Literature for peptidase A01.009: cathepsin D

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Parker,K.L., Clarke,J.D., Liu,X., Gomes,B.F., Eyssen,L.E.A., Furnham,N., Paes Silva-Jr,F. and Owens,R.J. Crystal structure of Schistosoma mansoni cathepsin D1 in complex with a nanobody reveals the conformation of the propeptide-bound state Acta Crystallogr D Struct Biol (2026) 82, 140-150. PubMed Europe PubMed DOI PMC EPMC
Rodriguez-Rios,M., McHugh,B.J., Liang,Z., Megia-Fernandez,A., Lilienkampf,A., Dockrell,D. and Bradley,M. Author Correction: A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages Commun Chem (2026) 9, 18-18. PubMed Europe PubMed DOI PMC EPMC
Zhan,W., Fu,Y., Liu,Y., Cai,R., Bai,F., Guo,C., Cheng,Y., Wu,Z., Qin,G., Xie,Y., Zhang,J. and Deng,Y. Cathepsin-D-mediated MHC class I degradation contributes to immune evasion in colorectal cancer Cell Rep Med (2026) 7, 102534-102534. PubMed Europe PubMed DOI

2025

Alzoubi,L., Hamzat,Y., Alqudah,A. and Aljabali,A.A.A. The Cathepsin Family in Disease: From Molecular Mechanisms to Therapeutic Applications Curr Neuropharmacol (2025) PubMed Europe PubMed DOI
Barbosa da Silva,E., Crane,M.J., Liu,L., Gelsinger,D.J., Jordon,A.R.D., Le,P., Haggett,J.G., Myers,S.A., McKinney,R.L., Eberson,C.P., Jamieson,A.M. and O'Donoghue,A.J. The Impact of pH on Proteolytic Activity in Wound Fluid: Implications for Acid Therapy J Biol Chem (2025) , 110723-110723. PubMed Europe PubMed DOI
Francisco,C.C., Josafat Marina,E.B., Francisco Javier,C.M., Alonso Alexis,L.Z., Hisila Del Carmen,S.O., Ignacio Alfredo,R.E., Ofelia,R.S. and Jose Luis,C.L. The Impact of Thermal and pH Variations on the Structure of Cathepsin D in the Hepatopancreas of Japanese Clam (Ruditapes philippinarum) Curr Protein Pept Sci (2025) PubMed Europe PubMed DOI
Haddad,G. and Blaine,J. miR-204-5p Protects Nephrin from Enzymatic Degradation in Cultured Mouse Podocytes Treated with Nephrotoxic Serum Cells (2025) 14 PubMed Europe PubMed DOI PMC EPMC
Jiang,H., Wang,Y., Wang,C., Yang,L., Wang,S., Wang,F., Xue,S., Zhang,Z., Fu,H., Dong,T., Yuan,J., Li,Z. and Li,K. Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins Cell Death Dis (2025) 16, 611-611. PubMed Europe PubMed DOI PMC EPMC
Kawada,T., Aoyama,M., Yasuda,K. and Satake,H. Cathepsin D mediates tachykinin-induced secondary follicle growth independent of the hypothalamic-pituitary-gonadal axis in mice Front Endocrinol (Lausanne) (2025) 16, 1621348-1621348. PubMed Europe PubMed DOI PMC EPMC
Lu,Y., Wang,F.Y., Levine,M.S., Shi,H.R., Wang,Y., Xiong,X., Yang,L.M., Shi,Y.Q., Zou,T., Sessler,J.L., Liang,H. and Huang,K.B. Oxoisoaporphine Alkaloid Iridium(III) Derivative: An Immunogenic Cell Death Inducer That Engages the Autophagy-Dependent Regulator Cathepsin D J Am Chem Soc (2025) PubMed Europe PubMed DOI
Nishimwe,D., Guillon,G., Mallavialle,A., Martin,C., Huvelle,S., Alcaraz,L.B., Romero,A., Garapon,C., Garambois,V., Mansouri,H., Boissiere-Michot,F., Berestjuk,I., Jarlier,M., Turtoi,A., Denevault-Sabourin,C., Roger,P., Guiu,S., Chardes,T., Joubert,N., Laurent-Matha,V. and Liaudet-Coopman,E. Anti-cathepsin D antibody-drug conjugates for the targeted delivery of monomethyl auristatin F and E elicit potent anticancer activity in breast cancer Biomed Pharmacother (2025) 193, 118775-118775. PubMed Europe PubMed DOI
Niu,L., Zhou,X., Li,D., Zheng,Y. and Li,H. Glycosylation Triggers Cathepsin D Maturation and Secretion to Promote Gastric Cancer Development Am J Pathol (2025) PubMed Europe PubMed DOI
Sulatsky,M.I., Stepanenko,O.V., Stepanenko,O.V., Mikhailova,E.V. and Sulatskaya,A.I. From protective enzyme to facilitator of amyloid propagation: Cathepsin D-mediated amyloid fibril fragmentation Int J Biol Macromol (2025) , 140971-140971. PubMed Europe PubMed DOI
Xi,Y., Wang,X., Ji,M., Zhang,J., Xu,X., He,S. and Song,S. Design and Preclinical Evaluation of First (68)Ga-Labeled Cathepsin D-Targeted Radiotracers J Med Chem (2025) 68, 25143-25156. PubMed Europe PubMed DOI

2024

Alves,S., Santos-Pereira,C., Oliveira,C.S.F., Preto,A., Chaves,S.R. and Corte-Real,M. Enhancement of Acetate-Induced Apoptosis of Colorectal Cancer Cells by Cathepsin D Inhibition Depends on Oligomycin A-Sensitive Respiration Biomolecules (2024) 14 PubMed Europe PubMed DOI PMC EPMC
Desroys du Roure,P., Lajoie,L., Mallavialle,A., Alcaraz,L.B., Mansouri,H., Fenou,L., Garambois,V., Rubio,L., David,T., Coenon,L., Boissiere-Michot,F., Chateau,M.C., Ngo,G., Jarlier,M., Villalba,M., Martineau,P., Laurent-Matha,V., Roger,P., Guiu,S., Chardes,T., Gros,L. and Liaudet-Coopman,E. A novel Fc-engineered cathepsin D-targeting antibody enhances ADCC, triggers tumor-infiltrating NK cell recruitment, and improves treatment with paclitaxel and enzalutamide in triple-negative breast cancer J Immunother Cancer (2024) 12 PubMed Europe PubMed DOI PMC EPMC
Gallwitz,L., Bleibaum,F., Voss,M., Schweizer,M., Spengler,K., Winter,D., Zophel,F., Muller,S., Lichtenthaler,S., Damme,M. and Saftig,P. Cellular depletion of major cathepsin proteases reveals their concerted activities for lysosomal proteolysis Cell Mol Life Sci (2024) 81, 227-227. PubMed Europe PubMed DOI PMC EPMC
Huber,R.J., Kim,W.D. and Wilson-Smillie,M.L.D.M. Mechanisms regulating the intracellular trafficking and release of CLN5 and CTSD Traffic (2024) 25, e12925-e12925. PubMed Europe PubMed DOI
Kamble,S.A., Barale,S.S., Mohammed,A.A., Paymal,S.B., Naik,N.M. and Sonawane,K.D. Structural insights into the potential binding sites of Cathepsin D using molecular modelling techniques Amino Acids (2024) 56, 33-33. PubMed Europe PubMed DOI PMC EPMC
Lee,S.G., Woo,S.M., Seo,S.U., Lee,C.H., Baek,M.C., Jang,S.H., Park,Z.Y., Yook,S., Nam,J.O. and Kwon,T.K. Cathepsin D promotes polarization of tumor-associated macrophages and metastasis through TGFBI-CCL20 signaling Exp Mol Med (2024) 56, 383-394. PubMed Europe PubMed DOI PMC EPMC
Mancano,A.S.F., Pina,J.G., Froes,B.R. and Sciani,J.M. Autophagy-lysosomal pathway impairment and cathepsin dysregulation in Alzheimer's disease Front Mol Biosci (2024) 11, 1490275-1490275. PubMed Europe PubMed DOI PMC EPMC V
Schneider,J., Mitschke,J., Bhat,M., Vogele,D., Schilling,O., Reinheckel,T. and Hess,L. Cathepsin D inhibition during neuronal differentiation selectively affects individual proteins instead of overall protein turnover Biochimie (2024) 226, 35-48. PubMed Europe PubMed DOI
Terron,H.M., Parikh,S.J., Abdul-Hay,S.O., Sahara,T., Kang,D., Dickson,D.W., Saftig,P., LaFerla,F.M., Lane,S. and Leissring,M.A. Prominent tauopathy and intracellular beta-amyloid accumulation triggered by genetic deletion of cathepsin D: implications for Alzheimer disease pathogenesis Alzheimers Res Ther (2024) 16, 70-70. PubMed Europe PubMed DOI PMC EPMC
Terzani,F., Belhattab,S., Le Guern,A., Guitot,K., Monasson,O., Zanato,C., Chelain,E., Leroy-Dudal,J. and Pytkowicz,J. Synthesis and biological evaluation of selective Pepstatin based trifluoromethylated inhibitors of Cathepsin D Eur J Med Chem (2024) 267, 116178-116178. PubMed Europe PubMed DOI I
Xiong,N., Du,Y., Huang,C., Yan,Q., Zhao,L., Yang,C., Sun,Q., Gao,Z., Wang,C., Zhan,J., Zhang,H., Wang,S., Ye,Y., Li,Y. and Shen,Z. N-glycosylation Modification of CTSD Affects Liver Metastases in Colorectal Cancer Adv Sci (Weinh) (2024) , e2411740-e2411740. PubMed Europe PubMed DOI
Zhao,D., Huang,Z.K., Liang,Y., Li,Z.J., Zhang,X.W., Li,K.H., Wu,H., Zhang,X.D., Li,C.S., An,D., Sun,X., An,M.X., Shi,J.X., Bao,Y.J., Tian,L., Wang,D.F., Wu,A.H., Chen,Y.H. and Zhao,W.D. Monocytes Release Pro-Cathepsin D to Drive Blood-to-Brain Transcytosis in Diabetes Circ Res (2024) 134, e17-e17. PubMed Europe PubMed DOI

2023

Chai,Y.L., Liang,N.H.P., Chong,J.R., Venketasubramanian,N., Tan,B.Y., Hilal,S., Chen,C.P. and Lai,M.K.P. Serum Cathepsin D Is a Potential Biomarker for Alzheimer's Disease Dementia and Cognitive Decline J Alzheimers Dis (2023) 91, 989-998. PubMed Europe PubMed DOI
Duarte-Olivenza,C., Moran,G., Hurle,J.M., Lorda-Diez,C.I. and Montero,J.A. Lysosomes, caspase-mediated apoptosis, and cytoplasmic activation of P21, but not cell senescence, participate in a redundant fashion in embryonic morphogenetic cell death Cell Death Dis (2023) 14, 813-813. PubMed Europe PubMed DOI PMC EPMC
Ikari,N. and Arakawa,H. Identification of a mitochondrial targeting sequence in cathepsin D and its localization in mitochondria Biochem Biophys Res Commun (2023) 655, 25-34. PubMed Europe PubMed DOI
Kim,H.S., Kong,H., Kim,T., Lim,C., Lee,S., Kim,S.H. and Suh,Y.G. Structural Congeners of Izenamides Responsible for Cathepsin D Inhibition: Insights from Synthesis-Derived Elucidation Mar Drugs (2023) 21 PubMed Europe PubMed DOI PMC EPMC
Kozak,A., Mikhaylov,G., Khodakivskyi,P., Goun,E., Turk,B. and Vasiljeva,O. A New Cathepsin D Targeting Drug Delivery System Based on Immunoliposomes Functionalized with Lipidated Pepstatin A Pharmaceutics (2023) 15 PubMed Europe PubMed DOI PMC EPMC I
Ma,M., Liu,P., Wang,C., Deng,X., Zhang,L. and Zhang,J. Oxidation of Cathepsin D by Hydroxy Radical: Its Effect on Enzyme Structure and Activity against Myofibrillar Proteins Extracted from Coregonus peled Molecules (2023) 28 PubMed Europe PubMed DOI PMC EPMC
Mitsui,S., Yamaguchi,J., Suzuki,C., Uchiyama,Y. and Tanida,I. TUNEL-positive structures in activated microglia and SQSTM1/p62-positive structures in activated astrocytes in the neurodegenerative brain of a CLN10 mouse model Glia (2023) 71, 2753-2769. PubMed Europe PubMed DOI
Ouyang,X., Wani,W.Y., Benavides,G.A., Redmann,M.J., Vo,H., van Groen,T., Darley-Usmar,V.M. and Zhang,J. Cathepsin D overexpression in the nervous system rescues lethality and Abeta42 accumulation of cathepsin D systemic knockout in vivo Acta Pharm Sin B (2023) 13, 4172-4184. PubMed Europe PubMed DOI PMC EPMC
Rodriguez-Rios,M., McHugh,B.J., Liang,Z., Megia-Fernandez,A., Lilienkampf,A., Dockrell,D. and Bradley,M. A fluorogenic, peptide-based probe for the detection of Cathepsin D in macrophages Commun Chem (2023) 6, 237-237. PubMed Europe PubMed DOI PMC EPMC
Terron,H.M., Maranan,D.S., Burgard,L.A., LaFerla,F.M., Lane,S. and Leissring,M.A. A Dual-Function "TRE-Lox" System for Genetic Deletion or Reversible, Titratable, and Near-Complete Downregulation of Cathepsin D Int J Mol Sci (2023) 24 PubMed Europe PubMed DOI PMC EPMC
Terron,H.M., Parikh,S.J., Abdul-Hay,S.O., Sahara,T., Kang,D., Dickson,D.W., Saftig,P., LaFerla,F.M., Lane,S. and Leissring,M.A. Prominent tauopathy and intracellular beta-amyloid accumulation triggered by genetic deletion of cathepsin D: Implications for Alzheimer disease pathogenesis Res Sq (2023) PubMed Europe PubMed DOI PMC EPMC
Wang,S., Tan,P., Wang,H., Wang,J., Zhang,C., Lu,H. and Zhao,B. Swainsonine inhibits autophagic degradation and causes cytotoxicity by reducing CTSD O-GlcNAcylation Chem Biol Interact (2023) 382, 110629-110629. PubMed Europe PubMed DOI
Ye,N., Miao,L., Wang,F., Wu,S., Wu,B., Zhou,Y., Wang,C. and Sun,G. Cathepsin D Attenuates the Proliferation of Vascular Smooth Muscle Cells Induced by the AGE/RAGE Pathway by Suppressing the ERK Signal Curr Pharm Des (2023) 29, 2387-2395. PubMed Europe PubMed DOI K
Zhang,Y., Yu,Y., Zhou,H., Zhao,M. and Pan,X. A novel function by cathepsin D in degradation of nucleic acids Biochem Biophys Res Commun (2023) 682, 250-258. PubMed Europe PubMed DOI

2022

Gallwitz,L., Schmidt,L., Marques,A.R.A., Tholey,A., Cassidy,L., Ulku,I., Multhaup,G., Di Spiezio,A. and Saftig,P. Cathepsin D: Analysis of its potential role as an amyloid beta degrading protease Neurobiol Dis (2022) 175, 105919-105919. PubMed Europe PubMed DOI
Li,Z., Li,H., Jiang,F., Wang,Z. and Zhang,W. Cathepsin D inhibitors based on tasiamide B derivatives with cell membrane permeability Bioorg Med Chem (2022) 57, 116646-116646. PubMed Europe PubMed DOI I
Limonte,C.P., Valo,E., Drel,V., Natarajan,L., Darshi,M., Forsblom,C., Henderson,C.M., Hoofnagle,A.N., Ju,W., Kretzler,M., Montemayor,D., Nair,V., Nelson,R.G., O'Toole,J.F., Toto,R.D., Rosas,S.E., Ruzinski,J., Sandholm,N., Schmidt,I.M., Vaisar,T., Waikar,S.S., Zhang,J., Rossing,P., Ahluwalia,T.S., Groop,P.H., Pennathur,S., Snell-Bergeon,J.K., Costacou,T., Orchard,T.J., Sharma,K. and de Boer,I.H. Urinary Proteomics Identifies Cathepsin D as a Biomarker of Rapid eGFR Decline in Type 1 Diabetes Diabetes Care (2022) 45, 1416-1427. PubMed Europe PubMed DOI PMC EPMC K
Pedram,K., Laqtom,N.N., Shon,D.J., Di Spiezio,A., Riley,N.M., Saftig,P., Abu-Remaileh,M. and Bertozzi,C.R. Lysosomal cathepsin D mediates endogenous mucin glycodomain catabolism in mammals Proc Natl Acad Sci U S A (2022) 119, e2117105119-e2117105119. PubMed Europe PubMed DOI PMC EPMC
Prieto Huarcaya,S., Drobny,A., Marques,A.R.A., Di Spiezio,A., Dobert,J.P., Balta,D., Werner,C., Rizo,T., Gallwitz,L., Bub,S., Stojkovska,I., Belur,N.R., Fogh,J., Mazzulli,J.R., Xiang,W., Fulzele,A., Dejung,M., Sauer,M., Winner,B., Rose-John,S., Arnold,P., Saftig,P. and Zunke,F. Recombinant pro-CTSD (cathepsin D) enhances SNCA/alpha-Synuclein degradation in alpha-Synucleinopathy models Autophagy (2022) 18, 1127-1151. PubMed Europe PubMed DOI
Seo,S.U., Woo,S.M., Min,K.J. and Kwon,T.K. Itch and autophagy-mediated NF-kappaB activation contributes to inhibition of cathepsin D-induced sensitizing effect on anticancer drugs Cell Death Dis (2022) 13, 552-552. PubMed Europe PubMed DOI PMC EPMC
Seo,S.U., Woo,S.M., Im,S.S., Jang,Y., Han,E., Kim,S.H., Lee,H., Lee,H.S., Nam,J.O., Gabrielson,E., Min,K.J. and Kwon,T.K. Cathepsin D as a potential therapeutic target to enhance anticancer drug-induced apoptosis via RNF183-mediated destabilization of Bcl-xL in cancer cells Cell Death Dis (2022) 13, 115-115. PubMed Europe PubMed DOI PMC EPMC
Skopal,A., Keki,T., Toth,P.A., Csoka,B., Koscso,B., Nemeth,Z.H., Antonioli,L., Ivessa,A., Ciruela,F., Virag,L., Hasko,G. and Kokai,E. Cathepsin D interacts with adenosine A2A receptors in mouse macrophages to modulate cell surface localization and inflammatory signaling J Biol Chem (2022) 298, 101888-101888. PubMed Europe PubMed DOI PMC EPMC
Suzuki,C., Yamaguchi,J., Sanada,T., Oliva Trejo,J.A., Kakuta,S., Shibata,M., Tanida,I. and Uchiyama,Y. Lack of Cathepsin D in the central nervous system results in microglia and astrocyte activation and the accumulation of proteinopathy-related proteins Sci Rep (2022) 12, 11662-11662. PubMed Europe PubMed DOI PMC EPMC
Yu,D., Cai,W., Chen,X., Lu,D., Hu,M., Lu,T., Qin,B., Wu,A., Ruan,H., Lu,Y., Liu,Z., Wei,L. and Lu,Z. Natural Killer Cells Disrupt Nerve Fibres through Granzyme H in Atheriosclerotic Cerebral Small Vessel Disease J Gerontol A Biol Sci Med Sci (2022) PubMed Europe PubMed DOI
Zhang,Z., Nakata,E., Shibano,Y. and Morii,T. FRET-Based Cathepsin Probes for Simultaneous Detection of Cathepsin B and D Activities Chembiochem (2022) 23, e202200319-e202200319. PubMed Europe PubMed DOI

