Europe PubMed DOI
Tardy,C., Tyynela,J., Hasilik,A., Levade,T. and Andrieu-Abadie,N.
Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D
Cell Death Differ10, 1090-1100. PubMed Europe PubMed DOI K
Wolf,M., Clark-Lewis,I., Buri,C., Langen,H., Lis,M. and Mazzucchelli,L.
Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer
Am J Pathol162, 1183-1190. PubMed Europe PubMed

2002

Athaudaa,S.B. and Takahashia,K.
Cleavage specificities of aspartic proteinases toward oxidized insulin B chain at different pH values
Protein Pept Lett9, 289-294. PubMed Europe PubMed DOI P
[YEAR:15-3-2002]Authier,F., Metioui,M., Fabrega,S., Kouach,M. and Briand,G.
Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D
J Biol Chem277, 9437-9446. PubMed Europe PubMed DOI
[YEAR:29-8-2002]Berchem,G., Glondu,M., Gleizes,M., Brouillet,J.P., Vignon,F., Garcia,M. and Liaudet-Coopman,E.
Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis
Oncogene21, 5951-5955. PubMed Europe PubMed DOI
Cho,J.H., Park,I.Y., Kim,H.S., Lee,W.T., Kim,M.S. and Kim,S.C.
Cathepsin D produces antimicrobial peptide parasin I from histone H2A in the skin mucosa of fish
FASEB J16, 429-431. PubMed Europe PubMed DOI
[YEAR:1-8-2002]Glondu,M., Liaudet-Coopman,E., Derocq,D., Platet,N., Rochefort,H. and Garcia,M.
Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells
Oncogene21, 5127-5134. PubMed Europe PubMed DOI
[YEAR:1-1-2002]Hiramatsu,N., Ichikawa,N., Fukada,H., Fujita,T., Sullivan,C.V. and Hara,A.
Identification and characterization of proteases involved in specific proteolysis of vitellogenin and yolk proteins in salmonids
J Exp Zool292, 11-25. PubMed Europe PubMed DOI
[YEAR:28-3-2002]Huo,S., Wang,J., Cieplak,P., Kollman,P.A. and Kuntz,I.D.
Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: insight into structure-based ligand design
J Med Chem45, 1412-1419. PubMed Europe PubMed DOI I
[YEAR:19-7-2002]Papassotiropoulos,A., Lewis,H.D., Bagli,M., Jessen,F., Ptok,U., Schulte,A., Shearman,M.S. and Heun,R.
Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene
Neuroreport13, 1291-1294. PubMed Europe PubMed M
Roberg,K., Kagedal,K. and Ollinger,K.
Microinjection of cathepsin D induces caspase-dependent apoptosis in fibroblasts
Am J Pathol161, 89-96. PubMed Europe PubMed DOI
[YEAR:13-3-2002]Silva,F.P., Jr., Ribeiro,F., Katz,N. and Giovanni-De-Simone,S.
Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling
FEBS Lett514, 141-148. PubMed Europe PubMed DOI P

