Literature for peptidase S08.039: PCSK9 peptidase

(References are filtered for relevance to Knockout. To remove the filter click here. See explanation.)

2024
1. Fassi,E.M.A., Citarella,A., Albani,M., Milano,E.G., Legnani,L., Lammi,C., Silvani,A. and Grazioso,G.
   PCSK9 inhibitors: a patent review 2018-2023
   Expert Opin Ther Pat1-17. PubMed  Europe PubMed DOI  K
2. Siddiqui,Z. and Frishman,W.
   New Oral PCSK9 Inhibitor: "MK-0616"
   Cardiol Rev PubMed  Europe PubMed DOI  K  I
3. Wang,Y., Chen,Y., Yang,J., Sun,W. and Zhang,X.
   Histone demethylase JMJD1C advances macrophage foam cell formation and atherosclerosis progression by promoting the transcription of PCSK9
   J Physiol Biochem PubMed  Europe PubMed DOI  K
2023
4. Cale,J.M., Ham,K.A., Li,D., McIntosh,C.S., Watts,G.F., Wilton,S.D. and Aung-Htut,M.T.
   Induced alternative splicing an opportunity to study PCSK9 protein isoforms at physiologically relevant concentrations
   Sci Rep13, 19725-19725. PubMed  Europe PubMed DOI  K
5. Chan,D.C. and Watts,G.F.
   The Promise of PCSK9 and Lipoprotein(a) as Targets for Gene Silencing Therapies
   Clin Ther45, 1034-1046. PubMed  Europe PubMed DOI  K  V
6. Fruchart Gaillard,C., Ouadda,A.B.D., Ciccone,L., Girard,E., Mikaeeli,S., Evagelidis,A., Le Devehat,M., Susan-Resiga,D., Lajeunesse,E.C., Nozach,H., Ramos,O.H.P., Thureau,A., Legrand,P., Prat,A., Dive,V. and Seidah,N.G.
   Molecular interactions of PCSK9 with an inhibitory nanobody, CAP1 and HLA-C: Functional regulation of LDLR levels
   Mol Metab67, 101662-101662. PubMed  Europe PubMed DOI  K
7. Luan,C., He,Y., Liu,W., Rong,Y., Gao,J., Xu,K., Yu,H., Hu,Y., Zhang,J., Chen,K. and Guo,W.
   PCSK9 inhibition interrupts the cross-talk between keratinocytes and macrophages and prevents UVB-induced skin damage
   J Biol Chem299, 104895-104895. PubMed  Europe PubMed DOI  K
2022
8. Huang,G., Lu,X., Duan,Z., Zhang,K., Xu,L., Bao,H., Xiong,X., Lin,M., Li,C., Li,Y., Zhou,H., Luo,Z. and Li,W.
   PCSK9 Knockdown Can Improve Myocardial Ischemia/Reperfusion Injury by Inhibiting Autophagy
   Cardiovasc Toxicol22, 951-961. PubMed  Europe PubMed DOI  K
9. Katzmann,J.L., Cupido,A.J. and Laufs,U.
   Gene Therapy Targeting PCSK9
   Metabolites12, PubMed  Europe PubMed DOI  K  V
10. Saitoski,K., Ryaboshapkina,M., Hamza,G.M., Jarnuczak,A.F., Berthault,C., Carlotti,F., Armanet,M., Sengupta,K., Underwood,C.R., Andersson,S., Guillas,I., Le Goff,W. and Scharfmann,R.