2021

Alcaraz,L.B., Mallavialle,A., David,T., Derocq,D., Delolme,F., Dieryckx,C., Mollevi,C., Boissiere-Michot,F., Simony-Lafontaine,J., du Manoir,S., Huesgen,P.F., Overall,C.M., Tartare-Deckert,S., Jacot,W., Chardes,T., Guiu,S., Roger,P., Reinheckel,T., Moali,C. and Liaudet-Coopman,E. A 9-kDa matricellular SPARC fragment released by cathepsin D exhibits pro-tumor activity in the triple-negative breast cancer microenvironment Theranostics (2021) 11, 6173-6192. PubMed Europe PubMed DOI PMC EPMC
Bassal,M., Liu,J., Jankowiak,W., Saftig,P. and Bartsch,U. Rapid and Progressive Loss of Multiple Retinal Cell Types in Cathepsin D-Deficient Mice-An Animal Model of CLN10 Disease Cells (2021) 10 PubMed Europe PubMed DOI PMC EPMC
Bunk,J., Prieto Huarcaya,S., Drobny,A., Dobert,J.P., Walther,L., Rose-John,S., Arnold,P. and Zunke,F. Cathepsin D Variants Associated With Neurodegenerative Diseases Show Dysregulated Functionality and Modified alpha-Synuclein Degradation Properties Front Cell Dev Biol (2021) 9, 581805-581805. PubMed Europe PubMed DOI PMC EPMC
Carvelli,L., Aguilera,A.C., Zyla,L., Pereyra,L.L., Morales,C.R., Hermo,L. and Sosa,M.A. Castration causes an increase in lysosomal size and upregulation of cathepsin D expression in principal cells along with increased secretion of procathepsin D and prosaposin oligomers in adult rat epididymis PLoS ONE (2021) 16, e0250454-e0250454. PubMed Europe PubMed DOI PMC EPMC
Caval,T., Hecht,E.S., Tang,W., Uy-Gomez,M., Nichols,A., Kil,Y.J., Sandoval,W., Bern,M. and Heck,A.J.R. The lysosomal endopeptidases Cathepsin D and L are selective and effective proteases for the middle-down characterization of antibodies FEBS J (2021) PubMed Europe PubMed DOI
Falkowski,P., Mrozek,P., Miluski,P., Lukaszewski,Z. and Gorodkiewicz,E. A Comparison of Various Chips Used for the Manufacture of Biosensors Applied in Non-Fluidic Array SPRi, Based on the Example of Determination of Cathepsin D Biosensors (Basel) (2021) 12 PubMed Europe PubMed DOI PMC EPMC I
Hattersley,K.J., Carosi,J.M., Hein,L.K., Bensalem,J. and Sargeant,T.J. PICALM regulates cathepsin D processing and lysosomal function Biochem Biophys Res Commun (2021) 570, 103-109. PubMed Europe PubMed DOI
Kunnapuu,J., Bokharaie,H. and Jeltsch,M. Proteolytic Cleavages in the VEGF Family: Generating Diversity among Angiogenic VEGFs, Essential for the Activation of Lymphangiogenic VEGFs Biology (Basel) (2021) 10 PubMed Europe PubMed DOI PMC EPMC
Liu,L. and Doray,B. Elevated mRNA expression and defective processing of cathepsin D in HeLa cells lacking the mannose 6-phosphate pathway FEBS Open Bio (2021) 11, 1695-1703. PubMed Europe PubMed DOI
Liu,Y.J., Zhang,T., Chen,S., Cheng,D., Wu,C., Wang,X., Duan,D., Zhu,L., Lou,H., Gong,Z., Wang,X.D., Ho,M.S. and Duan,S. The noncanonical role of the protease cathepsin D as a cofilin phosphatase Cell Res (2021) PubMed Europe PubMed DOI
Mijanovic,O., Petushkova,A.I., Brankovic,A., Turk,B., Solovieva,A.B., Nikitkina,A.I., Bolevich,S., Timashev,P.S., Parodi,A. and Zamyatnin,A.A., Jr. Cathepsin D-Managing the Delicate Balance Pharmaceutics (2021) 13 PubMed Europe PubMed DOI PMC EPMC
Suire,C.N. and Leissring,M.A. Cathepsin D: A Candidate Link between Amyloid beta-protein and Tauopathy in Alzheimer Disease J Exp Neurol (2021) 2, 10-15. PubMed Europe PubMed PMC EPMC V
Wang,X., Zou,Y., Chen,Z., Li,Y., Pan,L., Wang,Y., Liu,M., Yin,C., Wu,J., Yang,C., Zhang,L., Li,C., Huang,Z., Wang,D., Qian,J., Ge,J., Zou,Y. and Gong,H. Low-density lipoprotein receptor-related protein 6 regulates cardiomyocyte-derived paracrine signaling to ameliorate cardiac fibrosis Theranostics (2021) 11, 1249-1268. PubMed Europe PubMed DOI PMC EPMC I
Yang,J., Ding,X., Meng,S., Cai,J. and Zhou,W. The c.863A>G (p.Glu288Gly) variant of the CTSD gene is not associated with CLN10 disease Mol Genet Genomic Med (2021) , e1777-e1777. PubMed Europe PubMed DOI

2020

Araujo-Montoya,B.O., Senger,M.R., Gomes,B.F., Harris,G., Owens,R.J. and Silva-Jr,F.P. Schistosoma mansoni cathepsin D1: biochemical and biophysical characterization of the recombinant enzyme expressed in HEK293T cells Protein Expr Purif (2020) 167, 105532-105532. PubMed Europe PubMed DOI
Choi,H., Ko,Y. and Lee,C.Y. Pro-cathepsin D as a diagnostic marker in differentiating malignant from benign pleural effusion: a retrospective cohort study BMC Cancer (2020) 20, 825-825. PubMed Europe PubMed DOI PMC EPMC
Di,Y.Q., Han,X.L., Kang,X.L., Wang,D., Chen,C.H., Wang,J.X. and Zhao,X.F. Autophagy triggers CTSD (cathepsin D) maturation and localization inside cells to promote apoptosis Autophagy (2020) , 1-23. PubMed Europe PubMed DOI
Ding,L., Houben,T., Oligschlaeger,Y., Bitorina,A.V., Verwer,B.J., Tushuizen,M.E. and Shiri-Sverdlov,R. Plasma Cathepsin D Activity Rather Than Levels Correlates With Metabolic Parameters of Type 2 Diabetes in Male Individuals Front Endocrinol (Lausanne) (2020) 11, 575070-575070. PubMed Europe PubMed DOI PMC EPMC
Fu,Q., Yuan,J., Wang,L., Ran,H., Li,F., Liu,F., Zhang,J., Liu,W., Huang,W., Huang,Y. and Xia,X. Proteomic analysis of murine macrophages mitochondria and lysosomes reveal cathepsin D as a potential broad-spectrum antimicrobial protein J Proteomics (2020) 223, 103821-103821. PubMed Europe PubMed DOI
Gomez,L.A., Alvarez,F.I., Molina,R.E., Soto-Shara,R., Daza-Castro,C., Flores,M.R., Leon,Y. and Onate,A.A. A Zinc-Dependent Metalloproteinase of Brucella abortus Is Required in the Intracellular Adaptation of Macrophages Front Microbiol (2020) 11, 1586-1586. PubMed Europe PubMed DOI PMC EPMC
Goyal,S., Patel,K.V., Nagare,Y., Raykar,D.B., Raikar,S.S., Dolas,A., Khurana,P., Cyriac,R., Sarak,S., Gangar,M., Agarwal,A.K. and Kulkarni,A. Identification and structure-activity relationship studies of small molecule inhibitors of the human cathepsin D Bioorg Med Chem (2020) 29, 115879-115879. PubMed Europe PubMed DOI I
Henriques,B.S., Gomes,B., Oliveira,P.L., Garcia,E.S., Azambuja,P. and Genta,F.A. Characterization of the Temporal Pattern of Blood Protein Digestion in Rhodnius prolixus: First Description of Early and Late Gut Cathepsins Front Physiol (2020) 11, 509310-509310. PubMed Europe PubMed DOI PMC EPMC
Hoes,M.F., Tromp,J., Ouwerkerk,W., Bomer,N., Oberdorf-Maass,S.U., Samani,N.J., Ng,L.L., Lang,C.C., van der Harst,P., Hillege,H., Anker,S.D., Metra,M., van Veldhuisen,D.J., Voors,A.A. and van der Meer,P. The role of cathepsin D in the pathophysiology of heart failure and its potentially beneficial properties: a translational approach Eur J Heart Fail (2020) 22, 2102-2111. PubMed Europe PubMed DOI
Hossain,M.I., Marcus,J.M., Lee,J.H., Garcia,P.L., Singh,V., Shacka,J.J., Zhang,J., Gropen,T.I., Falany,C.N. and Andrabi,S.A. Restoration of CTSD (cathepsin D) and lysosomal function in stroke is neuroprotective Autophagy (2020) , 1-19. PubMed Europe PubMed DOI U
Houstecka,R., Hadzima,M., Fanfrlik,J., Brynda,J., Pallova,L., Hanova,I., Mertlikova-Kaiserova,H., Lepsik,M., Horn,M., Smrcina,M., Majer,P. and Mares,M. Biomimetic macrocyclic inhibitors of human cathepsin D: structure-activity relationship and binding mode analysis J Med Chem (2020) 63, 1576-1596. PubMed Europe PubMed DOI I
Jantas,D., Chwastek,J., Malarz,J., Stojakowska,A. and Lason,W. Neuroprotective Effects of Methyl Caffeate against Hydrogen Peroxide-Induced Cell Damage: Involvement of Caspase 3 and Cathepsin D Inhibition Biomolecules (2020) 10 PubMed Europe PubMed DOI
Kang,J., Yu,Y., Jeong,S., Lee,H., Heo,H.J., Park,J.J., Na,H.S., Ko,D.S. and Kim,Y.H. Prognostic role of high cathepsin D expression in breast cancer: a systematic review and meta-analysis Ther Adv Med Oncol (2020) 12, 1758835920927838-1758835920927838. PubMed Europe PubMed DOI PMC EPMC
Kang,J., Kim,J.W., Heo,H., Lee,J., Park,K.Y., Yoon,J.H. and Chang,J. Identification of BAG2 and Cathepsin D as Plasma Biomarkers for Parkinson's Disease Clin Transl Sci (2020) PubMed Europe PubMed DOI
Ketterer,S., Mitschke,J., Ketscher,A., Schlimpert,M., Reichardt,W., Baeuerle,N., Hess,M.E., Metzger,P., Boerries,M., Peters,C., Kammerer,B., Brummer,T., Steinberg,F. and Reinheckel,T. Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling Nat Commun (2020) 11, 5133-5133. PubMed Europe PubMed DOI PMC EPMC
Liu,Y.J., Zhang,T., Cheng,D., Yang,J., Chen,S., Wang,X., Li,X., Duan,D., Lou,H., Zhu,L., Luo,J., Ho,M.S., Wang,X.D. and Duan,S. Late endosomes promote microglia migration via cytosolic translocation of immature protease cathD Sci Adv (2020) 6 PubMed Europe PubMed DOI PMC EPMC
Maeser,S., Petre,B.A., Ion,L., Rawer,S., Kohlschutter,A., Santorelli,F.M., Simonati,A., Schulz,A. and Przybylski,M. Enzymatic diagnosis of neuronal lipofuscinoses in dried blood spots using substrates for concomitant tandem mass spectrometry and fluorimetry J Mass Spectrom (2020) , e4675-e4675. PubMed Europe PubMed DOI
Mahajan,U.M., Goni,E., Langhoff,E., Li,Q., Costello,E., Greenhalf,W., Kruger,S., Ormanns,S., Halloran,C., Ganeh,P., Marron,M., Lammerhirt,F., Zhao,Y., Beyer,G., Weiss,F.U., Sendler,M., Bruns,C.J., Kohlmann,T., Kirchner,T., Werner,J., D'Haese,J.G., von Bergwelt-Baildon,M., Heinemann,V., Neoptolemos,J.P., Buchler,M.W., Belka,C., Boeck,S., Lerch,M.M. and Mayerle,J. Cathepsin D expression and gemcitabine resistance in pancreatic cancer JNCI Cancer Spectr (2020) 4, kz060-kz060. PubMed Europe PubMed DOI PMC EPMC
Marques,A.R.A., Di Spiezio,A., Thiessen,N., Schmidt,L., Grotzinger,J., Lullmann-Rauch,R., Damme,M., Storck,S.E., Pietrzik,C.U., Fogh,J., Bar,J., Mikhaylova,M., Glatzel,M., Bassal,M., Bartsch,U. and Saftig,P. Enzyme replacement therapy with recombinant pro-CTSD (cathepsin D) corrects defective proteolysis and autophagy in neuronal ceroid lipofuscinosis Autophagy (2020) 16, 811-825. PubMed Europe PubMed DOI E U
Niu,R., Wang,J., Geng,C., Li,Y., Dong,L., Liu,L., Chang,Y., Shen,J., Nie,Z., Zhang,Y. and Hu,B. Tandem mass tag-based proteomic analysis reveals cathepsin-mediated anti-autophagic and pro-apoptotic effects under proliferative diabetic retinopathy Aging (Albany NY) (2020) 12 PubMed Europe PubMed DOI
Singh,M.P., Sharma,C. and Kang,S.C. Morin hydrate attenuates adenine-induced renal fibrosis via targeting cathepsin D signaling Int Immunopharmacol (2020) 90, 107234-107234. PubMed Europe PubMed DOI
Suire,C.N., Abdul-Hay,S.O., Sahara,T., Kang,D., Brizuela,M.K., Saftig,P., Dickson,D.W., Rosenberry,T.L. and Leissring,M.A. Cathepsin D regulates cerebral Abeta42/40 ratios via differential degradation of Abeta42 and Abeta40 Alzheimers Res Ther (2020) 12, 80-80. PubMed Europe PubMed DOI PMC EPMC K
Tam,J.M., Josephson,L., Pilozzi,A.R. and Huang,X. A novel dual fluorochrome near-infrared imaging probe for potential Alzheimer's enzyme biomarkers-BACE1 and cathepsin D Molecules (2020) 25 PubMed Europe PubMed DOI L
Tayebi,N., Lopez,G., Do,J. and Sidransky,E. Pro-cathepsin D, Prosaposin, and Progranulin: Lysosomal Networks in Parkinsonism Trends Mol Med (2020) 26, 913-923. PubMed Europe PubMed DOI
Triebel,J., Schauer,N., Zamora,M., Moreno-Vega,A.I., Escalera,G.M., Clapp,C. and Bertsch,T. Matrix metalloproteases and cathepsin D in human serum do not cleave prolactin to generate vasoinhibin Clin Lab (2020) 66 PubMed Europe PubMed DOI
Wang,Y., Wu,Q., Anand,B.G., Karthivashan,G., Phukan,G., Yang,J., Thinakaran,G., Westaway,D. and Kar,S. Significance of cytosolic cathepsin D in Alzheimer's disease pathology: Protective cellular effects of PLGA nanoparticles against beta-amyloid-toxicity Neuropathol Appl Neurobiol (2020) 46, 686-706. PubMed Europe PubMed DOI
Wu,Y., Li,C., Peng,H., Swaidan,A., Riehle,A., Pollmeier,B., Zhang,Y., Gulbins,E. and Grassme,H. Acid Sphingomyelinase Contributes to the Control of Mycobacterial Infection via a Signaling Cascade Leading from Reactive Oxygen Species to Cathepsin D Cells (2020) 9 PubMed Europe PubMed DOI
Zhang,T., Cheng,D., Wu,C., Wang,X., Ke,Q., Lou,H., Zhu,L., Wang,X.D., Duan,S. and Liu,Y.J. Lysosomal hydrolase cathepsin D non-proteolytically modulates dendritic morphology in Drosophila Neurosci Bull (2020) 36, 1147-1157. PubMed Europe PubMed DOI
Zheng,W., Chen,Q., Wang,C., Yao,D., Zhu,L., Pan,Y., Zhang,J., Bai,Y. and Shao,C. Inhibition of cathepsin D (CTSD) enhances radiosensitivity of glioblastoma cells by attenuating autophagy Mol Carcinog (2020) 59, 651-660. PubMed Europe PubMed DOI T

2019

Ashraf,Y., Mansouri,H., Laurent-Matha,V., Alcaraz,L.B., Roger,P., Guiu,S., Derocq,D., Robin,G., Michaud,H.A., Delpech,H., Jarlier,M., Pugniere,M., Robert,B., Puel,A., Martin,L., Landomiel,F., Bourquard,T., Achour,O., Fruitier-Arnaudin,I., Pichard,A., Deshayes,E., Turtoi,A., Poupon,A., Simony-Lafontaine,J., Boissiere-Michot,F., Pirot,N., Bernex,F., Jacot,W., du Manoir,S., Theillet,C., Pouget,J.P., Navarro-Teulon,I., Bonnefoy,N., Pelegrin,A., Chardes,T., Martineau,P. and Liaudet-Coopman,E. Immunotherapy of triple-negative breast cancer with cathepsin D-targeting antibodies J Immunother Cancer (2019) 7, 29-29. PubMed Europe PubMed DOI PMC EPMC
Butler,V.J., Cortopassi,W.A., Argouarch,A.R., Ivry,S.L., Craik,C.S., Jacobson,M.P. and Kao,A.W. Progranulin stimulates the in vitro maturation of pro-cathepsin D at acidic pH J Mol Biol (2019) 431, 1038-1047. PubMed Europe PubMed DOI
Butler,V.J., Cortopassi,W.A., Gururaj,S., Wang,A.L., Pierce,O.M., Jacobson,M.P. and Kao,A.W. Multi-granulin domain peptides bind to pro-cathepsin D and stimulate its enzymatic activity more effectively than progranulin in vitro Biochemistry (2019) 58, 2670-2674. PubMed Europe PubMed DOI
Cui,T., Chi,B., Heidbrink Thompson,J., Kasali,T., Sellick,C. and Turner,R. Cathepsin D: removal strategy on Protein A chromatography, near real time monitoring and characterisation during monoclonal antibody production J Biotechnol (2019) 305, 51-60. PubMed Europe PubMed DOI
Jha,S.K., Rauniyar,K., Chronowska,E., Mattonet,K., Maina,E.W., Koistinen,H., Stenman,U.H., Alitalo,K. and Jeltsch,M. KLK3/PSA and cathepsin D activate VEGF-C and VEGF-D elife (2019) 8 PubMed Europe PubMed DOI
Kang,J.M., Yoo,W.G., Le,H.G., Thai,T.L., Hong,S.J., Sohn,W.M. and Na,B.K. Partial characterization of two cathepsin D family aspartic peptidases of Clonorchis sinensis Korean J Parasitol (2019) 57, 671-680. PubMed Europe PubMed DOI
Khurana,P., Yadati,T., Goyal,S., Dolas,A., Houben,T., Oligschlaeger,Y., Agarwal,A.K., Kulkarni,A. and Shiri-Sverdlov,R. Inhibiting extracellular cathepsin D reduces hepatic steatosis in Sprague-Dawley rats Biomolecules (2019) 9 PubMed Europe PubMed DOI I
Li,X., Qin,L., Li,Y., Yu,H., Zhang,Z., Tao,C., Liu,Y., Xue,Y., Zhang,X., Xu,Z., Wang,Y., Lou,H., Tan,Z., Saftig,P., Chen,Z., Xu,T., Bi,G., Duan,S. and Gao,Z. Presynaptic endosomal cathepsin D regulates the biogenesis of GABAergic synaptic vesicles Cell Rep (2019) 28, 1015-1028. PubMed Europe PubMed DOI
Lim,C. Total syntheses of cathepsin D inhibitory izenamides A, B, and C and structural confirmation of izenamide B Molecules (2019) 24 PubMed Europe PubMed DOI I
Suzuki,C., Tanida,I., Ohmuraya,M., Oliva Trejo,J.A., Kakuta,S., Sunabori,T. and Uchiyama,Y. Lack of cathepsin D in the renal proximal tubular cells resulted in increased sensitivity against renal ischemia/reperfusion injury Int J Mol Sci (2019) 20 PubMed Europe PubMed DOI K
Thottath,J., Vellarikkal,S.K., Jayarajan,R., Verma,A., Manamel,M., Singh,A., Rajendran,V.R., Sivasubbu,S. and Scaria,V. A novel cathepsin D mutation in 2 siblings with late infantile neuronal ceroid lipofuscinosis Neurol Genet (2019) 5, e302-e302. PubMed Europe PubMed DOI PMC EPMC M
Vangala,G., Imhoff,F.M., Squires,C.M.L., Cridge,A.G. and Baird,S.K. Mesenchymal stem cell homing towards cancer cells is increased by enzyme activity of cathepsin D Exp Cell Res (2019) 383, 111494-111494. PubMed Europe PubMed DOI
Zoia,M.A.P., Azevedo,F.V.P., Vecchi,L., Mota,S.T.S., Rodovalho,V.R., Cordeiro,A.O., Correia,L.I.V., Silva,A.C.A., Avila,V.M.R., Araujo,T.G. and Goulart,L.R. Inhibition of triple-negative breast cancer cell aggressiveness by cathepsin D blockage: role of annexin A1 Int J Mol Sci (2019) 20 PubMed Europe PubMed DOI I