2001

[YEAR:15-1-2001]Brindley,P.J., Kalinna,B.H., Wong,J.Y.M., Bogitsh,B.J., King,L.T., Smyth,D.J., Verity,C.K., Abbenante,G., Brinkworth,R.I., Fairlie,D.P., Smythe,M.L., Milburn,P.J., Bielefeldt-Ohmann,H., Zheng,Y. and McManus,D.P.
Proteolysis of human hemoglobin by schistosome cathepsin D
Mol Biochem Parasitol112, 103-112. PubMed Europe PubMed DOI
[YEAR:19-10-2001]Brinkworth,R.I., Prociv,P., Loukas,A. and Brindley,P.J.
Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models
J Biol Chem276, 38844-38851. PubMed Europe PubMed DOI I
[YEAR:18-10-2001]Glondu,M., Coopman,P., Laurent-Matha,V., Garcia,M., Rochefort,H. and Liaudet-Coopman,E.
A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells
Oncogene20, 6920-6929. PubMed Europe PubMed DOI
Handley,C.J., Mok,M.T., Ilic,M.Z., Adcocks,C., Buttle,D.J. and Robinson,H.C.
Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH
Matrix Biol20, 543-553. PubMed Europe PubMed DOI
Hayes,M., Hurley,M.J., Larsen,L.B., Heegaard,C.W., Magboul,A.A.A., Oliveira,J.C., McSweeney,P.L.H. and Kelly,A.L.
Thermal inactivation kinetics of bovine cathepsin D
J Dairy Res68, 267-276. PubMed Europe PubMed DOI
[YEAR:29-5-2001]Kagedal,K., Johansson,U. and Ollinger,K.
The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress
FASEB J15, 1592-1594. PubMed Europe PubMed I
[YEAR:8-3-2001]Menzer,G., Muller-Thomsen,T., Meins,W., Alberici,A., Binetti,G., Hock,C., Nitsch,R.M., Stoppe,G., Reiss,J. and Finckh,U.
Non-replication of association between cathepsin D genotype and late onset Alzheimer disease
Am J Med Genet105, 179-182. PubMed Europe PubMed DOI M
[YEAR:1-10-2001]Nakanishi,H., Zhang,J., Koike,M., Nishioku,T., Okamoto,Y., Kominami,E., von Figura,K., Peters,C., Yamamoto,K., Saftig,P. and Uchiyama,Y.
Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice
J Neurosci21, 7526-7533. PubMed Europe PubMed K
[YEAR:12-1-2001]Pimenta,D.C., Oliveira,A., Juliano,M.A. and Juliano,L.
Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin
Biochim Biophys Acta1544, 113-122. PubMed Europe PubMed DOI A
Verity,C.K., Loukas,A., McManus,D.P. and Brindley,P.J.
Schistosoma japonicum cathepsin D aspartic protease cleaves human IgG and other serum components
Parasitology122, 415-421. PubMed Europe PubMed DOI
[YEAR:14-2-2001]Wang,F., Samudio,I. and Safe,S.
Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition
Mol Cell Endocrinol172, 91-103. PubMed Europe PubMed DOI

2000

[YEAR:7-7-2000]Bhojak,T.J., DeKosky,S.T., Ganguli,M. and Kamboh,M.I.
Genetic polymorphisms in the cathepsin D and interleukin-6 genes and the risk of Alzheimer's disease
Neurosci Lett288, 21-24. PubMed Europe PubMed DOI M
Bi,X., Haque,T.S., Zhou,J., Skillman,A.G., Lin,B., Lee,C.E., Kuntz,I.D., Ellman,J.A. and Lynch,G.
Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus
J Neurochem74, 1469-1477. PubMed Europe PubMed DOI I
[YEAR:28-7-2000]Crawford,F.C., Freeman,M.J., Schinka,J., Abdullah,L.I., Richards,D., Sevush,S., Duara,R. and Mullan,M.J.
The genetic association between cathepsin D and Alzheimer's disease
Neurosci Lett289, 61-65. PubMed Europe PubMed DOI M
Ju,B.G. and Kim,W.S.
Cloning of a cDNA encoding cathepsin D from salamander, Hynobius leechii, and its expression in the limb regenerates
DNA Seq11, 21-28. PubMed Europe PubMed
[YEAR:15-9-2000]Koike,M., Nakanishi,H., Saftig,P., Ezaki,J., Isahara,K., Ohsawa,Y., Schulz-Schaeffer,W., Watanabe,T., Waguri,S., Kametaka,S., Shibata,M., Yamamoto,K., Kominami,E., Peters,C., von Figura,K. and Uchiyama,Y.
Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons
J Neurosci20, 6898-6906. PubMed Europe PubMed K
Papassotiropoulos,A., Bagli,M., Kurz,A., Kornhuber,J., Forstl,H., Maier,W., Pauls,J., Lautenschlager,N. and Heun,R.
A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease
Ann Neurol47, 399-403. PubMed Europe PubMed DOI M
Pimenta,D.C., Chen,V.C., Chao,J., Juliano,M.A. and Juliano,L.
Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D
J Protein Chem19, 411-418. PubMed Europe PubMed DOI
[YEAR:30-12-2000]Riggio,M., Scudiero,R., Filosa,S. and Parisi,E.
Sex- and tissue-specific expression of aspartic proteinases in Danio rerio (zebrafish)
Gene260, 67-75. PubMed Europe PubMed DOI
[YEAR:15-2-2000]Rochefort,H., Garcia,M., Glondu,M., Laurent,V., Liaudet,E., Rey,J.M. and Roger,P.
Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview
Clin Chim Acta291, 157-170. PubMed Europe PubMed DOI
[YEAR:31-12-2000]Tsukuba,T., Okamoto,K., Yasuda,Y., Morikawa,W., Nakanishi,H. and Yamamoto,K.
New functional aspects of cathepsin D and cathepsin E
Mol Cells10, 601-611. PubMed Europe PubMed V
Tyynela,J., Sohar,I., Sleat,D.E., Gin,R.M., Donnelly,R.J., Baumann,M., Haltia,M. and Lobel,P.
A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration
EMBO J19, 2786-2792. PubMed Europe PubMed DOI
Yamamoto,H., Yamada,T. and Itoh,Y.
Probable involvement of cathepsin D in the degradation of beta2-microglobulin in acidic urine
Clin Chem Lab Med38, 495-499. PubMed Europe PubMed DOI