    Proprotein convertase PCSK9 affects expression of key surface proteins in human pancreatic beta cells via intracellular and extracellular regulatory circuits
    J Biol Chem298, 102096-102096. PubMed  Europe PubMed DOI  K
11. Seidah,N.G. and Garcon,D.
    Expanding Biology of PCSK9: Roles in Atherosclerosis and Beyond
    Curr Atheroscler Rep24, 821-830. PubMed  Europe PubMed DOI  K  V
2021
12. Ma,N., Fan,L., Dong,Y., Xu,X., Yu,C., Chen,J. and Ren,J.
    New PCSK9 inhibitor miR-552-3p reduces LDL-C via enhancing LDLR in high fat diet-fed mice
    Pharmacol Res167, 105562-105562. PubMed  Europe PubMed DOI  K
13. Mahboobnia,K., Pirro,M., Marini,E., Grignani,F., Bezsonov,E.E., Jamialahmadi,T. and Sahebkar,A.
    PCSK9 and cancer: Rethinking the link
    Biomed Pharmacother140, 111758-111758. PubMed  Europe PubMed DOI  K  V
14. Musunuru,K., Chadwick,A.C., Mizoguchi,T., Garcia,S.P., DeNizio,J.E., Reiss,C.W., Wang,K., Iyer,S., Dutta,C., Clendaniel,V., Amaonye,M., Beach,A., Berth,K., Biswas,S., Braun,M.C., Chen,H.M., Colace,T.V., Ganey,J.D., Gangopadhyay,S.A., Garrity,R., Kasiewicz,L.N., Lavoie,J., Madsen,J.A., Matsumoto,Y., Mazzola,A.M., Nasrullah,Y.S., Nneji,J., Ren,H., Sanjeev,A., Shay,M., Stahley,M.R., Fan,S.H.Y., Tam,Y.K., Gaudelli,N.M., Ciaramella,G., Stolz,L.E., Malyala,P., Cheng,C.J., Rajeev,K.G., Rohde,E., Bellinger,A.M. and Kathiresan,S.
    In vivo CRISPR base editing of PCSK9 durably lowers cholesterol in primates
    Nature593, 429-434. PubMed  Europe PubMed DOI  K
15. Peyot,M.L., Roubtsova,A., Lussier,R., Chamberland,A., Essalmani,R., Murthy Madiraju,S.R., Seidah,N.G., Prentki,M. and Prat,A.
    Substantial PCSK9 inactivation in beta-cells does not modify glucose homeostasis or insulin secretion in mice
    Biochim Biophys Acta Mol Cell Biol Lipids1866, 158968-158968. PubMed  Europe PubMed DOI  K
16. Seidah,N.G. and Prat,A.
    The multifaceted biology of PCSK9
    Endocr Rev PubMed  Europe PubMed DOI  K
17. Stulz,R., Milligan,F., Stovold,C., Love,I., Stromberg,R., Andersson,S. and Dahlen,A.
    (34)S-SIL of PCSK9-Active Oligonucleotide as Tools for Accurate Quantification by Mass Spectrometry
    Nucleic Acid Ther PubMed  Europe PubMed DOI  K
2017
18. Lintner,N.G., McClure,K.F., Petersen,D., Londregan,A.T., Piotrowski,D.W., Wei,L., Xiao,J., Bolt,M., Loria,P.M., Maguire,B., Geoghegan,K.F., Huang,A., Rolph,T., Liras,S., Doudna,J.A., Dullea,R.G. and Cate,J.H.
    Selective stalling of human translation through small-molecule engagement of the ribosome nascent chain
    PLoS Biol15, e2001882-e2001882. PubMed  Europe PubMed DOI  K
2016
19. Ferri,N., Marchiano,S., Tibolla,G., Baetta,R., Dhyani,A., Ruscica,M., Uboldi,P., Catapano,A.L. and Corsini,A.
    PCSK9 knock-out mice are protected from neointimal formation in response to perivascular carotid collar placement