2018

Aghdassi,A.A., John,D.S., Sendler,M., Weiss,F.U., Reinheckel,T., Mayerle,J. and Lerch,M.M. Cathepsin D regulates cathepsin B activation and disease severity predominantly in inflammatory cells during experimental pancreatitis J Biol Chem (2018) 293, 1018-1029. PubMed Europe PubMed DOI
Arodola,O.A. and Soliman,M.E. Hybrid 2D/3D-quantitative structure-activity relationship and modeling studies perspectives of pepstatin A analogs as cathepsin D inhibitors Future Med Chem (2018) 10, 5-26. PubMed Europe PubMed DOI I
Cornelio,V.E., de Moraes,M.C., Domingues,V.C., Fernandes,J.B., da Silva,M.F.D.G.F., Cass,Q.B. and Vieira,P.C. Cathepsin D immobilized capillary reactors for on-flow screening assays J Pharm Biomed Anal (2018) 151, 252-259. PubMed Europe PubMed DOI A
Guo,D.Z., Xiao,L., Liu,Y.J., Shen,C., Lou,H.F., Lv,Y. and Pan,S.Y. Cathepsin D deficiency delays central nervous system myelination by inhibiting proteolipid protein trafficking from late endosome/lysosome to plasma membrane Exp Mol Med (2018) 50, e457-e457. PubMed Europe PubMed DOI
Hanova,I., Brynda,J., Houstecka,R., Alam,N., Sojka,D., Kopacek,P., Maresova,L., Vondrasek,J., Horn,M., Schueler-Furman,O. and Mares,M. Novel structural mechanism of allosteric regulation of aspartic peptidases via an evolutionarily conserved exosite Cell Chem Biol (2018) 25, 318-329. PubMed Europe PubMed DOI
Kettwig,M., Ohlenbusch,A., Jung,K., Steinfeld,R. and Gartner,J. Cathepsin D polymorphism C224T in childhood-onset neurodegenerative disorders: no impact for childhood dementia J Pediatr Genet (2018) 7, 14-18. PubMed Europe PubMed DOI PMC EPMC M
Leyria,J., Fruttero,L.L., Ligabue-Braun,R., Defferrari,M.S., Arrese,E.L., Soulages,J.L., Settembrini,B.P., Carlini,C.R. and Canavoso,L.E. DmCatD, a cathepsin D-like peptidase of the hematophagous insect Dipetalogaster maxima (Hemiptera: Reduviidae): purification, bioinformatic analyses and the significance of its interaction with lipophorin in the internalization by developing oocytes J Insect Physiol (2018) 105, 28-39. PubMed Europe PubMed DOI
Ning,M., Yuan,M., Liu,M., Gao,Q., Wei,P., Gu,W., Wang,W. and Meng,Q. Characterization of cathepsin D from Eriocheir sinensis involved in Spiroplasma eriocheiris infection Dev Comp Immunol (2018) 86, 1-8. PubMed Europe PubMed DOI
Rodriguez-Siordia,I., Rojo-Arreola,L., Navarrete Del Toro,M.L.A. and Garcia-Carreno,F. American lobster cathepsin D, an aspartic peptidase resistant to proteolysis and active in organic solvents, non-ionic detergents and salts Int J Biol Macromol (2018) 107, 1501-1509. PubMed Europe PubMed DOI
Snir,J.A., Suchy,M., Bindseil,G.A., Kovacs,M., Chronik,B.A., Hudson,R.H.E., Pasternak,S.H. and Bartha,R. An aspartyl cathepsin targeted PET agent: application in an Alzheimer's disease mouse model J Alzheimers Dis (2018) 61, 1241-1252. PubMed Europe PubMed DOI L
Xu,X., Zheng,Y., Huang,Y., Chen,J., Gong,Z., Li,Y., Lu,C., Lai,W. and Xu,Q. Cathepsin D contributes to the accumulation of advanced glycation end products during photoaging J Dermatol Sci (2018) 90, 263-275. PubMed Europe PubMed DOI

2017

Al-Awadhi,F.H., Law,B.K., Paul,V.J. and Luesch,H. Grassystatins D-F, potent aspartic protease inhibitors from marine cyanobacteria as potential antimetastatic agents targeting invasive breast cancer J Nat Prod (2017) 80, 2969-2986. PubMed Europe PubMed DOI I
Aufschnaiter,A., Kohler,V. and Buttner,S. Taking out the garbage: cathepsin D and calcineurin in neurodegeneration Neural Regen Res (2017) 12, 1776-1779. PubMed Europe PubMed DOI
Carcel-Trullols,J., Kovacs,A.D. and Pearce,D.A. Role of the lysosomal membrane protein, CLN3, in the regulation of cathepsin D activity J Cell Biochem (2017) 118, 3883-3890. PubMed Europe PubMed DOI
Cheng,S., Wani,W.Y., Hottman,D.A., Jeong,A., Cao,D., LeBlanc,K.J., Saftig,P., Zhang,J. and Li,L. Haplodeficiency of cathepsin D does not affect cerebral amyloidosis and autophagy in APP/PS1 transgenic mice J Neurochem (2017) 142, 297-304. PubMed Europe PubMed DOI
Dubey,V. and Luqman,S. Cathepsin D as a promising target for the discovery of novel anticancer agents Curr Cancer Drug Targets (2017) 17, 404-422. PubMed Europe PubMed DOI T
Ellis,C.R., Tsai,C.C., Lin,F.Y. and Shen,J. Conformational dynamics of cathepsin D and binding to a small-molecule BACE1 inhibitor J Comput Chem (2017) 38, 1260-1269. PubMed Europe PubMed DOI I
Kang,T., Jin,R., Zhang,Y., Wan,H., Lee,K.S., Jin,B.R. and Li,J. Functional characterization of the aspartic proteinase cathepsin D in the beet armyworm (Spodoptera exigua) Gene (2017) 617, 1-7. PubMed Europe PubMed DOI
Koike,M., Shibata,M., Sunabori,T., Yamaguchi,J., Sakimura,K., Komatsu,M., Tanaka,K. and Uchiyama,Y. Purkinje cells are more vulnerable to the specific depletion of cathepsin D than to that of Atg7 Am J Pathol (2017) 187, 1586-1600. PubMed Europe PubMed DOI K
Li,Y., Chang,Y., Ye,N., Dai,D., Chen,Y., Zhang,N., Sun,G. and Sun,Y. Advanced glycation end products inhibit the proliferation of human umbilical vein endothelial cells by inhibiting cathepsin D Int J Mol Sci (2017) 18 PubMed Europe PubMed DOI
Martinez-Alarcon,D., Saborowski,R., Rojo-Arreola,L. and Garcia-Carreno,F. Is digestive cathepsin D the rule in decapod crustaceans? Comp Biochem Physiol B Biochem Mol Biol (2017) 215, 31-38. PubMed Europe PubMed DOI
Pimentel,A.C., Fuzita,F.J., Palmisano,G., Ferreira,C. and Terra,W.R. Role of cathepsins D in the midgut of Dysdercus peruvianus Comp Biochem Physiol B Biochem Mol Biol (2017) 204, 45-52. PubMed Europe PubMed DOI
Pranjol,M.Z.I., Gutowski,N.J., Hannemann,M. and Whatmore,J.L. Cathepsin D non-proteolytically induces proliferation and migration in human omental microvascular endothelial cells via activation of the ERK1/2 and PI3K/AKT pathways Biochim Biophys Acta (2017) 1865, 25-33. PubMed Europe PubMed DOI
Wu,P., Yuan,X., Li,F., Zhang,J., Zhu,W., Wei,M., Li,J. and Wang,X. Myocardial upregulation of cathepsin D by ischemic heart disease promotes autophagic flux and protects against cardiac remodeling and heart failure Circ Heart Fail (2017) 10 PubMed Europe PubMed DOI
Xu,H., Bao,K., Tang,S., Ai,J., Hu,H. and Zhang,W. Cyanobacterial peptides as a prototype for the design of cathepsin D inhibitors J Pept Sci (2017) 23, 701-706. PubMed Europe PubMed DOI I
Yu,C., Cha,Y., Wu,F., Xu,X., Qin,L. and Du,M. Molecular cloning and functional characterization of cathepsin D from sea cucumber Apostichopus japonicus Fish Shellfish Immunol (2017) 70, 553-559. PubMed Europe PubMed DOI
Zhou,X., Paushter,D.H., Feng,T., Pardon,C.M., Mendoza,C.S. and Hu,F. Regulation of cathepsin D activity by the FTLD protein progranulin Acta Neuropathol (2017) 134, 151-153. PubMed Europe PubMed DOI

2016

Al-Awadhi,F.H., Ratnayake,R., Paul,V.J. and Luesch,H. Tasiamide F, a potent inhibitor of cathepsins D and E from a marine cyanobacterium Bioorg Med Chem (2016) 24, 3276-3282. PubMed Europe PubMed DOI I
Anantaraju,H.S., Battu,M.B., Viswanadha,S., Sriram,D. and Yogeeswari,P. Cathepsin D inhibitors as potential therapeutics for breast cancer treatment: molecular docking and bioevaluation against triple-negative and triple-positive breast cancers Mol Divers (2016) 20, 521-535. PubMed Europe PubMed DOI I
Arodola,O.A. and Soliman,M.E. Molecular dynamics simulations of ligand-induced flap conformational changes in cathepsin-D- a comparative study J Cell Biochem (2016) 117, 2643-2657. PubMed Europe PubMed DOI
Boonen,M., Staudt,C., Gilis,F., Oorschot,V., Klumperman,J. and Jadot,M. Cathepsin D and its newly identified transport receptor Sez6l2 can modulate neurite outgrowth J Cell Sci (2016) 129, 557-568. PubMed Europe PubMed DOI
Castro-Gomes,T., Corrotte,M., Tam,C. and Andrews,N.W. Plasma membrane repair is regulated extracellularly by proteases released from lysosomes PLoS ONE (2016) 11, e0152583-e0152583. PubMed Europe PubMed DOI PMC EPMC
Cocchiaro,P., Fox,C., Tregidgo,N.W., Howarth,R., Wood,K.M., Situmorang,G.R., Pavone,L.M., Sheerin,N.S. and Moles,A. Lysosomal protease cathepsin D; a new driver of apoptosis during acute kidney injury Sci Rep (2016) 6, 27112-27112. PubMed Europe PubMed DOI PMC EPMC I
Di Domenico,F., Tramutola,A. and Perluigi,M. Cathepsin D as a therapeutic target in Alzheimer's disease Expert Opin Ther Targets (2016) 20, 1393-1395. PubMed Europe PubMed DOI T
Fritsch,J., Fickers,R., Klawitter,J., Sarchen,V., Zingler,P., Adam,D., Janssen,O., Krause,E. and Schutze,S. TNF induced cleavage of HSP90 by cathepsin D potentiates apoptotic cell death Oncotarget (2016) 7, 75774-75789. PubMed Europe PubMed DOI
Jancekova,B., Ondrouskova,E., Knopfova,L., Smarda,J. and Benes,P. Enzymatically active cathepsin D sensitizes breast carcinoma cells to TRAIL Tumour Biol (2016) 37, 10685-10696. PubMed Europe PubMed DOI
Ketscher,A., Ketterer,S., Dollwet-Mack,S., Reif,U. and Reinheckel,T. Neuroectoderm-specific deletion of cathepsin D in mice models human inherited neuronal ceroid lipofuscinosis type 10 Biochimie (2016) 122, 219-226. PubMed Europe PubMed DOI K
Macias-Vidal,J., Guerrero-Hernandez,M., Estanyol,J.M., Aguado,C., Knecht,E., Coll,M.J. and Bachs,O. Identification of lysosomal Npc1-binding proteins: cathepsin D activity is regulated by NPC1 Proteomics (2016) 16, 150-158. PubMed Europe PubMed DOI
Mehanna,S., Suzuki,C., Shibata,M., Sunabori,T., Imanaka,T., Araki,K., Yamamura,K., Uchiyama,Y. and Ohmuraya,M. Cathepsin D in pancreatic acinar cells is implicated in cathepsin B and L degradation, but not in autophagic activity Biochem Biophys Res Commun (2016) 469, 405-411. PubMed Europe PubMed DOI
Morrow,G., Kim,H.J., Pellerito,O., Bourrelle-Langlois,M., Le Pecheur,M., Groebe,K. and Tanguay,R.M. Changes in Drosophila mitochondrial proteins following chaperone-mediated lifespan extension confirm a role of Hsp22 in mitochondrial UPR and reveal a mitochondrial localization for cathepsin D Mech Ageing Dev (2016) 155, 36-47. PubMed Europe PubMed DOI
Vidoni,C., Follo,C., Savino,M., Melone,M.A. and Isidoro,C. The role of cathepsin D in the pathogenesis of human neurodegenerative disorders Med Res Rev (2016) 36, 845-870. PubMed Europe PubMed DOI
Zhou,Y., Wynia-Smith,S.L., Couvertier,S.M., Kalous,K.S., Marletta,M.A., Smith,B.C. and Weerapana,E. Chemoproteomic strategy to quantitatively monitor transnitrosation uncovers functionally relevant S-nitrosation sites on cathepsin D and HADH2 Cell Chem Biol (2016) 23, 727-737. PubMed Europe PubMed DOI
Zuhl,A.M., Nolan,C.E., Brodney,M.A., Niessen,S., Atchison,K., Houle,C., Karanian,D.A., Ambroise,C., Brulet,J.W., Beck,E.M., Doran,S.D., O'Neill,B.T., Am Ende,C.W., Chang,C., Geoghegan,K.F., West,G.M., Judkins,J.C., Hou,X., Riddell,D.R. and Johnson,D.S. Chemoproteomic profiling reveals that cathepsin D off-target activity drives ocular toxicity of beta-secretase inhibitors Nat Commun (2016) 7, 13042-13042. PubMed Europe PubMed DOI I

2015

Bae,E.J., Yang,N.Y., Lee,C., Kim,S., Lee,H.J. and Lee,S.J. Haploinsufficiency of cathepsin D leads to lysosomal dysfunction and promotes cell-to-cell transmission of alpha-synuclein aggregates Cell Death Dis (2015) 6, e1901-e1901. PubMed Europe PubMed DOI K
Bennett,N.R., Zwick,D.B., Courtney,A.H. and Kiessling,L.L. Multivalent antigens for promoting B and T cell activation ACS Chem Biol (2015) 10, 1817-1824. PubMed Europe PubMed DOI
Carcel-Trullols,J., Kovacs,A.D. and Pearce,D.A. Cell biology of the NCL proteins: what they do and don't do Biochim Biophys Acta (2015) 1852, 2242-2255. PubMed Europe PubMed DOI
Fernandez-Montoya,J. and Perez,M. Cathepsin D in a murine model of frontotemporal dementia with Parkinsonism-linked to chromosome 17 J Alzheimers Dis (2015) 45, 1-14. PubMed Europe PubMed DOI
Hu,H.Y., Lim,N.H., Ding-Pfennigdorff,D., Saas,J., Wendt,K.U., Ritzeler,O., Nagase,H., Plettenburg,O., Schultz,C. and Nazare,M. DOTAM derivatives as active cartilage-targeting drug carriers for the treatment of osteoarthritis Bioconjug Chem (2015) 26, 383-388. PubMed Europe PubMed DOI I
Okada,R., Wu,Z., Zhu,A., Ni,J., Zhang,J., Yoshimine,Y., Peters,C., Saftig,P. and Nakanishi,H. Cathepsin D deficiency induces oxidative damage in brain pericytes and impairs the blood-brain barrier Mol Cell Neurosci (2015) 64C, 51-60. PubMed Europe PubMed DOI K
Oliveira,C.S., Pereira,H., Alves,S., Castro,L., Baltazar,F., Chaves,S.R., Preto,A. and Corte-Real,M. Cathepsin D protects colorectal cancer cells from acetate-induced apoptosis through autophagy-independent degradation of damaged mitochondria Cell Death Dis (2015) 6, e1788-e1788. PubMed Europe PubMed DOI T I
Paz-Y-Mino,C.A., Garcia-Cardenas,J.M., Lopez-Cortes,A., Salazar,C., Serrano,M. and Leone,P.E. Positive association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease Am J Med Sci (2015) 350, 296-301. PubMed Europe PubMed DOI M
Snir,J.A., Suchy,M., Lawrence,K.S., Hudson,R.H., Pasternak,S.H. and Bartha,R. Prolonged in vivo retention of a cathepsin D targeted optical contrast agent in a mouse model of Alzheimer's disease J Alzheimers Dis (2015) 48, 73-87. PubMed Europe PubMed DOI L
Xiao,R., Zhang,Z., Wang,H., Han,Y., Gou,M., Li,B., Duan,D., Wang,J., Liu,X. and Li,Q. Identification and characterization of a cathepsin D homologue from lampreys (Lampetra japonica) Dev Comp Immunol (2015) 49, 149-156. PubMed Europe PubMed DOI
Zeleznik,T.Z., Kadin,A., Turk,V. and Dolenc,I. Aspartic cathepsin D degrades the cytosolic cysteine cathepsin inhibitor stefin B in the cells Biochem Biophys Res Commun (2015) 465, 213-217. PubMed Europe PubMed DOI
Zheng,Y., Chen,H., Lai,W., Xu,Q., Liu,C., Wu,L. and Maibach,H.I. Cathepsin D repairing role in photodamaged skin barrier Skin Pharmacol Physiol (2015) 28, 97-102. PubMed Europe PubMed DOI U
Zhou,R., Lu,Y., Han,Y., Li,X., Lou,H., Zhu,L., Zhen,X. and Duan,S. Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression Prog Neuropsychopharmacol Biol Psychiatry (2015) 63, 110-118. PubMed Europe PubMed DOI K

2014

Authier,F. and Desbuquois,B. Assessment of insulin proteolysis in rat liver endosomes: its relationship to intracellular insulin signaling Methods Enzymol (2014) 535, 3-23. PubMed Europe PubMed DOI
Azizan,S., Wan,K.-L. and Mohd-Adnan,A. Molecular characterisation and expression analysis of cathepsin D from the Asian seabass Lates calcarifer Sains Malays (2014) 43, 1139-1148.
Choi,K.M., Shim,S.H., An,C.M., Nam,B.H., Kim,Y.O., Kim,J.W. and Park,C.I. Cloning, characterisation, and expression analysis of the cathepsin D gene from rock bream (Oplegnathus fasciatus) Fish Shellfish Immunol (2014) 40, 253-258. PubMed Europe PubMed DOI
Dougall,A.M., Skwarczynski,M., Khoshnejad,M., Chandrudu,S., Daly,N.L., Toth,I. and Loukas,A. Lipid core peptide targeting the cathepsin D hemoglobinase of Schistosoma mansoni as a component of a schistosomiasis vaccine Hum Vaccin Immunother (2014) 10, 399-409. PubMed Europe PubMed DOI
Gradler,U., Czodrowski,P., Tsaklakidis,C., Klein,M., Werkmann,D., Lindemann,S., Maskos,K. and Leuthner,B. Structure-based optimization of non-peptidic cathepsin D inhibitors Bioorg Med Chem Lett (2014) 24, 4141-4150. PubMed Europe PubMed DOI I
Hersheson,J., Burke,D., Clayton,R., Anderson,G., Jacques,T.S., Mills,P., Wood,N.W., Gissen,P., Clayton,P., Fearnley,J., Mole,S.E. and Houlden,H. Cathepsin D deficiency causes juvenile-onset ataxia and distinctive muscle pathology Neurology (2014) 83, 1873-1875. PubMed Europe PubMed DOI M
Ishida,M., Maehara,M., Watanabe,T., Yanagisawa,Y., Takata,Y., Nakajima,R., Suzuki,M. and Harigaya,T. Vasoinhibins, N-terminal mouse prolactin fragments, participate in mammary gland involution J Mol Endocrinol (2014) 52, 279-287. PubMed Europe PubMed DOI
Jiao,Y., Li,C.H., Lu,X.J. and Chen,J. Characterization and expression of sweetfish (Pleco glossus altivelis) cathepsin D Dongwuxue Yanjiu (2014) 35, 294-299. PubMed Europe PubMed DOI
Khalkhali-Ellis,Z. and Hendrix,M.J.C. Two faces of cathepsin D: physiological guardian angel and pathological demon Biol Med (2014) 6, 206- PubMed Europe PubMed DOI V
Khalkhali-Ellis,Z., Goossens,W., Margaryan,N.V. and Hendrix,M.J. Cleavage of histone 3 by cathepsin D in the involuting mammary gland PLoS ONE (2014) 9, e103230-e103230. PubMed Europe PubMed DOI PMC EPMC
Mo,C., Peng,Q., Sui,J., Wang,J., Deng,Y., Xie,L., Li,T., He,Y., Qin,X. and Li,S. Lack of association between cathepsin D C224T polymorphism and Alzheimer's disease risk: an update meta-analysis BMC Neurol (2014) 14, 13-13. PubMed Europe PubMed DOI M
Sayad,A., Noruzinia,M., Zamani,M., Harirchian,M.H. and Kazemnejad,A. Association study of cathepsin D gene polymorphism in Iranian patients with sporadic late-onset Alzheimer's disease Dementia Geriatr Cogn Disord (2014) 37, 257-264. PubMed Europe PubMed DOI M
Tian,L., Zhang,K., Tian,Z.-Y., Wang,T., Shang,D.-S., Li,B., Liu,D.-X., Fang,W.-G., Wang,Z.-Y. and Chen,Y.-H. Decreased expression of cathepsin D in monocytes is related to the defective degradation of amyloid-beta in Alzheimer's disease J Alzheimer's Dis (2014) 42, 511-520. PubMed Europe PubMed DOI
Venugopal,A. and Siva Kumar,N. Biochemical characterization of cathepsin D from the mussel Lamellidens corrianus Comp Biochem Physiol B Biochem Mol Biol (2014) 169, 25-30. PubMed Europe PubMed DOI
Yu,J., Wu,F.Y., Zou,F.M., Cai,X.Y., Yu,H.Y., Liu,Y.W., Fang,Y., Ren,Z.X., Jia,J.Q., Zhang,G.Z., Guo,X.J., Jin,B.R. and Gui,Z.Z. Identification and functional analysis of the cathepsin D gene promoter of Bombyx mori Mol Biol Rep (2014) 41, 1623-1630. PubMed Europe PubMed DOI