1999

[YEAR:12-4-1999]Capasso,C., Lees,W.E., Capasso,A., Scudiero,R., Carginale,V., Kille,P., Kay,J. and Parisi,E.
Cathepsin D from the liver of the Antarctic icefish Chionodraco hamatus exhibits unusual activity and stability at high temperatures
Biochim Biophys Acta1431, 64-73. PubMed Europe PubMed DOI
Carnevali,O., Centonze,F., Brooks,S., Marota,I. and Sumpter,J.P.
Molecular cloning and expression of ovarian cathepsin D in seabream, Sparus aurata
Biol Reprod61, 785-791. PubMed Europe PubMed DOI
De Stasio,R., Borrelli,L., Kille,P., Parisi,E. and Filosa,S.
Isolation, characterization and molecular cloning of cathepsin D from lizard ovary: changes in enzyme activity and mRNA expression throughout ovarian cycle
Mol Reprod Dev52, 126-134. PubMed Europe PubMed DOI
[YEAR:8-1-1999]Lenarcic,B. and Turk,V.
Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D
J Biol Chem274, 563-566. PubMed Europe PubMed DOI
O'Driscoll,B.M., Rattray,F.P., McSweeney,P.L.H. and Kelly,A.L.
Protease activities in raw milk determined using a synthetic heptapeptide substrate
J Food Sci64, 606-611. A
[YEAR:12-3-1999]Papassotiropoulos,A., Bagli,M., Feder,O., Jessen,F., Maier,W., Rao,M.L., Ludwig,M., Schwab,S.G. and Heun,R.
Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease
Neurosci Lett262, 171-174. PubMed Europe PubMed DOI M
Rochefort,H. and Liaudet-Coopman,E.
Cathepsin D in cancer metastasis: a protease and a ligand
APMIS107, 86-95. PubMed Europe PubMed
Verity,C.K., McManus,D.P. and Brindley,P.J.
Developmental expression of cathepsin D aspartic protease in Schistosoma japonicum
Int J Parasitol29, 1819-1824. PubMed Europe PubMed DOI
Wittlin,S., Rosel,J., Hofmann,F. and Stover,D.R.
Mechanisms and kinetics of procathepsin D activation
Eur J Biochem265, 384-393. PubMed Europe PubMed DOI
Yasuda,Y., Kageyama,T., Akamine,A., Shibata,M., Kominami,E., Uchiyama,Y. and Yamamoto,K.
Characterization of new fluorogenic substrates for the rapid and sensitive assay of cathepsin E and cathepsin D
J Biochem125, 1137-1143. PubMed Europe PubMed A
Yonezawa,H., Uchikoba,T., Arima,K. and Kaneda,M.
Fluorogenic substrates for cathepsin D
Biosci Biotechnol Biochem63, 1471-1474. PubMed Europe PubMed A

1998

Beyer,B.M. and Dunn,B.M.
Prime region subsite specificity characterization of human cathepsin D: The dominant role of position 128
Protein Sci7, 88-95. PubMed Europe PubMed DOI
[YEAR:17-11-1998]Carroll,C.D., Johnson,T.O., Tao,S., Lauri,G., Orlowski,M., Gluzman,I.Y., Goldberg,D.E. and Dolle,R.E.
Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D
Bioorg Med Chem Lett8, 3203-3206. PubMed Europe PubMed I
[YEAR:14-4-1998]Deussing,J., Roth,W., Saftig,P., Peters,C., Ploegh,H.L. and Villadangos,J.A.
Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation
Proc Natl Acad Sci U S A95, 4516-4521. PubMed Europe PubMed DOI K
[YEAR:29-5-1998]Fruitier,I., Garreau,I. and Piot,J.M.
Cathepsin D is a good candidate for the specific release of a stable hemorphin from hemoglobin in vivo: VV-hemorphin-7
Biochem Biophys Res Commun246, 719-724. PubMed Europe PubMed DOI
Godbold,G.D., Ahn,K., Yeyeodu,S., Lee,L.F., Ting,J.P. and Erickson,A.H.
Biosynthesis and intracellular targeting of the lysosomal aspartic proteinase cathepsin D
Adv Exp Med Biol436, 153-162. PubMed Europe PubMed
Kageyama,T., Tatematsu,M., Ichinose,M., Yahagi,N., Miki,K., Moriyama,A. and Yonezawa,S.
Development-dependent expression of cathepsins D and E in various rat tissues, with special reference to the high expression of cathepsin E in fetal liver
Zoolog Sci15, 517-523. PubMed Europe PubMed DOI
Lee,A.Y., Gulnik,S.V. and Erickson,J.W.
Conformational switching in an aspartic proteinase
Nat Struct Biol5, 866-871. PubMed Europe PubMed DOI S
Peterson,J.J. and Meares,C.F.
Cathepsin substrates as cleavable peptide linkers in bioconjugates, selected from a fluorescence quench combinatorial library
Bioconjug Chem9, 618-626. PubMed Europe PubMed DOI
[YEAR:10-4-1998]Wu,G.S., Saftig,P., Peters,C. and El-Deiry,W.S.
Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity
Oncogene16, 2177-2183. PubMed Europe PubMed DOI