    Atherosclerosis253, 214-224. PubMed  Europe PubMed DOI  K
20. Wang,X., Raghavan,A., Chen,T., Qiao,L., Zhang,Y., Ding,Q. and Musunuru,K.
    CRISPR-Cas9 targeting of PCSK9 in human hepatocytes in vivo - brief report
    Arterioscler Thromb Vasc Biol36, 783-786. PubMed  Europe PubMed DOI  K
2015
21. Berger,J.M., Vaillant,N., Le May,C., Calderon,C., Bregeon,J., Prieur,X., Hadchouel,J., Loirand,G. and Cariou,B.
    PCSK9-deficiency does not alter blood pressure and sodium balance in mouse models of hypertension
    Atherosclerosis239, 252-259. PubMed  Europe PubMed DOI  K
22. van Poelgeest,E.P., Hodges,M.R., Moerland,M., Tessier,Y., Levin,A.A., Persson,R., Lindholm,M.W., Dumong Erichsen,K., Orum,H., Cohen,A.F. and Burggraaf,J.
    Antisense-mediated reduction of proprotein convertase subtilisin/kexin type 9 (PCSK9): a first-in-human randomized, placebo-controlled trial
    Br J Clin Pharmacol80, 1350-1361. PubMed  Europe PubMed DOI  K
2012
23. Denis,M., Marcinkiewicz,J., Zaid,A., Gauthier,D., Poirier,S., Lazure,C., Seidah,N.G. and Prat,A.
    Gene inactivation of proprotein convertase subtilisin/kexin type 9 reduces atherosclerosis in mice
    Circulation125, 894-901. PubMed  Europe PubMed DOI  K
24. Sun,X., Essalmani,R., Day,R., Khatib,A.M., Seidah,N.G. and Prat,A.
    Proprotein convertase subtilisin/kexin type 9 deficiency reduces melanoma metastasis in liver
    Neoplasia14, 1122-1131. PubMed  Europe PubMed DOI  K
2010
25. Gupta,N., Fisker,N., Asselin,M.C., Lindholm,M., Rosenbohm,C., Orum,H., Elmen,J., Seidah,N.G. and Straarup,E.M.
    A locked nucleic acid antisense oligonucleotide (LNA) silences PCSK9 and enhances LDLR expression in vitro and in vivo
    PLoS ONE5, e10682-e10682. PubMed  Europe PubMed DOI  K
26. Mbikay,M., Sirois,F., Mayne,J., Wang,G.S., Chen,A., Dewpura,T., Prat,A., Seidah,N.G., Chretien,M. and Scott,F.W.
    PCSK9-deficient mice exhibit impaired glucose tolerance and pancreatic islet abnormalities
    FEBS Lett584, 701-706. PubMed  Europe PubMed DOI  K
2009
27. Le May,C., Kourimate,S., Langhi,C., Chetiveaux,M., Jarry,A., Comera,C., Collet,X., Kuipers,F., Krempf,M., Cariou,B. and Costet,P.
    Proprotein convertase subtilisin kexin type 9 null mice are protected from postprandial triglyceridemia
    Arterioscler Thromb Vasc Biol29, 684-690. PubMed  Europe PubMed DOI  K
2006
28. Poirier,S., Prat,A., Marcinkiewicz,E., Paquin,J., Chitramuthu,B.P., Baranowski,D., Cadieux,B., Bennett,H.P. and Seidah,N.G.
    Implication of the proprotein convertase NARC-1/PCSK9 in the development of the nervous system
    J Neurochem98, 838-850. PubMed  Europe PubMed DOI  K
29. Scamuffa,N., Calvo,F., Chretien,M., Seidah,N.G. and Khatib,A.M.
    Proprotein convertases: lessons from knockouts
    FASEB J20, 1954-1963. PubMed  Europe PubMed DOI  K  V
2005
30. [YEAR:12-4-2005]Rashid,S., Curtis,D.E., Garuti,R., Anderson,N.N., Bashmakov,Y., Ho,Y.K., Hammer,R.E., Moon,Y.A. and Horton,J.D.
    Decreased plasma cholesterol and hypersensitivity to statins in mice lacking Pcsk9
    Proc Natl Acad Sci U S A102, 5374-5379. PubMed  Europe PubMed DOI  K