2013

Achour,O., Bridiau,N., Kacem,M., Delatouche,R., Bordenave-Juchereau,S., Sannier,F., Thiery,V., Piot,J.M., Maugard,T. and Arnaudin,I. Cathepsin D activity and selectivity in the acidic conditions of a tumor microenvironment: Utilization in the development of a novel cathepsin D substrate for simultaneous cancer diagnosis and therapy Biochimie (2013) 95, 2010-2017. PubMed Europe PubMed DOI
Amritraj,A., Wang,Y., Revett,T.J., Vergote,D., Westaway,D. and Kar,S. Role of cathepsin D in U18666A-induced neuronal cell death: potential implication in Niemann-Pick type C disease pathogenesis J Biol Chem (2013) 288, 3136-3152. PubMed Europe PubMed DOI
Ehling,R., Noskova,L., Stranecky,V., Hartmannova,H., Pristoupilova,A., Hodanova,K., Benke,T., Kovacs,G.G., Strobel,T., Niedermuller,U., Wagner,M., Nachbauer,W., Janecke,A., Budka,H., Boesch,S. and Kmoch,S. Cerebellar dysfunction in a family harboring the PSEN1 mutation co-segregating with a cathepsin D variant p.A58V J Neurol Sci (2013) 326, 75-82. PubMed Europe PubMed DOI M
Follo,C., Ozzano,M., Montalenti,C., Ekkapongpisit,M. and Isidoro,C. Similarities and differences in the biogenesis, processing and lysosomal targeting between zebrafish and human pro-cathepsin D: functional implications Int J Biochem Cell Biol (2013) 45, 273-282. PubMed Europe PubMed DOI
Follo,C., Ozzano,M., Montalenti,C., Santoro,M.M. and Isidoro,C. Knockdown of cathepsin D in zebrafish fertilized eggs determines congenital myopathy Biosci Rep (2013) 33, e00034-e00034. PubMed Europe PubMed DOI K
Frost,L.S., Lopes,V.S., Stefano,F.P., Bragin,A., Williams,D.S., Mitchell,C.H. and Boesze-Battaglia,K. Loss of melanoregulin (MREG) enhances cathepsin-D secretion by the retinal pigment epithelium Vis Neurosci (2013) 30, 55-64. PubMed Europe PubMed DOI
Kim,S.J., Kim,K.H., Ahn,E.R., Yoo,B.C. and Kim,S.Y. Depletion of cathepsin D by transglutaminase 2 through protein cross-linking promotes cell survival Amino Acids (2013) 44, 73-80. PubMed Europe PubMed DOI
Koch,S., Scifo,E., Rokka,A., Trippner,P., Lindfors,M., Korhonen,R., Corthals,G.L., Virtanen,I., Lalowski,M. and Tyynela,J. Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain Neurobiol Dis (2013) 50, 107-119. PubMed Europe PubMed DOI K
Mahmood,W., Viberg,L.T., Fischer,K., Walton,S.F. and Holt,D.C. An aspartic protease of the scabies mite Sarcoptes scabiei is involved in the digestion of host skin and blood macromolecules PLoS Negl Trop Dis (2013) 7, e2525-e2525. PubMed Europe PubMed DOI PMC EPMC
Maynadier,M., Vezenkov,L.L., Amblard,M., Martin,V., Gandreuil,C., Vaillant,O., Gary-Bobo,M., Basile,I., Hernandez,J.F., Garcia,M. and Martinez,J. Dipeptide mimic oligomer transporter mediates intracellular delivery of cathepsin D inhibitors: a potential target for cancer therapy J Control Release (2013) 171, 251-257. PubMed Europe PubMed DOI I
Maynadier,M., Farnoud,R., Lamy,P.J., Laurent-Matha,V., Garcia,M. and Rochefort,H. Cathepsin D stimulates the activities of secreted plasminogen activators in the breast cancer acidic environment Int J Oncol (2013) 43, 1683-1690. PubMed Europe PubMed DOI
Pulliero,A., Marengo,B., Longobardi,M., Fazzi,E., Orcesi,S., Olivieri,I., Cereda,C., Domenicotti,C., Balottin,U. and Izzotti,A. Inhibition of the de-myelinating properties of Aicardi-Goutieres Syndrome lymphocytes by cathepsin D silencing Biochem Biophys Res Commun (2013) 430, 957-962. PubMed Europe PubMed DOI K
Rojo,L., Garcia-Carreno,F. and de Los Angeles Navarrete Del Toro Cold-adapted digestive aspartic protease of the clawed lobsters Homarus americanus and Homarus gammarus: biochemical characterization Mar Biotechnol (NY) (2013) 15, 87-96. PubMed Europe PubMed DOI
Sheng,Q., Cao,D., Zhou,Y., Lei,Q., Han,H., Li,F., Lu,Y. and Wang,C. Detection of SNPs in the cathepsin D gene and their association with yolk traits in chickens PLoS ONE (2013) 8, e56656-e56656. PubMed Europe PubMed DOI PMC EPMC M
Sun,H., Lou,X., Shan,Q., Zhang,J., Zhu,X., Zhang,J., Wang,Y., Xie,Y., Xu,N. and Liu,S. Proteolytic characteristics of cathepsin D related to the recognition and cleavage of its target proteins PLoS ONE (2013) 8, e65733-e65733. PubMed Europe PubMed DOI PMC EPMC P
Ta,R., Suchy,M., Tam,J.H., Li,A.X., Martinez-Santiesteban,F.S., Scholl,T.J., Hudson,R.H., Bartha,R. and Pasternak,S.H. A dual magnetic resonance imaging/fluorescent contrast agent for cathepsin-D detection Contrast Media Mol Imaging (2013) 8, 127-139. PubMed Europe PubMed DOI L

2012

Appelqvist,H., Johansson,A.C., Linderoth,E., Johansson,U., Antonsson,B., Steinfeld,R., Kagedal,K. and Ollinger,K. Lysosome-mediated apoptosis is associated with cathepsin D-specific processing of bid at Phe24, Trp48, and Phe183 Ann Clin Lab Sci (2012) 42, 231-242. PubMed Europe PubMed P
Conus,S., Pop,C., Snipas,S.J., Salvesen,G.S. and Simon,H.U. Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis J Biol Chem (2012) 287, 21142-21151. PubMed Europe PubMed DOI
Dali,B., Keita,M., Megnassan,E., Frecer,V. and Miertus,S. Insight into selectivity of peptidomimetic inhibitors with modified statine core for plasmepsin II of Plasmodium falciparum over human cathepsin D Chem Biol Drug Des (2012) 79, 411-430. PubMed Europe PubMed DOI I
Dong,Z.D., Zhang,J., Ji,X.S., Zhou,F.N., Fu,Y., Chen,W., Zeng,Y.Q., Li,T.M. and Wang,H. Molecular cloning, characterization and expression of cathepsin D from grass carp (Ctenopharyngodon idella) Fish Shellfish Immunol (2012) 33, 1207-1214. PubMed Europe PubMed DOI
Fan,C., Lin,X. and Wang,E. Clinicopathological significance of cathepsin D expression in non-small cell lung cancer is conditional on apoptosis-associated protein phenotype: an immunohistochemistry study Tumour Biol (2012) 33, 1045-1052. PubMed Europe PubMed DOI
Fusek,M., Mares,M. and Vetvicka,V. Cathepsin D [ISSN:978-0-12-407744-7] (2012) 3, 54-63. DOI
Hah,Y.S., Noh,H.S., Ha,J.H., Ahn,J.S., Hahm,J.R., Cho,H.Y. and Kim,D.R. Cathepsin D inhibits oxidative stress-induced cell death via activation of autophagy in cancer cells Cancer Lett (2012) 323, 208-214. PubMed Europe PubMed DOI
Huber-Lang,M., Denk,S., Fulda,S., Erler,E., Kalbitz,M., Weckbach,S., Schneider,E.M., Weiss,M., Kanse,S.M. and Perl,M. Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro Mol Immunol (2012) 50, 60-65. PubMed Europe PubMed DOI
Karwowska,A., Lapinski,R., Gacko,M., Grzegorczyk,E., Zurawska,J. and Karczewski,J.K. Effect of heavy metal cations on the activity of cathepsin D (in vitro study) Folia Histochem Cytobiol (2012) 50, 432-435. PubMed Europe PubMed DOI I
Laurent-Matha,V., Huesgen,P.F., Masson,O., Derocq,D., Prebois,C., Gary-Bobo,M., Lecaille,F., Rebiere,B., Meurice,G., Orear,C., Hollingsworth,R.E., Abrahamson,M., Lalmanach,G., Overall,C.M. and Liaudet-Coopman,E. Proteolysis of cystatin C by cathepsin D in the breast cancer microenvironment FASEB J (2012) 26, 5172-5181. PubMed Europe PubMed DOI
Liu,X., Shi,G., Cui,D., Wang,R. and Xu,T. Molecular cloning and comprehensive characterization of cathepsin D in the Miiuy croaker Miichthys miiuy Fish Shellfish Immunol (2012) 32, 464-468. PubMed Europe PubMed DOI
Mahapatra,C. and Mahapatra,P.K. Immunohistochemical localization of cathepsin D and a possible role of melanocytes during tail resorption in tadpoles of a tropical toad J Morphol (2012) 273, 791-800. PubMed Europe PubMed DOI
McConnell,R.M., Inapudi,K., Kadasala,N., Yarlagadda,K., Velusamy,P., McConnell,M.S., Green,A., Trana,C., Sayyar,K. and McConnell,J.S. New cathepsin D inhibitor library utilizing hydroxyethyl isosteres with cyclic tertiary amines Med Chem (2012) 8, 1146-1154. PubMed Europe PubMed I
Melzer,I.M., Fernandez,S.B., Bosser,S., Lohrig,K., Lewandrowski,U., Wolters,D., Kehrloesser,S., Brezniceanu,M.L., Theos,A.C., Irusta,P.M., Impens,F., Gevaert,K. and Zornig,M. The Apaf-1-binding protein Aven is cleaved by cathepsin D to unleash its anti-apoptotic potential Cell Death Differ (2012) 19, 1435-1445. PubMed Europe PubMed DOI
Sakkiah,S., Thangapandian,S. and Lee,K.W. Ligand-based virtual screening and molecular docking studies to identify the critical chemical features of potent cathepsin D inhibitors Chem Biol Drug Des (2012) 80, 64-79. PubMed Europe PubMed DOI I
Shacka,J.J. Mouse models of neuronal ceroid lipofuscinoses: useful pre-clinical tools to delineate disease pathophysiology and validate therapeutics Brain Res Bull (2012) 88, 43-57. PubMed Europe PubMed DOI M

2011

Bewley,M.A., Marriott,H.M., Tulone,C., Francis,S.E., Mitchell,T.J., Read,R.C., Chain,B., Kroemer,G., Whyte,M.K. and Dockrell,D.H. A cardinal role for cathepsin D in co-ordinating the host-mediated apoptosis of macrophages and killing of pneumococci PLoS Pathog (2011) 7, e1001262-e1001262. PubMed Europe PubMed DOI PMC EPMC K
Buchold,C., Hemberger,Y., Heindl,C., Welker,A., Degel,B., Pfeuffer,T., Staib,P., Schneider,S., Rosenthal,P.J., Gut,J., Morschhauser,J., Bringmann,G. and Schirmeister,T. New cis-configured aziridine-2-carboxylates as aspartic acid protease inhibitors ChemMedChem (2011) 6, 141-152. PubMed Europe PubMed DOI I
Chen,L., Zhang,M. and Sun,L. Identification and expressional analysis of two cathepsins from half-smooth tongue sole (Cynoglossus semilaevis) Fish Shellfish Immunol (2011) 31, 1270-1277. PubMed Europe PubMed DOI
Devosse,T., Dutoit,R., Migeotte,I., De Nadai,P., Imbault,V., Communi,D., Salmon,I. and Parmentier,M. Processing of HEBP1 by cathepsin D gives rise to F2L, the agonist of formyl peptide receptor 3 J Immunol (2011) 187, 1475-1485. PubMed Europe PubMed DOI P
Feng,T., Zhang,H., Liu,H., Zhou,Z., Niu,D., Wong,L., Kucuktas,H., Liu,X., Peatman,E. and Liu,Z. Molecular characterization and expression analysis of the channel catfish cathepsin D genes Fish Shellfish Immunol (2011) 31, 164-169. PubMed Europe PubMed DOI
Follo,C., Ozzano,M., Mugoni,V., Castino,R., Santoro,M. and Isidoro,C. Knock-down of cathepsin D affects the retinal pigment epithelium, impairs swim-bladder ontogenesis and causes premature death in zebrafish PLoS ONE (2011) 6, e21908-e21908. PubMed Europe PubMed DOI PMC EPMC K
Jeong,B.H., Lee,K.H., Lee,Y.J., Yun,J., Park,Y.J., Kim,Y.H., Cho,Y.S., Choi,E.K., Carp,R.I. and Kim,Y.S. Genetic polymorphism in exon 2 of cathepsin D is not associated with vascular dementia Acta Neurol Scand (2011) 123, 419-423. PubMed Europe PubMed DOI M
Koch,S., Molchanova,S.M., Wright,A.K., Edwards,A., Cooper,J.D., Taira,T., Gillingwater,T.H. and Tyynela,J. Morphologic and functional correlates of synaptic pathology in the cathepsin D knockout mouse model of congenital neuronal ceroid lipofuscinosis J Neuropathol Exp Neurol (2011) 70, 1089-1096. PubMed Europe PubMed DOI K
Liang,Q., Ouyang,X., Schneider,L. and Zhang,J. Reduction of mutant huntingtin accumulation and toxicity by lysosomal cathepsins D and B in neurons Mol Neurodegener (2011) 6, 37-37. PubMed Europe PubMed DOI U
Mahapatra,C. and Mahapatra,P.K. Involvement of cathepsin D during tail regression in tadpoles of the common Indian tree frog, Polypedates maculatus (Anura: Rhacophoridae) Acta Histochem (2011) 113, 756-762. PubMed Europe PubMed DOI
Malik,M., Fenko,M.D., Sheikh,A.M., Wen,G. and Li,X. A Novel Approach for Characterization of Cathepsin D Protease and Its Effect on Tau and beta-Amyloid Proteins Neurochem Res (2011) 36, 754-760. PubMed Europe PubMed DOI
Masson,O., Prebois,C., Derocq,D., Meulle,A., Dray,C., Daviaud,D., Quilliot,D., Valet,P., Muller,C. and Liaudet-Coopman,E. Cathepsin-D, a key protease in breast cancer, is up-regulated in obese mouse and human adipose tissue, and controls adipogenesis PLoS ONE (2011) 6, e16452-e16452. PubMed Europe PubMed DOI PMC EPMC
Nakken,B., Varga,T., Szatmari,I., Szeles,L., Gyongyosi,A., Illarionov,P.A., Dezso,B., Gogolak,P., Rajnavolgyi,E. and Nagy,L. Peroxisome proliferator-activated receptor gamma-regulated cathepsin D is required for lipid antigen presentation by dendritic cells J Immunol (2011) 187, 240-247. PubMed Europe PubMed DOI
Pike,L.S., Tannous,B.A., Deliolanis,N.C., Hsich,G., Morse,D., Tung,C.H., Sena-Esteves,M. and Breakefield,X.O. Imaging gene delivery in a mouse model of congenital neuronal ceroid lipofuscinosis Gene Ther (2011) 18, 1173-1178. PubMed Europe PubMed DOI M U
Schuur,M., Ikram,M.A., van Swieten,J.C., Isaacs,A., Vergeer-Drop,J.M., Hofman,A., Oostra,B.A., Breteler,M.M. and van Duijn,C.M. Cathepsin D gene and the risk of Alzheimer's disease: a population-based study and meta-analysis Neurobiol Aging (2011) 32, 1607-1614. PubMed Europe PubMed DOI
Tulone,C., Sponaas,A.M., Raiber,E.A., Tabor,A.B., Langhorne,J. and Chain,B.M. Differential requirement for cathepsin D for processing of the full length and C-terminal fragment of the malaria antigen MSP1 PLoS ONE (2011) 6, e24886-e24886. PubMed Europe PubMed DOI PMC EPMC
Zebrakovska,I., Masa,M., Srp,J., Horn,M., Vavrova,K. and Mares,M. Complex modulation of peptidolytic activity of cathepsin D by sphingolipids Biochim Biophys Acta (2011) 1811, 1097-1104. PubMed Europe PubMed DOI

2010

Ahmed,W., Rani,M., Khan,I.A., Iqbal,A., Khan,K.M., Haleem,M.A. and Azim,M.K. Characterisation of hydrazides and hydrazine derivatives as novel aspartic protease inhibitors J Enzyme Inhib Med Chem (2010) 25, 673-678. PubMed Europe PubMed DOI I
Albayrak,O., Tirniceriu,A., Riemenschneider,M., Kurz,A., Scherag,A. and Egensperger,R. The cathepsin D (224C/T) polymorphism confers an increased risk to develop Alzheimer's disease in men J Gerontol A Biol Sci Med Sci (2010) 65, 219-224. PubMed Europe PubMed DOI M
Balti,R., Hmidet,N., Jellouli,K., Nedjar-Arroume,N., Guillochon,D. and Nasri,M. Cathepsin D from the hepatopancreas of the cuttlefish (Sepia officinalis): purification and characterization J Agric Food Chem (2010) 58, 10623-10630. PubMed Europe PubMed DOI
Beaujouin,M., Prebois,C., Derocq,D., Laurent-Matha,V., Masson,O., Pattingre,S., Coopman,P., Bettache,N., Grossfield,J., Hollingsworth,R.E., Zhang,H., Yao,Z., Hyman,B.T., van der Geer,P., Smith,G.K. and Liaudet-Coopman,E. Pro-cathepsin D interacts with the extracellular domain of the beta chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth J Cell Sci (2010) 123, 3336-3346. PubMed Europe PubMed DOI
Chahory,S., Keller,N., Martin,E., Omri,B., Crisanti,P. and Torriglia,A. Light induced retinal degeneration activates a caspase-independent pathway involving cathepsin D Neurochem Int (2010) 57, 278-287. PubMed Europe PubMed DOI
Fontanesi,L., Speroni,C., Buttazzoni,L., Scotti,E., Dall'Olio,S., Nanni Costa,L., Davoli,R. and Russo,V. The insulin-like growth factor 2 (IGF2) gene intron3-g.3072G>A polymorphism is not the only Sus scrofa chromosome 2p mutation affecting meat production and carcass traits in pigs: evidence from the effects of a cathepsin D (CTSD) gene polymorphism J Anim Sci (2010) 88, 2235-2245. PubMed Europe PubMed DOI M
Kovacs,G.G., Sanchez-Juan,P., Strobel,T., Schuur,M., Poleggi,A., Nocentini,S., Giannattasio,C., Belay,G., Bishop,M., Capellari,S., Parchi,P., Gelpi,E., Gal,A., Bakos,A., Molnar,M.J., Heinemann,U., Zerr,I., Knight,R.S., Mitrova,E., van Duijn,C. and Budka,H. Cathepsin D (C224T) polymorphism in sporadic and genetic Creutzfeldt-Jakob disease Alzheimer Dis Assoc Disord (2010) 24, 104-107. PubMed Europe PubMed DOI M
Li,C., Zhang,H., Li,L. and Song,L. Identification of a cathepsin D potentially involved in H2A cleavage from scallop Chlamys farreri Mol Biol Rep (2010) 37, 1451-1460. PubMed Europe PubMed DOI
Margaryan,N.V., Kirschmann,D.A., Lipavsky,A., Bailey,C.M., Hendrix,M.J.C. and Khalkhali-Ellis,Z. New insights into cathepsin D in mammary tissue development and remodeling Cancer Biol Ther (2010) 10, 457-466. PubMed Europe PubMed DOI
Masson,O., Bach,A.S., Derocq,D., Prebois,C., Laurent-Matha,V., Pattingre,S. and Liaudet-Coopman,E. Pathophysiological functions of cathepsin D: targeting its catalytic activity versus its protein binding activity? Biochimie (2010) 92, 1635-1643. PubMed Europe PubMed DOI
Mutka,A.L., Haapanen,A., Kakela,R., Lindfors,M., Wright,A.K., Inkinen,T., Hermansson,M., Rokka,A., Corthals,G., Jauhiainen,M., Gillingwater,T.H., Ikonen,E. and Tyynela,J. Murine cathepsin D deficiency is associated with dysmyelination/myelin disruption and accumulation of cholesteryl esters in the brain J Neurochem (2010) 112, 193-203. PubMed Europe PubMed DOI K
Nicotra,G., Manfroi,F., Follo,C., Castino,R., Fusco,N., Peracchio,C., Kerim,S., Valente,G. and Isidoro,C. High expression of cathepsin D in non-Hodgkin's lymphomas negatively impacts on clinical outcome Dis Markers (2010) 28, 167-183. PubMed Europe PubMed DOI
Nicotra,G., Castino,R., Follo,C., Peracchio,C., Valente,G. and Isidoro,C. The dilemma: does tissue expression of cathepsin D reflect tumor malignancy? The question: does the assay truly mirror cathepsin D mis-function in the tumor? Cancer Biomark (2010) 7, 47-64. PubMed Europe PubMed DOI
Nussbaumerova,M., Srp,J., Masa,M., Hradilek,M., Sanda,M., Reinis,M., Horn,M. and Mares,M. Single- and double-headed chemical probes for detection of active cathepsin D in a cancer cell proteome Chembiochem (2010) 11, 1538-1541. PubMed Europe PubMed DOI
Rojo,L., Sotelo-Mundo,R., Garcia-Carreno,F. and Graf,L. Isolation, biochemical characterization, and molecular modeling of American lobster digestive cathepsin D1 Comp Biochem Physiol B Biochem Mol Biol (2010) 157, 394-400. PubMed Europe PubMed DOI
Rojo,L., Muhlia-Almazan,A., Saborowski,R. and Garcia-Carreno,F. Aspartic cathepsin D endopeptidase contributes to extracellular digestion in clawed lobsters Homarus americanus and Homarus gammarus Mar Biotechnol (NY) (2010) 12, 696-707. PubMed Europe PubMed DOI
Shevtsova,Z., Garrido,M., Weishaupt,J., Saftig,P., Bahr,M., Luhder,F. and Kugler,S. CNS-Expressed Cathepsin D Prevents Lymphopenia in a Murine Model of Congenital Neuronal Ceroid Lipofuscinosis Am J Pathol (2010) 177, 271-279. PubMed Europe PubMed DOI K
Suchy,M., Ta,R., Li,A.X., Wojciechowski,F., Pasternak,S.H., Bartha,R. and Hudson,R.H. A paramagnetic chemical exchange-based MRI probe metabolized by cathepsin D: design, synthesis and cellular uptake studies Org Biomol Chem (2010) 8, 2560-2566. PubMed Europe PubMed DOI L