1997

Arnold,D., Keilholz,W., Schild,H., Dumrese,T., Stevanovic,S. and Rammensee,H.G.
Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools
Eur J Biochem249, 171-179. PubMed Europe PubMed
Brindley,P.J., Kalinna,B.H., Dalton,J.P., Day,S.R., Wong,J.Y., Smythe,M.L. and McManus,D.P.
Proteolytic degradation of host hemoglobin by schistosomes
Mol Biochem Parasitol89, 1-9. PubMed Europe PubMed DOI
Chevallier,N., Vizzavona,J., Marambaud,P., Baur,C.P., Spillantini,M., Fulcrand,P., Martinez,J., Goedert,M., Vincent,J.P. and Checler,F.
Cathepsin D displays in vitro beta-secretase-like specificity
Brain Res750, 11-19. PubMed Europe PubMed DOI
Claussen,M., Kubler,B., Wendland,M., Neifer,K., Schmidt,B., Zapf,J. and Braulke,T.
Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D
Endocrinology138, 3797-3803. PubMed Europe PubMed DOI
Gulnik,S.V., Suvorov,L.I., Majer,P., Collins,J., Kane,B.P., Johnson,D.G. and Erickson,J.W.
Design of sensitive fluorogenic substrates for human cathepsin D
FEBS Lett413, 379-384. PubMed Europe PubMed DOI A
[YEAR:15-11-1997]Hewitt,E.W., Treumann,A., Morrice,N., Tatnell,P.J., Kay,J. and Watts,C.
Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation
J Immunol159, 4693-4699. PubMed Europe PubMed
Mackay,E.A., Ehrhard,A., Moniatte,M., Guenet,C., Tardif,C., Tarnus,C., Sorokine,O., Heintzelmann,B., Nay,C., Remy,J.M., Higaki,J., Van Dorsselaer,A., Wagner,J., Danzin,C. and Mamont,P.
A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease
Eur J Biochem244, 414-425. PubMed Europe PubMed
Majer,P., Collins,J.R., Gulnik,S.V. and Erickson,J.W.
Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors
Protein Sci6, 1458-1466. PubMed Europe PubMed DOI I
Metaye,T., Kraimps,J.L., Goujon,J.M., Fernandez,B., Quellard,N., Ingrand,P., Barbier,J. and Begon,F.
Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues
J Clin Endocrinol Metab82, 3383-3388. PubMed Europe PubMed DOI
[YEAR:4-4-1997]Wong,J.Y., Harrop,S.A., Day,S.R. and Brindley,P.J.
Schistosomes express two forms of cathepsin D
Biochim Biophys Acta1338, 156-160. PubMed Europe PubMed DOI

1996

Filippova,I.Y., Lysogorskaya,E.N., Anisimova,V.V., Suvorov,L.I., Oksenoit,E.S. and Stepanov,V.M.
Fluorogenic peptide substrates for assay of aspartyl proteinases
Anal Biochem234, 113-118. PubMed Europe PubMed DOI A
Higaki,J., Catalano,R., Guzzetta,A.W., Quon,D., Nave,J.F., Tarnus,C., D'Orchymont,H. and Cordell,B.
Processing of beta-amyloid precursor protein by cathepsin D
J Biol Chem271, 31885-31893. PubMed Europe PubMed DOI
Kageyama,T., Yonezawa,S., Ichinose,M., Miki,K. and Moriyama,A.
Potential sites for processing of the human invariant chain by cathepsins D and E
Biochem Biophys Res Commun223, 549-553. PubMed Europe PubMed DOI