2009

Ahn,J.E. and Zhu-Salzman,K. CmCatD, a cathepsin D-like protease has a potential role in insect defense against a phytocystatin J Insect Physiol (2009) 55, 678-685. PubMed Europe PubMed DOI
Beckman,M., Freeman,C., Parish,C.R. and Small,D.H. Activation of cathepsin D by glycosaminoglycans FEBS J (2009) 276, 7343-7352. PubMed Europe PubMed DOI
Byun,H.O., Han,N.K., Lee,H.J., Kim,K.B., Ko,Y.G., Yoon,G., Lee,Y.S., Hong,S.I. and Lee,J.S. Cathepsin D and eukaryotic translation elongation factor 1 as promising markers of cellular senescence Cancer Res (2009) 69, 4638-4647. PubMed Europe PubMed DOI
Carrasco-Marin,E., Madrazo-Toca,F., de los Toyos,J.R., Cacho-Alonso,E., Tobes,R., Pareja,E., Paradela,A., Albar,J.P., Chen,W., Gomez-Lopez,M.T. and Alvarez-Dominguez,C. The innate immunity role of cathepsin-D is linked to Trp-491 and Trp-492 residues of listeriolysin O Mol Microbiol (2009) 72, 668-682. PubMed Europe PubMed DOI P
Castino,R., Peracchio,C., Salini,A., Nicotra,G., Trincheri,N.F., Demoz,M., Valente,G. and Isidoro,C. Chemotherapy drug response in ovarian cancer cells strictly depends on a cathepsin D-bax activation loop J Cell Mol Med (2009) 13, 1096-1109. PubMed Europe PubMed DOI
Cruz-Soto,M.E., Cosio,G., Jeziorski,M.C., Vargas-Barroso,V., Aguilar,M.B., Carabez,A., Berger,P., Saftig,P., Arnold,E., Thebault,S., Martinez de la Escalera,G. and Clapp,C. Cathepsin D is the primary protease for the generation of adenohypophyseal vasoinhibins: cleavage occurs within the prolactin secretory granules Endocrinology (2009) 150, 5446-5454. PubMed Europe PubMed DOI
Cullen,V., Lindfors,M., Ng,J., Paetau,A., Swinton,E., Kolodziej,P., Boston,H., Saftig,P., Woulfe,J., Feany,M.B., Myllykangas,L., Schlossmacher,M.G. and Tyynela,J. Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo Mol Brain (2009) 2, 5-5. PubMed Europe PubMed DOI PMC EPMC U
De Luca,V., Maria,G., De Mauro,G., Catara,G., Carginale,V., Ruggiero,G., Capasso,A., Parisi,E., Brier,S., Engen,J.R. and Capasso,C. Aspartic proteinases in Antarctic fish Mar Genomics (2009) 2, 1-10. PubMed Europe PubMed DOI
Fritchie,K., Siintola,E., Armao,D., Lehesjoki,A.E., Marino,T., Powell,C., Tennison,M., Booker,J.M., Koch,S., Partanen,S., Suzuki,K., Tyynela,J. and Thorne,L.B. Novel mutation and the first prenatal screening of cathepsin D deficiency (CLN10) Acta Neuropathol (2009) 117, 201-208. PubMed Europe PubMed DOI M
Jia,A. and Zhang,X.H. Molecular cloning, characterization and expression analysis of cathepsin D gene from turbot Scophthalmus maximus Fish Shellfish Immunol (2009) 26, 606-613. PubMed Europe PubMed DOI
Kuronen,M., Talvitie,M., Lehesjoki,A.E. and Myllykangas,L. Genetic modifiers of degeneration in the cathepsin D deficient Drosophila model for neuronal ceroid lipofuscinosis Neurobiol Dis (2009) 36, 488-493. PubMed Europe PubMed DOI K
Matsumoto,I., Asakura,T., Ohmori,T., Tamura,T. and Abe,K. Cathepsin D-like aspartic proteinase occurring in a maize weevil, Sitophilus zeamais, as a candidate digestive enzyme Biosci Biotechnol Biochem (2009) 73, 2338-2340. PubMed Europe PubMed DOI
Minarowska,A., Karwowska,A. and Gacko,M. Quantitative determination and localization of cathepsin D and its inhibitors Folia Histochem Cytobiol (2009) 47, 153-177. PubMed Europe PubMed DOI V
Padilha,M.H., Pimentel,A.C., Ribeiro,A.F. and Terra,W.R. Sequence and function of lysosomal and digestive cathepsin D-like proteinases of Musca domestica midgut Insect Biochem Mol Biol (2009) 39, 782-791. PubMed Europe PubMed DOI
Park,E.M., Kim,Y.O., Nam,B.H., Kong,H.J., Kim,W.J., Lee,S.J. and Kim,K.K. Cloning and expression analysis of cathepsin D in the olive flounder Paralichthys olivaceus Biosci Biotechnol Biochem (2009) 73, 1856-1859. PubMed Europe PubMed DOI
Suttiprapa,S., Mulvenna,J., Huong,N.T., Pearson,M.S., Brindley,P.J., Laha,T., Wongkham,S., Kaewkes,S., Sripa,B. and Loukas,A. Ov-APR-1, an aspartic protease from the carcinogenic liver fluke, Opisthorchis viverrini: functional expression, immunolocalization and subsite specificity Int J Biochem Cell Biol (2009) 41, 1148-1156. PubMed Europe PubMed DOI PMC EPMC
van der Hilst,J.C., Kluve-Beckerman,B., van der Meer,J.W. and Simon,A. Cathepsin D activity protects against development of type AA amyloid fibrils Eur J Clin Invest (2009) 39, 412-416. PubMed Europe PubMed DOI
Vetvicka,V., Ohri,S.S. and Vetvicka,V. Pleiotropic effects of cathepsin D Endocr Metab Immune Disord Drug Targets (2009) 9, 385-391. PubMed Europe PubMed DOI
Zaragoza,R., Torres,L., Garcia,C., Eroles,P., Corrales,F., Bosch,A., Lluch,A., Garcia-Trevijano,E.R. and Vina,J.R. Nitration of cathepsin D enhances its proteolytic activity during mammary gland remodelling after lactation Biochem J (2009) 419, 279-288. PubMed Europe PubMed DOI

2008

Azim,M.K., Ahmed,W., Khan,I.A., Rao,N.A. and Khan,K.M. Identification of acridinyl hydrazides as potent aspartic protease inhibitors Bioorg Med Chem Lett (2008) 18, 3011-3015. PubMed Europe PubMed DOI I
Beaujouin,M. and Liaudet-Coopman,E. Cathepsin D overexpressed by cancer cells can enhance apoptosis-dependent chemo-sensitivity independently of its catalytic activity Adv Exp Med Biol (2008) 617, 453-461. PubMed Europe PubMed DOI PMC EPMC
Benes,P., Vetvicka,V. and Fusek,M. Cathepsin D - many functions of one aspartic protease Crit Rev Oncol Hematol (2008) 68, 12-28. PubMed Europe PubMed DOI PMC EPMC V
Bishop,M.T., Kovacs,G.G., Sanchez-Juan,P. and Knight,R.S. Cathepsin D SNP associated with increased risk of variant Creutzfeldt-Jakob disease BMC Med Genet (2008) 9, 31-31. PubMed Europe PubMed DOI PMC EPMC M
Bretschneider,N., Kangaspeska,S., Seifert,M., Reid,G., Gannon,F. and Denger,S. E2-mediated cathepsin D (CTSD) activation involves looping of distal enhancer elements Mol Oncol (2008) 2, 182-190. PubMed Europe PubMed DOI
Conus,S., Perozzo,R., Reinheckel,T., Peters,C., Scapozza,L., Yousefi,S. and Simon,H.U. Caspase-8 is activated by cathepsin D initiating neutrophil apoptosis during the resolution of inflammation J Exp Med (2008) 205, 685-698. PubMed Europe PubMed DOI PMC EPMC
Jabs,S., Quitsch,A., Kakela,R., Koch,B., Tyynela,J., Brade,H., Glatzel,M., Walkley,S., Saftig,P., Vanier,M.T. and Braulke,T. Accumulation of bis(monoacylglycero)phosphate and gangliosides in mouse models of neuronal ceroid lipofuscinosis J Neurochem (2008) 106, 1415-1425. PubMed Europe PubMed DOI K
Mei,Y., Chen,Y., Li,J., Gao,P., Wang,C., Zhang,H., Ling,F., Li,Y., Xie,S., Li,S. and Zhang,G. Sequence identification, tissue distribution and polymorphism of the porcine cathepsin D (CTSD) gene Anim Biotechnol (2008) 19, 144-158. PubMed Europe PubMed DOI
Minarowska,A., Gacko,M., Karwowska,A. and Minarowski,L. Human cathepsin D Folia Histochem Cytobiol (2008) 46, 23-38. PubMed Europe PubMed DOI V
Morales,M.E., Rinaldi,G., Gobert,G.N., Kines,K.J., Tort,J.F. and Brindley,P.J. RNA interference of Schistosoma mansoni cathepsin D, the apical enzyme of the hemoglobin proteolysis cascade Mol Biochem Parasitol (2008) 157, 160-168. PubMed Europe PubMed DOI T
Ohri,S.S., Vashishta,A., Proctor,M., Fusek,M. and Vetvicka,V. The propeptide of cathepsin D increases proliferation, invasion and metastasis of breast cancer cells Int J Oncol (2008) 32, 491-498. PubMed Europe PubMed
Padron-Barthe,L., Courta,J., Lepretre,C., Nagbou,A. and Torriglia,A. Leukocyte elastase inhibitor, the precursor of L-DNase II, inhibits apoptosis by interfering with caspase-8 activation Biochim Biophys Acta (2008) 1783, 1755-1766. PubMed Europe PubMed DOI
Partanen,S., Haapanen,A., Kielar,C., Pontikis,C., Alexander,N., Inkinen,T., Saftig,P., Gillingwater,T.H., Cooper,J.D. and Tyynela,J. Synaptic changes in the thalamocortical system of cathepsin D-deficient mice: a model of human congenital neuronal ceroid-lipofuscinosis J Neuropathol Exp Neurol (2008) 67, 16-29. PubMed Europe PubMed DOI K
Prince,L.R., Bianchi,S.M., Vaughan,K.M., Bewley,M.A., Marriott,H.M., Walmsley,S.R., Taylor,G.W., Buttle,D.J., Sabroe,I., Dockrell,D.H. and Whyte,M.K. Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin J Immunol (2008) 180, 3502-3511. PubMed Europe PubMed PMC EPMC
Qiao,L., Hamamichi,S., Caldwell,K.A., Caldwell,G.A., Yacoubian,T.A., Wilson,S., Xie,Z.L., Speake,L.D., Parks,R., Crabtree,D., Liang,Q., Crimmins,S., Schneider,L., Uchiyama,Y., Iwatsubo,T., Zhou,Y., Peng,L., Lu,Y., Standaert,D.G., Walls,K.C., Shacka,J.J., Roth,K.A. and Zhang,J. Lysosomal enzyme cathepsin D protects against alpha-synuclein aggregation and toxicity Mol Brain (2008) 1, 17-17. PubMed Europe PubMed DOI PMC EPMC
Rosochacki,S.J., Juszczuk-Kubiak,E., Barton,L., Sakowski,T., PoLoszynowicz,J., Baranowski,A. and Matejczyk,M. Preliminary observations upon relation between the G77A polymorphism in CATD gene and lysosomal proteinases activity and sensory traits of meat from bulls of three breeds Anim Sci Pap Rep (2008) 26, 25-35. M
Sagulenko,V., Muth,D., Sagulenko,E., Paffhausen,T., Schwab,M. and Westermann,F. Cathepsin D protects human neuroblastoma cells from doxorubicin-induced cell death Carcinogenesis (2008) 29, 1869-1877. PubMed Europe PubMed DOI
Schechter,I. and Ziv,E. Kinetic properties of cathepsin D and BACE 1 indicate the need to search for additional beta-secretase candidate(s) Biol Chem (2008) 389, 313-320. PubMed Europe PubMed DOI
Sevlever,D., Jiang,P. and Yen,S.H. Cathepsin D is the main lysosomal enzyme involved in the degradation of alpha-synuclein and generation of its carboxy-terminally truncated species Biochemistry (2008) 47, 9678-9687. PubMed Europe PubMed DOI PMC EPMC
Sojka,D., Franta,Z., Horn,M., Hajdusek,O., Caffrey,C.R., Mares,M. and Kopacek,P. Profiling of proteolytic enzymes in the gut of the tick Ixodes ricinus reveals an evolutionarily conserved network of aspartic and cysteine peptidases Parasit Vectors (2008) 1, 7-7. PubMed Europe PubMed DOI PMC EPMC
Tufet,M. Apoptosis: killing neutrophils the cathepsin way Nat Rev Immunol (2008) 8, 244- DOI
Urbanelli,L., Emiliani,C., Massini,C., Persichetti,E., Orlacchio,A., Pelicci,G., Sorbi,S., Hasilik,A., Bernardi,G. and Orlacchio,A. Cathepsin D expression is decreased in Alzheimer's disease fibroblasts Neurobiol Aging (2008) 29, 12-22. PubMed Europe PubMed DOI
Zaidi,N., Maurer,A., Nieke,S. and Kalbacher,H. Cathepsin D: a cellular roadmap Biochem Biophys Res Commun (2008) 376, 5-9. PubMed Europe PubMed DOI V

2007

Castino,R., Bellio,N., Nicotra,G., Follo,C., Trincheri,N.F. and Isidoro,C. Cathepsin D-Bax death pathway in oxidative stressed neuroblastoma cells Free Radic Biol Med (2007) 42, 1305-1316. PubMed Europe PubMed DOI
Follo,C., Castino,R., Nicotra,G., Trincheri,N.F. and Isidoro,C. Folding, activity and targeting of mutated human cathepsin D that cannot be processed into the double-chain form Int J Biochem Cell Biol (2007) 39, 638-649. PubMed Europe PubMed DOI
Haapanen,A., Ramadan,U.A., Autti,T., Joensuu,R. and Tyynela,J. In vivo MRI reveals the dynamics of pathological changes in the brains of cathepsin D-deficient mice and correlates changes in manganese-enhanced MRI with microglial activation Magn Reson Imaging (2007) 25, 1024-1031. PubMed Europe PubMed DOI K
[YEAR:9-2-2007]Hilfiker-Kleiner,D., Kaminski,K., Podewski,E., Bonda,T., Schaefer,A., Sliwa,K., Forster,O., Quint,A., Landmesser,U., Doerries,C., Luchtefeld,M., Poli,V., Schneider,M.D., Balligand,J.L., Desjardins,F., Ansari,A., Struman,I., Nguyen,N.Q., Zschemisch,N.H., Klein,G., Heusch,G., Schulz,R., Hilfiker,A. and Drexler,H. A cathepsin D-cleaved 16 KDa form of prolactin mediates postpartum cardiomyopathy Cell (9-2-2007) 128, 589-600. PubMed Europe PubMed DOI
Kim,S., Ock,J., Kim,A.K., Lee,H.W., Cho,J.Y., Kim,D.R., Park,J.Y. and Suk,K. Neurotoxicity of microglial cathepsin D revealed by secretome analysis J Neurochem (2007) 103, 2640-2650. PubMed Europe PubMed DOI T
Minarowska,A., Minarowski,L., Karwowska,A. and Gacko,M. Regulatory role of cathepsin D in apoptosis Folia Histochem Cytobiol (2007) 45, 159-163. PubMed Europe PubMed
Schestkowa,O., Geisel,D., Jacob,R. and Hasilik,A. The catalytically inactive precursor of cathepsin D induces apoptosis in human fibroblasts and HeLa cells J Cell Biochem (2007) 101, 1558-1566. PubMed Europe PubMed DOI
Shacka,J.J., Klocke,B.J., Young,C., Shibata,M., Olney,J.W., Uchiyama,Y., Saftig,P. and Roth,K.A. Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis J Neurosci (2007) 27, 2081-2090. PubMed Europe PubMed DOI K M
Shacka,J.J. and Roth,K.A. Cathepsin D deficiency and NCL/Batten disease: there's more to death than apoptosis Autophagy (2007) 3, 474-476. PubMed Europe PubMed
Trincheri,N.F., Nicotra,G., Follo,C., Castino,R. and Isidoro,C. Resveratrol induces cell death in colorectal cancer cells by a novel pathway involving lysosomal cathepsin D Carcinogenesis (2007) 28, 922-931. PubMed Europe PubMed DOI I
Tulone,C., Uchiyama,Y., Novelli,M., Grosvenor,N., Saftig,P. and Chain,B.M. Haematopoietic development and immunological function in the absence of cathepsin D BMC Immunol (2007) 8, 22-22. PubMed Europe PubMed DOI PMC EPMC K
Vashishta,A., Ohri,S.S., Proctor,M., Fusek,M. and Vetvicka,V. Ribozyme-targeting procathepsin D and its effect on invasion and growth of breast cancer cells: an implication in breast cancer therapy Int J Oncol (2007) 30, 1223-1230. PubMed Europe PubMed T
Vashishta,A., Saraswat Ohri,S., Vetvickova,J., Fusek,M., Ulrichova,J. and Vetvicka,V. Procathepsin D secreted by HaCaT keratinocyte cells - a novel regulator of keratinocyte growth Eur J Cell Biol (2007) 86, 303-313. PubMed Europe PubMed DOI PMC EPMC
[YEAR:11-5-2007]Walls,K.C., Klocke,B.J., Saftig,P., Shibata,M., Uchiyama,Y., Roth,K.A. and Shacka,J.J. Altered regulation of phosphatidylinositol 3-kinase signaling in cathepsin D-deficient brain Autophagy (11-5-2007) 3, 222-229. PubMed Europe PubMed K
Wang,P.A., Stenvik,J., Larsen,R., Maehre,H. and Olsen,R.L. Cathepsin D from Atlantic cod (Gadus morhua L.) liver. Isolation and comparative studies Comp Biochem Physiol B Biochem Mol Biol (2007) 147, 504-511. PubMed Europe PubMed DOI
Zaidi,N., Herrmann,T., Baechle,D., Schleicher,S., Gogel,J., Driessen,C., Voelter,W. and Kalbacher,H. A new approach for distinguishing cathepsin E and D activity in antigen-processing organelles FEBS J (2007) 274, 3138-3149. PubMed Europe PubMed DOI A
Zou,J., Henderson,L., Thomas,V., Swan,P., Turner,A.N. and Phelps,R.G. Presentation of the Goodpasture autoantigen requires proteolytic unlocking steps that destroy prominent T cell epitopes J Am Soc Nephrol (2007) 18, 771-779. PubMed Europe PubMed DOI

2006

[YEAR:28-12-2006]Awano,T., Katz,M.L., O'Brien,D.P., Taylor,J.F., Evans,J., Khan,S., Sohar,I., Lobel,P. and Johnson,G.S. A mutation in the cathepsin D gene (CTSD) in American Bulldogs with neuronal ceroid lipofuscinosis Mol Genet Metab (28-12-2006) 87, 341-348. PubMed Europe PubMed DOI M
[YEAR:14-12-2006]Baechle,D., Flad,T., Cansier,A., Steffen,H., Schittek,B., Tolson,J., Herrmann,T., Dihazi,H., Beck,A., Mueller,G.A., Mueller,M., Stevanovic,S., Garbe,C., Mueller,C.A. and Kalbacher,H. Cathepsin D is present in human eccrine sweat and involved in the postsecretory processing of the antimicrobial peptide DCD-1L J Biol Chem (14-12-2006) 281, 5406-5415. PubMed Europe PubMed DOI
[YEAR:5-12-2006]Beaujouin,M., Baghdiguian,S., Glondu-Lassis,M., Berchem,G. and Liaudet-Coopman,E. Overexpression of both catalytically active and -inactive cathepsin D by cancer cells enhances apoptosis-dependent chemo-sensitivity Oncogene (5-12-2006) 25, 1967-1973. PubMed Europe PubMed DOI PMC EPMC
[YEAR:27-6-2006]Bjelic,S. and Aqvist,J. Catalysis and linear free energy relationships in aspartic proteases Biochemistry (27-6-2006) 45, 7709-7723. PubMed Europe PubMed DOI
Davidson,Y., Gibbons,L., Pritchard,A., Hardicre,J., Wren,J., Tian,J., Shi,J., Stopford,C., Julien,C., Thompson,J., Payton,A., Thaker,U., Hayes,A.J., Iwatsubo,T., Pickering-Brown,S.M., Pendleton,N., Horan,M.A., Burns,A., Purandare,N., Lendon,C.L., Neary,D., Snowden,J.S. and Mann,D.M. Genetic associations between cathepsin D exon 2 C - >T polymorphism and Alzheimer's disease, and pathological correlations with genotype J Neurol Neurosurg Psychiatry (2006) 77, 515-517. PubMed Europe PubMed DOI PMC EPMC
[YEAR:1-2-2006]del Cerro-Vadillo,E., Madrazo-Toca,F., Carrasco-Marin,E., Fernandez-Prieto,L., Beck,C., Leyva-Cobian,F., Saftig,P. and Alvarez-Dominguez,C. Cutting edge: a novel nonoxidative phagosomal mechanism exerted by cathepsin-D controls Listeria monocytogenes intracellular growth J Immunol (1-2-2006) 176, 1321-1325. PubMed Europe PubMed K
[YEAR:19-8-2006]Demoz,M., Castino,R., Follo,C., Hasilik,A., Sloane,B.F. and Isidoro,C. High yield synthesis and characterization of phosphorylated recombinant human procathepsin D expressed in mammalian cells Protein Expr Purif (19-8-2006) 45, 157-167. PubMed Europe PubMed DOI E
Gui,Z.Z., Lee,K.S., Kim,B.Y., Choi,Y.S., Wei,Y.D., Choo,Y.M., Kang,P.D., Yoon,H.J., Kim,I., Je,Y.H., Seo,S.J., Lee,S.M., Guo,X., Sohn,H.D. and Jin,B.R. Functional role of aspartic proteinase cathepsin D in insect metamorphosis BMC Dev Biol (2006) 6, 49-49. PubMed Europe PubMed DOI
Haidar,B., Kiss,R.S., Sarov-Blat,L., Brunet,R., Harder,C., McPherson,R. and Marcel,Y.L. Cathepsin D, a lysosomal protease, regulates ABCA1-mediated lipid efflux J Biol Chem (2006) 281, 39971-39981. PubMed Europe PubMed DOI
Laurent-Matha,V., Derocq,D., Prebois,C., Katunuma,N. and Liaudet-Coopman,E. Processing of human cathepsin D is independent of its catalytic function and auto-activation: involvement of cathepsins L and B J Biochem (2006) 139, 363-371. PubMed Europe PubMed DOI PMC EPMC
[YEAR:18-7-2006]Liaudet-Coopman,E., Beaujouin,M., Derocq,D., Garcia,M., Glondu-Lassis,M., Laurent-Matha,V., Prebois,C., Rochefort,H. and Vignon,F. Cathepsin D: newly discovered functions of a long-standing aspartic protease in cancer and apoptosis Cancer Lett (18-7-2006) 237, 167-179. PubMed Europe PubMed DOI
[YEAR:26-12-2006]Masa,M., Maresova,L., Vondrasek,J., Horn,M., Jezek,J. and Mares,M. Cathepsin D propeptide: mechanism and regulation of its interaction with the catalytic core Biochemistry (26-12-2006) 45, 15474-15482. PubMed Europe PubMed DOI
McConnell,R.M., Green,A.W., Trana,C.J., McConnell,M.S., Lindley,J.F., Sayyar,K., Godwin,W.E. and Hatfield,S.E. New cathepsin D inhibitors with hydroxyethylamine isosteres: preparation and characterization Med Chem (2006) 2, 27-38. PubMed Europe PubMed DOI I
Navarrete del Toro,M., Garcia-Carreno,F., Lopez,M.D., Celis-Guerrero,L. and Saborowski,R. Aspartic proteinases in the digestive tract of marine decapod crustaceans J Exp Zoolog Part A Comp Exp Biol (2006) 305, 645-654. PubMed Europe PubMed DOI
Payton,A., van den Boogerd,E., Davidson,Y., Gibbons,L., Ollier,W., Rabbitt,P., Worthington,J., Horan,M. and Pendleton,N. Influence and interactions of cathepsin D, HLA-DRB1 and APOE on cognitive abilities in an older non-demented population Genes Brain Behav (2006) 5 Suppl 1, 23-31. PubMed Europe PubMed DOI
Piwnica,D., Fernandez,I., Binart,N., Touraine,P., Kelly,P.A. and Goffin,V. A new mechanism for prolactin processing into 16K PRL by secreted cathepsin D Mol Endocrinol (2006) 20, 3263-3278. PubMed Europe PubMed DOI
[YEAR:1-5-2006]Riemenschneider,M., Blennow,K., Wagenpfeil,S., Andreasen,N., Prince,J.A., Laws,S.M., Forstl,H. and Kurz,A. The cathepsin D rs17571 polymorphism: effects on CSF tau concentrations in Alzheimer disease Hum Mutat (1-5-2006) 27, 532-537. PubMed Europe PubMed DOI M
[YEAR:14-8-2006]Sato,Y., Suzuki,Y., Ito,E., Shimazaki,S., Ishida,M., Yamamoto,T., Yamamoto,H., Toda,T., Suzuki,M., Suzuki,A. and Endo,T. Identification and characterization of an increased glycoprotein in aging: age-associated translocation of cathepsin D Mech Ageing Dev (14-8-2006) 127, 771-778. PubMed Europe PubMed DOI
[YEAR:2-5-2006]Siintola,E., Partanen,S., Stromme,P., Haapanen,A., Haltia,M., Maehlen,J., Lehesjoki,A.E. and Tyynela,J. Cathepsin D deficiency underlies congenital human neuronal ceroid-lipofuscinosis Brain (2-5-2006) 129, 1438-1445. PubMed Europe PubMed DOI M
Steinfeld,R., Reinhardt,K., Schreiber,K., Hillebrand,M., Kraetzner,R., Bruck,W., Saftig,P. and Gartner,J. Cathepsin D deficiency is associated with a human neurodegenerative disorder Am J Hum Genet (2006) 78, 988-998. PubMed Europe PubMed DOI PMC EPMC M
[YEAR:21-9-2006]Zhou,W., Scott,S.A., Shelton,S.B. and Crutcher,K.A. Cathepsin D-mediated proteolysis of apolipoprotein E: possible role in Alzheimer's disease Neuroscience (21-9-2006) 143, 689-701. PubMed Europe PubMed DOI

2005

[YEAR:11-10-2005]Baechle,D., Cansier,A., Fischer,R., Brandenburg,J., Burster,T., Driessen,C. and Kalbacher,H. Biotinylated fluorescent peptide substrates for the sensitive and specific determination of cathepsin D activity J Pept Sci (11-10-2005) 11, 166-174. PubMed Europe PubMed DOI
Caffrey,C.R., Placha,L., Barinka,C., Hradilek,M., Dostal,J., Sajid,M., McKerrow,J.H., Majer,P., Konvalinka,J. and Vondrasek,J. Homology modeling and SAR analysis of Schistosoma japonicum cathepsin D (SjCD) with statin inhibitors identify a unique active site steric barrier with potential for the design of specific inhibitors Biol Chem (2005) 386, 339-349. PubMed Europe PubMed DOI
Capurso,C., Solfrizzi,V., D'Introno,A., Colacicco,A.M., Capurso,S.A., Mastroianni,F., Liaci,M., Vendemiale,G., Capurso,A. and Panza,F. The cathepsin D gene exon 2 (C224T) polymorphism and sporadic Alzheimer's disease in european populations J Gerontol A Biol Sci Med Sci (2005) 60, 991-996. PubMed Europe PubMed
Emert-Sedlak,L., Shangary,S., Rabinovitz,A., Miranda,M.B., Delach,S.M. and Johnson,D.E. Involvement of cathepsin D in chemotherapy-induced cytochrome c release, caspase activation, and cell death Mol Cancer Ther (2005) 4, 733-742. PubMed Europe PubMed DOI
[YEAR:15-6-2005]Fukuda,M.E., Iwadate,Y., Machida,T., Hiwasa,T., Nimura,Y., Nagai,Y., Takiguchi,M., Tanzawa,H., Yamaura,A. and Seki,N. Cathepsin D is a potential serum marker for poor prognosis in glioma patients Cancer Res (15-6-2005) 65, 5190-5194. PubMed Europe PubMed DOI
Fusek,M. and Vetvicka,V. Dual role of cathepsin D: ligand and protease Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub (2005) 149, 43-50. PubMed Europe PubMed
[YEAR:6-12-2005]Goldfarb,N.E., Lam,M.T., Bose,A.K., Patel,A.M., Duckworth,A.J. and Dunn,B.M. Electrostatic Switches That Mediate the pH-Dependent Conformational Change of "Short" Recombinant Human Pseudocathepsin D Biochemistry (6-12-2005) 44, 15725-15733. PubMed Europe PubMed DOI PMC EPMC
Koike,M., Shibata,M., Waguri,S., Yoshimura,K., Tanida,I., Kominami,E., Gotow,T., Peters,C., von Figura,K., Mizushima,N., Saftig,P. and Uchiyama,Y. Participation of autophagy in storage of lysosomes in neurons from mouse models of neuronal ceroid-lipofuscinoses (Batten disease) Am J Pathol (2005) 167, 1713-1728. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:31-1-2005]Laurent-Matha,V., Maruani-Herrmann,S., Prebois,C., Beaujouin,M., Glondu,M., Noel,A., Alvarez-Gonzalez,M.L., Blacher,S., Coopman,P., Baghdiguian,S., Gilles,C., Loncarek,J., Freiss,G., Vignon,F. and Liaudet-Coopman,E. Catalytically inactive human cathepsin D triggers fibroblast invasive growth J Cell Biol (31-1-2005) 168, 489-499. PubMed Europe PubMed DOI PMC EPMC
[YEAR:24-6-2005]Matsumoto,N., Jo,O.D., Shih,R.N. and Yanagawa,N. Altered cathepsin D metabolism in PHEX antisense human osteoblast cells Biochem Biophys Res Commun (24-6-2005) 332, 248-253. PubMed Europe PubMed DOI
Merlen,C., Fayol-Messaoudi,D., Fabrega,S., El Hage,T., Servin,A. and Authier,F. Proteolytic activation of internalized cholera toxin within hepatic endosomes by cathepsin D FEBS J (2005) 272, 4385-4397. PubMed Europe PubMed DOI
[YEAR:31-10-2005]Moss,C.X., Villadangos,J.A. and Watts,C. Destructive potential of the aspartyl protease cathepsin D in MHC class II-restricted antigen processing Eur J Immunol (31-10-2005) 35, 3442-3451. PubMed Europe PubMed DOI
Myllykangas,L., Tyynela,J., Page-McCaw,A., Rubin,G.M., Haltia,M.J. and Feany,M.B. Cathepsin D-deficient Drosophila recapitulate the key features of neuronal ceroid lipofuscinoses Neurobiol Dis (2005) 19, 194-199. PubMed Europe PubMed DOI K
Naseem,R.H., Hedegard,W., Henry,T.D., Lessard,J., Sutter,K. and Katz,S.A. Plasma cathepsin D isoforms and their active metabolites increase after myocardial infarction and contribute to plasma renin activity Basic Res Cardiol (2005) 100, 139-146. PubMed Europe PubMed DOI
[YEAR:21-1-2005]Schulmeister,A., Heyers,O., Morales,M.E., Brindley,P.J., Lucius,R., Meusel,G. and Kalinna,B.H. Organization and functional analysis of the Schistosoma mansoni cathepsin D-like aspartic protease gene promoter Biochim Biophys Acta (21-1-2005) 1727, 27-34. PubMed Europe PubMed DOI
[YEAR:30-6-2005]Shimizu,T., Hayashi,Y., Yamasaki,R., Yamada,J., Zhang,J., Ukai,K., Koike,M., Mine,K., von Figura,K., Peters,C., Saftig,P., Fukuda,T., Uchiyama,Y. and Nakanishi,H. Proteolytic degradation of glutamate decarboxylase mediates disinhibition of hippocampal CA3 pyramidal cells in cathepsin D-deficient mice J Neurochem (30-6-2005) 94, 680-690. PubMed Europe PubMed DOI K
[YEAR:4-8-2005]Steet,R., Lee,W.S. and Kornfeld,S. Identification of the minimal lysosomal enzyme recognition domain in cathepsin D J Biol Chem (4-8-2005) 280, 33318-33323. PubMed Europe PubMed DOI
Sun,Y., Shi,J.J., Zhang,S.Z., Tang,M.N., Han,H.Y., Guo,Y.B., Ma,C., Liu,X.H. and Li,T. [The C224T polymorphism in the cathepsin D gene is not associated with sporadic Alzheimer's disease in Chinese] Yi Chuan (2005) 27, 190-194. PubMed Europe PubMed M
Wohlke,A., Distl,O. and Drogemuller,C. The canine CTSD gene as a candidate for late-onset neuronal ceroid lipofuscinosis Anim Genet (2005) 36, 530-532. PubMed Europe PubMed DOI M

2004

Alexov,E. Calculating proton uptake/release and binding free energy taking into account ionization and conformation changes induced by protein-inhibitor association: application to plasmepsin, cathepsin D and endothiapepsin-pepstatin complexes Proteins (2004) 56, 572-584. PubMed Europe PubMed DOI I
Brunelle,F., Cloutier,C. and Michaud,D. Colorado potato beetles compensate for tomato cathepsin D inhibitor expressed in transgenic potato Arch Insect Biochem Physiol (2004) 55, 103-113. PubMed Europe PubMed DOI
Conner,G.E. Cathepsin D [ISSN:0-12-079610-4] (2004) 2, 43-52. V
[YEAR:1-6-2004]Egberts,F., Heinrich,M., Jensen,J.M., Winoto-Morbach,S., Pfeiffer,S., Wickel,M., Schunck,M., Steude,J., Saftig,P., Proksch,E. and Schutze,S. Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation J Cell Sci (1-6-2004) 117, 2295-2307. PubMed Europe PubMed DOI
Faridi,J.S., Mohan,S. and De Leon,D.D. Modulation of cathepsin D routing by IGF-II involves IGF-II binding to IGF-II/M6P receptor in MCF-7 breast cancer cells Growth Factors (2004) 22, 169-177. PubMed Europe PubMed DOI
[YEAR:1-11-2004]Gopalakrishnan,M.M., Grosch,H.W., Locatelli-Hoops,S., Werth,N., Smolenova,E., Nettersheim,M., Sandhoff,K. and Hasilik,A. Purified recombinant human prosaposin forms oligomers that bind procathepsin D and affect its autoactivation Biochem J (1-11-2004) 383, 507-515. PubMed Europe PubMed DOI PMC EPMC
Igarashi,S., Takizawa,T., Takizawa,T., Yasuda,Y., Uchiwa,H., Hayashi,S., Brysk,H., Robinson,J.M., Yamamoto,K., Brysk,M.M. and Horikoshi,T. Cathepsin D, but not cathepsin E, degrades desmosomes during epidermal desquamation Br J Dermatol (2004) 151, 355-361. PubMed Europe PubMed DOI
Komai,T., Kawabata,C., Amano,M., Lee,B.R. and Ichishima,E. Todarepsin, a new cathepsin D from hepatopancreas of Japanese common squid (Todarodes pacificus) Comp Biochem Physiol B Biochem Mol Biol (2004) 137, 373-382. PubMed Europe PubMed DOI
[YEAR:20-2-2004]Li,X., Rayford,H., Shu,R., Zhuang,J. and Uhal,B.D. Essential role for cathepsin D in bleomycin-induced apoptosis of alveolar epithelial cells Am J Physiol Lung Cell Mol Physiol (20-2-2004) 287, L46-L51. PubMed Europe PubMed DOI
Mommsen,T.P. Salmon spawning migration and muscle protein metabolism: the August Krogh principle at work Comp Biochem Physiol B Biochem Mol Biol (2004) 139, 383-400. PubMed Europe PubMed DOI
[YEAR:18-8-2004]Morales,M.E., Kalinna,B.H., Heyers,O., Mann,V.H., Schulmeister,A., Copeland,C.S., Loukas,A. and Brindley,P.J. Genomic organization of the Schistosoma mansoni aspartic protease gene, a platyhelminth orthologue of mammalian lysosomal cathepsin D Gene (18-8-2004) 338, 99-109. PubMed Europe PubMed DOI
[YEAR:15-3-2004]Ntais,C., Polycarpou,A. and Ioannidis,J.P. Meta-analysis of the association of the cathepsin D Ala224Val gene polymorphism with the risk of Alzheimer's disease: a HuGE gene-disease association review Am J Epidemiol (15-3-2004) 159, 527-536. PubMed Europe PubMed DOI M
[YEAR:10-6-2004]Piwnica,D., Touraine,P., Struman,I., Tabruyn,S., Bolbach,G., Clapp,C., Martial,J.A., Kelly,P.A. and Goffin,V. Cathepsin D processes human prolactin into multiple 16K-like N-terminal fragments: study of their antiangiogenic properties and physiological relevance Mol Endocrinol (10-6-2004) 18, 2522-2542. PubMed Europe PubMed DOI
Vetvicka,V., Vetvickova,J. and Benes,P. Role of enzymatically inactive procathepsin D in lung cancer Anticancer Res (2004) 24, 2739-2743. PubMed Europe PubMed
Wille,A., Gerber,A., Heimburg,A., Reisenauer,A., Peters,C., Saftig,P., Reinheckel,T., Welte,T. and Buhling,F. Cathepsin L is involved in cathepsin D processing and regulation of apoptosis in A549 human lung epithelial cells Biol Chem (2004) 385, 665-670. PubMed Europe PubMed DOI

2003

Bidere,N., Lorenzo,H.K., Carmona,S., Laforge,M., Harper,F., Dumont,C. and Senik,A. Cathepsin D triggers Bax activation, resulting in selective apoptosis-inducing factor (AIF) relocation in T lymphocytes entering the early commitment phase to apoptosis J Biol Chem (2003) 278, 31401-31411. PubMed Europe PubMed DOI
Carnevali,O. and Maradonna,F. Exposure to xenobiotic compounds: looking for new biomarkers Gen Comp Endocrinol (2003) 131, 203-208. PubMed Europe PubMed DOI
Johansson,A.C., Steen,H., Ollinger,K. and Roberg,K. Cathepsin D mediates cytochrome c release and caspase activation in human fibroblast apoptosis induced by staurosporine Cell Death Differ (2003) 10, 1253-1259. PubMed Europe PubMed DOI
Koike,M., Shibata,M., Ohsawa,Y., Nakanishi,H., Koga,T., Kametaka,S., Waguri,S., Momoi,T., Kominami,E., Peters,C., Figura,K., Saftig,P. and Uchiyama,Y. Involvement of two different cell death pathways in retinal atrophy of cathepsin D-deficient mice Mol Cell Neurosci (2003) 22, 146-161. PubMed Europe PubMed DOI K
[YEAR:1-1-2003]Partanen,S., Storch,S., Loffler,H.G., Hasilik,A., Tyynela,J. and Braulke,T. A replacement of the active-site aspartic acid residue 293 in mouse cathepsin D affects its intracellular stability, processing and transport in HEK-293 cells Biochem J (1-1-2003) 369, 55-62. PubMed Europe PubMed DOI PMC EPMC
[YEAR:11-9-2003]Perchick,G.B. and Jabbour,H.N. Cyclooxygenase-2 overexpression inhibits cathepsin D-mediated cleavage of plasminogen to the potent antiangiogenic factor angiostatin Endocrinology (11-9-2003) 144, 5322-5328. PubMed Europe PubMed DOI
Tardy,C., Tyynela,J., Hasilik,A., Levade,T. and Andrieu-Abadie,N. Stress-induced apoptosis is impaired in cells with a lysosomal targeting defect but is not affected in cells synthesizing a catalytically inactive cathepsin D Cell Death Differ (2003) 10, 1090-1100. PubMed Europe PubMed DOI K
Wolf,M., Clark-Lewis,I., Buri,C., Langen,H., Lis,M. and Mazzucchelli,L. Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer Am J Pathol (2003) 162, 1183-1190. PubMed Europe PubMed PMC EPMC