1995

Aguilar,C.F., Dhanaraj,V., Guruprasad,K., Dealwis,C., Badasso,M., Cooper,J.B., Wood,S.P. and Blundell,T.L.
Comparisons of the three-dimensional structures, specificities and glycosylation of renins, yeast proteinase A and cathepsin D
Adv Exp Med Biol362, 155-166. PubMed Europe PubMed
Becker,M.M., Harrop,S.A., Dalton,J.P., Kalinna,B.H., McManus,D.P. and Brindley,P.J.
Cloning and characterization of the Schistosoma japonicum aspartic proteinase involved in hemoglobin degradation
J Biol Chem270, 24496-24501. PubMed Europe PubMed DOI
Evin,G., Cappai,R., Li,Q.X., Culvenor,J.G., Small,D.H., Beyreuther,K. and Masters,C.L.
Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta a4 amyloid: possible involvement of cathepsin D
Biochemistry34, 14185-14192. PubMed Europe PubMed
Fortenberry,S.C. and Chirgwin,J.M.
The propeptide is nonessential for the expression of human cathepsin D
J Biol Chem270, 9778-9782. PubMed Europe PubMed DOI E
Kim,K., Homma,Y., Ikeuchi,Y. and Suzuki,A.
Cleavage of connectin by calpain and cathepsin D
Biosci Biotechnol Biochem59, 896-899. DOI
Metcalf,P. and Fusek,M.
Cathepsin D crystal structures and lysosomal sorting
Adv Exp Med Biol362, 193-200. PubMed Europe PubMed S
Mukai,M., Obara,M. and Yoshizato,K.
Characterization of gene of anuran cathepsin D as a metamorphosis- associated enzyme
Dev Growth Differ37, 463-477.
Nishimura,Y. and Himeno,M.
Cathepsin D associates with lysosomal membranous protein
Biol Pharm Bull18, 1340-1346. PubMed Europe PubMed
Nishimura,Y., Takeshima,H., Sakaguchi,M., Mihara,K., Omura,T., Kato,K. and Himeno,M.
Expression of rat cathepsin D cDNA in Saccharomyces cerevisiae: implications for intracellular targeting of cathepsin D to vacuoles
J Biochem118, 168-177. PubMed Europe PubMed E
Saftig,P., Hetman,M., Schmahl,W., Weber,K., Heine,L., Mossmann,H., Koster,A., Hess,B., Evers,M., von Figura,K. and Peters,C.
Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells
EMBO J14, 3599-3608. PubMed Europe PubMed K

1994

Fusek,M. and Vetvicka,V.
Mitogenic function of human procathepsin D: the role of the propeptide
Biochem J303, 775-780. PubMed Europe PubMed
Hetman,M., Perschl,A., Saftig,P., von Figura,K. and Peters,C.
Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization
DNA Cell Biol13, 419-427. PubMed Europe PubMed
Maric,M.A., Taylor,M.D. and Blum,J.S.
Endosomal aspartic proteinases are required for invariant-chain processing
Proc Natl Acad Sci U S A91, 2171-2175. PubMed Europe PubMed
Richo,G.R. and Conner,G.E.
Structural requirements of procathepsin D activation and maturation
J Biol Chem269, 14806-14812. PubMed Europe PubMed
Scarborough,P.E. and Dunn,B.M.
Redesign of the substrate specificity of human cathepsin D: the dominant role of position 287 in the S2 subsite
Protein Eng7, 495-502. PubMed Europe PubMed
Simon,D.I., Ezratty,A.M. and Loscalzo,J.
The fibrin(ogen)olytic properties of cathepsin D
Biochemistry33, 6555-6563. PubMed Europe PubMed

1993

[YEAR:15-7-1993]Baldwin,E.T., Bhat,T.N., Gulnik,S., Hosur,M.V., Sowder,R.C., Cachau,R.E., Collins,J., Silva,A.M. and Erickson,J.W.
Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design
Proc Natl Acad Sci U S A90, 6796-6800. PubMed Europe PubMed S
Cavailles,V., Augereau,P. and Rochefort,H.
Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells
Proc Natl Acad Sci U S A90, 203-207. PubMed Europe PubMed DOI
Metcalf,P. and Fusek,M.
Two crystal structures for cathepsin D: the lysosomal targeting signal and active site
EMBO J12, 1293-1302. PubMed Europe PubMed S
Rao,C., Scarborough,P.E., Lowther,W.T., Kay,J., Batley,B., Rapundalo,S., Klutchko,S., Taylor,M.D. and Dunn,B.M.
Structure-function database for active site binding to the aspartic proteinases
Adv Exp Med Biol306, 143-147.
Scarborough,P.E., Beyer,B.M., Rafanan,M.M. and Dunn,B.M.
Mutagenesis of human cathepsin D as dictated by kinetics and rule-based molecular modelling
Protein Eng Des Sel6, 37- DOI
Scarborough,P.E., Guruprasad,K., Topham,C., Richo,G.R., Conner,G.E., Blundell,T.L. and Dunn,B.M.
Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling
Protein Sci2, 264-276. PubMed Europe PubMed DOI

1992

Carraway,R.E., Mitra,S.P. and Salmonsen,R.
Pepsin-mediated processing of synthetic precursor-like sequence yields neurotensin-like peptide
Peptides13, 319-322. PubMed Europe PubMed DOI
[YEAR:25-10-1992]Cho,W.L. and Raikhel,A.S.
Cloning of cDNA for mosquito lysosomal aspartic protease. Sequence analysis of an insect lysosomal enzyme similar to cathepsins D and E
J Biol Chem267, 21823-21829. PubMed Europe PubMed
Retzek,H., Steyrer,E., Sanders,E.J., Nimpf,J. and Schneider,W.J.
Molecular cloning and functional characterization of chicken cathepsin D, a key enzyme for yolk formation
DNA Cell Biol11, 661-672. PubMed Europe PubMed

1991

[YEAR:15-1-1991]Horst,M. and Hasilik,A.
Expression and maturation of human cathepsin D in baby-hamster kidney cells
Biochem J273, 355-361. PubMed Europe PubMed
Redecker,B., Heckendorf,B., Grosch,H.W., Mersmann,G. and Hasilik,A.
Molecular organization of the human cathepsin D gene
DNA Cell Biol10, 423-431. PubMed Europe PubMed
Scarborough,P.E., Richo,G.R., Kay,J., Conner,G.E. and Dunn,B.M.
Comparison of kinetic properties of native and recombinant human cathepsin D
Adv Exp Med Biol306, 343-347. PubMed Europe PubMed
Smith,L.J. and Yada,Y.R.
Chemical modification of amino groups in Mucor miehei aspartyl proteinase, porcine pepsin, and chymosin. II. Conformational stability
Agric Biol Chem55, 2017-2024. DOI
Smith,L.J., Billings,E.G. and Yada,Y.R.
Chemical modification of amino groups in Mucor miehei aspartyl proteinase, porcine pepsin, and chymosin. I. Structure and function
Agric Biol Chem55, 2009-2016. DOI

1990

Birch,N.P. and Loh,Y.P.
Cloning, sequence and expression of rat cathepsin D
Nucleic Acids Res18, 6445-6446. PubMed Europe PubMed
Conner,G.E. and Udey,J.A.
Expression and refolding of recombinant human fibroblast procathepsin D
DNA Cell Biol9, 1-9. PubMed Europe PubMed

1989

Conner,G.E.
Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme
Biochem J263, 601-604. PubMed Europe PubMed I
Samarel,A.M., Ferguson,A.G., Decker,R.S. and Lesch,M.
Effects of cysteine protease inhibitors on rabbit cathepsin D maturation
Am J Physiol257, C1069-C1079. PubMed Europe PubMed

1988

[YEAR:15-12-1988]D'Agrosa,R.M. and Callahan,J.W.
In vitro activation of neuraminidase in the beta-galactosidase-neuraminidase-protective protein complex by cathepsin C
Biochem Biophys Res Commun157, 770-775. PubMed Europe PubMed
Jacobson,L.A., Jen-Jacobson,L., Hawdon,J.M., Owens,G.P., Bolanowski,M.A., Emmons,S.W., Shah,M.V., Pollock,R.A. and Conklin,D.S.
Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans
Genetics119, 355-363. PubMed Europe PubMed

1987

Gildberg,A.
Purification and characterisation of cathepsin D from the digestive gland of the pelagic squid Todarodes sagittatus
J Sci Food Agric39, 85-94. DOI
Imoto,T., Okazaki,K., Koga,H. and Yamada,H.
Specificity of rat liver cathepsin D
J Biochem101, 575-580. PubMed Europe PubMed

1986

Agarwal,N.S. and Rich,D.H.
Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin
J Med Chem29, 2519-2524. PubMed Europe PubMed I

1985

Gieselmann,V., Hasilik,A. and von Figura,K.
Processing of human cathepsin D in lysosomes in vitro
J Biol Chem260, 3215-3220. PubMed Europe PubMed