2002

Athaudaa,S.B. and Takahashia,K. Cleavage specificities of aspartic proteinases toward oxidized insulin B chain at different pH values Protein Pept Lett (2002) 9, 289-294. PubMed Europe PubMed DOI P
[YEAR:15-3-2002]Authier,F., Metioui,M., Fabrega,S., Kouach,M. and Briand,G. Endosomal proteolysis of internalized insulin at the C-terminal region of the B chain by cathepsin D J Biol Chem (15-3-2002) 277, 9437-9446. PubMed Europe PubMed DOI
[YEAR:29-8-2002]Berchem,G., Glondu,M., Gleizes,M., Brouillet,J.P., Vignon,F., Garcia,M. and Liaudet-Coopman,E. Cathepsin-D affects multiple tumor progression steps in vivo: proliferation, angiogenesis and apoptosis Oncogene (29-8-2002) 21, 5951-5955. PubMed Europe PubMed DOI
Cho,J.H., Park,I.Y., Kim,H.S., Lee,W.T., Kim,M.S. and Kim,S.C. Cathepsin D produces antimicrobial peptide parasin I from histone H2A in the skin mucosa of fish FASEB J (2002) 16, 429-431. PubMed Europe PubMed DOI
[YEAR:1-8-2002]Glondu,M., Liaudet-Coopman,E., Derocq,D., Platet,N., Rochefort,H. and Garcia,M. Down-regulation of cathepsin-D expression by antisense gene transfer inhibits tumor growth and experimental lung metastasis of human breast cancer cells Oncogene (1-8-2002) 21, 5127-5134. PubMed Europe PubMed DOI
[YEAR:1-1-2002]Hiramatsu,N., Ichikawa,N., Fukada,H., Fujita,T., Sullivan,C.V. and Hara,A. Identification and characterization of proteases involved in specific proteolysis of vitellogenin and yolk proteins in salmonids J Exp Zool (1-1-2002) 292, 11-25. PubMed Europe PubMed DOI
[YEAR:28-3-2002]Huo,S., Wang,J., Cieplak,P., Kollman,P.A. and Kuntz,I.D. Molecular dynamics and free energy analyses of cathepsin D-inhibitor interactions: insight into structure-based ligand design J Med Chem (28-3-2002) 45, 1412-1419. PubMed Europe PubMed DOI I
[YEAR:19-7-2002]Papassotiropoulos,A., Lewis,H.D., Bagli,M., Jessen,F., Ptok,U., Schulte,A., Shearman,M.S. and Heun,R. Cerebrospinal fluid levels of beta-amyloid(42) in patients with Alzheimer's disease are related to the exon 2 polymorphism of the cathepsin D gene Neuroreport (19-7-2002) 13, 1291-1294. PubMed Europe PubMed M
Roberg,K., Kagedal,K. and Ollinger,K. Microinjection of cathepsin D induces caspase-dependent apoptosis in fibroblasts Am J Pathol (2002) 161, 89-96. PubMed Europe PubMed DOI PMC EPMC
[YEAR:13-3-2002]Silva,F.P., Jr., Ribeiro,F., Katz,N. and Giovanni-De-Simone,S. Exploring the subsite specificity of Schistosoma mansoni aspartyl hemoglobinase through comparative molecular modelling FEBS Lett (13-3-2002) 514, 141-148. PubMed Europe PubMed DOI P

2001

[YEAR:15-1-2001]Brindley,P.J., Kalinna,B.H., Wong,J.Y.M., Bogitsh,B.J., King,L.T., Smyth,D.J., Verity,C.K., Abbenante,G., Brinkworth,R.I., Fairlie,D.P., Smythe,M.L., Milburn,P.J., Bielefeldt-Ohmann,H., Zheng,Y. and McManus,D.P. Proteolysis of human hemoglobin by schistosome cathepsin D Mol Biochem Parasitol (15-1-2001) 112, 103-112. PubMed Europe PubMed DOI
[YEAR:19-10-2001]Brinkworth,R.I., Prociv,P., Loukas,A. and Brindley,P.J. Hemoglobin-degrading, aspartic proteases of blood-feeding parasites: substrate specificity revealed by homology models J Biol Chem (19-10-2001) 276, 38844-38851. PubMed Europe PubMed DOI I
[YEAR:18-10-2001]Glondu,M., Coopman,P., Laurent-Matha,V., Garcia,M., Rochefort,H. and Liaudet-Coopman,E. A mutated cathepsin-D devoid of its catalytic activity stimulates the growth of cancer cells Oncogene (18-10-2001) 20, 6920-6929. PubMed Europe PubMed DOI
Handley,C.J., Mok,M.T., Ilic,M.Z., Adcocks,C., Buttle,D.J. and Robinson,H.C. Cathepsin D cleaves aggrecan at unique sites within the interglobular domain and chondroitin sulfate attachment regions that are also cleaved when cartilage is maintained at acid pH Matrix Biol (2001) 20, 543-553. PubMed Europe PubMed DOI
Hayes,M., Hurley,M.J., Larsen,L.B., Heegaard,C.W., Magboul,A.A.A., Oliveira,J.C., McSweeney,P.L.H. and Kelly,A.L. Thermal inactivation kinetics of bovine cathepsin D J Dairy Res (2001) 68, 267-276. PubMed Europe PubMed DOI
[YEAR:29-5-2001]Kagedal,K., Johansson,U. and Ollinger,K. The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress FASEB J (29-5-2001) 15, 1592-1594. PubMed Europe PubMed I
[YEAR:8-3-2001]Menzer,G., Muller-Thomsen,T., Meins,W., Alberici,A., Binetti,G., Hock,C., Nitsch,R.M., Stoppe,G., Reiss,J. and Finckh,U. Non-replication of association between cathepsin D genotype and late onset Alzheimer disease Am J Med Genet (8-3-2001) 105, 179-182. PubMed Europe PubMed DOI M
[YEAR:1-10-2001]Nakanishi,H., Zhang,J., Koike,M., Nishioku,T., Okamoto,Y., Kominami,E., von Figura,K., Peters,C., Yamamoto,K., Saftig,P. and Uchiyama,Y. Involvement of nitric oxide released from microglia-macrophages in pathological changes of cathepsin D-deficient mice J Neurosci (1-10-2001) 21, 7526-7533. PubMed Europe PubMed K
[YEAR:12-1-2001]Pimenta,D.C., Oliveira,A., Juliano,M.A. and Juliano,L. Substrate specificity of human cathepsin D using internally quenched fluorescent peptides derived from reactive site loop of kallistatin Biochim Biophys Acta (12-1-2001) 1544, 113-122. PubMed Europe PubMed DOI A
Verity,C.K., Loukas,A., McManus,D.P. and Brindley,P.J. Schistosoma japonicum cathepsin D aspartic protease cleaves human IgG and other serum components Parasitology (2001) 122, 415-421. PubMed Europe PubMed DOI
[YEAR:14-2-2001]Wang,F., Samudio,I. and Safe,S. Transcriptional activation of cathepsin D gene expression by 17beta-estradiol: mechanism of aryl hydrocarbon receptor-mediated inhibition Mol Cell Endocrinol (14-2-2001) 172, 91-103. PubMed Europe PubMed DOI

2000

[YEAR:7-7-2000]Bhojak,T.J., DeKosky,S.T., Ganguli,M. and Kamboh,M.I. Genetic polymorphisms in the cathepsin D and interleukin-6 genes and the risk of Alzheimer's disease Neurosci Lett (7-7-2000) 288, 21-24. PubMed Europe PubMed DOI M
Bi,X., Haque,T.S., Zhou,J., Skillman,A.G., Lin,B., Lee,C.E., Kuntz,I.D., Ellman,J.A. and Lynch,G. Novel cathepsin D inhibitors block the formation of hyperphosphorylated tau fragments in hippocampus J Neurochem (2000) 74, 1469-1477. PubMed Europe PubMed DOI I
[YEAR:28-7-2000]Crawford,F.C., Freeman,M.J., Schinka,J., Abdullah,L.I., Richards,D., Sevush,S., Duara,R. and Mullan,M.J. The genetic association between cathepsin D and Alzheimer's disease Neurosci Lett (28-7-2000) 289, 61-65. PubMed Europe PubMed DOI M
Ju,B.G. and Kim,W.S. Cloning of a cDNA encoding cathepsin D from salamander, Hynobius leechii, and its expression in the limb regenerates DNA Seq (2000) 11, 21-28. PubMed Europe PubMed
[YEAR:15-9-2000]Koike,M., Nakanishi,H., Saftig,P., Ezaki,J., Isahara,K., Ohsawa,Y., Schulz-Schaeffer,W., Watanabe,T., Waguri,S., Kametaka,S., Shibata,M., Yamamoto,K., Kominami,E., Peters,C., von Figura,K. and Uchiyama,Y. Cathepsin D deficiency induces lysosomal storage with ceroid lipofuscin in mouse CNS neurons J Neurosci (15-9-2000) 20, 6898-6906. PubMed Europe PubMed K
Papassotiropoulos,A., Bagli,M., Kurz,A., Kornhuber,J., Forstl,H., Maier,W., Pauls,J., Lautenschlager,N. and Heun,R. A genetic variation of cathepsin D is a major risk factor for Alzheimer's disease Ann Neurol (2000) 47, 399-403. PubMed Europe PubMed DOI M
Pimenta,D.C., Chen,V.C., Chao,J., Juliano,M.A. and Juliano,L. Alpha1-antichymotrypsin and kallistatin hydrolysis by human cathepsin D J Protein Chem (2000) 19, 411-418. PubMed Europe PubMed DOI
[YEAR:30-12-2000]Riggio,M., Scudiero,R., Filosa,S. and Parisi,E. Sex- and tissue-specific expression of aspartic proteinases in Danio rerio (zebrafish) Gene (30-12-2000) 260, 67-75. PubMed Europe PubMed DOI
[YEAR:15-2-2000]Rochefort,H., Garcia,M., Glondu,M., Laurent,V., Liaudet,E., Rey,J.M. and Roger,P. Cathepsin D in breast cancer: mechanisms and clinical applications, a 1999 overview Clin Chim Acta (15-2-2000) 291, 157-170. PubMed Europe PubMed DOI
[YEAR:31-12-2000]Tsukuba,T., Okamoto,K., Yasuda,Y., Morikawa,W., Nakanishi,H. and Yamamoto,K. New functional aspects of cathepsin D and cathepsin E Mol Cells (31-12-2000) 10, 601-611. PubMed Europe PubMed V
Tyynela,J., Sohar,I., Sleat,D.E., Gin,R.M., Donnelly,R.J., Baumann,M., Haltia,M. and Lobel,P. A mutation in the ovine cathepsin D gene causes a congenital lysosomal storage disease with profound neurodegeneration EMBO J (2000) 19, 2786-2792. PubMed Europe PubMed DOI PMC EPMC
Yamamoto,H., Yamada,T. and Itoh,Y. Probable involvement of cathepsin D in the degradation of beta2-microglobulin in acidic urine Clin Chem Lab Med (2000) 38, 495-499. PubMed Europe PubMed DOI

1999

[YEAR:12-4-1999]Capasso,C., Lees,W.E., Capasso,A., Scudiero,R., Carginale,V., Kille,P., Kay,J. and Parisi,E. Cathepsin D from the liver of the Antarctic icefish Chionodraco hamatus exhibits unusual activity and stability at high temperatures Biochim Biophys Acta (12-4-1999) 1431, 64-73. PubMed Europe PubMed DOI
Carnevali,O., Centonze,F., Brooks,S., Marota,I. and Sumpter,J.P. Molecular cloning and expression of ovarian cathepsin D in seabream, Sparus aurata Biol Reprod (1999) 61, 785-791. PubMed Europe PubMed DOI
De Stasio,R., Borrelli,L., Kille,P., Parisi,E. and Filosa,S. Isolation, characterization and molecular cloning of cathepsin D from lizard ovary: changes in enzyme activity and mRNA expression throughout ovarian cycle Mol Reprod Dev (1999) 52, 126-134. PubMed Europe PubMed DOI
[YEAR:8-1-1999]Lenarcic,B. and Turk,V. Thyroglobulin type-1 domains in equistatin inhibit both papain-like cysteine proteinases and cathepsin D J Biol Chem (8-1-1999) 274, 563-566. PubMed Europe PubMed DOI
O'Driscoll,B.M., Rattray,F.P., McSweeney,P.L.H. and Kelly,A.L. Protease activities in raw milk determined using a synthetic heptapeptide substrate J Food Sci (1999) 64, 606-611. A
[YEAR:12-3-1999]Papassotiropoulos,A., Bagli,M., Feder,O., Jessen,F., Maier,W., Rao,M.L., Ludwig,M., Schwab,S.G. and Heun,R. Genetic polymorphism of cathepsin D is strongly associated with the risk for developing sporadic Alzheimer's disease Neurosci Lett (12-3-1999) 262, 171-174. PubMed Europe PubMed DOI M
Rochefort,H. and Liaudet-Coopman,E. Cathepsin D in cancer metastasis: a protease and a ligand APMIS (1999) 107, 86-95. PubMed Europe PubMed
Verity,C.K., McManus,D.P. and Brindley,P.J. Developmental expression of cathepsin D aspartic protease in Schistosoma japonicum Int J Parasitol (1999) 29, 1819-1824. PubMed Europe PubMed DOI
Wittlin,S., Rosel,J., Hofmann,F. and Stover,D.R. Mechanisms and kinetics of procathepsin D activation Eur J Biochem (1999) 265, 384-393. PubMed Europe PubMed DOI
Yasuda,Y., Kageyama,T., Akamine,A., Shibata,M., Kominami,E., Uchiyama,Y. and Yamamoto,K. Characterization of new fluorogenic substrates for the rapid and sensitive assay of cathepsin E and cathepsin D J Biochem (1999) 125, 1137-1143. PubMed Europe PubMed A
Yonezawa,H., Uchikoba,T., Arima,K. and Kaneda,M. Fluorogenic substrates for cathepsin D Biosci Biotechnol Biochem (1999) 63, 1471-1474. PubMed Europe PubMed A

1998

Beyer,B.M. and Dunn,B.M. Prime region subsite specificity characterization of human cathepsin D: The dominant role of position 128 Protein Sci (1998) 7, 88-95. PubMed Europe PubMed DOI PMC EPMC
[YEAR:17-11-1998]Carroll,C.D., Johnson,T.O., Tao,S., Lauri,G., Orlowski,M., Gluzman,I.Y., Goldberg,D.E. and Dolle,R.E. Evaluation of a structure-based statine cyclic diamino amide encoded combinatorial library against plasmepsin II and cathepsin D Bioorg Med Chem Lett (17-11-1998) 8, 3203-3206. PubMed Europe PubMed I
[YEAR:14-4-1998]Deussing,J., Roth,W., Saftig,P., Peters,C., Ploegh,H.L. and Villadangos,J.A. Cathepsins B and D are dispensable for major histocompatibility complex class II-mediated antigen presentation Proc Natl Acad Sci U S A (14-4-1998) 95, 4516-4521. PubMed Europe PubMed DOI PMC EPMC K
[YEAR:29-5-1998]Fruitier,I., Garreau,I. and Piot,J.M. Cathepsin D is a good candidate for the specific release of a stable hemorphin from hemoglobin in vivo: VV-hemorphin-7 Biochem Biophys Res Commun (29-5-1998) 246, 719-724. PubMed Europe PubMed DOI
Godbold,G.D., Ahn,K., Yeyeodu,S., Lee,L.F., Ting,J.P. and Erickson,A.H. Biosynthesis and intracellular targeting of the lysosomal aspartic proteinase cathepsin D Adv Exp Med Biol (1998) 436, 153-162. PubMed Europe PubMed
Kageyama,T., Tatematsu,M., Ichinose,M., Yahagi,N., Miki,K., Moriyama,A. and Yonezawa,S. Development-dependent expression of cathepsins D and E in various rat tissues, with special reference to the high expression of cathepsin E in fetal liver Zoolog Sci (1998) 15, 517-523. PubMed Europe PubMed DOI
Lee,A.Y., Gulnik,S.V. and Erickson,J.W. Conformational switching in an aspartic proteinase Nat Struct Biol (1998) 5, 866-871. PubMed Europe PubMed DOI S
Peterson,J.J. and Meares,C.F. Cathepsin substrates as cleavable peptide linkers in bioconjugates, selected from a fluorescence quench combinatorial library Bioconjug Chem (1998) 9, 618-626. PubMed Europe PubMed DOI
[YEAR:10-4-1998]Wu,G.S., Saftig,P., Peters,C. and El-Deiry,W.S. Potential role for cathepsin D in p53-dependent tumor suppression and chemosensitivity Oncogene (10-4-1998) 16, 2177-2183. PubMed Europe PubMed DOI

1997

Arnold,D., Keilholz,W., Schild,H., Dumrese,T., Stevanovic,S. and Rammensee,H.G. Substrate specificity of cathepsins D and E determined by N-terminal and C-terminal sequencing of peptide pools Eur J Biochem (1997) 249, 171-179. PubMed Europe PubMed
Brindley,P.J., Kalinna,B.H., Dalton,J.P., Day,S.R., Wong,J.Y., Smythe,M.L. and McManus,D.P. Proteolytic degradation of host hemoglobin by schistosomes Mol Biochem Parasitol (1997) 89, 1-9. PubMed Europe PubMed DOI
Chevallier,N., Vizzavona,J., Marambaud,P., Baur,C.P., Spillantini,M., Fulcrand,P., Martinez,J., Goedert,M., Vincent,J.P. and Checler,F. Cathepsin D displays in vitro beta-secretase-like specificity Brain Res (1997) 750, 11-19. PubMed Europe PubMed DOI
Claussen,M., Kubler,B., Wendland,M., Neifer,K., Schmidt,B., Zapf,J. and Braulke,T. Proteolysis of insulin-like growth factors (IGF) and IGF binding proteins by cathepsin D Endocrinology (1997) 138, 3797-3803. PubMed Europe PubMed DOI
Gulnik,S.V., Suvorov,L.I., Majer,P., Collins,J., Kane,B.P., Johnson,D.G. and Erickson,J.W. Design of sensitive fluorogenic substrates for human cathepsin D FEBS Lett (1997) 413, 379-384. PubMed Europe PubMed DOI A
[YEAR:15-11-1997]Hewitt,E.W., Treumann,A., Morrice,N., Tatnell,P.J., Kay,J. and Watts,C. Natural processing sites for human cathepsin E and cathepsin D in tetanus toxin: implications for T cell epitope generation J Immunol (15-11-1997) 159, 4693-4699. PubMed Europe PubMed
Mackay,E.A., Ehrhard,A., Moniatte,M., Guenet,C., Tardif,C., Tarnus,C., Sorokine,O., Heintzelmann,B., Nay,C., Remy,J.M., Higaki,J., Van Dorsselaer,A., Wagner,J., Danzin,C. and Mamont,P. A possible role for cathepsins D, E, and B in the processing of beta-amyloid precursor protein in Alzheimer's disease Eur J Biochem (1997) 244, 414-425. PubMed Europe PubMed
Majer,P., Collins,J.R., Gulnik,S.V. and Erickson,J.W. Structure-based subsite specificity mapping of human cathepsin D using statine-based inhibitors Protein Sci (1997) 6, 1458-1466. PubMed Europe PubMed DOI PMC EPMC I
Metaye,T., Kraimps,J.L., Goujon,J.M., Fernandez,B., Quellard,N., Ingrand,P., Barbier,J. and Begon,F. Expression, localization, and thyrotropin regulation of cathepsin D in human thyroid tissues J Clin Endocrinol Metab (1997) 82, 3383-3388. PubMed Europe PubMed DOI
[YEAR:4-4-1997]Wong,J.Y., Harrop,S.A., Day,S.R. and Brindley,P.J. Schistosomes express two forms of cathepsin D Biochim Biophys Acta (4-4-1997) 1338, 156-160. PubMed Europe PubMed DOI