1984

Nakao,Y., Kozutsumi,Y., Kawasaki,T., Yamashina,I., van Halbeek,H. and Vliegenthart,J.F.G.
Oligosaccharides on cathepsin D from porcine spleen
Arch Biochem Biophys229, 43-54. PubMed Europe PubMed
[YEAR:1-4-1983]Agarwal,N. and Rich,D.H.
An improved cathepsin-D substrate and assay procedure
Anal Biochem130, 158-165. PubMed Europe PubMed A

1983

Watabe,S. and Yago,N.
Phospholipids activate cathepsin D
Biochem Biophys Res Commun110, 934-939. PubMed Europe PubMed

1982

Hasilik,A., von Figura,K., Conzelmann,E., Nehrkorn,H. and Sandhoff,K.
Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2
Eur J Biochem125, 317-321. PubMed Europe PubMed
Hembry,R.M., Knight,C.G., Dingle,J.T. and Barrett,A.J.
Evidence that extracellular cathepsin D is not responsible for the resorption of cartilage matrix in culture
Biochim Biophys Acta714, 307-312. PubMed Europe PubMed
[YEAR:1-6-1982]Kay,J., Afting,E.G., Aoyagi,T. and Dunn,B.M.
The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D
Biochem J203, 795-797. PubMed Europe PubMed I

1981

[YEAR:28-9-1981]Puizdar,V. and Turk,V.
Cathepsinogen D: characterization and activation to cathepsin D and inhibitory peptides
FEBS Lett132, 299-304. PubMed Europe PubMed I
Takahashi,T. and Tang,J.
Cathepsin D from porcine and bovine spleen
Methods Enzymol80, 565-581. PubMed Europe PubMed DOI V

1980

Doke,S.N. and Nadkarni,G.B.
Characterization of cathepsin D from the skeletal muscle of fresh water fish, Tilapia mossambica
Agric Biol Chem44, 1521-1528. DOI
[YEAR:25-5-1980]Hasilik,A. and Neufeld,E.F.
Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight
J Biol Chem255, 4937-4945. PubMed Europe PubMed

1979

Dionyssiou-Asteriou,A. and Rakitzis,E.T.
Activation of cathepsin D by glycine ethyl ester
Biochem J177, 355-356. PubMed Europe PubMed
Whitaker,J.N. and Seyer,J.M.
The sequential limited degradation of bovine myelin basic protein by bovine brain cathepsin D
J Biol Chem254, 6956-6963. PubMed Europe PubMed

1978

Dionyssiou-Asteriou,A. and Rakitzis,E.T.
Inactivation of cathepsin D from human gastric mucosa and from stomach carcinoma by diazoacetyl-DL-norleucine methyl ester
Biochem Pharmacol27, 827-829. PubMed Europe PubMed DOI I

1977

Barrett,A.J.
Cathepsin D and other carboxyl proteinases
1, 209-248.
Keilova,H. and Tomasek,V.
Naturally occurring inhibitors of intracellular proteinases
Acta Biol Med Ger36, 1873-1881. PubMed Europe PubMed
Woessner,J.F., Jr.
Specificity and biological role of cathepsin D
Adv Exp Med Biol95, 313-327. PubMed Europe PubMed

1976

[YEAR:21-6-1976]Fraki,J.E.
Human skin proteases. Separation and characterization of two acid proteases resembling cathepsin B1 and cathepsin D and of an inhibitor of cathepsin B1
Arch Dermatol Res255, 317-330. PubMed Europe PubMed
Keilova,H. and Tomasek,V.
Isolation and some properties of cathepsin D inhibitor from potatoes
Collect Czech Chem Commun41, 489-497.
Keilova,H. and Tomasek,V.
Further characteristics of cathepsin D inhibitor from potatoes
Collect Czech Chem Commun41, 2440-2447.
Knight,C.G. and Barrett,A.J.
Interaction of human cathepsin D with the inhibitor pepstatin
Biochem J155, 117-125. PubMed Europe PubMed I

1974

Misono,K., Murakami,K., Michelakis,A., Inagami,T. and Lin,T.Y.
Characterization of submaxillary renin and comparison with cathepsin D
Fed Proc33,
Sampath-Kumar,P.S. and Fruton,J.S.
Studies on the extended active sites of acid proteinases
Proc Natl Acad Sci U S A71, 1070-1072. PubMed Europe PubMed P