1996

Filippova,I.Y., Lysogorskaya,E.N., Anisimova,V.V., Suvorov,L.I., Oksenoit,E.S. and Stepanov,V.M. Fluorogenic peptide substrates for assay of aspartyl proteinases Anal Biochem (1996) 234, 113-118. PubMed Europe PubMed DOI A
Higaki,J., Catalano,R., Guzzetta,A.W., Quon,D., Nave,J.F., Tarnus,C., D'Orchymont,H. and Cordell,B. Processing of beta-amyloid precursor protein by cathepsin D J Biol Chem (1996) 271, 31885-31893. PubMed Europe PubMed DOI
Kageyama,T., Yonezawa,S., Ichinose,M., Miki,K. and Moriyama,A. Potential sites for processing of the human invariant chain by cathepsins D and E Biochem Biophys Res Commun (1996) 223, 549-553. PubMed Europe PubMed DOI

1995

Aguilar,C.F., Dhanaraj,V., Guruprasad,K., Dealwis,C., Badasso,M., Cooper,J.B., Wood,S.P. and Blundell,T.L. Comparisons of the three-dimensional structures, specificities and glycosylation of renins, yeast proteinase A and cathepsin D Adv Exp Med Biol (1995) 362, 155-166. PubMed Europe PubMed
Becker,M.M., Harrop,S.A., Dalton,J.P., Kalinna,B.H., McManus,D.P. and Brindley,P.J. Cloning and characterization of the Schistosoma japonicum aspartic proteinase involved in hemoglobin degradation J Biol Chem (1995) 270, 24496-24501. PubMed Europe PubMed DOI
Evin,G., Cappai,R., Li,Q.X., Culvenor,J.G., Small,D.H., Beyreuther,K. and Masters,C.L. Candidate gamma-secretases in the generation of the carboxyl terminus of the Alzheimer's disease beta a4 amyloid: possible involvement of cathepsin D Biochemistry (1995) 34, 14185-14192. PubMed Europe PubMed
Fortenberry,S.C. and Chirgwin,J.M. The propeptide is nonessential for the expression of human cathepsin D J Biol Chem (1995) 270, 9778-9782. PubMed Europe PubMed DOI E
Kim,K., Homma,Y., Ikeuchi,Y. and Suzuki,A. Cleavage of connectin by calpain and cathepsin D Biosci Biotechnol Biochem (1995) 59, 896-899. DOI
Metcalf,P. and Fusek,M. Cathepsin D crystal structures and lysosomal sorting Adv Exp Med Biol (1995) 362, 193-200. PubMed Europe PubMed S
Mukai,M., Obara,M. and Yoshizato,K. Characterization of gene of anuran cathepsin D as a metamorphosis- associated enzyme Dev Growth Differ (1995) 37, 463-477.
Nishimura,Y., Takeshima,H., Sakaguchi,M., Mihara,K., Omura,T., Kato,K. and Himeno,M. Expression of rat cathepsin D cDNA in Saccharomyces cerevisiae: implications for intracellular targeting of cathepsin D to vacuoles J Biochem (1995) 118, 168-177. PubMed Europe PubMed E
Nishimura,Y. and Himeno,M. Cathepsin D associates with lysosomal membranous protein Biol Pharm Bull (1995) 18, 1340-1346. PubMed Europe PubMed
Saftig,P., Hetman,M., Schmahl,W., Weber,K., Heine,L., Mossmann,H., Koster,A., Hess,B., Evers,M., von Figura,K. and Peters,C. Mice deficient for the lysosomal proteinase cathepsin D exhibit progressive atrophy of the intestinal mucosa and profound destruction of lymphoid cells EMBO J (1995) 14, 3599-3608. PubMed Europe PubMed PMC EPMC K

1994

Fusek,M. and Vetvicka,V. Mitogenic function of human procathepsin D: the role of the propeptide Biochem J (1994) 303, 775-780. PubMed Europe PubMed PMC EPMC
Hetman,M., Perschl,A., Saftig,P., von Figura,K. and Peters,C. Mouse cathepsin D gene: molecular organization, characterization of the promoter, and chromosomal localization DNA Cell Biol (1994) 13, 419-427. PubMed Europe PubMed
Maric,M.A., Taylor,M.D. and Blum,J.S. Endosomal aspartic proteinases are required for invariant-chain processing Proc Natl Acad Sci U S A (1994) 91, 2171-2175. PubMed Europe PubMed PMC EPMC
Richo,G.R. and Conner,G.E. Structural requirements of procathepsin D activation and maturation J Biol Chem (1994) 269, 14806-14812. PubMed Europe PubMed
Scarborough,P.E. and Dunn,B.M. Redesign of the substrate specificity of human cathepsin D: the dominant role of position 287 in the S2 subsite Protein Eng (1994) 7, 495-502. PubMed Europe PubMed
Simon,D.I., Ezratty,A.M. and Loscalzo,J. The fibrin(ogen)olytic properties of cathepsin D Biochemistry (1994) 33, 6555-6563. PubMed Europe PubMed

1993

[YEAR:15-7-1993]Baldwin,E.T., Bhat,T.N., Gulnik,S., Hosur,M.V., Sowder,R.C., Cachau,R.E., Collins,J., Silva,A.M. and Erickson,J.W. Crystal structures of native and inhibited forms of human cathepsin D: implications for lysosomal targeting and drug design Proc Natl Acad Sci U S A (15-7-1993) 90, 6796-6800. PubMed Europe PubMed PMC EPMC S
Cavailles,V., Augereau,P. and Rochefort,H. Cathepsin D gene is controlled by a mixed promoter, and estrogens stimulate only TATA-dependent transcription in breast cancer cells Proc Natl Acad Sci U S A (1993) 90, 203-207. PubMed Europe PubMed DOI PMC EPMC
Metcalf,P. and Fusek,M. Two crystal structures for cathepsin D: the lysosomal targeting signal and active site EMBO J (1993) 12, 1293-1302. PubMed Europe PubMed PMC EPMC S
Rao,C., Scarborough,P.E., Lowther,W.T., Kay,J., Batley,B., Rapundalo,S., Klutchko,S., Taylor,M.D. and Dunn,B.M. Structure-function database for active site binding to the aspartic proteinases Adv Exp Med Biol (1993) 306, 143-147.
Scarborough,P.E., Guruprasad,K., Topham,C., Richo,G.R., Conner,G.E., Blundell,T.L. and Dunn,B.M. Exploration of subsite binding specificity of human cathepsin D through kinetics and rule-based molecular modeling Protein Sci (1993) 2, 264-276. PubMed Europe PubMed DOI PMC EPMC
Scarborough,P.E., Beyer,B.M., Rafanan,M.M. and Dunn,B.M. Mutagenesis of human cathepsin D as dictated by kinetics and rule-based molecular modelling Protein Eng Des Sel (1993) 6, 37- DOI

1992

Carraway,R.E., Mitra,S.P. and Salmonsen,R. Pepsin-mediated processing of synthetic precursor-like sequence yields neurotensin-like peptide Peptides (1992) 13, 319-322. PubMed Europe PubMed DOI
[YEAR:25-10-1992]Cho,W.L. and Raikhel,A.S. Cloning of cDNA for mosquito lysosomal aspartic protease. Sequence analysis of an insect lysosomal enzyme similar to cathepsins D and E J Biol Chem (25-10-1992) 267, 21823-21829. PubMed Europe PubMed
Retzek,H., Steyrer,E., Sanders,E.J., Nimpf,J. and Schneider,W.J. Molecular cloning and functional characterization of chicken cathepsin D, a key enzyme for yolk formation DNA Cell Biol (1992) 11, 661-672. PubMed Europe PubMed

1991

[YEAR:15-1-1991]Horst,M. and Hasilik,A. Expression and maturation of human cathepsin D in baby-hamster kidney cells Biochem J (15-1-1991) 273, 355-361. PubMed Europe PubMed PMC EPMC
Redecker,B., Heckendorf,B., Grosch,H.W., Mersmann,G. and Hasilik,A. Molecular organization of the human cathepsin D gene DNA Cell Biol (1991) 10, 423-431. PubMed Europe PubMed
Scarborough,P.E., Richo,G.R., Kay,J., Conner,G.E. and Dunn,B.M. Comparison of kinetic properties of native and recombinant human cathepsin D Adv Exp Med Biol (1991) 306, 343-347. PubMed Europe PubMed
Smith,L.J. and Yada,Y.R. Chemical modification of amino groups in Mucor miehei aspartyl proteinase, porcine pepsin, and chymosin. II. Conformational stability Agric Biol Chem (1991) 55, 2017-2024. DOI
Smith,L.J., Billings,E.G. and Yada,Y.R. Chemical modification of amino groups in Mucor miehei aspartyl proteinase, porcine pepsin, and chymosin. I. Structure and function Agric Biol Chem (1991) 55, 2009-2016. DOI

1990

Birch,N.P. and Loh,Y.P. Cloning, sequence and expression of rat cathepsin D Nucleic Acids Res (1990) 18, 6445-6446. PubMed Europe PubMed PMC EPMC
Conner,G.E. and Udey,J.A. Expression and refolding of recombinant human fibroblast procathepsin D DNA Cell Biol (1990) 9, 1-9. PubMed Europe PubMed

1989

Conner,G.E. Isolation of procathepsin D from mature cathepsin D by pepstatin affinity chromatography. Autocatalytic proteolysis of the zymogen form of the enzyme Biochem J (1989) 263, 601-604. PubMed Europe PubMed PMC EPMC I
Samarel,A.M., Ferguson,A.G., Decker,R.S. and Lesch,M. Effects of cysteine protease inhibitors on rabbit cathepsin D maturation Am J Physiol (1989) 257, C1069-C1079. PubMed Europe PubMed

1988

[YEAR:15-12-1988]D'Agrosa,R.M. and Callahan,J.W. In vitro activation of neuraminidase in the beta-galactosidase-neuraminidase-protective protein complex by cathepsin C Biochem Biophys Res Commun (15-12-1988) 157, 770-775. PubMed Europe PubMed
Jacobson,L.A., Jen-Jacobson,L., Hawdon,J.M., Owens,G.P., Bolanowski,M.A., Emmons,S.W., Shah,M.V., Pollock,R.A. and Conklin,D.S. Identification of a putative structural gene for cathepsin D in Caenorhabditis elegans Genetics (1988) 119, 355-363. PubMed Europe PubMed PMC EPMC

1987

Gildberg,A. Purification and characterisation of cathepsin D from the digestive gland of the pelagic squid Todarodes sagittatus J Sci Food Agric (1987) 39, 85-94. DOI
Imoto,T., Okazaki,K., Koga,H. and Yamada,H. Specificity of rat liver cathepsin D J Biochem (1987) 101, 575-580. PubMed Europe PubMed

1986

Agarwal,N.S. and Rich,D.H. Inhibition of cathepsin D by substrate analogues containing statine and by analogues of pepstatin J Med Chem (1986) 29, 2519-2524. PubMed Europe PubMed I

1985

Gieselmann,V., Hasilik,A. and von Figura,K. Processing of human cathepsin D in lysosomes in vitro J Biol Chem (1985) 260, 3215-3220. PubMed Europe PubMed

1984

Nakao,Y., Kozutsumi,Y., Kawasaki,T., Yamashina,I., van Halbeek,H. and Vliegenthart,J.F.G. Oligosaccharides on cathepsin D from porcine spleen Arch Biochem Biophys (1984) 229, 43-54. PubMed Europe PubMed

1983

[YEAR:1-4-1983]Agarwal,N. and Rich,D.H. An improved cathepsin-D substrate and assay procedure Anal Biochem (1-4-1983) 130, 158-165. PubMed Europe PubMed A
Watabe,S. and Yago,N. Phospholipids activate cathepsin D Biochem Biophys Res Commun (1983) 110, 934-939. PubMed Europe PubMed

1982

Hasilik,A., von Figura,K., Conzelmann,E., Nehrkorn,H. and Sandhoff,K. Lysosomal enzyme precursors in human fibroblasts. Activation of cathepsin D precursor in vitro and activity of beta-hexosaminidase A precursor towards ganglioside GM2 Eur J Biochem (1982) 125, 317-321. PubMed Europe PubMed
Hembry,R.M., Knight,C.G., Dingle,J.T. and Barrett,A.J. Evidence that extracellular cathepsin D is not responsible for the resorption of cartilage matrix in culture Biochim Biophys Acta (1982) 714, 307-312. PubMed Europe PubMed
[YEAR:1-6-1982]Kay,J., Afting,E.G., Aoyagi,T. and Dunn,B.M. The effects of lactoyl-pepstatin and the pepsin inhibitor peptide on pig cathepsin D Biochem J (1-6-1982) 203, 795-797. PubMed Europe PubMed PMC EPMC I

1981

[YEAR:28-9-1981]Puizdar,V. and Turk,V. Cathepsinogen D: characterization and activation to cathepsin D and inhibitory peptides FEBS Lett (28-9-1981) 132, 299-304. PubMed Europe PubMed I
Takahashi,T. and Tang,J. Cathepsin D from porcine and bovine spleen Methods Enzymol (1981) 80, 565-581. PubMed Europe PubMed DOI V

1980

Doke,S.N. and Nadkarni,G.B. Characterization of cathepsin D from the skeletal muscle of fresh water fish, Tilapia mossambica Agric Biol Chem (1980) 44, 1521-1528. DOI
[YEAR:25-5-1980]Hasilik,A. and Neufeld,E.F. Biosynthesis of lysosomal enzymes in fibroblasts. Synthesis as precursors of higher molecular weight J Biol Chem (25-5-1980) 255, 4937-4945. PubMed Europe PubMed

1979

Dionyssiou-Asteriou,A. and Rakitzis,E.T. Activation of cathepsin D by glycine ethyl ester Biochem J (1979) 177, 355-356. PubMed Europe PubMed PMC EPMC
Whitaker,J.N. and Seyer,J.M. The sequential limited degradation of bovine myelin basic protein by bovine brain cathepsin D J Biol Chem (1979) 254, 6956-6963. PubMed Europe PubMed

1978

Dionyssiou-Asteriou,A. and Rakitzis,E.T. Inactivation of cathepsin D from human gastric mucosa and from stomach carcinoma by diazoacetyl-DL-norleucine methyl ester Biochem Pharmacol (1978) 27, 827-829. PubMed Europe PubMed DOI I

1977

Barrett,A.J. Cathepsin D and other carboxyl proteinases (1977) 1, 209-248.
Keilova,H. and Tomasek,V. Naturally occurring inhibitors of intracellular proteinases Acta Biol Med Ger (1977) 36, 1873-1881. PubMed Europe PubMed
Woessner,J.F., Jr. Specificity and biological role of cathepsin D Adv Exp Med Biol (1977) 95, 313-327. PubMed Europe PubMed

1976

[YEAR:21-6-1976]Fraki,J.E. Human skin proteases. Separation and characterization of two acid proteases resembling cathepsin B1 and cathepsin D and of an inhibitor of cathepsin B1 Arch Dermatol Res (21-6-1976) 255, 317-330. PubMed Europe PubMed
Keilova,H. and Tomasek,V. Further characteristics of cathepsin D inhibitor from potatoes Collect Czech Chem Commun (1976) 41, 2440-2447.
Keilova,H. and Tomasek,V. Isolation and some properties of cathepsin D inhibitor from potatoes Collect Czech Chem Commun (1976) 41, 489-497.
Knight,C.G. and Barrett,A.J. Interaction of human cathepsin D with the inhibitor pepstatin Biochem J (1976) 155, 117-125. PubMed Europe PubMed PMC EPMC I

1974

Misono,K., Murakami,K., Michelakis,A., Inagami,T. and Lin,T.Y. Characterization of submaxillary renin and comparison with cathepsin D Fed Proc (1974) 33
Sampath-Kumar,P.S. and Fruton,J.S. Studies on the extended active sites of acid proteinases Proc Natl Acad Sci U S A (1974) 71, 1070-1072. PubMed Europe PubMed PMC EPMC P

1973

Ferguson,J.B., Andrews,J.R., Voynick,I.M. and Fruton,J.S. The specificity of cathepsin D J Biol Chem (1973) 248, 6701-6708. PubMed Europe PubMed P
Woessner,J.F., Jr. Purification of cathepsin D from cartilage and uterus and its action on the protein-polysaccharide complex of cartilage J Biol Chem (1973) 248, 1634-1642. PubMed Europe PubMed

1972

Barrett,A.J. and Dingle,J.T. The inhibition of tissue acid proteinases by pepstatin Biochem J (1972) 127, 439-441. PubMed Europe PubMed PMC EPMC I
Harris,E.D., Locke,S. and Lin,T.-Y. Limited degradation of gelatin substrate by cathepsin D Connect Tissue Res (1972) 1, 103-108. DOI
Iodice,A.A., Chin,J., Perker,S. and Weinstock,I.M. Cathepsins A, B, C, D and autolysis during development of breast muscle of normal and dystrophic chickens Arch Biochem Biophys (1972) 152, 166-174. PubMed Europe PubMed
Keilova,H. and Tomasek,V. Effect of pepsin inhibitor from Ascaris lumbricoides on cathepsin D and E Biochim Biophys Acta (1972) 284, 461-464. PubMed Europe PubMed
Poole,A.R., Dingle,J.T. and Barrett,A.J. The immunocytochemical demonstration of cathepsin D J Histochem Cytochem (1972) 20, 261-265. PubMed Europe PubMed
Woessner,J.F., Jr. Pepstatin inhibits the digestion of hemoglobin and protein-polysaccharide complex by cathepsin D Biochem Biophys Res Commun (1972) 47, 965-970. PubMed Europe PubMed I

1970

Barrett,A.J. Cathepsin D. Purification of isoenzymes from human and chicken liver Biochem J (1970) 117, 601-607. PubMed Europe PubMed PMC EPMC

1969

Keilova,H., Markovic,O. and Keil,B. Characterisation and chemical modification of cathepsin D from bovine spleen Collect Czech Chem Commun (1969) 34, 2154-2157.
Smith,G.D., Murray,M.A., Nichol,L.W. and Trikojus,V.M. Thyroid acid proteinase. Properties and inactivation by diazoacetyl-norleucine methyl ester Biochim Biophys Acta (1969) 171, 288-298. PubMed Europe PubMed I
Stepanov,V.M., Orekhovich,V.N., Lobareva,L.S. and Mzhel'skaia,T.I. [Action of the pepsin inhibitor on bovine spleen cathepsin D] Biokhimiia (1969) 34, 209-210. PubMed Europe PubMed
Suzuki,A., Okitani,A. and Fujimaki,M. Studies on proteolysis in stored muscle: part III. Some physicochemical properties and proteolytic specificity of the rabbit muscular cathepsin D Agric Biol Chem (1969) 33, 579-585. DOI
Weston,P.D. A specific antiserum to lysosomal cathepsin D Immunology (1969) 17, 421-428. PubMed Europe PubMed PMC EPMC

1968

Keilova,H., Blaha,K. and Keil,B. Effect of steric factors on digestibility of peptides containing aromatic amino acids by cathepsin D and pepsin Eur J Biochem (1968) 4, 442-447. PubMed Europe PubMed P
Keilova,H. and Keil,B. On proteins. CXIII. Specificity of cleavage of heptapeptide substrate with bovine spleen cathepsin D Collect Czech Chem Commun (1968) 33, 131-140. P

1967

Barrett,A.J. Lysosomal acid proteinase of rabbit liver Biochem J (1967) 104, 601-608. PubMed Europe PubMed

1966

Parrish,F.C., Jr. and Bailey,M.E. Food processing - physicochemical properties and partial purification of porcine muscle cathepsin J Agric Food Chem (1966) 14, 232-237.

1963

McMaster,P.B. and Webb,T. [The purification and properties of cathepsin D from human spleen] Ann Inst Pasteur (Paris) (1963) 104, 90-101. PubMed Europe PubMed

1960

Press,E.M., Porter,R.R. and Cebra,J. The isolation and properties of a proteolytic enzyme, cathepsin D, from bovine spleen Biochem J (1960) 74, 501-514. PubMed Europe PubMed PMC EPMC

1940

[YEAR:20-7-1940]Anson,M.L. The purification of cathepsin J Gen Physiol (20-7-1940) 23, 695-704. PubMed Europe PubMed DOI

1939

[YEAR:20-9-1938]Anson,M.L. The estimation of pepsin, trypsin, papain and cathepsin with hemoglobin J Gen Physiol (20-9-1938) 22, 79-89. PubMed Europe PubMed DOI A

1937

Anson,M.L. The estimation of cathepsin with hemoglobin and the partial purification of cathepsin J Gen Physiol (1937) 20, 565-574. PubMed Europe PubMed DOI A

1903

Hedin,S.G. Investigations on the proteolytic enzymes of the spleen of the ox J Physiol (1903) 30, 155-175. PubMed Europe PubMed