1973

Ferguson,J.B., Andrews,J.R., Voynick,I.M. and Fruton,J.S.
The specificity of cathepsin D
J Biol Chem248, 6701-6708. PubMed Europe PubMed P
Woessner,J.F., Jr.
Purification of cathepsin D from cartilage and uterus and its action on the protein-polysaccharide complex of cartilage
J Biol Chem248, 1634-1642. PubMed Europe PubMed

1972

Barrett,A.J. and Dingle,J.T.
The inhibition of tissue acid proteinases by pepstatin
Biochem J127, 439-441. PubMed Europe PubMed I
Harris,E.D., Locke,S. and Lin,T.-Y.
Limited degradation of gelatin substrate by cathepsin D
Connect Tissue Res1, 103-108. DOI
Iodice,A.A., Chin,J., Perker,S. and Weinstock,I.M.
Cathepsins A, B, C, D and autolysis during development of breast muscle of normal and dystrophic chickens
Arch Biochem Biophys152, 166-174. PubMed Europe PubMed
Keilova,H. and Tomasek,V.
Effect of pepsin inhibitor from Ascaris lumbricoides on cathepsin D and E
Biochim Biophys Acta284, 461-464. PubMed Europe PubMed
Poole,A.R., Dingle,J.T. and Barrett,A.J.
The immunocytochemical demonstration of cathepsin D
J Histochem Cytochem20, 261-265. PubMed Europe PubMed
Woessner,J.F., Jr.
Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D
Biochem Biophys Res Commun47, 965-970. PubMed Europe PubMed I

1970

Barrett,A.J.
Cathepsin D. Purification of isoenzymes from human and chicken liver
Biochem J117, 601-607. PubMed Europe PubMed

1969

Keilova,H., Markovic,O. and Keil,B.
Characterisation and chemical modification of cathepsin D from bovine spleen
Collect Czech Chem Commun34, 2154-2157.
Smith,G.D., Murray,M.A., Nichol,L.W. and Trikojus,V.M.
Thyroid acid proteinase. Properties and inactivation by diazoacetyl-norleucine methyl ester
Biochim Biophys Acta171, 288-298. PubMed Europe PubMed I
Stepanov,V.M., Orekhovich,V.N., Lobareva,L.S. and Mzhel'skaia,T.I.
[Action of the pepsin inhibitor on bovine spleen cathepsin D]
Biokhimiia34, 209-210. PubMed Europe PubMed
Suzuki,A., Okitani,A. and Fujimaki,M.
Studies on proteolysis in stored muscle: part III. Some physicochemical properties and proteolytic specificity of the rabbit muscular cathepsin D
Agric Biol Chem33, 579-585. DOI
Weston,P.D.
A specific antiserum to lysosomal cathepsin D
Immunology17, 421-428. PubMed Europe PubMed

1968

Keilova,H. and Keil,B.
On proteins. CXIII. Specificity of cleavage of heptapeptide substrate with bovine spleen cathepsin D
Collect Czech Chem Commun33, 131-140. P
Keilova,H., Blaha,K. and Keil,B.
Effect of steric factors on digestibility of peptides containing aromatic amino acids by cathepsin D and pepsin
Eur J Biochem4, 442-447. PubMed Europe PubMed P

1967

Barrett,A.J.
Lysosomal acid proteinase of rabbit liver
Biochem J104, 601-608. PubMed Europe PubMed

1966

Parrish,F.C., Jr. and Bailey,M.E.
Food processing - physicochemical properties and partial purification of porcine muscle cathepsin
J Agric Food Chem14, 232-237.

1963

McMaster,P.B. and Webb,T.
[The purification and properties of cathepsin D from human spleen]
Ann Inst Pasteur (Paris)104, 90-101. PubMed Europe PubMed

1960

Press,E.M., Porter,R.R. and Cebra,J.
The isolation and properties of a proteolytic enzyme, cathepsin D, from bovine spleen
Biochem J74, 501-514. PubMed Europe PubMed

1941

[YEAR:20-7-1940]Anson,M.L.
The purification of cathepsin
J Gen Physiol23, 695-704. PubMed Europe PubMed DOI

1939

[YEAR:20-9-1938]Anson,M.L.
The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin
J Gen Physiol22, 79-89. PubMed Europe PubMed DOI A

1937

Anson,M.L.
The estimation of cathepsin with hemoglobin and the partial purification of cathepsin
J Gen Physiol20, 565-574. PubMed Europe PubMed DOI A

1903

Hedin,S.G.
Investigations on the proteolytic enzymes of the spleen of the ox
J Physiol30, 155-175. PubMed Europe PubMed